Abstract: The present invention comprises a humanized monoclonal antibody that binds to the chemokine receptor CCR4. This antibody is derived from Mab 1567 and recognizes the same epitope. Binding of the invented antibody to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer. Moreover, the antibody is used in combination with vaccines to suppress the activity of regulatory T cells.
Type:
Grant
Filed:
January 14, 2015
Date of Patent:
August 16, 2016
Assignees:
Dana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital
Inventors:
Wayne Marasco, Jianhua Sui, Quan Zhu, Thomas Kupper
Abstract: A power module includes a first substrate, at least two power elements, at least one first conductive structure and at least one leadframe. The first substrate includes a dielectric frame, two first fan-out circuit structure layers and two dielectric plates. The two first fan-out circuit structure layers are respectively disposed on two opposite surfaces of the dielectric frame, the two dielectric plates are respectively disposed on the two first fan-out circuit structure layers, each of the dielectric plates has at least one opening, and the opening and the corresponding first fan-out circuit structure layer form a concavity. The two power elements are respectively embedded in the two concavities. The two power elements are electrically connected to each other through the first conductive structure. The leadframe disposed at the first substrate is electrically connected to the two power elements, and is partially extended outside the first substrate.
Type:
Grant
Filed:
December 11, 2015
Date of Patent:
August 16, 2016
Assignee:
Industrial Technology Research Institute
Inventors:
Shu-Jung Yang, Yu-Lin Chao, Heng-Chieh Chien, Chun-Kai Liu
Abstract: The present invention features methods and compositions for identifying markers of minimum residual disease (MRD), as well as markers of metastatic cells. The present invention further provides methods for detecting MRD and metastatic cell in a subject.
Type:
Grant
Filed:
February 17, 2006
Date of Patent:
August 16, 2016
Assignee:
Sloan-Kettering Institute for Cancer Research
Abstract: A method for arranging a plurality of message blocks in a lattice form and generating a message matrix includes deciding lengths of rows of the message matrix such that a length difference is equal to or less than a first critical point, deciding lengths of the message blocks such that a length difference is equal to or less than a second critical point, and arranging the message blocks in each row of the message matrix such that a length difference of columns of the message matrix is equal to or less than a third critical point.
Type:
Grant
Filed:
September 26, 2014
Date of Patent:
August 16, 2016
Assignees:
SK HYNIX INC., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Dae-Sung Kim, Jeong-Seok Ha, Chol-Su Chae, Seok-Jin Joo, Sang-Chul Lee
Abstract: Disclosed is a receiver including: a partial filter generating unit selecting a signal as large as a predetermined magnitude among sampled signals and extracting a filter coefficient for the selected signal magnitude to perform QR resolution for the filter coefficient; a partial ML setting unit determining the lengths and the number of candidate symbol combinations of a signal to be detected and generating a candidate ML symbol combination based on the determined lengths and number of candidate symbol combinations; a signal detecting unit detecting residual symbols in a predetermined part of the sampled signal based on the generated candidate ML symbol combination; and a final signal selecting unit choosing a candidate symbol closest to the sampled signal among the detected candidate symbols as a finally detected signal.
Type:
Grant
Filed:
January 27, 2015
Date of Patent:
August 16, 2016
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Myung Sun Beak, Hun Hee Lee, Hyoung Soo Lim, Nam Ho Hur
Abstract: Systems and methods are included for adjusting a set of predicted future data points for a time series data set including a receiver for receiving a time series data set. One or more processors and one or more non-transitory computer readable storage mediums containing instructions may be utilized. A count series forecasting engine, utilizing the one or more processors, generates a set of counts corresponding to discrete values of the time series data set. An optimal discrete probability distribution for the set of counts is selected. A set of parameters are generated for the optimal discrete probability distribution. A statistical model is selected to generate a set of predicted future data points. The set of predicted future data points are adjusted using the generated set of parameters for the optimal discrete probability distribution in order to provide greater accuracy with respect to predictions of future data points.
