Abstract: The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors with additional functional domains. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.

Abstract: A half-bridge dc/dc converter includes a first converter receiving a current and generating a first resonant current; a transformer connecting to the first converter, receiving the first resonant current and generating a second resonant current; and a second converter connecting to the transformer, receiving the second resonant current; wherein the pulse width of currents in the first converter and second convert are adjustable to further stabilize voltage level as well as adjust output power of the transformer for zero voltage switching operation.

Abstract: Novel methods to fabricate biological sensors and electronics are disclosed. A silicon-on-insulator wafer can be employed by etching a pattern of holes in the silicon layer, then a pattern of cavities in the insulating layer, and then sealing the top of the cavities. Further, n or p doped regions and metallic regions can be defined in the processed wafer, thereby enabling integration of biological sensing and electronic capabilities in the same wafer.

Abstract: A system and method are provided, the system and method for providing a tile map related to a region having low data frequency or a region having same color property, by providing the tile map using not only national territorial information on land but also marine spatial information and dynamic sensing information.

Abstract: A fluid fillable catheter capsule assembly is provided suitable for use with an appropriate catheter in imaging applications for medical or surgical procedures. Methods of constructing such fluid fillable catheter capsule assemblies, methods of using the fluid fillable catheter capsule assemblies, and imaging systems provided with fluid fillable catheter capsule assemblies are provided.

Abstract: A preparation method of a hollow carbon sphere includes preparing a hollow carbon sphere including fine pores by using mold particles and a material including metal-phthalocyanine. The prepared hollow carbon sphere has a carbon shell surface including fine pores, and the hollow carbon sphere may be impregnated with sulfur to prepare a carbon shell-sulfur composite and may be utilized as an anode material of a lithium-sulfur secondary battery. The carbon-sulfur composite material may improve extremely low electrical conductivity of sulfur, confine sulfur and lithium polysulfide originated from sulfur in the carbon shell in which fine pores are distributed to prevent lithium polysulfide having an extended chain structure from being dissolved in an electrolyte, minimize a shuttle reaction, reduce an overcharge amount between charging and discharging, and improve performance of a secondary battery.

Abstract: Disclosed is a method for multi-input multi-output transmission of a base station in a wireless communication system. The method includes obtaining channel information of one or more terminals, classifying the one or more terminals into one or more classes and one or more groups dependent on the class based on the channel information, determining a group beamforming matrix for each of the one or more groups, performing group beamforming transmission on terminals belonging to each of the one or more groups based on the group beamforming matrix, obtaining single user-channel quality indicator (SU-CQI) information and interference signal information of each of the terminals belonging to each of the one or more groups, and scheduling the terminals based on the SU-CQI information and the interference signal information.

Abstract: A product quality monitoring system includes: an RFID tag which is attached to a first packing container in which a product is packed, and transmits atmospheric history information and an identifier for a product distribution history; a QR code which is attached to a second packing container and stores the identifier and address information of a product quality predicting server; a product distribution history DB which stores the atmospheric history information and the identifier which are received from the RFID tag; a user terminal which connects with the product quality predicting server corresponding to the address information stored in the captured QR code, and requests a quality index of the product; and the product quality predicting server which calculates the quality index of the product or a time when the product has a specific quality index, from the atmospheric history information.

Abstract: A filtration device including a contoured support having 1) an interior surface, 2) an outside peripheral surface spaced farther from a center of the contoured support than the interior surface, and 3) a rim enclosed and sealed to a perimeter of the contoured support. The filtration device includes macroscopic openings in the contoured support extending from the interior surface to the outside peripheral surface, and a plurality of nanofibers having diameters less than 1 micron. The nanofibers are disposed on the outside peripheral surface of the contoured support, and cover the macroscopic openings to form a filtration medium on the contoured support.

Abstract: The invention relates to an immunogenic composition and its use. It comprises “OLPs,” or overlapping peptides, derived from a longer, tumor antigen, in combination with polyICLC, and Montanide.

Abstract: Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent or chronic depressive symptoms (>2 years).

