Abstract: The present invention provides a combination product, which comprises immediate release pellet of phentermine and sustained-release pellet of topiramate, wherein the pellet of topiramate includes: a) a blank pellet core; b) an active drug layer that contains topiramate and is free of binding agent, the layer being located on surface of the blank pellet core; c) a sustained-release coating layer containing ethyl cellulose and PVP K30, the sustained-release coating layer being located on external of the active drug layer. The present invention further discloses a method for preparing the combination product.

Abstract: The invention relates to methods for harvesting macromolecules such as lipids and proteins by culturing in growth medium a photo synthetic cyanobacteria that secretes vesicles into the growth medium, and separating the secreted vesicles from the cyanobacteria and/or from the growth medium.

Abstract: For efficient analysis of a protein-protein interaction, the present disclosure provides a kit for analyzing a protein-protein interaction, the kit including: a 1st expression vector including a 1st polynucleotide and a multi-cloning site, wherein, the 1st polynucleotide is operably linked to a promoter and encodes a 1st fusion protein having a 1st fluorescence protein and a 1st self-assembly protein, and the multi-cloning site is a site where a polynucleotide encoding a bait protein may be operably linked to the polynucleotide encoding the 1st fusion protein; and a 2nd expression vector including a 2nd polynucleotide and a multi-cloning site, wherein, the 2nd polynucleotide is operably linked to a promoter and encodes a 2nd fusion protein having a 2nd fluorescence protein and a 2nd self-assembly protein, and the multi-cloning site is a site where a polynucleotide encoding a prey protein may be operably linked to the polynucleotide encoding the 2nd fusion protein.

Abstract: A method for producing a recombinant protein includes steps of: (a) culturing a transformed cell in a protein-free and lipid-free medium containing no exogenous growth factors, in which the transformed cell is produced by transfecting a cell of a cell line derived from Chinese Hamster Ovary (CHO) cells, the cell line is adapted to a protein-free and lipid-free medium, and the cell is capable of proliferating in a suspended state in a protein-free and lipid-free medium containing no exogenous growth factors, with a vector containing a gene coding for the protein to be produced under the control of a promoter operable in the cell, and (b) recovering the protein produced by the transformed cell.

Abstract: A microlens array and a method for fabricating thereof are provided. The microlens array of the present invention comprises a lens structure part formed by bistable dielectric polymer thin film; first and second electrode parts each formed on the upper surface and the bottom surface of the lens structure part to apply voltage for shape changes of the lens structure part; a circuit part applying heat to the dielectric polymer thin film to change the property of the dielectric polymer thin film to be soft; and a base part formed on the bottom surface of the second electrode in predetermined intervals. The method further comprises a hydraulic part to apply predetermined voltage to the bottom surface of the lens structure part. The microlens array is thus able to change optical properties by deform the shape of a transparent dielectric polymer thin film having bistablity to various sizes of lens shapes by the purposes.

Abstract: Methods to simultaneously test and screen multiplexed, mixed cell populations, e.g., populations comprising genetically heterogeneous cancer cells, in common conditions.

Abstract: The present invention relates to a target-specific probe containing T7 bacteriophage with a targeting antibody, and a detection method or a detection kit for a biomarker using the target-specific probe. The biomarker can be detected by using the genetically-modified T7 bacteriophage expressing various heterogeneous proteins and peptides on its surface and antibody-antigen specific reaction which can make the probe targeted to a biomarker or bacteria; and a detectable labeling agent, for example a quantum dot.

Abstract: A method for preparing scandium-doped hafnium oxide film includes preparing a hafnium target having scandium granules distributed on a peripheral surface thereof; and proceeding a sputtering process to form a scandium-doped hafnium oxide film on a substrate, wherein the scandium doping of the scandium-doped hafnium oxide film is in the range of 3-13%. Such scandium-doped hafnium oxide film is able to be used as an oxide layer in semiconductor element which effectively suppresses the current leakage and reduces the dimension of the semiconductor element.

Abstract: Provided are a method of manufacturing a metal oxide and a substrate for a solar cell. The method of manufacturing the metal oxide according to the inventive concept includes mixing a metal precursor material, a basic material, amphiphilic molecules and distilled water to prepare a metal precursor solution, performing a first heat treatment with the metal precursor solution to form a metal oxide, and performing a second heat treatment with the metal oxide to form a pair of metal oxide disks having a single crystalline structure. A pair of zinc oxide disks includes a first disk, and a second disk separated from the first disk in a perpendicular direction to the first disk.

Abstract: A method and system for preconcentrating analytes at a microvalve in a microfluidic device is disclosed. The system includes a sample channel loaded with a sample solution. The sample channel includes a semi-permeable membrane microvalve. An electric potential is applied at or across the microvalve to preconcentrate the sample solution when the microvalve is closed.

