Abstract: The present disclosure provides a three-dimensional hydrogel-graphene-based biosensor and a preparation method thereof, belonging to the technical field of biosensors. The present disclosure provides a three-dimensional hydrogel-graphene-based biosensor, including a substrate, an electrode layer, a graphene film, and a three-dimensional hydrogel material layer that are stacked in sequence; where the three-dimensional hydrogel material layer is formed of a hydrogel material having a three-dimensional network structure; the hydrogel material is obtained by polymerization of raw materials including an acrylamide monomer and a modified probe molecule; and the modified probe molecule is a probe molecule modified with an acrylamide group. The three-dimensional hydrogel-graphene-based biosensor has a desirable stability and a high sensitivity.

Abstract: The present disclosure relates to compositions and methods for the preparation and use of free fatty acids as crystals and in solution, optionally in array format, for assay of lipotoxicity and related effects (in certain cases, indicators of diseases or disorders, such as type II diabetes) in contacted cells. Identification and therapeutic targeting of high-value gene targets discovered via joint assessment of lipotoxicity/transcriptome data and genetic association study data are also provided.

Abstract: Systems and methods for reconstructing images for computed tomography are provided. Image reconstruction can be based on a realistic polychromatic physical model, and can include use of both an analytical algorithm and a single-variable optimization method. The optimization method can be used to solve the non-linear polychromatic X-ray integral model in the projection domain, resulting in an accurate decomposition for sinograms of two physical basis components.

Abstract: An immunochromatography test strip for detecting pollution of diacetoxyscirpenol includes a bottom plate, where a water absorption pad, a detection pad, a gold-labeled pad and a sample pad are sequentially attached to one side of the bottom plate from top to bottom, adjacent pads are connected in an overlapping manner at a joint, the detection pad uses a nitrocellulose membrane as a base pad, a quality control line and a detection line are transversely arranged on the nitrocellulose membrane, the quality control line is coated with a rabbit antimouse polyclonal antibody, the detection line is located below the quality control line, and the detection line is coated with a diacetoxyscirpenol-ovalbumin conjugate; the gold-labeled pad is transversely spray-coated with a nanogold-labeled anti-diacetoxyscirpenol monoclonal antibody; and the anti-diacetoxyscirpenol monoclonal antibody is secreted by a hybridoma cell strain DAS5G11E7 with the preservation number of CCTCC NO.C201881.

Abstract: A ternary logic circuit includes: a first inverter unit; a second inverter unit arranged in parallel with the first inverter unit; a first junction unit arranged between the first inverter unit and an output terminal and including a tunnel PN junction; and a second junction unit arranged between the second inverter unit and the output terminal and including a tunnel PN junction, wherein, when an absolute value of an input voltage applied to an input terminal is less than a first input voltage, the output terminal outputs a first output voltage, and when the absolute value of the input voltage is greater than the first input voltage and less than a second input voltage, the output terminal outputs a second output voltage, and when the absolute value of the input terminal is greater than the second input voltage, the output terminal outputs a third output voltage.

Abstract: The present invention relates to bifunctional compounds, compositions, and methods for treating diseases or conditions mediated by aberrant histone deacetylase (HCADC) (e.g., HDAC3) activity.

Abstract: A design method for undisturbed switching of linear controllers is provided for solving the problem of sudden system response change or an unstable control circuit caused by switching of multiple linear controllers, in which the linear controllers include proportional-integral-derivative (PID), linear-quadratic-Gaussian (LQG), linear active disturbance rejection control (LADRC), H?, model reference adaptive control (MRAC), and open-loop controllers. Firstly, differentials tbr outputs of the controllers are found, then through controller decision, a controller is selected to be connected to a closed-loop control circuit, and a differential term of the controller connected to the closed-loop control circuit is integrated through a common integrator, thereby ensuring smooth controller switching. The design method has a simple structure and good versatility, is operable, and can be easily applied to various actual control systems without requiring parameter adjustment.

Abstract: An analog-to-digital converter, including a sample/hold circuit; a reference voltage driver; a digital-to-analog converter; a comparator; and a logic circuit, wherein the reference voltage driver includes: a first voltage supplier circuit configured to output an external supply voltage provided from outside of the analog-to-digital converter; a second voltage supplier circuit configured to output a sampled reference voltage that is obtained during a sampling phase based on control signals received from the logic circuit; and a switching driver configured to electrically connect the first voltage supplier circuit to the digital-to-analog converter during a first conversion phase after the sampling phase based on the control signals received from the logic circuit, and to electrically connect the second voltage supplier circuit to the digital-to-analog converter during a second conversion phase based on the control signals received from the logic circuit.

Abstract: Described are a process and a system for processing aromatics-rich fraction oil. The process includes: (1) introducing an aromatics-rich fraction oil into a fifth reaction unit for hydrosaturation, followed by fractionation, to provide a first light component and a first heavy component; (2) introducing a deoiled asphalt and an aromatics-comprising stream including the first heavy component into a hydrogen dissolving unit to be mixed with hydrogen, and introducing the mixed material into a first reaction unit for a hydrogenation reaction; (3) fractionating a liquid-phase product from the first reaction unit to provide a second light component and a second heavy component; (41) introducing the second light component into a second reaction unit for reaction; and (42) introducing the second heavy component into a delayed coking unit for reaction; or using the second heavy component as a component of low sulfur ship fuel oil.