Abstract: Provided are a transporter gene involved in the promotion or inhibition of Cd absorption by roots, a mutant gene thereof and a transporter protein thereof, as well as a rice plant in which Cd absorption is inhibited and a method for selecting and raising a Cd absorption-inhibiting rice plant, which are a gene encoding a transporter protein involved in the regulation of cadmium absorption, which contains the DNA nucleotide sequence shown in SEQ ID NO:2, a gene encoding a transporter protein involved in the regulation of cadmium absorption, which contains the DNA nucleotide sequence shown in SEQ ID NO:3, a gene encoding a transporter protein involved in the regulation of cadmium absorption, which contains the DNA nucleotide sequence shown in SEQ ID NO:4, and a transporter protein involved in the regulation of cadmium absorption, which contains the amino acid sequence of SEQ ID NO:1.

Abstract: Neutron-detecting structures and methods of fabrication are provided which include: a substrate with a plurality of cavities extending into the substrate from a surface; a p-n junction within the substrate and extending, at least in part, in spaced opposing relation to inner cavity walls of the substrate defining the plurality of cavities; and a neutron-responsive material disposed within the plurality of cavities. The neutron-responsive material is responsive to neutrons absorbed for releasing ionization radiation products, and the p-n junction within the substrate spaced in opposing relation to and extending, at least in part, along the inner cavity walls of the substrate reduces leakage current of the neutron-detecting structure.

Abstract: Disclosed is a method and apparatus for deducing a viewing household member profile. According to the method and apparatus, a viewing pattern of a general viewing household is analyzed based on viewer group classification criteria generated using the standard household member profile, and thus the member profile of the viewing household may be deduced and the deduced profile may be provided, thereby effectively providing advertisements corresponding to the inclination of viewing household members.

Abstract: The invention in some aspects relates to devices and methods for nucleating crystals under controlled conditions. In some aspects of the invention, devices and methods are provided for continuous crystallization.

Abstract: A high-altitude wind power generation system with a cycloidal turbine and a motor-generator, and a method of operating the same. The system includes a buoyant apparatus configured to be inflated when buoyancy generating gas is injected therein; a cycloidal turbine configured to be placed under the buoyant apparatus, and comprise a rotary shaft arranged to be substantially horizontal to the ground, and a plurality of blades arranged along a circumferential direction of the rotary shaft while their pitch center lines are long extended to be parallel with a center line of the rotary shaft and are spaced apart from the rotary shaft at a preset distance as being arranged to be substantially perpendicular to a flowing direction of fluid blowing from a front, having pitch angles individually adjustable with respect to the pitch center line; and a motor-generator configured to connect with the rotary shaft of the cycloidal turbine.

Abstract: Disclosed is a modularized AMTEC cell which does not require a separate collector by using a metal support as an internal electrode, has durability and stability even at a high temperature and a high pressure, very easily joins the cell to a housing by inserting the cell into an insulating portion and sealing, minimizes the number of the parts and expands easily the system scale through the serial-parallel structure.

Abstract: An arc flash hazard assessment method includes storing electrical equipment data in memory, defining an arc flash model function based on the data, and estimating the model function based on a weighted average of interpolated and extrapolated values. The electrical equipment data may include an operating voltage, a fault current, and a clearing time. The model function is defined for at least three reference voltages V1, V2 and V3, with the interpolated value at operating voltage V, between voltages V1 and V2, and the extrapolated value from reference voltages V2 and V3. At the arc flash protection boundary, the estimated model function has a predefined incident energy value of 1.2 cal/cm2 (or about 5.02 J/cm2), or less.

Abstract: Disclosed herein is an apparatus and method for managing a heterogeneous multi-core processor system, which can allocate a core to the execution of an application based on the states of cores included in heterogeneous multi-core processors. The apparatus for managing a heterogeneous multi-core processor system includes a management unit for receiving states of cores included in heterogeneous multi-core processors from an operating system layer and managing the states of the cores. A determination unit determines a core to be allocated to execution of an application among the cores included in the heterogeneous multi-core processors, based on the states of the cores received from the management unit. An allocation unit allocates the core determined by the determination unit to the execution of the application.

Abstract: A node processor and method for performing matrix operations includes storing, in memory, non-zero matrix elements of a first sparse matrix, non-zero matrix elements of a second sparse matrix, and matrix elements of a sparse results matrix mapped to the node processor. A matrix communications module exchanges with other node processors, non-zero matrix elements of one or more of the first sparse matrix, second sparse matrix, and sparse results matrix. An arithmetic logic unit generates partial results based on the non-zero matrix elements of the first sparse matrix and on the non-zero matrix elements of the second sparse matrix stored in memory. The arithmetic logic unit further generates a final value for each matrix element of the sparse results matrix mapped to the node processor based on the partial results generated by the arithmetic logic unit and on partial results received from the other node processors.