Abstract: It has been discovered that even mild changes in cerebrospinal fluid (CSF) pressure or intracranial pressure (ICP) can be detected immediately as evidenced by distortions in the ONS surface structure. Further, the changes in the ONS persist after the CSF pressure has returned to normal. The stability of ONS distortions provides a method of detecting transient changes in brain pressure even when the use of the diagnostic ultrasound is delayed. One embodiment provides systems and methods for detecting or diagnosing brain injury by detecting distortions or deformations of the ONS, preferably using ultrasound.
Type:
Grant
Filed:
July 1, 2015
Date of Patent:
April 27, 2021
Assignee:
AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
Abstract: Disclosed herein are a three-way authentication apparatus and method in a cloud environment. The three-way authentication method in a cloud environment includes performing, by a control device and a service device, mutual authentication through an IF-1 interface, performing, by the control device and a function server, mutual authentication through an IF-2 interface, requesting, by the control device, the function server to issue an authentication token for authentication between the service device and the function server, and delivering an authentication token issued by the function server to the service device, and performing, by the service device, mutual authentication with the function server using the delivered authentication token through an IF-3 interface.
Type:
Grant
Filed:
November 25, 2019
Date of Patent:
April 27, 2021
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Abstract: The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present invention relates to a novel pyrrolidine carboxylic acid derivative, its manufacture, pharmaceutical compositions containing it and its use as a catalyst.
Type:
Grant
Filed:
September 28, 2016
Date of Patent:
April 27, 2021
Assignee:
OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION
Abstract: A system and method for optical tomography including illuminating an object with pulsing stimulus light and pulsing the stimulus light at a repetition frequency having a pulse period that is greater than a dead-time of a detector. Coordinating the pulse with the dead-time of the detector allows for higher powered light source and improves early photon detection.
Type:
Grant
Filed:
April 26, 2017
Date of Patent:
April 27, 2021
Assignee:
ILLINOIS INSTITUTE OF TECHNOLOGY
Inventors:
Kenneth M. Tichauer, Jovan G. Brankov, Lagnojita Sinha
Abstract: A preparation method of adiposomes, and use thereof. Provided is a method for preparing adiposomes consisting of neutral lipids and a monolayer phospholipid membrane, comprising a1) vortexing phospholipid and neutral lipids in a buffer, centrifuging the resulting mixture, and collecting an upper liquid phase; a2) purifying the upper liquid phase twice or more by uniformly mixing the upper liquid phase with the buffer, layering the mixture, and collecting an upper liquid phase; and a3) uniformly mixing the upper liquid phase obtained in step a2) with the buffer, layering the mixture, and collecting a lower liquid phase in containing adiposomes. For the adiposomes prepared by the method, one or more resident proteins and/or functional proteins can be recruited to obtain artificial lipid droplets, and one or more apolipoproteins can be recruited to obtain artificial lipoproteins; and they all play important roles in preparing drugs and/or drug carriers.
Type:
Grant
Filed:
November 22, 2016
Date of Patent:
April 27, 2021
Assignee:
INSTITUTE OF BIOPHYSICS, CHINESE ACADEMY OF SCIENCES
Abstract: An ultrasonic testing device that can make a robotic testing system reach the surface of a complex curved composite workpiece that is not easy to reach and perform a quality testing. By pumping a coupling liquid into the device so that the coupling liquid enters a waveguide and jets onto the surface of the workpiece, an ultrasonic wave can be transmitted in the waveguide and reach the surface of the workpiece and penetrate the workpiece, thereby achieving the purpose of quality testing of the workpiece. By providing two ultrasonic testing devices without a waveguide on both sides of a tested workpiece, respectively, and by mounting the waveguide on one side or both sides of the ultrasonic testing devices, it is possible to transmit the ultrasonic waves to the surface of the workpiece or to receive the ultrasonic waves from the surface of the workpiece.
Abstract: The present disclosure provides a method for preparing an extract of Chrysanthemum morifolium with an effect of treating skin diseases, including: (a) performing an extraction procedure on Chrysanthemum morifolium with an extraction solvent to obtain an extract solution; and (b) adding at least one glycoside hydrolases to the extract solution to make an enzyme reaction occur to produce a precipitate, wherein the precipitate is the extract of Chrysanthemum morifolium with an effect of treating skin diseases.
