Patents Assigned to INSTITUTE
  • Method of Treating Mixed Lineage Leukemia Gene-Rearranged Acute Lymphoblastic Leukemias
    Publication number: 20170209458
    Abstract: The present invention relates to a method of treating a warm-blooded animal, especially a human, having Mixed Lineage Leukemia (MLL rearranged ALL) comprising administering to said animal a therapeutically effective amount of a staurosporine derivative, especially PKC412 or a pharmaceutically acceptable salt thereof, alone or in combination with further therapeutic measures, for example, those defined herein; to the use of a staurosporine derivative for the preparation of a medicament for the treatment of MLL rearranged ALL; and to a commercial package comprising a staurosporine derivative together with instructions for its use in the treatment of MLL rearranged ALL.
    Type: Application
    Filed: October 30, 2015
    Publication date: July 27, 2017
    Applicant: DANA-FARBER CANCER INSTITUTE INC.
    Inventors: James Douglas Griffin, Doriano Fabbro, Scott A. Armstrong
  • PHARMACEUTICAL COMPOSITION FOR TREATING OR ALLEVIATING AUTOIMMUNE-RELATED DISEASES AND METHOD FOR TREATING OR ALLEVIATING AUTOIMMUNE-RELATED DISEASES
    Publication number: 20170209519
    Abstract: A pharmaceutical composition for treating or alleviating autoimmune-related diseases is provided, including an extract of Amomum tsao-ko as an active ingredient and a pharmaceutically acceptable carrier, in which the extract comprises Vanillin, Tsaokoin, or the combination thereof.
    Type: Application
    Filed: January 26, 2017
    Publication date: July 27, 2017
    Applicant: Industrial Technology Research Institute
    Inventors: Kuo-Kuei HUANG, I-Horng PAN, Meng-Nan LIN, Jir-Mehng LO, Jennline SHEU, Pei-Ru LIAU, Yi-Cheng CHENG
  • METHOD AND COMPOSITIONS FOR ORALLY ADMINISTERED CONTRAST AGENTS FOR MR IMAGING
    Publication number: 20170209602
    Abstract: Disclosed is CT or MR contrast agent which comprises a base or carrier scaffold formed of a polyhydroxol compound having a linker to which a Gd-DOTA is covalently bonded. Also disclosed is a method of screening a patient for colon cancer using a CT or MR contrast, which method comprises administering to a patient undergoing screening a compound as above described.
    Type: Application
    Filed: May 11, 2015
    Publication date: July 27, 2017
    Applicants: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, H. Lee Moffitt Cancer Center and Research Institute
    Inventors: Eugene A. Mash, Parastou Foroutan, Navath Suryakiran, Robert J. Gillies, Gary V. Martinez, David L. Morse
  • INVERSE REINFORCEMENT LEARNING BY DENSITY RATIO ESTIMATION
    Publication number: 20170213151
    Abstract: A method of inverse reinforcement learning for estimating cost and value functions of behaviors of a subject includes acquiring data representing changes in state variables that define the behaviors of the subject; applying a modified Bellman equation given by Eq. (1) to the acquired data: q(x)+gV(y)?V(x)=?1n{pi(y|x))/(p(y|x)} (1) where q(x) and V(x) denote a cost function and a value function, respectively, at state x, g represents a discount factor, and p(y|x) and pi(y|x) denote state transition probabilities before and after learning, respectively; estimating a density ratio pi(y|x)/p(y|x) in Eq. (1); estimating q(x) and V(x) in Eq. (1) using the least square method in accordance with the estimated density ratio pi(y|x)/p(y|x), and outputting the estimated q(x) and V(x).
    Type: Application
    Filed: August 7, 2015
    Publication date: July 27, 2017
    Applicant: Okinawa Institute of Science and Technology School Corporation
    Inventors: Eiji UCHIBE, Kenji DOYA
  • LOW DROPOUT VOLTAGE (LDO) REGULATOR INCLUDING A DUAL LOOP CIRCUIT AND AN APPLICATION PROCESSOR AND A USER DEVICE INCLUDING THE SAME
    Publication number: 20170212540
    Abstract: A low dropout voltage (LDO) regulator including: a coarse loop circuit configured to receive an input voltage, generate a coarse code and adjust a coarse current according to the coarse code; a digital controller configured to receive the coarse code and generate a fine loop control signal according to the coarse code; and a fine loop circuit configured to receive the input voltage and the fine loop control signal and adjust a fine current according to the input voltage and the fine loop control signal, wherein the coarse current and the fine current adjust a level of an output voltage.
