Patents Assigned to INSTITUTE
  • Pseudotyped lentiviral vectors and uses thereof
    Patent number: 7078031
    Abstract: A vector system that will produce a pseudotyped lentiviral vector that can be used to deliver a desired gene is disclosed. The vector constructs that are described include a number of modifications that enhance the safety of the vector. The vector can be used to more specifically target cells for expression of certain genes.
    Type: Grant
    Filed: May 13, 2004
    Date of Patent: July 18, 2006
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Wayne A. Marasco, Sandra Ogueta
  • Sound generating apparatus and method, sound generating space and sound, each provided for significantly increasing cerebral blood flows of persons
    Patent number: 7079659
    Abstract: In a sound generating apparatus, a sound generating space, a sound, and a method for generating a sound, a sound is generated which has a frequency within a first frequency range beyond a predetermined audible frequency range and up to a predetermined maximum frequency, and which is non-stationary so as to change in a micro-temporal area in a second frequency range beyond 10 kHz. Then, the generated sound is applied to a person, thereby increasing cerebral blood flows of the person. This causes improvement and enhancement of the person's state of mind and body, so as to relieve stresses, thereby relaxing the person.
    Type: Grant
    Filed: September 26, 1996
    Date of Patent: July 18, 2006
    Assignee: Advanced Telecommunications Research Institute International
    Inventors: Tsutomu Oohashi, Norie Kawai, Emi Nishina, Yoshitaka Fuwamotot, Reiko Yagi, Masako Morimoto
  • Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries
    Patent number: 7078166
    Abstract: The invention describes the display of exogenous polypeptides on filamentous phage using a fusion between the exogenous polypeptide and phage pVII or pIX proteins. In particular, phage particles and phagemid vectors are described for expression and display of heterodimeric proteins such as antibody Fv heterodimers in combinatorial libraries, and uses thereof.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: July 18, 2006
    Assignee: The Scripps Research Institute
    Inventors: Kim D. Janda, Peter Wirsching, Richard A. Lerner, Changshou Gao
  • Photonic crystal laser sources for chemical detection
    Patent number: 7079240
    Abstract: A system, method and apparatus provide the ability to detect a chemical in an analyte. To detect the chemical, the invention utilizes a laser having an open cavity. A photonic crystal lattice structure having a defect defines a suitable geometry for such a cavity. The analyte is introduced directly into a high optical field of the cavity. Thereafter, the cavity is pumped and an emission from the laser is used to detect the presence of the chemical in the analyte.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: July 18, 2006
    Assignee: California Institute of Technology
    Inventors: Axel Scherer, Marko Loncar
  • Exception analysis for multimissions
    Patent number: 7080290
    Abstract: A generalized formalism for diagnostics and prognostics in an instrumented system which can provide sensor data and discrete system variable takes into consideration all standard forms of data, both time-varying (sensor or extracted feature) quantities and discrete measurements, embedded physical and symbolic models, and communication with other autonomy-enabling components such as planners and schedulers. This approach can be adapted to on-board or off-board implementations with no change to the underlying principles.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: July 18, 2006
    Assignee: California Institute of Technology
    Inventors: Mark L. James, Ryan M. E. Mackey, Han G. Park, Michail Zak
  • Bias weaving machine
    Patent number: 7077167
    Abstract: A bias-weaving machine is provided. In one embodiment, the bias-weaving machine includes a plurality of yarn carriers, each holding a yarn under tension that extends in a downstream direction towards a woven product. The yarn carriers are translatable in at least one direction other than the downstream direction. The apparatus further includes a plurality of reeds disposed to comb the yarns in a downstream direction. The reeds have a range of motion extending between positions upstream and downstream of the yarn carriers. Embodiment of this invention may advantageously be utilized to weave three-dimensional woven products, such as textile preforms for aerospace composites.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: July 18, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Samir A. Nayfeh, Jonathan D. Rohrs, Osamah Rifai, Sappinandana Akamphon, Mauricio Diaz, Emily C. Warman
  • Topoisomerase linker-mediated amplification methods
    Patent number: 7078501
    Abstract: A Vaccinia topoisomerase-adapted linker, which contains an oligonucleotide primer binding site of known sequence, useful for specifically joining the linker to the end of a polynucleotide of unknown sequence and allowing subsequent PCR amplification of the polynucleotide or DNA is provided. Kits containing the invention Vaccinia topoisomerase-adapted linker and one or more linker-specific oligonucleotides for annealing to the linker in PCR are also provided. In addition, the invention provides methods for using the invention linkers in linker-mediated PCR amplification procedures for isolation and optional sequencing of isolated PCR amplification products.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: July 18, 2006
    Assignees: Invitrogen Corporation, South Carolina Research Institute
    Inventors: John A. Heyman, Gabor Szalai, Michael Felder, Knut R. Madden
  • Multistage interconnection networks of multicast concentrators with self-routing control mechanism
    Patent number: 7079532
