Abstract: Described herein is a reversible aptamer selection technology for production-scale isolation of label-free cells (e.g., CD8+ T cells). Provided herein are methods for isolating a cell of interest from a biological sample by contacting the biological sample with an aptamer that specifically binds a cell surface marker specific for the cell of interest; separating the aptamer-bound cells from cells not bound to the aptamer; and recovering a cell of interest by disrupting binding of the aptamer to the cell surface marker.

Abstract: The present invention discloses an exploiting structure for a natural gas hydrate reservoir, comprising: a drilling well located in the natural gas hydrate reservoir; and a fractured fracture provided in communication with the drilling well, which is located in the natural gas hydrate reservoir and in which a gas containing calcium oxide powder is provided. In the present invention, the calcium oxide powder is filled with the fractured fracture by means of the gas. Then, the natural gas hydrate in the fractured fracture is decomposed, and the water generated from the decomposition reacts with the calcium oxide to release a large amount of heat, and a high-porosity calcium hydroxide filler can be formed. The exploiting method provided in the present invention is simple and easy to operate, and has low exploitation costs, and is suitable for commercial promotion and application.

Abstract: The present disclosure relates to 2-dimensional MXenes surface-modified with catechol derivatives, a method for preparing the same, MXene organic ink including the same, and use thereof (e.g. flexible electrodes, conducive cohesive/adhesive materials, electromagnetic wave-shielding materials, flexible heaters, sensors, energy storage devices). Particularly, the simple, fast, and scalable surface-functionalization process of MXenes using catechol derivatives (e.g. ADOPA) organic ligands significantly improves the dispersion stability in various organic solvents (including ethanol, isopropyl alcohol, acetone and acetonitrile) and produces highly concentrated organic liquid crystals of various MXenes (including Ti2CTx, Nb2CTx, V2CTx, Mo2CTx, Ti3C2Tx, Ti3CNTx, Mo2TiC2Tx, and Mo2Ti2C3Tx). Such products offer excellent electrical conductivity, improved oxidation stability, excellent coating and adhesion abilities to various hydrophobic substrates, and composite processability with hydrophobic polymers.

Abstract: A vascular interventional instrument control device capable of operating double guide wires or balloons, includes a main finger assembly, a first sub-finger assembly, a second sub-finger assembly, a driving assembly and a clamping assembly, wherein the main finger assembly, the sub-finger assembly, the driving assembly and the clamping assembly are separately installed to the body structural member and separately connected to the controller through a communication link, one of the operated double guide wires or balloons is clamped by the main finger assembly and the first sub-finger assembly, and the other is clamped by the main finger assembly and the second sub-finger assembly; and the operated double guide wires or double balloons can be separately moved axially or rotated about its own axial direction.

Abstract: The present invention relates to an anti-influenza virus agent comprising Bifidobacterium bifidum as an active ingredient.

Abstract: A method for forming a desired hydrocarbon fuel product from a mixed oxygenate feedstock by utilizing chemical processes to form ketones from the oxygenate feed, upgrade the ketones, recycle selected upgraded ketones through the upgrading process to obtain a desired intermediate and hydrogenating the desired intermediate to obtain the desired hydrocarbon fuel product. In various alternative configurations and embodiments this can be accomplished in a number of ways, and originate in a number of different positions and occasions.

Abstract: The disclosure provides an outdoor device for simulating a pond ecosystem comprising a plurality of simulated ponds connected together by pipelines and including an adjusting pool, a plurality of control groups and a plurality of treatment groups with different concentrations; the plurality of control groups and the treatment groups are randomly distributed in the ponds according to a random draw method or a random allocation method, and the adjusting pool is a transfer station for water inlets and outlets of the ponds. According to the device, the plurality of control groups and treatment groups are arranged in a system, achieving a scale of a middle-scale pond ecological simulation system, which can stimulate an actual complex hydrostatic ecological system including a plurality of aquatic macrophytes, algae, zooplankton, benthos and microorganisms, and evaluate the effects of the complex ecological efficiency caused by chemical pollutants entering an actual water body.

Abstract: Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers.

Abstract: This invention relates to the delivery of heterologous peptides or proteins such as therapeutic peptides, therapeutic proteins or antigens to mucosal sites using vesicles derived from the outer membrane of commensal bacteria, recombinant bacteria capable of producing such vesicles, and methods for the production of such vesicles. The invention further relates to an inducible expression system for use in recombinant bacteria.

Abstract: Antigen specific regulatory T cells are described and related compositions, methods and systems. Methods to generate an antigen specific anti-inflammatory regulatory T cell is provided, the method comprising contacting either a T cell or an antigen presenting cell with a zwitterionic polysaccharide conjugated to the antigen for a time and under condition to generate an antigen specific regulatory T cell that is capable of inhibiting a pro-inflammatory response against the antigen.

