Abstract: Provided are a genome editing system CRISPR-C2c1 for site-specific modification of target sequences in a cell genome and the use thereof, wherein the system comprises a C2c1 protein or variants thereof and a guide RNA. Also provided are a method for site-specific modification of target sequences in a cell genome using the genome editing system CRISPR-C2c1, and a pharmaceutical composition comprising the genome editing system CRIPSR-C2c1.

Abstract: A device for gripping an object includes a pair of grippers each having a gripping surface formed with a plurality of fine channels, a driver for driving the pair of grippers, a pump connected to at least one of the plurality of fine channels, to supply a fluid to the at least one of the plurality of fine channels, and a controller for controlling the driver to enable the pair of grippers to grip the object or controlling the pump to adjust an amount of the fluid supplied to the gripping surface.

Abstract: Admixture for cementitious building materials can provide a self-healing mechanism to improve material longevity. In certain embodiments, the admixture can include the combination of both a quicklime-based replacement for fine and coarse aggregates and an SCM replacement for OPC in standard mortar and concrete.

Abstract: A process for producing catalytic cracking gasoline includes the following steps: i) subjecting a heavy feedstock oil to a catalytic cracking reaction in the presence of a first catalytic cracking catalyst to obtain a first reaction product; ii) subjecting a hydrogenated cycle oil to a catalytic cracking reaction in the presence of a second catalytic cracking catalyst to obtain a second reaction product; iii) separating a mixture of the first reaction product and the second reaction product to obtain a catalytic cracking gasoline and a catalytic cracking light cycle oil; iv) subjecting the catalytic cracking light cycle oil or a fraction thereof to hydrogenation to obtain a hydrogenated product; and v) recycling the hydrogenated product to the step ii) as the hydrogenated cycle oil.

Abstract: A porous porphyrin polymer and a method of recovering precious metal elements using the same are described. A porous porphyrin polymer represented by Formula 1 has high selectivity for precious metal elements and a high ability to adsorb precious metal elements, and can be applied to the recovery of precious metal elements either from metal leachates of waste electronic products or from river water or seawater.

Abstract: A method for surface planarization of an object using a light source of a specific wavelength according to an embodiment includes: providing an object in a main chamber; injecting an etching gas into the main chamber; inputting the light source of a specific wavelength onto a surface of the object; and controlling a temperature of the object. According to the method, it is possible to minimize the side effects such as scratches or contamination of the sample that occur in a conventional chemical-mechanical planarization process. In addition, it is possible to allow precise planarization in nanometers (nm) and simultaneously perform planarization to a side surface of a device as well as a large-sized surface, thereby reducing cost and time required for the planarization process. Moreover, since the surface roughness and the electrical conductivity are improved, it is possible to increase the efficiency and output of the LED device.

Abstract: An exosome active formulation for promoting endothelial cell angiogenesis, and a preparation method and use thereof include the following steps: isolating primary umbilical vein endothelial cells and performing cell culture and passage; adding anisodamine to a culture medium of the subcultured endothelial cells to treat the endothelial cells, and then replacing the culture medium with a new endothelial cell culture medium to continue the culture of the endothelial cells; extracting exosomes from the endothelial cell culture medium obtained after the endothelial cells are cultivated; and identifying the exosomes. The exosome active formulation for promoting endothelial cell angiogenesis prepared by the preparation method and its use in the manufacture of a medicament for treating microvascular injury, microcirculation dysfunction and cardio-cerebral infarction.

Abstract: The invention is related to the field of biotechnology, specifically to the investigation of biomolecular interactions and sensing of biomolecules using a surface plasmon resonance. The biological sensor and a method of its production based on the thin films of graphene, graphene oxide, or single-walled or multi-walled carbon nanotubes are described. The technical results of the invention are a high sensitivity of the biosensor in combination with a high biospecificity; an expansion of the range of device applications; the protection of the metal film from an environmental exposure; the possibility to detect large biological objects.

Abstract: A base station divides a subframe into a downlink time duration for downlink, an uplink time duration for uplink, and a guard period between the downlink time duration and the uplink time duration. The base station transmits a downlink control channel including information on a downlink packet duration allocated for downlink transmission of a terminal and information on an uplink packet duration allocated for uplink transmission of the terminal to the terminal in the downlink time duration.

