Abstract: This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides and their use in methods of enhancing Nav1.1 activity and for treating or preventing conditions associated with Nav1.1 activity.

Abstract: Compositions and methods are provided for the identification of peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.

Abstract: A Magnetic Random Access Memory (MRAM), a method of manufacturing the same, and an electronic device including the same are provided. The MRAM includes a substrate, an array of memory cells arranged in rows and columns, bit lines, and word lines. The memory cells each include a vertical switch device and a magnetic tunnel junction on the switch device and electrically connected to a first terminal of the switch device. An active region of the switch device at least partially includes a single-crystalline semiconductor material. Each of the memory cell columns is disposed on a corresponding bit line, and a second terminal of each of the respective switch devices in the memory cell column is electrically connected to the corresponding bit line. Each of the word lines is electrically connected to a control terminal of the respective switch devices of the respective memory cells in a corresponding memory cell row.

Abstract: A pigment composite particle is provided, which includes an organic pigment core, a polyelectrolyte shell wrapped around the organic pigment core, and an oxide shell wrapped around the polyelectrolyte shell. The organic pigment core is water-insoluble. The organic pigment core and the polyelectrolyte shell have a weight ratio of 1:0.25 to 1:1. The oxide shell is formed from tetraalkyl orthosilicate, tetraalkyl orthotitanate, or a combination thereof, and the organic pigment core and the tetraalkyl orthosilicate, tetraalkyl orthotitanate, or the combination thereof have a weight ratio of 1:0.7 to 1:3.

Abstract: An aluminum nitride film includes a polycrystalline aluminum nitride. A withstand voltage of the aluminum nitride film is 100 kV/mm or more.

Abstract: Systems and methods for reconstructing images for computed tomography are provided. Image reconstruction can be based on a realistic polychromatic physical model, and can include use of both an analytical algorithm and a single-variable optimization method. The optimization method can be used to solve the non-linear polychromatic X-ray integral model in the projection domain, resulting in an accurate decomposition for sinograms of two physical basis components.

Abstract: Provided are a lithium ion secondary battery in which heat generation is suppressed when the battery is internally short-circuited by an external impact, such as nail penetration or collapse, or short-circuited by foreign matter contamination or the like; and an electrical appliance using the battery. More specifically, the following lithium ion secondary battery and electrical appliance comprising the lithium ion secondary battery are provided.

Abstract: An examination system that recognizes a glycosylated antigen in Dane particles of hepatitis B virus (HBV) and a neutralizing antibody that recognizes the glycosylated antigen and that exhibits an infection-inhibiting activity. It was elucidated that Dane particles are associated with specific glycan structures, and this enabled the construction of a new detection system for infectious, i.e., nucleic acid-containing, hepatitis B virus particles and the provision of a neutralizing antibody that recognizes a glycosylated antigen and that exhibits an infection-inhibiting activity.

Abstract: In order to sufficiently capture spatial distortion specific to an X-ray CT device and evaluate the three-dimensional shape measurement accuracy of the X-ray CT device, in a utensil, by attaching support rods fixing spheres to the tip thereof and having different lengths to a base spheres are arranged in an XYZ space on the base. On a flat surface on the top of the base, the support rods supporting the spheres and having different lengths are arranged at predetermined intervals. In doing so, the spheres are arranged in the XYZ space respectively at appropriate inter-sphere distances.

Abstract: A foam production method includes mixing liquid nitrogen with a foaming material to produce foam. A gas is produced in situ from liquid nitrogen. As the ratio of the volume of the gas produced by gasification of liquid nitrogen to the volume of the liquid nitrogen is relatively high, when a large gas supply flow is needed to generate a large foam flow, a liquid nitrogen storage device of a small volume can be used instead of bulky air supply devices such as high-pressure gas cylinders, air compressors, air compressor sets and the like, reducing the volume of the air supply device. In addition, the liquid nitrogen used in foaming will release nitrogen gas after the foam blast, such that the nitrogen is also able to inhibit combustion on the surface of burning materials, accelerating the extinguishing of the fire.