Type:
Grant
Filed:
December 22, 2017
Date of Patent:
April 27, 2021
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: Disclosed is a catalyst pre-contact method for the continuous polymerization of an olefin, wherein a primary catalyst, a co-catalyst and, optionally, an external electron donor are mixed and then undergo a pre-contact reaction, with the pre-contact reaction temperature being ?30° C. to 35° C. and adjustable, and the pre-contact reaction time being 0.5 min to 10 min and adjustable, and the pre-contacted catalyst is brought into a catalyst prepolymerization system and then into a catalyst polymerization system, or is directly brought into the catalyst polymerization system. Further disclosed is a catalyst pre-contact device for the continuous polymerization of an olefin, which can adjust the pre-contact time and pre-contact temperature of the catalyst so that the performance of the catalyst achieves a better level according to the process.
Type:
Grant
Filed:
June 23, 2017
Date of Patent:
April 27, 2021
Assignees:
CHINA PETROLEUM & CHEMICAL CORPORATION, BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION
Inventors:
Xianzhi Xia, Tianyi Zhang, Yuexiang Liu, Jin Zhao
Abstract: Provided is a microorganism that is capable of efficiently producing para-aminobenzoic acid (4-ABA) or a salt thereof, using saccharides as raw materials, and a method for efficiently producing 4-ABA or a salt thereof by using this microorganism. A transformant obtained by introducing, into a coryneform bacterium, a gene that encodes 4-amino-4-deoxychorismate lyase, a gene that encodes a para-aminobenzoate synthase component I, and a gene that encodes a para-aminobenzoate synthase component II, is capable of efficiently producing 4-ABA or a salt thereof from saccharides.
Type:
Grant
Filed:
February 24, 2017
Date of Patent:
April 27, 2021
Assignees:
RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH, SUMITOMO BAKELITE CO., LTD.
Abstract: A method for industrial production of a butadiene-isoprene copolymer rubber having a trans-1,4-structure (TBIR) and an apparatus for implementing the method. The production method includes: pumping a predetermined amount of a butadiene and an isoprene into a polymerization reactor, and performing bulk polymerization in the presence of a catalyst to obtain TBIR; performing extrusion, devolatilization, granulation and drying on the produced TBIR, and then packaging the produced TBIR; and separating unreacted monomers by a recovery and separation device followed by separately refining the unreacted monomers, and then returning the unreacted monomers to a batching device or a storage tank. The production apparatus has a recovery and refining unit, a polymerization unit, a post-treatment unit and a utility unit. By the production apparatus and the production method industrial production of TBIR by bulk polymerization is realized.
Type:
Grant
Filed:
November 15, 2016
Date of Patent:
April 27, 2021
Assignees:
QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY, SHANDONG HUAJU POLYMER MATERIALS CO., LTD., CHAMBROAD CHEMICAL INDUSTRY RESEARCH INSTITUTE CO., LTD.
Inventors:
Aihua He, Yunsheng Ma, Huafeng Shao, Gang Yao, Chenguang Liu, Bo Luan, Riguo Wang
Abstract: An ion resonance excitation operation method and device by applying a quadrupolar electric field combined with a dipolar electric field. The method includes applying a main RF to any pair of plates of the ion trap mass analyzer, and applying a quadrupolar excitation signal to any pair of plates, and applying a reverse phase dipolar excitation signal to any pair of plates. Also provided is an ion resonance excitation operation method and device by using a quadrupolar electric field combined with a dipolar electric field, which includes applying a positive main RF to a pair of electrode rods of the quadrupole, and applying a negative main RF to the other pair of electrode rods; applying a quadrupolar excitation signal to any pair of electrode rods, applying a reverse phase dipolar excitation signal to any pair of electrode rods.
Abstract: An apparatus includes a processor to: within each collection thread, assemble a row group from stored rows, generate row group metadata corresponding to the row group, and store the row group and row group metadata within a data buffer of a queue; operate the queue as a FIFO buffer; within each aggregation thread, retrieve multiple row groups and corresponding row group metadata from multiple data buffers of the queue, assemble a data set part from the multiple row groups, generate part metadata that includes the row group metadata, and transmit, to storage device(s) and/or a requesting device, the data set part and/or the part metadata; and in response to each retrieval of at least a row group from a data buffer of the queue for an aggregation thread, analyze availability of storage space within the node device to determine whether to dynamically adjust the quantity of data buffers.
Abstract: The flash memory system according to the embodiment of the present invention is characterized by programming a selected page in a quantization signal generating operation, providing a reference read voltage to a selected word line connected to the selected page, A flash memory for generating a flash memory; And a memory controller for receiving a quantized signal from the flash memory and generating a response using the quantized signal, wherein the memory controller receives an challenge from a host and the flash memory performs the quantized signal generation.
