Abstract: The invention relates to the identification of genetic signatures and expression profiles that are a part of the Base Excision Repair (BER) pathway, a major DNA repair pathway that modifies base lesions. In one embodiment, the present invention provides a method of determining responsiveness of treatment by BER inhibitors for malignant glioma by determining the presence of a low level of expression of Apex 1, a low level of expression of Apex 2, and a high level of expression of MPG.

Abstract: A two-speed transmission having two clutches for an electric vehicle includes an electric motor, a middle shaft, a first clutch, a second clutch, a first gear assembly and a second gear assembly. The electric motor includes a spindle. The first and second clutches are furnished on the middle shaft coaxially. The first gear assembly is furnished on the spindle and the first clutch respectively to generate a first gear ratio. The second gear assembly is furnished on the spindle and the first clutch respectively to generate a second gear ratio different from the first gear ratio. When the first clutch is activated to connect with the middle shaft, the second clutch separates from the middle shaft, and the electric motor outputs a first torque corresponding to the first gear ratio to the middle shaft. Similarly, the electric motor outputs a second torque corresponding to the second gear ratio.

Abstract: An apparatus for cell management in a mobile communication system based on a beam forming scheme includes: a storage unit storing a cell management scenario for at least one floating cell inlayed with a fixed cell of a base station and managed by the base station or other base stations; a determination unit determining a processing scheme of the at least one floating cell on the basis of the cell management scenario stored in the storage unit when a service request event is generated within the fixed cell; and a controller processing the at least one floating cell on the basis of the cell management scenario corresponding to the determined processing scheme.

Abstract: The present disclosure provides imidazolyl compounds of Formula (I) and methods of preparing the compounds. The provided compounds are able to bind protein kinases and may be useful in modulating (e.g., inhibiting) the activity of a protein kinase in a subject or cell and/or in treating or preventing a disease (e.g., proliferative disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.

Abstract: A two-speed transmission having two clutches includes an electric motor, a middle shaft, a first clutch, a second clutch, a first gear assembly and a second gear assembly. The electric motor includes a spindle. The first clutch and the second clutch are furnished on the middle shaft coaxially. The first gear assembly and the second gear assembly are coupled to the first clutch and the second clutch through a first shaft portion and a second shaft portion of the middle shaft to generate a first gear ratio and a second gear ratio, respectively. When the first clutch is activated to connect with the first shaft portion, the second clutch separates from the second shaft portion, so that the electric motor outputs a first torque corresponding to the first gear ratio through the first gear assembly. Similarly, the electric motor outputs a second torque corresponding to the second gear ratio.

Abstract: A method for preparing a polyarylene sulfide includes reacting a methyl 4-(arylthio)aryl sulfoxide compound with sulfuric acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid or trifluoromethanesulfonic acid to obtain a polysulfonium intermediate; and demethylating the polysulfonium intermediate to obtain a polyarylene sulfide, wherein the polysulfonium intermediate is demethylated with aqueous HCl, HBr, or HI.

Abstract: According an embodiment of the disclosure, a sensing display apparatus including a display panel, an encapsulation layer, a sensing circuit layer and a cover is provided. The display panel includes a display region. The encapsulation layer encapsulates the display panel, and a minimum thickness of the encapsulation layer ranges from 1 micrometer (?m) to 10 ?m. The sensing circuit layer is disposed on the encapsulation layer. The ratio of a layout area of the sensing circuit layer to an area of the display region ranges from 3% to 15%. The encapsulation layer and the sensing circuit layer are covered by the cover and the thickness of the cover ranges from 10 ?m to 120 ?m.

Abstract: Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.

Abstract: Provided are a polymer capsule loaded with transition metal particles having excellent water dispersibility and stability, and a method for preparing the same. Specifically, the polymer capsule loaded with transition metal particles according to the present invention includes a surface-modified polymer capsule surface-modified to thereby have a positive zeta potential in a dispersed state in water; and transition metal particles loaded on a surface of the surface-modified polymer capsule. In addition, a method for preparing a polymer capsule loaded with transition metal particles according to the present invention includes a) preparing a polymer capsule; b) surface-modifying the polymer capsule to prepare a polymer capsule having a positive zeta potential in a dispersed state in water; and c) sequentially adding a water-soluble transition metal precursor and a reducing agent to a water dispersion of the surface-modified polymer capsule obtained in step b).

Abstract: The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H-pyrido[2,3-b]pyrazin-3-one and related compounds (denoted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2,3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti-cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea.