Abstract: The present invention discloses a molecular sieve and its preparation method. The molecular sieve has micromorphology in a football shape and consists of molecular sieve framework and active elements. The molecular sieve framework comprises silicon element and aluminum element; the active elements comprise copper element and rare earth elements. The rare earth elements are one or more selected from the group consisting of La, Ce, Pr, Nd, Pm, Sm, Eu, Sc and Y. The mass ratio of the silicon element to the aluminum element is 3-9:1. The content of the copper element in the molecular sieve is 1.5-3.2 wt %. The mass of rare earth elements is 50 ppm-2 wt % of the molecular sieve framework. The mass of the silicon element is calculated by silicon dioxide, the mass of aluminum element is calculated by aluminum oxide, the mass of copper element is calculated by copper oxides, and the mass of rare earth elements is calculated by rare earth oxides.

Abstract: A medical gripping device includes a housing, a gripping mechanism at one end of the housing, an operation unit, and a reaction force actuator and a gripping actuator installed in the housing. The operation unit is operated by a gripping operation of an operator, and the reaction force actuator applies an operation reaction force to the operation unit. The gripping actuator causes the gripping mechanism to perform a gripping operation. A control unit controls a force and a position that are output by the gripping actuator in an operation of the gripping mechanism in accordance with an operation with respect to the operation unit, and controls a force and a position that are output by the reaction force actuator in an operation of applying the operation reaction force to the operation unit in accordance with a reaction from a gripped object with respect to the gripping mechanism.

Abstract: Disclosed are immunomodulatory compounds, pharmaceutical compositions containing them, and methods of making and using the compounds to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon.

Abstract: An apparatus for genome sequence alignment attempts a search for the hash tables to align a target nucleotide sequence, from a hash table having a large seed size to a hash table having a small seed size, and when there is at least one matched seed to the target nucleotide sequence on a hash table, aligns the target nucleotide sequence by using candidate positions from the hash table without further hash table searching.

Abstract: A scheduling method includes: a server receiving a first request of a first peer (P2P) node; the first request containing service content; using position information on different network hierarchies of the first P2P node and the service content to determine at least one candidate P2P node for the first P2P node; the at least one candidate P2P node can provide a service for the first P2P node; the position information being position information generated on the basis of a network topology structure; using the at least one candidate P2P node to generate a candidate P2P node information list; P2P node information in the information list representing a transmission distance between the at least one candidate P2P node and the first P2P node; and returning the information list to the first P2P node. Further disclosed at the same time are a server, a first P2P node and a computer-readable storage medium.

Abstract: The invention features compositions comprising in vitro generated beta cells capable of glucose-stimulated insulin secretion, methods of inducing beta cell maturation from embryonic or induced pluripotent stem cell-derived beta-like cells, and methods of using in vitro generated beta cells for the treatment of type 1 diabetes, type 2 diabetes, or a related disorder.

Abstract: A neurovascular coupling analytical method based on an electroencephalogram and functional near-infrared spectroscopy includes: S100: acquiring an electroencephalogram signal and a brain hemodynamic signal; S110: extracting an event-related potential signal from the electroencephalogram signal; S120: extracting a time characteristic from the event-related potential signal; S130: extracting a hemodynamic response function from the brain hemodynamic signal; S140: extracting an amplitude characteristic and time characteristics from the hemodynamic response function; and S150: analyzing influence of the time characteristic of the event-related potential signal on the amplitude characteristic and the time characteristics of the hemodynamic response function to obtain a coupling result. The time characteristic of the event-related potential signal is a delay.

Abstract: A polymer blend is provided, which includes 100 parts by weight of a first polyolefin, 3 to 100 parts by weight of a thermoplastic polyurethane, and 3 to 10 parts by weight of a modified polyolefin. The modified polyolefin is formed by grafting maleic anhydride or acrylate onto a second polyolefin. The blend can be used to form fiber.

Abstract: Systems and methods for optimizing the simulation of a robot in an environment are disclosed herein. The system includes an environment sensor configured to generate signals indicative of objects within the environment. The system further includes a computing device having a processor and a non-transitory computer-readable memory and a machine-readable instruction set stored in the non-transitory computer-readable memory.

Abstract: Provided is a wireless communication terminal that communicates wirelessly. The terminal includes: a transceiver; and a processor. The processor is configured to receive a frame through the transceiver, determine whether the frame is classified into an Intra-Basic Service Set (BSS) frame or an Inter-BSS frame according to a BSS from which the frame is transmitted, and access a channel according to whether the frame is an Intra-BSS frame or an Inter-BSS frame.