    Abstract: Application of the technique of statistical line grouping to banyan-type networks to practically alleviate the problems of output contention, traffic fluctuation, burstiness, and so forth without incurring additional preprocessing and buffering on the input traffic by introducing alternate-routing ingredient to the unique-routing banyan-type network, but without complicating the switching control too much through alternate routing. The multicast concentrator, a concentrator with the capability of multicasting, composed of interconnected bicast cells is employed to fill in each of the dilated nodes of the banyan-type network to give a hybrid network. An extremely simple self-routing control mechanism over the hybrid network which is the natural melting of the self-routing control inside the multicast concentrators and the self-routing control over the banyan-type network is presented.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: July 18, 2006
    Assignee: Industrial Technology Research Institute
    Inventor: Shuo-Yen Robert Li
  • Class BI and CI scavenger receptors
    Patent number: 7078511
    Abstract: Two distinct scavenger receptor type proteins having high affinity for modified lipoproteins and other ligands have been isolated, characterized and cloned. HaSR-BI, an AcLDL and LDL binding scavenger receptor, which is distinct from the type I and type II macrophage scavenger receptors, has been isolated and characterized and DNA encoding the receptor cloned from a variant of Chinese Hamster Ovary Cells, designated Var-261. dSR-CI, a non-mammalian AcLDL binding scavenger receptor having high ligand affinity and broad specificity, was isolated from Drosophila melanogaster. The isolated receptors are useful in screening for drugs that inhibit uptake of cholesterol in endothelial or adipose cells or macrophages, respectively. They are also useful as probes for the isolation of other lipoprotein receptors and in research the roles of these receptors.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: July 18, 2006
    Assignee: Massachusette Institute of Technology
    Inventors: Monty Krieger, Susan L. Acton
  • Adaptive frequency hopping apparatus in wireless personal area network system
    Patent number: 7079516
    Abstract: The present invention relates to an adaptive frequency hopping apparatus in a wireless personal area network (WPAN) system, wherein predetermined packets of data can be correctly transmitted by estimating the channel qualities of operating bands in advance and transmitting the packets through a proper band.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: July 18, 2006
    Assignee: Korea Electronics Technology Institute
    Inventors: Young-Hwan You, Cheol-Hee Park, Min-Chul Ju, Kee-Hyun Park, Jin-Woong Cho
  • System and method of determining the speed of digital application specific integrated circuits
    Publication number: 20060156050
    Abstract: According to one embodiment of the present invention, a system for identifying a running speed of an integrated circuit is provided. An asynchronous multi-rail circuit is configured to receive input data and transmit output data. A completion detection circuit is configured to generate a completion detection signal for the asynchronous multi-rail circuit. A variable clock generator configured to be driven by at least the completion detection signal. A synchronous circuit element configured to receive at least a portion of the output data and configured to be clock driven by a clock signal from the variable clock generator. A period of the clock signal represents a running speed of the asynchronous circuit.
    Type: Application
    Filed: December 23, 2005
    Publication date: July 13, 2006
    Applicant: Institute of Computer Science, Foundation for Research and Technology - Hellas ("ICS")
    Inventor: Christos Sotiriou
  • B7-4 polypeptides and uses therefor
    Publication number: 20060153841
    Abstract: The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing B7-4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-4 gene has been introduced or disrupted. The invention still further provides isolated B7-4 proteins, fusion proteins, antigenic peptides and anti-B7-4 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: January 26, 2006
    Publication date: July 13, 2006
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Gordon Freeman, Vassiliki Boussiotis, Tatyana Chernova, Nelly Malenkovich
  • Information support system
    Publication number: 20060153571
    Abstract: A battery-less terminal (1) has means (21) for photoelectrically converting an optical signal from an information transmission device (2), means (12) for outputting the electric signal generated by the photoelectric conversion means (21) as sound, means (13) for reflecting infrared light for position emitted by a position detection device (3), a light source (14) for infrared light for ID, means (15) for storing ID data, and means (16) for modulating the infrared light for ID in accordance with the ID data. The information transmission device (2) has a light source (21) for an optical signal and means (22) for modulating the strength of the optical signal in accordance with the electric signals of sound information.
    Type: Application
    Filed: November 26, 2003
    Publication date: July 13, 2006
    Applicant: National Institute Of Advanced Industrial Science And Technology
    Inventors: Takuichi Nishimura, Yoshiyuki Nakamura, Hideo Itoh, Hideyuki Nakashima, Takeshi Kurata
  • System and method for wireless access to an application server
    Publication number: 20060155822
    Abstract: A communication method, comprising constructing a Virtual Private Network (VPN) tunnel between a mobile device and an Intranet; and performing an Extensible Authentication Protocol-Subscriber Identification Module (EAP-SIM) authentication through the VPN tunnel. Access right of target service can be verified according to information in a SIM card no matter what kind of network access technology the service subscriber is using with the proposed communication method. A system utilizing the method is further provided.