Type:
Grant
Filed:
November 23, 2015
Date of Patent:
August 16, 2016
Assignee:
SAS Institute, Inc.
Inventors:
Michael James Leonard, David Bruce Elsheimer
Abstract: A nanomesh phononic structure includes: a sheet including a first material, the sheet having a plurality of phononic-sized features spaced apart at a phononic pitch, the phononic pitch being smaller than or equal to twice a maximum phonon mean free path of the first material and the phononic size being smaller than or equal to the maximum phonon mean free path of the first material.
Type:
Grant
Filed:
October 20, 2011
Date of Patent:
August 16, 2016
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Jen-Kan Yu, Slobodan Mitrovic, James R. Heath
Abstract: A visual display for use by a user for navigation and obstacle avoidance. A typical user employs the invention in operating a vehicle. The display may include a conventional video feed. A visual arch metaphor is also provided. A ranging device mounted on the vehicle collects ranging data around the vehicle. As an example, the ranging device might collect 180 degrees of ranging data extending from the vehicle's left side, across the vehicle's front, and over to the vehicle's right side. The ranging data is correlated to a predefined color scale. The ranging data is also correlated to a position on the arch metaphor.
Type:
Grant
Filed:
December 5, 2012
Date of Patent:
August 16, 2016
Assignee:
Florida Institute for Human and Machine Cognition, Inc.
Inventors:
Thomas Eskridge, Matthew Johnson, Chua Wei Liang Kenny
Abstract: A method for producing controlled-release fertilizer coated with polyurethane is provided, wherein granular fertilizer is preheated under fluidized state in a fluidized bed; the surface of the granular fertilizer is pretreated after liquid paraffin being atomized; polyol and isocyanate are mixed in a nozzle, then atomized and sprayed onto the surface of the granular fertilizer; after the reaction materials are added, liquid paraffin is added for surface release treatment.
Type:
Grant
Filed:
August 6, 2014
Date of Patent:
August 16, 2016
Assignee:
CHINESE ACADEMY OF AGRICULTURAL SCIENCES INSTITUTE OF AGRICULTURAL RESOURCES AND REGIONAL PLANNING
Abstract: Disclosed is an energy conversion apparatus. An energy conversion apparatus may comprise a control part controlling a length of a first time duration in which input current is inputted and accumulated, a length of a second time duration in which the accumulated current is provided to a load, and a length of a third time duration in which inverse current flows; and a DC-to-DC converter including an inductor, a output capacitor, and at least one switching element, wherein the input current is accumulated during the first time duration by switching the at least one switching element according to a control of the control part so as to perform input impedance matching, and the DC-to-DC convert provides a current corresponding to a difference between the accumulated current provided during the second time duration and the inverse current flowing from the output capacitor during the third time duration to the load.
Type:
Grant
Filed:
December 10, 2013
Date of Patent:
August 16, 2016
Assignee:
ELECTRONICS & TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Sung Eun Kim, Tae Wook Kang, Kyung Hwan Park, Sung Weon Kang, Myung Ae Chung
Abstract: Systems, devices, and methods are provided for self-cleaning photovoltaic panels that utilize piezo devices capable of causing vibrational movement in the panels.
Abstract: Methods for wireless communications based on relay and apparatuses for the same are disclosed. The method for a terminal to transmit signals comprises receiving scheduling information from a base station connected to the terminal; generating uplink data based on the scheduling information; performing punctuation on a data symbol positioned in a region through a downlink synchronization signal is transmitted in the generated uplink data; and transmitting the punctured uplink data. Therefore, the terminal may acquire synchronization signal easily, and perform neighbor cell search correctly based on the acquired synchronization signal.
Type:
Grant
Filed:
March 18, 2014
Date of Patent:
August 16, 2016
Assignee:
Electronics & Telecommunications Research Institute
Abstract: This invention relates to an immunosuppressive cell, and methods of obtaining the cell and using the cell. The immunosuppressive cell is obtained by culturing a precursor cell in a medium that contains a GRO chemokine.