    Type: Application
    Filed: July 21, 2016
    Publication date: July 27, 2017
    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: GYU-HYEONG CHO, YONGJIN LEE, DAE-YONG KIM, SANGHO KIM
  • A METHOD OF CONTROLLING CULTURE WATER TEMPERATURE IN A WATER TANK FOR AQUARIUM FISH AND A CULTURE WATER THERMOSTAT USING A PLURALITY OF PELTIER ELEMENTS
    Publication number: 20170208783
    Abstract: A peltier device comprises peltier elements specified in cooling or heating temperature, a heating heat sink connected in contact on one side surface of the peltier element, a chilling heat sink connected in contact on the other side surface of the peltier element, and a cooling fan. Using peltier elements each of which is specified in a cooling or a heating activity, a heat exchange efficiency is enhanced thank to a plurality of functions of a single peltier element; thermal radiation is separated by bringing the peltier element into contact with a heating heat sink and a cooling heat sink independently from each other; the surface area in contact with the fluid is maximized through the “X” shaped aperture formed with four wings protruding from the inner surface of the aperture towards the center part, directly transferring the endothermic and exothermic effects from the Peltier element to the fluid.
    Type: Application
    Filed: June 22, 2015
    Publication date: July 27, 2017
    Applicant: National Fisheries Research and Development Institute
    Inventors: Minmin JUNG, Bongseok KIM, Jaeu KIM, Sanggu LIM
  • METHOD AND DEVICE FOR CONTROLLING MRI NOISE
    Publication number: 20170209069
    Abstract: A device according to one disclosed embodiment comprises: a control part which determines at least one target frequency of an MRI noise signal generated in an MRI device and generates a control signal for the determined target frequency; and an output part which outputs the control signal, wherein the target frequency is the frequency of the MRI noise signal to be controlled and the control signal is a signal in which at least one of the size and the phase of the MRI noise signal is changed.
    Type: Application
    Filed: September 22, 2015
    Publication date: July 27, 2017
    Applicants: SAMSUNG ELECTRONICS CO., LTD., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Gun-woo LEE, Nokhaeng LEE, Sang-chul KO, Youngjin PARK
  • VIDEO ENCODING AND DECODING METHOD AND APPARATUS USING THE SAME
    Publication number: 20170214942
    Abstract: The present invention is related to a method for moving the position of a base view from an arbitrary GOP (Group Of Pictures) start position to implement an efficient encoding structure in multi-view video encoding. The existing multi-view video encoding method exhibits low encoding efficiency when correlation between the base view and a dependent view is low, since the base view is assumed to be fixed. Moreover, in case the view in a live broadcasting program desired by a producer changes from the base view to another, the user has to consume more bit streams and decoder complexity than those consumed when decoding is performed with respect to the base view. Therefore, to alleviate the drawbacks of the existing multi-view video encoding method, the present invention provides a method for designing syntax elements by which the base view can be moved, thereby supporting an efficient encoding structure.
    Type: Application
    Filed: April 10, 2017
    Publication date: July 27, 2017
    Applicants: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, INDUSTRY-ACADEMIC COOPERATION GROUP OF SEJONG UNIVERSITY
    Inventors: Jung Won KANG, Ha Hyun LEE, Jin Ho LEE, Jin Soo CHOI, Jin Woong KIM, Jong Ki HAN, Jae Yung LEE
  • METHOD AND APPARATUS FOR RECEIVING OR TRANSMITTING DATA
    Publication number: 20170215188
    Abstract: A base station divides a subframe into a downlink time duration for downlink, an uplink time duration for uplink, and a guard period between the downlink time duration and the uplink time duration. The base station transmits a downlink control channel including information on a downlink packet duration allocated for downlink transmission of a terminal and information on an uplink packet duration allocated for uplink transmission of the terminal to the terminal in the downlink time duration.
