Abstract: The present invention relates to novel 4-substituted pyridine-2,6-dicarboxylic acid derivatives, compounds of formula I, wherein R1 and R2 are defined herein. The compounds of formula I are useful for making pharmaceutical compositions to treat proliferative diseases. The present invention also relates to concise methods for preparing compounds of formula I that may be performed under mild reaction conditions.

Abstract: There are provided a localized surface plasmon resonance sensing chip in which a linewidth of an absorption spectrum originating from localized plasmon resonance is narrow and with which a peak wavelength shift of an optical spectrum accompanying a change in refractive index of a surface can be accurately measured, and a localized surface plasmon resonance sensing system using this sensing chip. A sensing chip 10 includes a base 14 having a flat-plate shape, a plurality of protruding portions 16, and a metal layer 18 covering each front surface of the plurality of protruding portions 16. The protruding portions 16 each have a shape like a semi-oblate spheroid which is one of three-dimensional parts obtained by dividing an oblate spheroid in half along an equatorial plane and are arranged such that a divided surface 16a of the semi-oblate spheroid faces a front surface 14a of the base 14.

Abstract: The present invention provides a communication method based on an assembled communication protocol stack. The method comprises: construct protocols to form protocol modules, and place the protocol modules into a protocol module library; extract required protocol modules from the protocol module library, and assemble the extracted protocol modules to form a communication protocol stack; install the assembled communication protocol stack into a protocol stack running device; and an application on the protocol stack running device implements data communication by using the installed protocol stack. The specific process of constructing protocol modules comprises: constructing execution codes of protocols corresponding to an operating system to form protocol modules; and defining PDUs, that is, defining a corresponding data length and a data structure when each protocol module is in a mutual input/output relationship with other protocol modules in the protocol module library.

Abstract: In situ investigation of microbial life in extreme environments can be carried out with microscopes capable of imaging 3-dimensional volumes and tracking particle motion. A lensless digital holographic microscope is disclosed that provides roughly 1.5 micron resolution in a compact, robust package suitable for remote deployment. High resolution is achieved by generating high numerical-aperture input beams with radial gradient-index rod lenses. The ability to detect and track prokaryotes was explored using bacterial strains of two different sizes. In the larger strain, a variety of motions were seen, while the smaller strain was used to demonstrate a detection capability down to micron scales.

Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

Abstract: The present invention relates to a new gene fragment derived from Chinese hamster ovary (CHO) cell for enhancement of recombinant protein expression in animal cells and a use thereof. It has been found that using the vector comprising a gene fragment of the present invention enhances the expression of a target protein in animal cells. Accordingly, the vector comprising a gene fragment of the present invention could be usefully used in the production of biopharmaceuticals such as therapeutic antibodies, etc.

Abstract: The invention relates in aspects to hybrid RNAs lacking a poly-A tail and nucleic acid vectors for expressing the RNA. The hybrid RNAs in some instances have a 3? terminal stabilizing triple helical structure. Related methods for expressing said RNAs in vivo and in vitro are also disclosed.

Abstract: This invention provides a method for a first communication device, such as a base station, to estimate a channel-quality profile of a channel when a second communication device, e.g., a user equipment, returns only channel-quality indicators (CQIs) of selected subbands and a wideband CQI. The profile is obtained by including, for any two neighboring frequencies of the selected subbands, an estimated CQI of a middle frequency between the two neighboring frequencies. After translating the CQIs of the two neighboring frequencies into corresponding linear CQI values, a linear estimated-CQI value for the middle frequency is determined by subtracting an offset from an average of said corresponding linear CQI values. The offset is determined according to a frequency separation between the two neighboring frequencies. Preferably, the offset is linearly proportional to the frequency separation. Interpolation, preferably linear interpolation, is used to obtain linear CQI values of other frequencies.

Abstract: Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.

Abstract: A master device, a slave device, and methods are disclosed. The method is performed by a first slave device connected to a master-slave tree network, comprising: determining whether a beacon has not been received within a predetermined time period; and distributing a first beacon to a second slave device if no beacon has been received within the predetermined time period; wherein for the first slave device to remain in the master-slave-network, a beacon be received by the first slave device within the predetermined time period.

Abstract: The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

Abstract: The present invention relates to a CT contrast agent for detecting a thrombus, comprising fibrin-targeted peptide sequence-conjugated glycol chitosan-gold nanoparticles. The CT contrast agent for detecting a thrombus according to an embodiment of the present invention may allow rapid and repeated acquisition of CT image information related to the size and location of a thrombus in cardio-cerebral vascular thrombosis, and also enables the imaging monitoring of cerebral thrombus.

