Abstract: The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.
Type:
Grant
Filed:
July 1, 2014
Date of Patent:
November 29, 2016
Assignee:
Dana-Farber Cancer Institute, Inc.
Inventors:
Hwan Geun Choi, Taebo Sim, Nathanael Gray, Wenjun Zhou, Jae Won Chang, Jianming Zhang, Ellen Weisberg
Abstract: A geographical location rendering method executed in a geographical location rendering system for identifying at least one semantic region is provided. A density clustering is performed on a plurality of user generated contents of respective geographical location name information to generate a plurality of region candidates. A name extraction is performed on the region candidates to extract and confirm a common region name of the region candidates as a name of the semantic region. A region scope of the region candidates is detected as a location scope of the semantic region according to a spatial density analysis.
Type:
Grant
Filed:
September 5, 2012
Date of Patent:
November 29, 2016
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: A microfluidic device for manipulating particles can include a substrate and one or more obstacles, each obstacle comprising a plurality of aligned nanostructures including a plurality of nanoparticles or a plurality of polymer layers, or a combination thereof. The obstacle on a substrate can be forests with intra-carbon nanotube spacing ranging between 5-100 nm for isolation of particles such as very small viruses and proteins.
Type:
Grant
Filed:
August 8, 2013
Date of Patent:
November 29, 2016
Assignees:
Massachusetts Institute of Technology, The General Hospital Corporation
Inventors:
Michael Rubner, Brian L. Wardle, Robert E. Cohen, Mehmet Toner, Fabio Fachin
Abstract: According to the present invention, a multi-dimensional image detection apparatus includes a touch surface, at least one two-vision image sensing module located proximally to the touch surface, and a control module coupled to the image sensing module. The multiple-dimensional image detection apparatus can detect a foreign object's image with at least two different dimensional modes. A method of multiple-dimensional image detection is also disclosed by reading the image data acquired by the image sensing module and comparing with a pre-stored background data to determine detecting the foreign object under a predetermined dimensional mode.
Type:
Grant
Filed:
June 13, 2012
Date of Patent:
November 29, 2016
Assignee:
Hong Kong Applied Science and Technology Research Institute Company Limited
Abstract: Disclosed is a method of preparing calcium carbonate using a direct carbonation reaction. The method includes dissolving fuel gas desulfurization gypsum into an ammonia solution, performing a filtering process after making a carbonation reaction by feeding carbon dioxide into the ammonia solution in which the fuel gas desulfurization gypsum is dissolved, and performing a filtering process after precipitating the calcium carbonate by maintaining a filtered solution in a stationary state.
Type:
Grant
Filed:
August 15, 2014
Date of Patent:
November 29, 2016
Assignee:
Korea Institute of Geoscience and Mineral Resources
Abstract: The present disclosure provides a steam cracking process, comprising heating a liquid feed stock in a convection section of a cracking furnace and subsequently conveying the material to a radiant section of the cracking furnace for cracking reaction therein, wherein a monoolefin-containing stream is conveyed to the cracking furnace for cracking reaction through at least one of modes A to C.
Type:
Grant
Filed:
October 28, 2013
Date of Patent:
November 29, 2016
Assignees:
China Petroleum & Chemical Corporation, Beijing Research Institute of Chemical Industry, China Petroleum & Chemical Corporation
Abstract: A method and apparatus for the distributed processing of a file are disclosed. The apparatus includes a shared data block selection unit, a modified data block selection unit, a first file distributed-processing unit, and a second file distributed-processing unit. The shared data block selection unit selects at least one first data block to remain without change after distributed processing of a file. The modified data block selection unit selects at least one second data block to be modified after the distributed processing of a file. The first file distributed-processing unit allows an inode after the distributed processing of a file to point to the first data blocks so that the first data block is shared before and after the distributed processing of a file. The second file distributed-processing unit allows the inode after the distributed processing of a file to point to at least one third data block.