    Type: Application
    Filed: September 29, 2005
    Publication date: July 13, 2006
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jen-Shun Yang, Da-Jiun Chou, Chun-Chieh Wang
  • Method and apparatus for vibrating a substrate during material formation
    Publication number: 20060151073
    Abstract: A method and apparatus for affecting the properties of a material comprise vibrating the material during its formation (i.e., “surface sifting”). The method comprises the steps of providing a material formation device and applying a plurality of vibrations to the material during formation, which vibrations comprise oscillations having dissimilar, non-harmonic frequencies and at least two different directions. The apparatus comprises a plurality of vibration sources that impart vibrations to the material.
    Type: Application
    Filed: January 13, 2005
    Publication date: July 13, 2006
    Applicant: Battelle Memorial Institute
    Inventors: Jeffrey Bailey, Roger Johnson, John Munley, Walter Park
  • Biologically active surfaces and methods of their use
    Publication number: 20060154894
    Abstract: The invention relates to the immobilization of polysaccharides on a substrate. In particular, the invention relates to biologically active surfaces formed by the immobilization of glycosaminoglycans on a substrate. The invention also provides biologically active surfaces that contain one or more different glycosaminoglycans and, optionally, one or more other agents. These agents can be biological or therapeutic agents. The invention also relates to methods of using the surfaces of the invention, such as, methods of affecting biological processes, eliciting patterns of cellular response, screening, treatment, diagnosis and preventing food contamination and/or spoilage.
    Type: Application
    Filed: September 15, 2005
    Publication date: July 13, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: David Berry, Alireza Khademhosseini, Kahp Suh, Ram Sasisekharan, Robert Langer
  • Flexible introducer sheath
    Publication number: 20060155302
    Abstract: An introducer apparatus and a method for forming an introducer apparatus. The apparatus comprises an inner liner having a passageway extending longitudinally therethrough. A coil in a stressed, radially expanded condition is positioned longitudinally around said inner tube. A polymeric outer tube is positioned longitudinally around the coil and the inner liner, and is bonded to the inner liner through the spaces between the turns of the coil. The polymeric outer tube is formed in a manner such that it maintains the coil in its stressed radially expanded condition. In a preferred embodiment, the inner liner and outer tube comprise a polyimide.
    Type: Application
    Filed: November 15, 2005
    Publication date: July 13, 2006
    Applicants: MED Institute, Inc., Cook Incorporated
    Inventors: Richard Sisken, Fred Parker
  • Optical sensor for determining the concentrations of dyes and/or particles in liquid or gaseous media and method for operating the same
    Publication number: 20060152730
    Abstract: The invention relates to an optical sensor (1) for determining particle and/or dye concentrations in liquid or gaseous media and to a method for operating the same. The optical sensor (1) comprises at least one measuring head. The measuring head consists of an emitter unit (2) with a semiconductor emitting element (9), which emits visible emission light beams (8), and with a receiver unit (3) with a semiconductor receiving element (10). The portion of the emission light beams (8), which pass through an absorption section containing liquid or gaseous medium, is guided onto the receiving element (10). An evaluating unit (6) is coupled to the measuring head via electric leads (4, 4?), and the received signals, which are present at the output of the semiconductor receiving element (10), are evaluated inside said evaluating unit in order to determine the particle or die concentration.
    Type: Application
    Filed: September 24, 2003
    Publication date: July 13, 2006
    Applicant: Institu fur Textilchemie de Deutschen Institute fur Textil- und Faserforschung Stuttgart
    Inventor: Reinhold Schneider
  • Buffy coat tube and float system and method
    Publication number: 20060154308
    Abstract: A tube and float system for use in separation and axial expansion of the buffy coat is provided. The system includes a transparent, or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The sample tube has an elongated sidewall having a first cross-sectional inner diameter. The float consists of a main body portion and one or more support members protruding from the main body portion to engage and support the sidewall of the sample tube. The main body portion and the support members of the float have a cross-sectional diameter less than that of the first cross-sectional inner diameter of the tube when the sample tube is expanded, such as by centrifugation. The main body portion of the float together with an axially aligned portion of the sidewall define an annular volume therebetween.
    Type: Application
    Filed: March 7, 2006
    Publication date: July 13, 2006
    Applicant: Battelle Memorial Institute
    Inventors: Thomas Haubert, Stephen Wardlaw
  • Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
    Patent number: RE39196
    Abstract: Methods for synthesis of nanocyrstalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having aveage crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m2/g and can be of high density. Hydroxyapatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: July 18, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Jackie Y. Ying, Edward S. Ahn, Atsushi Nakahira