    Type: Application
    Filed: January 20, 2017
    Publication date: July 27, 2017
    Applicant: Electronics and Telecommunications Research Institute
    Inventors: Cheulsoon KIM, Eunkyung KIM, Gi Yoon PARK, Young Jo KO
  • SEMICONDUCTOR ELEMENT, METHOD FOR MANUFACTURING SAME, SEMICONDUCTOR SUBSTRATE, AND CRYSTAL LAMINATE STRUCTURE
    Publication number: 20170213918
    Abstract: A semiconductor element includes a base substrate that includes a Ga2O3-based crystal having a thickness of not less than 0.05 ?m and not more than 50 ?m, and an epitaxial layer that includes a Ga2O3-based crystal and is epitaxially grown on the base substrate. A semiconductor element includes an epitaxial layer that includes a Ga2O3-based crystal including an n-type dopant, an ion implanted layer that is formed on a surface of the epitaxial layer and includes a higher concentration of n-type dopant than the epitaxial layer, an anode electrode connected to the epitaxial layer, and a cathode electrode connected to the ion implanted layer.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 27, 2017
    Applicants: TAMURA CORPORATION, National Institute of Information and Communications Technology
    Inventors: Kohei SASAKI, Akito KURAMATA, Masataka HIGASHIWAKI
  • NOVEL CRISPR ENZYMES AND SYSTEMS
    Publication number: 20170211142
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
    Type: Application
    Filed: October 21, 2016
    Publication date: July 27, 2017
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Aaron Andrew Smargon, Fenq Zhang
  • NANO-COATING MATERIAL, METHOD FOR MANUFACTURING SAME, COATING AGENT, FUNCTIONAL MATERIAL, AND METHOD FOR MANUFACTURING SAME
    Publication number: 20170214047
    Abstract: A nano-coating material, capable of being bonded to the surface of a metal or an alloy substrate, the nano-coating material includes a compound having, in a polymer main chain, (A) a first side chain or a terminal, each having a binding group containing a benzene ring having at least one pair of adjacent hydroxyl groups; and (B) a functional second side chain.
    Type: Application
    Filed: March 30, 2015
    Publication date: July 27, 2017
    Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
    Inventors: Masanobu NAITO, Debabrata PAYRA, Sachiko HIROMOTO, Alok SINGH
  • NOVEL RECOMBINASES AND TARGET SEQUENCES
    Publication number: 20170211061
    Abstract: The disclosure provides novel large serine recombinases and their respective recognition sites, as well as libraries of orthogonal recombinase recognition sites. Uses of the large serine recombinases, recognition sites, and libraries of orthogonal recombinase recognition sites also are provided.
    Type: Application
    Filed: January 20, 2017
    Publication date: July 27, 2017
    Applicants: Massachusetts Institute of Technology, INRIA (French Institute for Research in Computer Science and Automation)
    Inventors: RON WEISS, Xavier Cesar Duportet, Gregory Batt, Yinqing Li
  • METHOD FOR MEASURING THE DISPLACEMENTS OF A VERTEBRAL COLUMN
    Publication number: 20170209085
    Abstract: A method for measuring the displacements of a vertebral column having a segment comprising at least one vertebra having a body delimited by an upper vertebral end plate and a lower vertebral end plate, and each vertebra in the segment having a location marker associated, attached thereto and providing a location system with an orientation of the location marker, the method comprising: a detection of the initial orientations of the location marker; a determination, for each vertebra, of an initial orientation of a vertebral plane parallel to at least one end plate of the vertebra; and a detection, for each vertebra, of the current orientation of the vertebral plane of the vertebra from the current orientation of the location marker associated and the geometrical transformation associated with the vertebra.
    Type: Application
    Filed: July 23, 2015
    Publication date: July 27, 2017
    Applicant: SURGIQUAL INSTITUTE
    Inventors: Jean-Charles LE HUEC, Estelle DUVEAU, Sylvain BESSON, Philippe AUGERAT
  • SEMICONDUCTOR DEVICE AND METHOD OF FABRICATING THE SAME
    Publication number: 20170213904
    Abstract: A semiconductor device includes a semiconductor structure including a substrate, a first semiconductor layer on the substrate, and a second semiconductor layer on the first semiconductor layer, a first passivation pattern provided on the semiconductor structure, and first and second conductive patterns provided on the semiconductor structure and spaced from the first passivation pattern.