Type:
Grant
Filed:
May 20, 2014
Date of Patent:
November 29, 2016
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Abstract: The present invention relates to a laminar structure which is used in a microporous layer, an electrode layer or the like of a membrane electrode assembly for a fuel cell, and also relates to a production method for same. The laminar structure is a laminar structure which is comprised in the membrane electrode assembly (MEA) of a polymer electrolyte membrane fuel cell (PEMFC), and comprises an electrosprayed layer which is formed by the lamination of electrospraying ink, that has been charged by means of an electric field, through an electrospraying process in which the electrospraying ink is dispersed and sprayed as electrospraying liquid droplets, and, in the electrospraying process, the electrospraying substance transmission mode is set in accordance with the adjustment of electrospraying process variables.
Type:
Grant
Filed:
June 8, 2012
Date of Patent:
November 29, 2016
Assignee:
KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGY
Abstract: A mirror or mirror assembly fabricated by molding, pressing, assembling, or depositing one or more bulk metal glass (BMG), bulk metal glass composite (BMGMC), or amorphous metal (AM) parts and where the optical surface and backing of the mirror can be fabricated without machining or polishing by utilizing the unique molding capabilities of this class of materials.
Type:
Grant
Filed:
November 16, 2012
Date of Patent:
November 29, 2016
Assignee:
California Institute of Technology
Inventors:
Douglas C. Hofmann, Gregory L. Davis, Gregory S. Agnes, Andrew A. Shapiro
Abstract: A fastening component is a molded article of a mixture in which microfibrillated cellulose fibers are dispersed in a thermoplastic resin, wherein the thermoplastic resin has a melting point of between 150 and 200° C., and wherein when the total mass % of the thermoplastic resin and the cellulose fibers is set to be 100 mass %, the mass % of the cellulose fibers included in the mixture is greater than 20 mass % and less than 60 mass %. When the total mass % of the thermoplastic resin and the cellulose fibers is set to be 100%, the mass % of the cellulose fibers included in the mixture is preferably equal to or greater than 30 mass % and equal to or less than 50 mass %.
Type:
Grant
Filed:
November 5, 2012
Date of Patent:
November 29, 2016
Assignees:
Kyoto Municipal Institute of Industrial Technology and Culture, YKK Corporation
Abstract: An apparatus and method for generating a Software Defined Network (SDN)-based virtual network. The apparatus includes a network information generator and a virtual network generator, in which an SDN-based virtual network desired by a user may be generated efficiently by allocating physical resources to reflect various user demands.
Type:
Grant
Filed:
July 16, 2015
Date of Patent:
November 29, 2016
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Byung Yun Lee, Yong Yoon Shin, Ji Young Kwak, Sae Hoon Kang, Sun Hee Yang
Abstract: The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth.
Type:
Grant
Filed:
May 5, 2015
Date of Patent:
November 29, 2016
Assignee:
Massachusetts Institute of Technology
Inventors:
Douglas P. Hart, Federico Frigerio, Davide M. Marini
Abstract: Provided is an optical module. The optical module includes: an optical bench having a first trench of a first depth and a second trench of a second depth that is lower than the first depth; a lens in the first trench of the optical bench; at least one semiconductor chip in the second trench of the optical bench; and a flexible printed circuit board covering an upper surface of the optical bench except for the first and second trenches, wherein the optical bench is a metal optical bench or a silicon optical bench.
Type:
Grant
Filed:
January 5, 2016
Date of Patent:
November 29, 2016
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Young-Tak Han, Jang Uk Shin, Sang-Pil Han, Sang Ho Park, Yongsoon Baek
Abstract: A reflection-type light control element according to the present invention is provided with a light control layer configured to exhibit a reversible change between a transparent state and a reflection state in a reversible reaction with a hydrogen and a catalyst layer configured to accelerate the reversible reaction of the light control layer, wherein the reflection-type light control element is such that the light control layer includes an alloy that contains at least one kind of element selected from a group composed of group 2 elements and at least two kinds of elements selected from a group composed of group 3 elements and rare earth elements, or a hydride of the alloy.
