Patents Assigned to INSTITUTE
  • Patent number: 8957057
    Abstract: The present invention concerns the uses of an azaphilone compound of formula (I): formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification for modulation of the activity of a nuclear hormone receptor and for prevention and/or treatment of a disease or disorder related to nuclear hormone receptor activity.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: February 17, 2015
    Assignee: Food Industry Research and Development Institute
    Inventors: Ta-Wei D. Liu, Yen-Lin Chen, Ming-Der Wu, Ming-Jen Cheng, Hui-Ping Chen, Wen-Jung Wu, Kai-Ping Chen, Yu-Shan Lin, Gwo-Fang Yuan
  • Patent number: 8959659
    Abstract: A software authorization system has a server end and a user end. A software authorization method includes acquiring a software identification code of a protected software when the user end downloads the protected software from the server end; transmitting the software identification code and an inherent user identification code to the server end; acquiring a first key and main key by the server end according to the user identification code and the software identification code, respectively, so as to generate a second key by operating the main key and the first key and transmit the second key to the user end; restoring the main key by the user end with the second key combined with the first key; and decrypting the protected software by the main key. Therefore, the protected software is hard to be decrypted.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: February 17, 2015
    Assignee: Industrial Technology Research Institute
    Inventor: Ming-Chih Kao
  • Patent number: 8957197
    Abstract: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAi. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene function. The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: February 17, 2015
    Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V., Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, University of Massachusetts
    Inventors: Thomas Tuschl, Phillip D. Zamore, Phillip A. Sharp, David P. Bartel
  • Patent number: 8957185
    Abstract: Peptides from the MUC1 cytoplasmic domain and methods of use therefor are described. These peptides can inhibit MUC1 oligomerization, thereby preventing tumor cell growth, inducing tumor cell apoptosis and necrosis of tumor tissue in vivo.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: February 17, 2015
    Assignees: Dana-Farber Cancer Institute, Inc., Genus Oncology, LLC
    Inventors: Donald W. Kufe, Surender Kharbanda
  • Patent number: 8957727
    Abstract: A radio frequency (RF) circuit includes a power supply configured to generate a plurality of voltages, a plurality of power amplifiers, each having an RF output port and a power supply input port, a switch network having a plurality of input ports coupled to the power supply and a plurality of switch network output ports coupled to the power supply input ports of the plurality of power amplifiers, wherein the switch network is configured to output selected ones of the plurality of voltages from the plurality of switch network output ports, at least two of the switch network output port voltages capable of being different ones of the plurality of voltages, and an RF power combiner circuit having a plurality of input ports coupled to RF output ports of the plurality of power amplifiers and an output port at which is provided an output signal of the RF circuit.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: February 17, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Joel L. Dawson, David J. Perreault, SungWon Chung, Philip Godoy, Everest Huang
  • Patent number: 8957886
    Abstract: A context-showing and power-saving display information converting system and a corresponding apparatus are provided for lowering the power consumption of displaying images on a pixel self-emissive display device. The display information converting system includes a context-showing module and a power-saving conversion module. The context-showing module receives display information that describes the content of an image, wherein the display information includes one or more elements, and each element corresponds to a plurality of pixels displayed by a display device. In addition, the context-showing module determines a relevance of the one or more elements according to the viewing interest of the user. The power-saving conversion module converts the display information in unit of the one or more elements according to the relevance and provides the converted display information to the display device.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: February 17, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: Tun-Hao You, Yi-Jui Wu, Hsiang-Tsung Kung, Koan-Sin Tan, Chen-Hwa Song, Yi-Jen Yeh
  • Patent number: 8958296
    Abstract: An access point (AP) measures a congestion level of a transmission channel representing a collision probability between frames at a channel busy duration and transmits the congestion level to a terminal. Therefore, the terminal extracts a congestion level that is included in a frame that is received from the AP through a scan process for searching for an AP to which the terminal is to connect. The terminal selects an AP to connect from at least one AP based on the extracted congestion level of the transmission channel.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: February 17, 2015
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Ki Jong Koo, Do Young Kim, Byung Sun Lee
  • Patent number: 8959015
    Abstract: Provided is an apparatus for integrally encoding and decoding a speech signal and an audio signal. An encoding apparatus for integrally encoding a speech signal and an audio signal, may include: a module selection unit to analyze a characteristic of an input signal and to select a first encoding module for encoding a first frame of the input signal; a speech encoding unit to encode the input signal according to a selection of the module selection unit and to generate a speech bitstream; an audio encoding unit to encode the input signal according to the selection of the module selection unit and to generate an audio bitstream; and a bitstream generation unit to generate an output bitstream from the speech encoding unit or the audio encoding unit according to the selection of the module selection unit.