Abstract: A method for preparing a polyoxymethylene dimethyl ether carbonyl compound and/or methyl methoxyacetate as intermediates for producing ethylene glycol, which comprises passing a raw material: polyoxymethylene dimethyl ether or methylal together with carbon monoxide and hydrogen gas through a reactor carrying an acidic molecular sieve catalyst, and performing a reaction to prepare a corresponding product under an appropriate condition where no other solvent is added, in which the process of the reaction is a gas-liquid-solid three-phase reaction, the raw material of polyoxymethylene dimethyl ether or methylal has a high conversion rate, each product has a high selectivity, the catalyst has a long service life, additional solvents are not required to be used, and reaction conditions are relatively mild.

Abstract: The present invention provides a method and a reactor for removing organic matters by immobilized-enzymatic electrode coupled electro-coagulation. In the method, in a single electrochemical system, an enzyme-modified electrode is combined with electro-coagulation to synergistically remove organic matters from water. Certain electrochemical parameters are controlled such that a polymerization reaction is performed between hydrogen peroxide generated by a cathode reaction and organic matters catalyzed by the immobilized-enzymatic electrode. After the polymerization reaction, the organic product enters an anode chamber through a pump. The organic product is precipitated and removed by performing a reaction between the organic product and different hydrolysis products from the electro-coagulation through a coagulating/flocculating effect of compression of a double electric layer, adsorption and electric neutralization as well as precipitation capture.

Abstract: An apparatus and method for managing energy are disclosed herein. The apparatus for managing energy includes a State-of-Health (SOH) determination unit and an energy distribution unit. The SOH determination unit collects information about energy storage systems and energy facilities, and determines the SOH of each of the energy storage systems based on the information. The energy distribution unit distributes energy stored in the energy storage system to loads inside a building based on the information and the SOH.

Abstract: Fuel management system for enhanced operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder. It is preferred that the direct injection occur after the inlet valve is closed. It is also preferred that stoichiometric operation with a three way catalyst be used to minimize emissions. In addition, it is also preferred that the anti-knock agents have a heat of vaporization per unit of combustion energy that is at least three times that of gasoline.

Abstract: Provided are a wireless communication system and method using distributed antennas. A physical channel and reference signal (RS) transmission/reception method for downlink and uplink communication using a plurality of points is provided for a case in which the plurality of points have different physical cell identities (PCIs), or in a wireless communication environment using distributed antennas in which the plurality of points belong to the same cell and have the same PCI. Also, a method of transmitting a physical channel and an RS in an uplink and a downlink by introducing a virtual cell identity (VCI) is provided. Further, a cooperative transmission method using a plurality of points is provided, so that communication efficiency of a wireless communication system using distributed antennas can be improved.

Abstract: A solvent system comprising a diluent and a nitrogenous base for the removal of CO2 from mixed gas streams is provided. Also provided is a process for removing CO2 from mixed gas streams using the disclosed solvent system. The solvent system may be utilized within a gas processing system.

Abstract: The present invention relates to an antibubble generator and a preparation method. The antibubble preparation method includes: generating a jet flow or droplets in a discrete phase from a first fluid through a gas phase; and under the action of an external force, the jet flow or droplets passing through a liquid membrane and moving towards a second fluid in a continuous phase, to form antibubbles. The present invention can generate a large number of antibubbles in a simple and convenient way, and can meet the needs of large-scale industrial applications.

Abstract: Provided is an image display apparatus using a transflective electro-optic device. When a tiled large-screen image display apparatus using a plurality of flat panel displays is implemented, light emitted in two directions may be combined using the transflective electro-optic device. Accordingly, it is possible to effectively remove a visual obstacle caused by the frames of the plurality of flat panel displays, increase the degree of visual immersion, and also enable minimization of the volume of the image display apparatus and modularization of the same.

Abstract: The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

Abstract: The present invention provides HA polypeptides (e.g., H1 HA polypeptides) that bind to umbrella-topology glycans, and reagents and methods relating thereto. The present invention provides binding agents that bind to HA polypeptides (e.g., H1 HA polypeptides), and reagents and methods relating thereto. The present invention provides interfering agents that inhibit the binding of HA polypeptides (e.g., H1 HA polypeptides) to HA receptors, and reagents and methods relating thereto. The present invention provides compositions and methods for treating, preventing, and/or diagnosing influenza infection utilizing HA polypeptides, HA polypeptide binding agents, HA polypeptide interfering agents, and/or vaccine compositions comprising any of the foregoing.