Abstract: The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.

Abstract: An LIN slave node control system, an LIN slave node and a method are provided. The system includes an electronic control part, which includes: an LIN signal detection, reception, and control module, a processing module connected to the LIN signal detection, reception, and control module and an LIN signal transmitting module connected to the processing module; the processing module generates, according to acquired analysis results, control signals for activating the LIN signal transmitting module, and transmits the control signals to the LIN signal detection, reception, and control module, or blocks LIN signal transmitting module and/or processing module control signals; the LIN signal detection, reception, and control module activates the processing module according to awake signals from an LIN bus, activates the LIN signal transmitting module according to the control signals from the processing module, or can block the LIN signal transmitting module and/or the processing module.

Abstract: Building environment data collection systems and methods are described. According to one aspect, a system includes a plurality of sensor devices which store different types of environment data, a base system comprising a plurality of interface devices configured to receive the environment data from the sensor devices, storage circuitry configured to store the environment data, and communications circuitry configured to implement communications, and a user interface apparatus comprising communications circuitry configured to communicate with the communications circuitry of the base system, a user interface configured to receive user inputs during installation of the sensor devices, and processing circuitry configured to control the user interface to generate the displayed information and to process the user inputs received via the user interface, and wherein different ones of the sensor devices are configured to generate the different types of environment data as a result of the user inputs.

Abstract: [Problem] To provide a novel light up-conversion organic luminescent substance having a high light up-conversion efficiency. [Solution] A light up-conversion luminescent substance which comprises a compound represented by general formula (1).

Abstract: A new compliant polymer seal and process for sealing sodium conducting energy storage devices and batteries are disclosed. Compliant polymer seals become viscous at the operation temperature which seals cathode and anode chambers and other components together following assembly. Seals can accommodate thermal expansion mismatches between selected components during operation.

Abstract: The present invention relates to the stabilisation of foot-and-mouth disease virus (FMDV) capsids, by specific substitution of amino acids in a specific region of FMDV VP2. The invention provides stabilised FMDV capsids and vaccines against FMD.

Abstract: Catalysts for poly(lactide) synthesis are provided herein. Also provided are methods of synthesizing the catalysts, methods of using the catalysts to make poly(lactides), and compositions comprising the same.

Abstract: A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.

Abstract: The present invention provides a method for detecting cancer using a protein expressed in various cancers, and a pharmaceutical composition for the treatment or prevention of such cancer using the protein as an indicator. Furthermore, the present invention provides a pharmaceutical composition containing a cancer antigen peptide derived from the protein. More particularly, the method comprises the step of determining the presence or amount of an eEF2 polypeptide or an eEF2 antibody in a sample obtained from a subject.

Abstract: A handheld inkjet printer includes an inkjet print head and a tip. One or more sensors measure the position of points on a curved surface that are physically touched by the tip while the tip is moved relative to the surface. Based on these measurements, a computer generates or modifies a computer model that specifies at least (i) position of the curved surface, and (ii) a target region of the curved surface on which a pattern is to be printed. In addition, the one or more sensors measure position and orientation of nozzles in the print head, while the handset is moved relative to the surface. The computers also calculate, based on the computer model and these additional measurements, which of the nozzles to fire at a different times, such that the pattern is printed on the target region as the handset is moved relative to the surface.

Abstract: A method for supporting 3D printing includes identifying a product, searching and providing a 3D model present on a web in relation to the identified product, calculating and simulating suitability between the identified product and the searched 3D model based on information of the identified product and the searched 3D model, and transmitting the 3D model information to a 3D printer to produce the 3D model. Accordingly, the 3D printing technique may be actively utilized for DIY in various fields, business models or the like.

Abstract: Provided is an organic EL element which has excellent luminous efficiency by improving the cathode. An organic EL element which is configured of a cathode, an anode and one or more organic compound layers provided between the electrodes, and wherein the cathode is formed of a transparent conductive film that is formed on a glass substrate and is configured from an indium oxide compound and an element having a high work function, so that the cathode has a high work function matched to the HOMO of an organic hole transport layer among the organic compound layers. Consequently, holes can be easily injected from the cathode to the organic hole transport layer, and the present invention is therefore suitable for manufacturing an organic EL element having excellent luminous efficiency.

Abstract: The present invention relates to a nanocomposite ultra-thin separation membrane and a method for manufacturing the same, wherein the nanocomposite ultra-thin separation membrane for seawater desalination according to the present invention includes: 1) a polyamide-based polymer active layer; 2) a polyethersulfone support membrane; 3) an external support body; and 4) carbon nanotube, to remarkably improve hydrophilicity of the porous support membrane, thereby having more than doubled water permeability of the entire separation film. In addition, due to a physiochemical reaction of the functionalized carbon nanotube, a support membrane exposed to air for a long period of time is also usable as a lower body of the ultra-thin separation membrane.

Abstract: Methods of assembling modified adenoviruses, libraries of adenoviral gene modules and compositions thereof are provided herein.

Abstract: The present invention relates to a flexible thermoelectric device and a manufacturing method thereof, and a thermoelectric material is formed on a mesh type substrate made of a glass fabric, and the like. According to the present invention, since the thermoelectric material is supported by a mesh type substrate without a substrate made of alumina, and the like, the thermoelectric device has a high flexibility and a light weight, and thermal loss is minimized by the substrate to maximize thermoelectric efficiency.

Abstract: Compounds having methyltransferase inhibitory activity are disclosed. The compounds have the structure and are useful in the treatment of cancer and similar diseases associated with inappropriate methyltransferase activity.

Abstract: The thermostable cellobiohydrolase of the present invention is a polypeptide which has cellobiohydrolase activity at least under conditions of a temperature of 75° C. and a pH of 5.5, and which includes a polypeptide including an amino acid sequence represented by SEQ ID NO: 1, 3, 5, or 7, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in an amino acid sequence represented by SEQ ID NO: 1, 3, 5, or 7, or a polypeptide including an amino acid sequence having 80% or greater but less than 100% sequence identity with an amino acid sequence represented by SEQ ID NO: 1, 3, 5, or 7.

Abstract: A method for forming a wiring for a semiconductor device according to an aspect of the present invention includes: forming a predetermined pattern on a first surface of a silicon substrate by selectively etching the first surface; coating, with a metal layer, a selected area of the first surface, including an area whereat the predetermined pattern is formed; forming organic material in the first surface to fill an etched portion and cover the coated metal layer; forming a plurality of via holes in the organic material and connecting the metal wiring to the coated metal layer through the via holes; and grinding a second surface corresponding to the first surface to remove a part of the metal layer formed in the etched portion.

Abstract: A cloud service system includes at least one user device, a plurality of clouds for providing different cloud services, and a gateway connected between the user device and the clouds. The gateway selects at least one of the clouds according to predefined Service Level Agreement (SLA) information, and stores content provided from the user device to the selected cloud.

Abstract: A power divider for a Wilkinson power divider includes a dielectric layer arranged at a lower part of the Wilkinson power divider and composed of at least one composite material: and a first composite right/left handed (CRLH) transmission line connected in series between the transformer line and the first output line. Further, the power divider for the Wilkinson power divider includes a second CRLH transmission line connected in series between the transformer line and the second output line.