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: February 17, 2015
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Tae Jin Lee, Seung Kwon Beack, Minje Kim, Dae Young Jang, Kyeongok Kang, Jin Woo Hong, Hochong Park, Young-Cheol Park
  • Patent number: 8956615
    Abstract: T cell memory can persist in the absence of antigen. However, some memory cells by default are subject to signals accompanying periodic antigen exposure. OX40 is essential to the extent and persistence of Th2 memory when antigen is re-encountered. In an animal model of allergic asthma, inhibiting OX40/OX40L signaling during the secondary response to inhaled antigen suppressed lung inflammation. Inhibiting OX40 at the time of memory cell reactivation reduced the longevity of memory with further inflammation prevented upon tertiary encounter with antigen.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: February 17, 2015
    Assignee: La Jolla Institute for Allergy and Immunology
    Inventors: Michael Croft, Shahram Salek-Ardakani
  • Patent number: 8957706
    Abstract: The present disclosure provides a dynamic comparator with equalization function including a preamplifier, switched latch and dynamic transconductance circuit. The preamplifier amplifies input signals of the dynamic comparator. The dynamic transconductance circuit is inserted between the preamplifier and the switched latch for operating in a reset mode or a comparison mode. When operating in the reset mode, the dynamic transconductance circuit in conjunction with the switched latch performs voltage equalization of output signals of the switched latch, or when operating in the comparison mode, the dynamic transconductance circuit in conjunction with the switched latch receives the output signals generated by the preamplifier and carries out signal transconductance. The switched latch generates output signals as a comparison result of the dynamic comparator based on the transconductance signals generated by the dynamic transconductance circuit.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: February 17, 2015
    Assignee: Industrial Technology Research Institute
    Inventor: Bo-Wei Chen
  • Patent number: 8956522
    Abstract: A method for electrochemically producing a tin/lithium oxide composite thin film includes providing a solution comprising 10?3 to 10?2 M lithium nitrate and 10?4 to 10?3 M stannic chloride or stannous chloride; electrodepositing the tin/lithium oxide composite thin film on a conductive substrate with a reference electrode of Ag/AgCI and a voltage of 900 to 1500 mV; and drying the tin/lithium oxide composite thin film at a temperature of 15 to 40° C. and a relative humidity of at least 75%.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: February 17, 2015
    Assignee: Taiwan Textile Research Institute
    Inventors: Wen-Hsien Ho, Shiow-Kang Yen, Ching-Fei Li
  • Patent number: 8957800
    Abstract: Provided is an electronic signal conversion apparatus and an operation method of the electronic signal conversion apparatus, including: a first converter to perform a compression and conversion of an input signal to a digital signal based on a first sampling; a second converter to perform a compression and conversion of the input signal to the digital signal based on a second sampling different from the first sampling; and a processor to restore the input signal using an output signal of the first converter and an output signal of the second converter.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: February 17, 2015
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Woo Yong Lee, Jin Kyeong Kim
  • Patent number: 8957819
    Abstract: A dielectric antenna includes at least one dielectric unit. Each dielectric unit is separated into a first region and a second region, and the second region could have a bending portion. A conductor covers a surface of the second region of the dielectric unit to form a waveguide structure. The waveguide structure has a first endpoint connected to the first region and a second endpoint serving as a signal feeding terminal for feeding or receiving signals.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: February 17, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: Hung-Hsuan Lin, Ta-Chun Pu, Chun-Yih Wu
  • Publication number: 20150044676
    Abstract: Methods to simultaneously test and screen multiplexed, mixed cell populations, e.g., populations comprising genetically heterogeneous cancer cells, in common conditions.
    Type: Application
    Filed: March 14, 2013
    Publication date: February 12, 2015
    Applicant: The Broad Institute, Inc.
    Inventors: Channing Yu, Todd R. Golub
  • Publication number: 20150044719
    Abstract: A method for producing a recombinant protein includes steps of: (a) culturing a transformed cell in a protein-free and lipid-free medium containing no exogenous growth factors, in which the transformed cell is produced by transfecting a cell of a cell line derived from Chinese Hamster Ovary (CHO) cells, the cell line is adapted to a protein-free and lipid-free medium, and the cell is capable of proliferating in a suspended state in a protein-free and lipid-free medium containing no exogenous growth factors, with a vector containing a gene coding for the protein to be produced under the control of a promoter operable in the cell, and (b) recovering the protein produced by the transformed cell.