Abstract: A carrier-gas mixture is directed through a fluid flow path in a combined heat and mass transfer device, which can be operated at sub-atmospheric pressure. Heat and mass are transferred from or to the carrier-gas mixture via interaction with a liquid composition that includes a vaporizable component in a liquid state to substantially change the content of the vaporizable component in the carrier-gas mixture via evaporation or condensation. The mass flow rate of the carrier-gas mixture is varied by extracting or injecting the carrier-gas mixture from at least one intermediate location in the fluid flow path, and/or the mass flow rate of the liquid composition is varied by extracting or injecting the liquid composition from at least one intermediate location in the fluid flow path; and the flow of the carrier-gas mixture or the liquid composition is regulated to reduce the average local enthalpy pinch in the device.
Type:
Grant
Filed:
June 24, 2013
Date of Patent:
August 16, 2016
Assignees:
Massachusetts Institute of Technology, King Fahd University of Petroleum Minerals
Inventors:
Prakash Narayan Govindan, Gregory P. Thiel, Ronan K. McGovern, John H. Lienhard, Sarit K. Das, Karim M. Chehayeb, Syed M. Zubair, Mohammed A. Antar
Abstract: An equalizer provided in a digital transmitter compensates for attenuation in a signal channel to a digital receiver. The equalizer generates signal levels as a logical function of bit history to emphasize transition signal levels relative to repeated signal levels. The preferred equalizer includes an FIR transition filter using a look-up table. Parallel circuits including FIR filters and digital-to-analog converters provide a high speed equalizer with lower speed circuitry. The equalizer is particularly suited to in-cabinet and local area network transmissions where feedback circuitry facilitates adaptive training of the equalizer.
Abstract: One embodiment of present invention provides a method for manufacturing a semiconductor structure, which comprises: forming a gate stack on a semiconductor substrate and removing parts of the substrates situated on two sides of the gate stack; forming sidewall spacers on sidewalls of the gate stack and on sidewalls of the part of the substrate under the gate stack; forming doped regions in parts of the substrate on two sides of the gate stack, and forming a first dielectric layer to cover the entire semiconductor structure; selectively removing parts of the gate stack and parts of the first dielectric layer to form a channel region opening and source/drain region openings; forming a high K dielectric layer on sidewalls of the channel region opening; and implementing epitaxy process to form a continuous fin structure that spans across the channel region opening and the source/drain region openings.
Type:
Grant
Filed:
August 17, 2012
Date of Patent:
August 16, 2016
Assignee:
INSTITUTE OF MICROELECTRONICS, CHINESE ACADEMY OF SCIENCES
Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to the novel phosphorylation sites, and laboratory and clinical uses thereof.
Abstract: A method for manufacturing a fin structure is provided. A method according to an embodiment may include: forming a patterned pattern transfer layer on a substrate; forming a first spacer on sidewalls of the pattern transfer layer; forming a second spacer on sidewalls of the first spacer; selectively removing the pattern transfer layer and the first spacer; and patterning the substrate with the second spacer as a mask, so as to form an initial fin.
Type:
Grant
Filed:
December 17, 2012
Date of Patent:
August 16, 2016
Assignee:
Institute of Microelectronics, Chinese Academy of Sciences
Abstract: Provided are a method, apparatus, and system for providing a multi-tenant cloud service, which can guarantee quality of service (QOS) in units of flows and virtual machines (VMs). A dynamic virtual flow switch includes a switch flow agent configured to receive and store virtual machine QOS information about each of a plurality of virtual machines operating in a plurality of computer servers and flow QOS information about a flow generated by the virtual machine from a virtual flow controller and a flow processing unit configured to receive the flow generated by the virtual machine and determine a QOS priority of the flow based on the stored virtual machine QOS information of the virtual machine and flow QOS information of the flow.
Type:
Grant
Filed:
January 10, 2014
Date of Patent:
August 16, 2016
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Kang-II Choi, Bhum-Cheol Lee, Jung-Hee Lee, Young-Ho Park, Sang-Min Lee, Seung-Woo Lee