    Type: Application
    Filed: January 24, 2017
    Publication date: July 27, 2017
    Applicant: Electronics and Telecommunications Research Institute
    Inventors: Jeho NA, Hyung Seok LEE, Chi Hoon JUN, Sang Choon KO, Myungjoon KWACK, Young Rak PARK, Woojin CHANG, Hyun-Gyu JANG, Dong Yun JUNG
  • OZONE WATER AND METHOD FOR PRODUCING THE SAME
    Publication number: 20170210650
    Abstract: An object of the present invention is to provide an ozone water having enhanced storage stability and a method for producing the ozone water. An ozone water of the present invention as a means for resolution is produced by dissolving 0.1 ?M to 1 mM of an organic iron compound and 1 to 300 mM of an inorganic salt in a water with ozone-microbubbles generated using an ozone gas at a concentration of 1 to 300 g/Nm3. The half-life of ozone of the ozone water of the present invention is 3 days or longer, for example, when the water filled in an airtight container under atmospheric pressure is stored under a temperature condition of 40° C.
    Type: Application
    Filed: August 1, 2015
    Publication date: July 27, 2017
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventor: Masayoshi TAKAHASHI
  • SECURE RAID SCHEMES FOR DISTRIBUTED STORAGE
    Publication number: 20170213047
    Abstract: Disclosed are low-complexity schemes to store information in a distributed manner across multiple nodes of a computer system. The schemes are resilient to node failures and resistant to node eavesdropping. The disclosed schemes may be used in conjunction with RAID systems, and when used in such systems may be referred to as“secure RAID”.
    Type: Application
    Filed: January 25, 2017
    Publication date: July 27, 2017
    Applicant: California Institute of Technology
    Inventors: Wentao Huang, Jehoshua Bruck
  • GENERATION AND USE OF POLYCLONAL AND MONOCLONAL ANTIBODIES SPECIFIC FOR 3-PHOSPHOHISTIDINE
    Publication number: 20170210824
    Abstract: Isolated monoclonal antibodies and or antigen binding fragments thereof are disclosed herein that specifically bind polypeptides comprising a histidine phosphorylated at N3 (3-pHis). Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors and nucleic acids are also disclosed. Methods are also disclosed for using these antibodies, such as for detection of polypeptides comprising a histidine phosphorylated at N3 (3-pHis). In some embodiments, the methods can be used to investigate signal transduction pathways.
    Type: Application
    Filed: July 1, 2015
    Publication date: July 27, 2017
    Applicants: Salk Institute for Biological Studies, Sanofi
    Inventors: Tony Hunter, Stephen Rush Fuhs, Jill Meisenhelder, Jacques Mauger, Fahad Al-Obeidi, Robert A. Binne
  • FREQUENCY COMPARISON AND PHASE SYNCHRONIZATION IN OPTICAL SIGNALS
    Publication number: 20170214464
    Abstract: An optical oscillator 10 combines optical signals L1? and L2 to generate an optical signal L3. The optical signal L1? includes light waves W1? and W2? having frequencies spaced apart by a frequency difference ?f1. The optical signal L2 includes light waves W3 and W4 having frequencies spaced apart by a frequency difference ?f2. The optical oscillator 10 separates the optical signal L3 into optical signals L4 and L5, wherein the optical signal L4 includes the light waves W1? and W3 and the optical signal L5 includes the light waves W2? and W4. The optical oscillator 10 compares the frequency differences ?f1 and ?f2 based on frequency difference ?f3 between the light waves W1? and W3 included in the optical signal L4 and frequency difference ?f4 between the light waves W2? and W4 included in the optical signal L5.
    Type: Application
    Filed: October 18, 2016
    Publication date: July 27, 2017
    Applicant: NATIONAL INSTITUTES OF NATURAL SCIENCES
    Inventor: Hitoshi KIUCHI
  • PROBIOTIC FORMULATIONS AND METHODS FOR USE
    Publication number: 20170209504
    Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
    Type: Application
    Filed: September 6, 2016
    Publication date: July 27, 2017
    Applicants: Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
    Inventors: Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey