Abstract: In accordance with the present invention, there are provided expression systems for the production of function glucocorticoid receptor proteins, methods for the recombinant production of glucocorticoid receptor proteins as well as sequences encoding novel members of the steroid/thyroid hormone superfamily of receptors (e.g., glucocorticoid receptor). Invention expression systems comprise host cells containing DNA encoding functional glucocorticoid receptor proteins, wherein the DNA is operably linked to control sequences compatible with host cells, thereby enabling the expression of functional receptor proteins. The invention method is carried out by culturing such recombinant host cells, and recovering the functional glucocorticoid receptor proteins produced thereby.

Abstract: System and method for balancing load among access points in a LAN are disclosed. Each access point has a SSID. After resetting an access point, the access point entering a SSID hidden state for hiding its SSID so as to prohibit mobile stations from accessing the access point. When in the SSID hidden state, an access point enters into a SSID showing state for showing its SSID and for enabling mobile stations to couple to the access point if no show-SSID-rejection frame is received. When in the SSID showing state, an access point enters into a SSID pre-hiding state for showing its SSID if the show-SSID-rejection frame is received. When in the SSID pre-hiding state, an access point enters into the SSID hidden state if the show-SSID-rejection frame is received, otherwise the first access point entering into the SSID showing state.

Abstract: Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods, screening methods, as well as specific transthyretin stabilizing compounds are disclosed.

Abstract: Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods, screening methods, as well as specific transthyretin stabilizing compounds are disclosed.

Abstract: The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, pharmaceutical compositions and the formulation of such compositions comprising said nucleic acids or proteins expressed therefrom, methods for treating a cell using such nucleic acids, proteins or pharmaceutical compositions, and the use of such nucleic acids or proteins in formulating a pharmaceutical preparation.

Abstract: A stable field-emission electron source that does not suffer from a current drop even after a high-current density operation for a long time is provided. The field-emission electron source includes: a substrate; an insulating layer that is formed on the substrate and that has a plurality of openings; cathodes arranged at the respective openings in order to emit electron beams; a lead electrode formed on the insulating layer in order to control emission of electrons from the respective cathodes; and a surface-modifying layer formed on the surface of each of the cathodes emitting electrons, comprising a chemical bond between a cathode material composing the cathodes and a material different from the cathode material.

Abstract: The specification discloses a device and method for generating a virtual keyboard/display. By means of optical scanning, a virtual display/keyboard is generated on a physical plane through a scan laser switch. Using the code reading technology, the key position entered by the user can be read and transmitted to a computer. The disclosed device includes a first laser emitter, a second laser emitter, and a laser receiver. The disclosed method has the following steps. First, the first laser emitter performs a surface scan to generate the patterns of the keyboard/display. The second laser emitter simultaneously generates a first reflective beam and a second reflective beam when the user enters input using the virtual keyboard. Finally, the laser receiver receives the first and second reflective beams, thereby obtaining the signals entered by the user.

Abstract: The present invention is directed to diagnostic methods based upon the expression of the protein prostasin. In particular, it is concerned with assays performed on women to determine their risk of ovarian cancer.

Abstract: A method and apparatus for locating a mobile communications device such as a cell phone includes apparatus for communicating with base stations and apparatus for communicating with satellites. Signals received from satellites and the base stations are combined to provide the necessary information to calculate the location of the mobile communications device.

Abstract: An apparatus for transmitting and receiving a signal in Code Division Multiple Access/Orthogonal Frequency Division Multiplexing (CDMA/OFDM) system is provided. The apparatus discriminates user signals with a unique spreading code and the orthogonal codes, increases data transmission rate with the non-binary value without increasing of entire bandwidth used by the users, solves signal interference with interleaver and diversity effect of interleaving and OFDM, and maximizes transmission efficiency by varying modulation schemes depending on channel states.

Abstract: The present invention refers to a method of separating casein from animal milk, especially, after defatting the animal milk as the pretreatment, the processing of the defatted milk aforesaid through a ceramic filtration membrane to remove the casein in the milk. The pretreatment process of separating the casein from the milk is then complemented by other processes of purification, so as to obtain the target protein of higher purity.

Abstract: A radiation or neutron detector wherein lateral side light detecting optical fibers prepared from clear optical fibers that are scraped on a lateral side to permit side incidence of fluorescence are used to detect the fluorescence from a phosphor or a scintillator such that the background to gamma-rays is reduced. If desired, the optical fibers may be bent at 90 degrees and guided to a photomultiplier tube in order to reduce the size of the detector. Fabrication and maintenance of the detector can be facilitated by adopting such a design that a detecting block comprising a detection medium and lateral side light detecting optical fibers is separated from a readout block comprising clear optical fibers.

Abstract: The compact steam reformer of the present invention integrally comprises a housing; a reforming reactor having an upper mixing compartment for mixing natural gas and steam and a lower compartment for accommodating a catalyst bed; a natural gas feeding coiled pipe through which natural gas is introduced while being heated; a steam generating coiled pipe in which pure water is converted to steam by the exhaust; a metal fiber burner for heating the reforming reactor; a high-temperature converter for primarily removing carbon monoxide from a synthetic gas; a low-temperature converter for secondarily reducing the carbon monoxide level of the synthetic gas; and a heat exchanger, provided between the high-temperature converter and the low-temperature converter, for cooling the gas effluent from the high-temperature converter.

Abstract: A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or “nested” polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.

Abstract: A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcription from response elements present in steroid-inducible cytochrome P450 genes in response to hundreds of natural and synthetic compounds with biological activity, including therapeutic steroids as well as dietary steroids and lipids. Instead of hundreds of receptors, one for each inducing compound, the invention SXR receptors monitor aggregate levels of inducers to trigger production of metabolizing enzymes in a coordinated metabolic pathway. Agonists and antagonists of SXR are administered to subjects to achieve a variety of therapeutic goals dependent upon modulating metabolism of one or more endogenous steroids or xenobiotics to establish homeostasis.

Abstract: cDNAs (RISBZ1, RISBZ4, and RISBZ5) encoding bZIP transcription factors were isolated from a cDNA library originating in rice plant seed. The cDNAs encode novel proteins and have binding activity to the GCN4 motif. Among them, RISBZ1 activated transcription mediated by the GCN4 motif by 100-fold or more. Since the expression of RISBZ1 precedes the expression of a seed storage protein gene and is expressed only in maturing seeds, it is suggested that RISBZ1 controls the expression of rice seed storage proteins. In addition, by linking the recognition sequence of the transcription factor, the GCN4 motif, in tandem and introducing it into the promoter for a gene encoding seed storage protein to facilitate its binding to the transcription factor RISBZ1, expression of a foreign gene under the control of the modified promoters is greatly enhanced.

Abstract: The present invention relates to a deflector of a micro-column electron beam apparatus and method for fabricating the same, which forms a seed metal layer and a mask layer on both sides of a substrate, and exposes some of the seed metal layer on which deflecting plates, wirings and pads are to be formed by lithography process using a predetermined mask. The wirings and pads are formed by plating metal on the exposed portion, and some of the metal layer is also exposed on which the deflecting plates are to be formed using a predetermined mask, and then the metal is plated with desired thickness, thereby the deflecting plates are completed. Therefore, by forming plurality of deflecting plates on both sides of the substrate at the same time through plating process, alignment between the deflecting plates formed on both sides of the substrate can be exactly made, and by fabricating a deflector integrated with the substrate and deflecting plates in a batch process, productivity and reproducibility is improved.

Abstract: An optical path switching method includes converging and irradiating, on a light absorption layer film provided in a thermal lens forming element including at least the film, each of a control light having a wavelength selected from a wavelength band which is absorbed by the film and a signal light having a wavelength selected from a wavelength band which is not absorbed by the film. A thermal lens is reversibly formed according to a distribution of refraction index created by a temperature increase generated in and around an area of the film in which the control light is absorbed according to whether or not the control light is irradiated. The converged signal light is output either in its converged form or after its spread angle is changed. A includes a hole and reflector where the signal light output is either passed through the hole or reflected by reflector.

Abstract: A memory processing approach involves implementation of memory status-driven access. According to an example embodiment, addresses received at an address buffer are processed for access to a memory relative to an active location in the memory. Addresses corresponding to an active location in the memory array are processed prior to addresses that do not correspond to an active location. Data is read from the memory to a read buffer and ordered in a manner commensurate with the order of received addresses at the address buffer (e.g., thus facilitating access to the memory in an order different from that received at the address buffer while maintaining the order from the read buffer).

Abstract: The present invention provides a human antibody against blood coagulation factor VIII (hereinafter also referred to as “FVIII”) and an antibody fragment that binds to human FVIII and specifically inhibits the coagulation activity of human FVIII. ScFv display phage libraries, prepared by using scFv DNAs constructed by random combinations of immunoglobulin VH chain genes and VL chain genes from lymphocytes from hemophilia A patients, is reacted with FVIII immobilized to a solid phase via anti-FVIII monoclonal antibody, and scFv clones capable of binding to FVIII are cloned to reveal VH and VL chains of FVIII-specific antibody.