Abstract: Disclosed is an apparatus and method for calculating a raw-cost necessary for combining images into one image by matching of stereo images. The raw-cost calculation apparatus includes an image acquirer, a window generator, a window mask generator, a window masker, and a raw-cost calculator. In the raw-cost calculation apparatus and method, a raw cost may be calculated by using an adaptive window mask so that accurate 3D information may be obtained on the boundary of thin structures even when stereo images are matched and combined.

Abstract: A method for preparing a light olefin using an oxygen-containing compound, and a device for use thereof, more specifically, taking methanol and/or dimethyl ether as main starting materials, using a multi-stage (n?2) dense phase fluidized bed reactor and a multi-stage (m?2) catalyst regenerator, which solves the problem in the prior art of the uniformity of catalyst carbon deposition and the carbon content being difficult to control and the light olefin selectivity being low.

Abstract: Systems and methods axe disclosed herein that generally involve a double pinch criterion for optimization of regenerative Rankine cycles. In some embodiments, operating variables such as bleed extraction pressure and bleed flow rate are selected such that a double pinch is obtained in a feedwater heater, thereby improving the efficiency of the Rankine cycle. In particular, a first pinch point is obtained at the onset of condensation of the bleed and a second pinch point is obtained at the exit of the bleed from the feedwater heater. The minimal approach temperature at the first pinch point can be approximately equal to the minimal approach temperature at the second pinch point. Systems that employ regenerative Rankine cycles, methods of operating such systems, and methods of optimizing the operation of such systems are disclosed herein in connection with the double pinch criterion.

Abstract: An apparatus for quantum cryptographic communication includes a light source configured to generate an optical pulse which is transmitted to a plurality of quantum code sending devices, and a quantum entanglement measuring unit configured to receive the optical signal generated from each of the plurality of quantum code sending devices and measure a relation among quantum states of the optical signals received from the plurality of quantum code sending devices; the optical signal being generated by encoding a key to a quantum state of the optical pulse. The apparatus for quantum cryptographic communication may further include a signal direction determining unit, a reflector for reflecting the optical pulse or the optical signal, an arbitrary phase shifter, or a modulator for encoding a digital signal corresponding to the key to the optical pulse.

Abstract: The present invention is a method for forming a porous film of an inorganic substance on a base material by spraying fine particles of an inorganic substance on the base material such that the fine particles are bonded to the base material and bonded to one another, in which the fine particles include at least two kinds of fine particles which are small-size particles and large-size particles having different average particle sizes. According to the present invention, it is possible to provide a film forming method for forming a porous film formed of an inorganic substance without requiring a baking step, a body having a film formed thereon that is produced by the film forming method, and a dye-sensitized solar cell including the body having a film formed thereon.

Abstract: A control device using image tracking technology for controlling overhead crane system is disclosed, in which a plurality of image capturers are used to monitor a operating space and a position of the hoisted load, a respective image of two of which are used to establish a 3D coordinate data, so that an image processor calculates parameters including a hoisted load position (P), a swing angle (?) and a cable length (l) by referring to the images received, and generates a feedback signal to a crane controller. The crane controller issues a drive signal according to the feedback signal to drive the overhead crane system.

Abstract: The present disclosure relates to a dual-channel orthogonal carriers assisted optical signal transmitting device, and a direct detection method and a direct detection system using the dual-channel orthogonal carriers assisted optical signal. The direct detection system using the dual-channel orthogonal carriers assisted optical signal comprises a transmitting device and a receiving device. The transmitting device is configured to generate and transmit a dual-channel orthogonal carriers assisted optical signal to be detected, wherein the dual-channel orthogonal carriers assisted optical signal is modulated with a modulation signal. The receiving device is configured to receive the dual-channel orthogonal carriers assisted optical signal, and recover amplitude and phase information of the modulation signal based on the dual-channel orthogonal carriers assisted optical signal.

Abstract: Isoxazoles of formula (A) or (B) are inhibitors of HSP90 activity, and useful for treatment of, for example cancers: wherein R1, is a group of formula (IA): —Ar1-(Alk1)p-(Z)r-(Alk2)s-Q, wherein in any compatible combination Ar1 is an optionally substituted aryl or heteroaryl radical, Alk1 and Alk2 are optionally substituted divalent C1-C6 alkylene or C2-C6 alkenylene radicals, p, r and s are independently 0 or 1, Z is —O—, —S—, —(C?O)—, —(C?S)—, —SO.sub.