    Type: Application
    Filed: February 21, 2014
    Publication date: February 12, 2015
    Applicants: NATIONAL INSTITUTE FOR MATERIALS SCIENCE, KYOKUTO PHARMACEUTICAL INDUSTRIAL CO., LTD.
    Inventors: Tetsuji Sasaki, Akiyoshi Taniguchi
  • Publication number: 20150045033
    Abstract: A data relay method includes receiving a relay request from a BS, and when the relay request is accepted, relaying data between the BS and at least one external terminal, or the data relay method includes determining relaying between a first terminal among a plurality of terminals, and other remaining terminals excluding the first terminal among the plurality of terminals, and relaying data between the first terminal and the other remaining terminals.
    Type: Application
    Filed: August 8, 2014
    Publication date: February 12, 2015
    Applicant: Electronics and Telecommunications Research Institute
    Inventors: Eunkyung KIM, Jae Sun CHA, Jae Joon PARK, Hyun LEE, Kwang Jae LIM, Sung Cheol CHANG
  • Publication number: 20150045207
    Abstract: A film for the retention and controlled release of organic or inorganic molecules consists essentially of a phyllosilicate clay and a organic polyanion. The film may be a built-up layered film of alternating layers of the clay and the polyanion. Organic or inorganic molecules are absorbed into the film from solution, and released in response to changes in the film's environment. The film may be built up using layer-by-layer (LbL) methods, or deposited on a substrate from a mixture of the clay and polyanion. Articles may be coated with the film by the same methods. The film is useful for the controlled release of antibiotics in response to infections, and also retains antibiotics such that bacteria may be killed by direct contact with the film.
    Type: Application
    Filed: December 18, 2012
    Publication date: February 12, 2015
    Applicant: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY
    Inventors: Svetlana Sukhishvili, Svetlana Pavlukhina
  • Publication number: 20150041312
    Abstract: Provided is a Li-containing phosphoric-acid compound sintered body of both high relative density and very small crystal grain diameter with reduced incidence of defects (voids) such as air holes, the Li-containing phosphoric-acid compound sintered body causing a Li-containing phosphoric-acid compound thin film useful as a solid electrolyte for a secondary cell or the like to be stabilized without any incidence of target cracking or irregular electrical discharge, and offering high-speed film-forming capability. This Li-containing phosphoric-acid compound sintered body contains no defects measuring 50 ?m or larger within a 1 mm2 cross-sectional region in the interior thereof, while having an average crystal grain diameter of no more than 15 ?m and a relative density of at least 85%.
    Type: Application
    Filed: April 10, 2013
    Publication date: February 12, 2015
    Applicant: KOBELCO RESEARCH INSTITUTE, INC.
    Inventors: Yuichi Taketomi, Yuki Tao, Moriyoshi Kanamaru
  • Publication number: 20150045537
    Abstract: The invention relates to methods for harvesting macromolecules such as lipids and proteins by culturing in growth medium a photo synthetic cyanobacteria that secretes vesicles into the growth medium, and separating the secreted vesicles from the cyanobacteria and/or from the growth medium.
    Type: Application
    Filed: March 12, 2013
    Publication date: February 12, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: Sallie Watson Chisholm, Steven James Biller, Anne Williford Thompson
  • Publication number: 20150043067
    Abstract: A microlens array and a method for fabricating thereof are provided. The microlens array of the present invention comprises a lens structure part formed by bistable dielectric polymer thin film; first and second electrode parts each formed on the upper surface and the bottom surface of the lens structure part to apply voltage for shape changes of the lens structure part; a circuit part applying heat to the dielectric polymer thin film to change the property of the dielectric polymer thin film to be soft; and a base part formed on the bottom surface of the second electrode in predetermined intervals. The method further comprises a hydraulic part to apply predetermined voltage to the bottom surface of the lens structure part. The microlens array is thus able to change optical properties by deform the shape of a transparent dielectric polymer thin film having bistablity to various sizes of lens shapes by the purposes.
    Type: Application
    Filed: April 7, 2014
    Publication date: February 12, 2015
    Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Sung-Ryul YUN, Ki-Uk KYUNG, Sun-Tak PARK, Bong-Je PARK, Sae-Kwang NAM