Abstract: Methods and compositions are provided for diagnosing or inhibiting invasion or metastasis of a cancer in a subject based on MenaINV.

Abstract: A fiber is provided that has been thermally drawn from a fiber preform, having a longitudinal-axis length and including at least one core that has a longitudinal core axis parallel to the longitudinal axis and internally disposed to at least one outer fiber cladding material layer along the fiber length. The fiber is fed through a localized heating site having a heating site temperature, T, that is above a melting temperature of the fiber core, with a feed speed, ?f, that melts a portion of the fiber core at the heating site, causing molten droplets to pinch off of fiber core material, one droplet at a time, with a time period of molten droplet formation set by the fiber feed speed, ?f. The fiber is fed through the localized heating site to move the molten droplets out of the heating site and solidify the molten droplets into solid in-fiber particles.

Abstract: Disclosed is a multi-stage plasma reactor system with hollow cathodes for cracking carbonaceous material with each stage comprising: hollow cathodes and hollow anodes cooled by recycling cooling medium or refrigerant; working gas inlet(s); inlet(s) of carbonaceous material and carrier gas as feedstock; reaction tubes in connection with the anode or cathode, in addition, the reactor system also comprises: at least one inlet(s) of quench medium located lower portion of last one of the reaction tubes; and at least one outlet(s) of quenched products and gases located on bottom or lower portion of last one of the reaction tubes, wherein chambers are formed between the first hollow cathode or the hollow cathode used as the reaction tube of any stage and the anode so as to generate plasma gas and/or electric arc therein, generated plasma gas jet fully contacts and efficiently mixes with the carbonaceous material and carrier gas as feedstock and/or volatiles caused by pyrolysis within or nearby highest temperature re

Abstract: An active diffuser for reducing a speckle in accordance with an embodiment of the present invention includes: an electroactive polymer film having at least one or more scattering patterns; a first transparent electrode coated on one surface of the electroactive polymer film; and a second transparent electrode coated on the other surface of the electroactive polymer film, and a shape of the scattering pattern of the electroactive polymer film is varied by voltage applied through the first transparent electrode and the second transparent electrode.

Abstract: Provided is a bonding structure of an electronic equipment including first electrodes extended in a first direction and arranged in a second direction on a stretchable display panel having stretchability, second electrodes extended in a first direction and arranged in a second direction on a substrate and facing the first electrodes, and solder bonding parts interposed between the first electrodes and the second electrodes, facing each other in the second direction, and constituting a plurality of rows in the first direction.

Abstract: A computer implemented method of load shedding used in stream computing system that considers the relative importance of each of the applications processing the incoming input data or events. The method of load shedding method also accounts for system physical constraints, such as memories and CPU utilization. The load shedding method first observes the workload of each application and arriving rate of the incoming input data or events. If the system is under an overloading condition, calculate a input data or event drop ratio for each application such that the projected sum of all applications' workload will be at or below the system capacity when the unprocessed input data or events are dropped according to the drop ratio for each application.

Abstract: Provided is a particle control device for controlling fine particles. The particle control device includes: a base with a predetermined area and including an insulator; a first electrode and a second electrode disposed on the base such that they are separated from each other by a predetermined distance; and a fluid flow path disposed on the base so as to pass between the first electrode and the second electrode and to allow a solution to flow. The first electrode includes a plurality of branch electrodes with fine widths, each branch electrode having one end that is adjacent to the second electrode, with the fluid flow path interposed between the branch electrode and the second electrode.

Abstract: Systems and methods for fabricating multi-functional articles comprised of additively formed gradient materials are provided. The fabrication of multi-functional articles using the additive deposition of gradient alloys represents a paradigm shift from the traditional way that metal alloys and metal/metal alloy parts are fabricated. Since a gradient alloy that transitions from one metal to a different metal cannot be fabricated through any conventional metallurgy techniques, the technique presents many applications. Moreover, the embodiments described identify a broad range of properties and applications.

Abstract: The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.

Abstract: This disclosures provides an adsorbent which, on the basis of the total weight of the adsorbent, comprises: 1) a Si—Al molecular sieve having an A-FAU structure, wherein A represents a monovalent cation, in an amount of 1-20 wt %, 2) at least one binder selected from the group consisting of titanium dioxide, stannic oxide, zirconium oxide and alumina, in an amount of 3-35 wt %, 3) a silica source, in an amount of 5-40 wt %, 4) zinc oxide, in an amount of 10-80 wt %, and 5) at least one promoter metal selected from the group consisting of cobalt, nickel, iron and manganese, based on the metal, in an amount of 5-30 wt %, wherein at least 10 wt % of the promoter metal is present in a reduced valence state. This adsorbent exhibits improved activity and stability, and at the same time, is capable of significantly improving the octane number of the product gasoline.