Abstract: A fluidized bed regenerator, a device for preparing low-carbon olefins, and a use thereof are provided. The fluidized bed regenerator includes a second activation zone, a first activation zone, and a gas-solid separation zone from bottom to top; the second activation zone axially communicates with the gas-solid separation zone; the first activation zone is arranged on a periphery of a junction between the second activation zone and the gas-solid separation zone; the first activation zone is an annular cavity; n baffles are radially arranged in the first activation zone, and the n baffles divide the first activation zone into n first activation zone subzones; and a catalyst circulation hole is formed in each of n?1 of the baffles such that a catalyst entering the first activation zone flows in an annular direction.

Abstract: An X-ray imaging apparatus includes an X-ray generator including a plurality of X-ray sources, an X-ray detector configured to detect X-rays radiated from the plurality of X-ray sources and generate a plurality of pieces of projection data, and a processor configured to apply log projection to each of the plurality of pieces of projection data, to apply weighted projection to the log-projected projection data, to apply a bidirectional ramp filter to the weighted-projected projection data, and to generate a tomographic image reconstructed based on each of the projection data to which the bidirectional ramp filter is applied.

Abstract: An information processing device, including a resistive analog neuromorphic device element having a pair of electrodes and an oxide layer provided between the pair of electrodes, and a parallel circuit having a low resistance component and a capacitance component. The parallel circuit and the resistive analog neuromorphic device element are connected in series.

Abstract: An expandable liner and a method for running the same are provided. The expandable liner includes a base pipe, wherein the base pipe is provided with a passage extending through an axial direction of the base pipe, a connection structure disposed at both ends of the base pipe, and screen openings on a wall of the base pipe; a porous expandable layer is fixedly attached to an exterior of the base pipe and made of a non-memory foamed and compressible material. The expandable liner and the method, by adopting a non-memory porous expandable layer, realize a sand-control performance and a wellbore-supporting capability of a prior art technology where memory materials are used, which significantly reduces costs in manufacturing, operating and running.

Abstract: This disclosure is generally directed to electrochemical readout of rapid diagnostics related to use of CRISPR effector systems. In one aspect, the disclosure provides a nucleic acid detection system. Generally, the system comprises: (1) a detection CRISPR system comprising an effector protein and one or more guide nucleic acid (gNA) strands designed to bind to corresponding target nucleic acid molecules; (2) an effector strand and (3) an electrode.

Abstract: A treatment system and method for cephalosporin wastewater are disclosed. The treatment system includes: a flocculation and sedimentation device, an alkali reaction tank, a PAC reaction tank, a PAM reaction tank, a wastewater heat exchanger, a wastewater heater and an oxidation reactor that are connected with each other in sequence, wherein the wastewater heat exchanger is provided with a material inlet, a material outlet, a heat source inlet and a heat source outlet. An oxidized water from the oxidation reactor enters the wastewater heat exchanger from the heat source inlet, the heat source outlet is connected with a product canister, the product canister is connected with a membrane filtration device to realize concentration treatment of a landfill leachate, the material inlet is connected with the PAM reaction tank, and the material outlet is connected with the wastewater heater.

Abstract: Disclosed is an LPC residual signal encoding/decoding apparatus of an MDCT based unified voice and audio encoding device. The LPC residual signal encoding apparatus analyzes a property of an input signal, selects an encoding method of an LPC filtered signal, and encode the LPC residual signal based on one of a real filterbank, a complex filterbank, and an algebraic code excited linear prediction (ACELP).

Abstract: The present invention provides a simpler method for sharpening a tip of an emitter. In addition, the present invention provides an emitter including a nanoneedle made of a single crystal material, an emitter including a nanowire made of a single crystal material such as hafnium carbide (HfC), both of which stably emit electrons with high efficiency, and an electron gun and an electronic device using any one of these emitters. A method for manufacturing the emitter according to an embodiment of the present invention comprises processing a single crystal material in a vacuum using a focused ion beam to form an end of the single crystal material, through which electrons are to be emitted, into a tapered shape, wherein the processing is performed in an environment in which a periphery of the single crystal material fixed to a support is opened.

Abstract: A Unified Speech and Audio Codec (USAC) that may process a window sequence based on mode switching is provided. The USAC may perform encoding or decoding by overlapping between frames based on a folding point when mode switching occurs. The USAC may process different window sequences for each situation to perform encoding or decoding, and thereby may improve a coding efficiency.

Abstract: Disclosed are compounds with immunomodulatory activity, methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysfunctional protein activity.

Abstract: Disclosed are a compound selected from novel pyrimido[4,5-d]pyrimidin-2-one derivative compounds having excellent anti-proliferative activity against cancer cells, pharmaceutically acceptable salts thereof, hydrates thereof and stereoisomers thereof, a method for preparing the compound, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative diseases containing the compound as an active ingredient, and an anticancer composition against cancer cells, containing the compound as an active ingredient. The compounds of this invention exhibit most excellent selective inhibitory activity against LCK and anti-proliferative activity against cancer cells, thus being useful for inhibiting cancer cells, and for preventing or treating cancer metastasis and proliferative diseases.