Type:
Grant
Filed:
September 21, 2012
Date of Patent:
November 29, 2016
Assignee:
National Institute of Advanced Industrial Science and Technology
Abstract: Methods are provided for protecting against ventilation-induced lung injury both directly, by lowering surface tension, and indirectly, by promoting equitable liquid distribution in pulmonary alveolar edema, in which liquid- and air-filled alveoli are normally interspersed. Since a pressure barrier is responsible for trapping liquid in discrete edematous alveoli and the magnitude of the barrier is proportional to surface tension at the air-liquid interface, the present invention provides various methods for promoting equitable redistribution of edema liquid amongst alveoli to help protect the lung during ventilation, including: i) use of an additive that lowers surface tension; ii) use of active, accelerated deflation during mechanical ventilation; and iii) high frequency (>50 Hz) vibration of the lung.
Type:
Grant
Filed:
October 12, 2012
Date of Patent:
November 29, 2016
Assignee:
THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY
Abstract: The disclosure relates to oligonucleotide compounds (oligomers) that target Myc mRNA in a cell, leading to reduced expression of Myc. Reduction of Myc expression is beneficial for the treatment of certain disorders, such as hyperproliferative disorders (e.g., cancer). The disclosure provides therapeutic compositions comprising oligomers and methods for modulating the expression of Myc using said oligomers, including methods of treatment.
Type:
Grant
Filed:
February 15, 2013
Date of Patent:
November 29, 2016
Assignees:
DANA-FARBER CANCER INSTITUTE, INC., ENZON PHARMACEUTICALS, INC.
Inventors:
Rajanikanth Bandaru, Yixian Zhang, Zhengxing Qu, Lee Greenberger, Christopher Ott, James Elliott Bradner
Abstract: A method of enhancing handover by using chain handover over a wireless connection, for use in a plurality of moving devices, is introduced. In the method, a control message is received by one of a plurality of moving devices. A report message is transmitted by the one of the plurality of moving devices, in which the one of the plurality of moving devices sets in a state for group handover and represents all others of the plurality of moving devices for a handover decision. It is determined that a part or all of the plurality of moving devices are allowed to perform the group handover according to the report message. The part or all of the plurality of moving devices allowed to perform the group handoversequentially perform a handover procedure after receiving a reconfiguration message.
Type:
Grant
Filed:
September 4, 2013
Date of Patent:
November 29, 2016
Assignee:
Industrial Technology Research Institute
Abstract: A polybenzimidazole based polymer in which substituted or non-substituted benzyl groups are introduced to the two nitrogen atoms of benzimidazole ring. The benzimidazole ring is not decomposed by the attack of hydroxide ions but shows excellent alkali resistance, and thus maintains high ion conductivity. The polybenzimidazole based polymers are particularly useful for not only solid alkali exchange membrane fuel cells (SAEMFC) but also various industrial fields in which polybenzimidazole based polymers are used.
Type:
Grant
Filed:
February 20, 2015
Date of Patent:
November 29, 2016
Assignee:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Hyoung-Juhn Kim, Jin Young Kim, Sung Jong Yoo, Jong Hyun Jang, Eun Ae Cho, Sun-Hee Choi, Jonghee Han, Hyung Chul Ham, Dirk Henkensmeier
Abstract: Toe cushioning device for protecting a patient's toes. A toe cushion device includes two tubular cushions positioned in a transverse plane on the plantar side of a patient's toes during use. The toe cushion relieves foot or toe pain and conforms to the changing contour of the patient's foot and toes during use.
Type:
Grant
Filed:
January 28, 2014
Date of Patent:
November 29, 2016
Assignee:
The Feinstein Institute for Medical Research