Abstract: A display device includes a cover part, a driving unit for transmitting an external force to the human body through the cover part, and a display unit that is provided at a position of the cover part through which the external force is transmitted to the human body, and indicates a display in accordance with the external force transmitted from the driving unit.

Abstract: A light modulation element according to example embodiments includes a substrate; a first lower DBR layer on the substrate including a first material layer alternately stacked with a second material layer having a different refractive index from the first material layer; a second lower DBR layer on the first lower DBR layer with a surface area less than the first lower DBR layer and including a third material layer alternately stacked with a fourth material layer having a different refractive index from the third material layer; an active layer on the second lower DBR layer, including a semiconductor material having a multi-quantum well structure and having a refractive index that varies according to an applied voltage; and an upper DBR layer on the active layer including a fifth material layer alternately stacked with a sixth material layer having a different refractive index from the fifth material layer.

Abstract: The present invention relates to a method for determining loss of gas in a gas container. According to an embodiment of the present invention, the method for determining the loss of gas in the gas container is characterized by including the steps of (a) filling a first container (10) with a component gas and a balance gas, (b) measuring a gas pressure inside the first gas container (11), (c) allowing the first gas container and a second gas container having an evacuated inside to communicate and performing a first-stage gas pressure split, and (d) measuring a gas pressure inside the second gas container, wherein an amount of the component gas adsorbed inside the gas container is calculated through a difference between a measured value of step (b) and a measured value of step (d) and is determined as an amount of gas loss.

Abstract: A decoder comprises a feature extraction circuit for calculating one or more feature vectors; an acoustic model circuit coupled to receive one or more feature vectors from said feature extraction circuit and assign one or more likelihood values to the one or more feature vectors; a memory for storing states of transition of the decoder; and a search circuit for receiving an input from said acoustic model circuit corresponding to the one or more likelihood values based upon the one or more feature vectors, and for choosing states of transition from the memory based on the input from said acoustic model.

Abstract: Computerized pipelines can transform input data into data structures compatible with models in some examples. In one such example, a system can obtain a first table that includes first data referencing a set of subjects. The system can then execute a sequence of processing operations on the first data in a particular order defined by a data-processing pipeline to modify an analysis table to include features associated with the set of subjects. Executing each respective processing operation in the sequence to generate the modified analysis table may involve: deriving a respective set of features from the first data by executing a respective feature-extraction operation on the first data; and adding the respective set of features to the analysis table. The system may then execute a predictive model on the modified analysis table for generating a predicted value based on the modified analysis table.

Abstract: The present application discloses a PEGylated asparaginase and use thereof. In this application, the polyethylene glycol (PEG) is coupled to the N-terminal amino of 1 or 2 subunits of L-asparaginase, and the molecular weight of the PEG is 30-40 KDa. The PEG is preferably branched and has an aldehyde serving as an activating group. The PEGylated asparaginase is useful in the preparation of anti-tumor drugs.

Abstract: The invention relates to BODIPY derivatives of Formula (I): that bear one or more functional groups which in the photochemical reaction upon irradiation with visible light undergo deamination and deliver quinone methides. Furthermore, the invention relates to the antiproliferative activity of BODIPY derivatives and their use for pharmaceutical applications and for fluorescent labeling, particularly for labeling proteins.

Abstract: A graph upscaling method and apparatus is disclosed. The graph upscaling apparatus may store, in a main memory, original graph data including topological data including a vertex and an edge, determine a parent edge using a hash function and the original graph data, and generate a new edge based on the determined parent edge. The graph upscaling apparatus may store, in a main memory, original graph data including topological data including a vertex and an edge, allocate identities (IDs) of edges to be generated to cores included in a central processing unit (CPU) based on the number of the cores, and generate new edges based on the IDs of the edges using a hash function and the original graph data.

Abstract: According to an embodiment, a magnetic tunnel junction includes a tunnel barrier layer provided between a first magnetic layer and a second magnetic layer. The tunnel barrier layer is a crystal body made of a stacked structure of a first insulating layer and a second insulating layer. The crystal body is oriented. The first insulating layer is made of an oxide of Mg1-xXx (0?x?0.15). X includes at least one element selected from the group consisting of Al and Ti. The second insulating layer is made of an oxide of an alloy including at least two elements selected from the group consisting of Mg, Al, Zn, and Li. Both the first magnetic layer and the second magnetic layer are made of an alloy including B and at least one element selected from the group consisting of Co and Fe.

Abstract: A bit interleaver, a bit-interleaved coded modulation (BICM) device and a bit interleaving method are disclosed herein. The bit interleaver includes a first memory, a processor, and a second memory. The first memory stores a low-density parity check (LDPC) codeword having a length of 64800 and a code rate of 4/15. The processor generates an interleaved codeword by interleaving the LDPC codeword on a bit group basis. The size of the bit group corresponds to a parallel factor of the LDPC codeword. The second memory provides the interleaved codeword to a modulator for 1024-symbol mapping.