Type:
Grant
Filed:
May 29, 2019
Date of Patent:
April 27, 2021
Assignee:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Abstract: Vehicle developer devices, systems and methods are disclosed. In one embodiment, a vehicle developer device includes a management computing device, a plurality of electronic control units, and a plurality peripheral devices, wherein one or more individual peripheral devices of the plurality of peripheral devices is a physical representation of an actual vehicle peripheral device. The vehicle developer device further includes a plurality of ports for receiving one or more of at least one additional electronic control units and at least one additional peripheral devices. The management computing device configures the plurality of electronic control units, and simulates operation of a full-scale simulated vehicle. The vehicle developer device is smaller in size than the full-scale simulated vehicle.
Type:
Application
Filed:
October 20, 2020
Publication date:
April 22, 2021
Applicant:
TOYOTA RESEARCH INSTITUTE ADVANCED DEVELOPMENT, INC.
Abstract: In order to improve the efficiency of inducing differentiation of pluripotent stem cells, provided is a method for promoting differentiation of pluripotent stem cells, the method including a step of culturing pluripotent stem cells in a medium, wherein the medium is a medium containing a) an insulin-like growth factor, b) an insulin analogue preparation containing no zinc, c) an insulin analogue preparation containing a low concentration of zinc, or d) a compound exhibiting an insulin-like action.
Type:
Application
Filed:
April 25, 2019
Publication date:
April 22, 2021
Applicants:
TOKYO INSTITUTE OF TECHNOLOGY, Ajinomoto Co., Inc.
Abstract: Approaches, apparatuses and methods for LIDAR applications based on mode-selective frequency conversion are disclosed. In one embodiment, a pulse generation unit includes a mode-locked fiber laser and optical fiber bandpass filters. In the second embodiment, a LIDAR transceiver unit based on a simple, bidirectional monostatic coaxial arrangement using off-the-shelf tele-com-grade optical components includes optical fiber, fiber collimator, optical fiber circulator, optical fiber isolator and wavelength combiner. A frequency conversion detection system with single photon sensitivity includes a nonlinear optical material for frequency conversion, coupled with optimized pump pulses for efficient conversion and noise rejection, optical band pass filters for noise rejection and a single photon detection system for detecting the converted signal.
Type:
Application
Filed:
June 13, 2019
Publication date:
April 22, 2021
Applicant:
THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY
Abstract: The present disclosure relates to a polymer electrolyte membrane for medium and high temperature, a preparation method thereof and a high-temperature polymer electrolyte membrane fuel cell including the same, more particularly to a technology of preparing a composite membrane including an inorganic phosphate nanofiber incorporated into a phosphoric acid-doped polybenzimidazole (PBI) polymer membrane by adding an inorganic precursor capable of forming a nanofiber in a phosphoric acid solution when preparing phosphoric acid-doped polybenzimidazole and using the same as a high-temperature polymer electrolyte membrane which is thermally stable even at high temperatures of 200-300° C. without degradation of phosphoric acid and has high ion conductivity.
Type:
Application
Filed:
April 27, 2020
Publication date:
April 22, 2021
Applicant:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
So Young LEE, Seung Ju LEE, Min Jae LEE, Hyun Seo PARK, Jong Hyun JANG, Hyoung-Juhn KIM, Suk Woo NAM, Young Suk JO, Yeong Cheon KIM
Abstract: A heparin structure with increased anticoagulant activity and method of making the same are disclosed. A heparin sample is provided and treated with a heparan sulfate sulfotransferase in an enzymatic reaction to add sulfuryl groups from a sulfuryl group source to the heparin sample, resulting in a heparin structure having above about 8% more 3-O-sulfo groups relative to wild-type bovine intestinal heparin. The added sulfuryl groups modify the heparin structure and increase the sample's binding to antithrombin III and its anticoagulant activity to be more similar and a viable alternative to porcine intestinal heparin. The modified heparin exhibits an anti-FXa activity and an anti-FIIa activity greater than about 180 U/mg, and a ratio of the anti-FXa activity to the anti-FIIa activity of about 0.9 to about 1.1, consistent with U.S. Pharmacopeia (USP) heparin activity specifications.
Type:
Application
Filed:
November 10, 2020
Publication date:
April 22, 2021
Applicant:
RENSSELAER POLYTECHNIC INSTITUTE
Inventors:
Li Fu, Kevin Li, Daisuke Mori, Makoto Hirakane, Jonathan S. Dordick, Robert J. Linhardt
Abstract: A swing arm restraint system for an automotive lift includes a movable carriage including a swing arm mounting portion. A first swing arm restraint housing is non-rotatably connected to the swing arm mounting portion, the first swing arm restraint housing including a first internal space. A first swing arm is pivotally connected to the swing arm mounting portion and is rotatable relative to the first swing arm restraint housing. A first restraint device is located in the first internal space and connected to the the swing arm restraint housing. A second restraint device is operably connected to the first swing arm such that the second restraint device rotates with the first swing arm relative to the first swing arm restraint housing.