Abstract: A motion control method and system for a biomimetic robotic fish based on an adversarial structured control, includes: taking the accuracy and speed of motion to the target point as a reward term, and taking a power sum of servomotors as a loss term to construct an optimization objective function; optimizing parameters of a central pattern generator model that generates a global control quantity of a servomotor, after curing its parameters, optimizing the parameters of the servomotor compensation control model; iteratively optimizing the parameters of the model; obtaining the global control signal and compensation control signal of the biomimetic robotic fish through the trained model, and using the linear combination of the two sets of output signals as the control signal of the servomotor of the robotic fish to realize the motion control of the fish.

Abstract: The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

Abstract: An insole design method and an insole design system are provided, and the method includes: capturing an uncompressed free foot model by a depth camera and obtaining a free foot model three-dimensional image; capturing a pressed foot model stepped on a transparent pedal by the depth camera and obtaining a pressed foot model three-dimensional image; aligning the free foot model three-dimensional image with the pressed foot model three-dimensional image; calculating and obtaining a plantar deformation quantity according to the aligned free foot model three-dimensional image and the aligned pressed foot model three-dimensional image; and completing the designed insole according to a sole projection plane or a three-dimensional profile of the specific sole and the plantar deformation quantity.

Abstract: Provided is a coating composition capable of forming a coating film which exhibits excellent durability and is suitable for repair. It is a coating composition containing a resin component and a pigment, in which a linear expansion coefficient at a temperature equal to or less than a glass transition temperature of a nonvolatile component is 3.2×10?5/K or less.

Abstract: Disclosed is a building envelope for a building wall, floor, or roof of a building, the building envelope comprising at least two shells spaced apart from one another that enclose an intermediate space there between, the intermediate space being sealed against the interior and the exterior of the building and being filled with structural weight-bearing and building-technology components, and at least in sections with a porous, open-celled 3D-pattern material. A plurality of heat pipes which are connected to a heat-collector element on the shell facing the exterior and the interior of the building and which end in the intermediate space are arranged in the intermediate space.

Abstract: A training apparatus 1000 using a method of decoding nerve activity includes: a brain activity detecting device 108 for detecting brain activity at a prescribed area within a brain of a subject; and an output device 130 for presenting neurofeedback information (presentation information) to the subject. A processing device 102 decodes a pattern of cranial nerve activity, generates a reward value based on a degree of similarity of the decoded pattern with respect to a target activation pattern obtained in advance for the event as the object of training, and generates presentation information corresponding to the reward value.

Abstract: The present invention relates to a metal fluoride red phosphor and an application of the phosphor as a light emitting element, the metal fluoride red phosphor having a tetragonal crystal structure of a novel composition, and emitting light in the red color wavelength by being excited by ultraviolet rays or a blue excitation source, thereby being usefully applicable to a light emitting element such as a light emitting diode, a laser diode, a surface emitting laser diode, an inorganic electroluminescence element, and an organic electroluminescence element.

Abstract: Provided are a class of vancomycin derivatives with a structure as shown in the general formula below and pharmaceutically acceptable salts thereof, a preparation method, a pharmaceutical composition containing the compound thereof, and the use of these compounds in preparing drugs for treating and/or preventing bacterial infection diseases, in particular drugs for treating infection diseases caused by Gram-positive bacteria.

Abstract: A method and apparatus for drug dissolution testing may include an overflow vessel with an overflow outlet port at a predetermined height from a bottom of the overflow vessel, a first water bath submerging the overflow vessel and configured to keep a temperature of the overflow vessel at a first predetermined temperature, a pressurized vessel containing a dissolution medium, a second water bath submerging the pressurized vessel and configured to keep the dissolution medium at a second predetermined temperature, a dissolution medium path with an output end connected in fluid communication with the flow cell and an input end attached in fluid communication to the pressurized vessel, where the dissolution medium path may transfer the dissolution medium from the pressurized vessel into the flow cell, a collection vessel connected to the overflow outlet port of the flow cell, and a third water bath submerging the collection vessel and configured to keep the collection vessel at a third predetermined temperature.

Abstract: An apparatus for monitoring file access in a virtual machine in a cloud-computing system based on a virtualized environment includes a hypervisor for implementing at least one virtual machine and managing the virtual machine by monitoring a task in which a the virtual machine accesses a file loaded from storage to memory, the storage storing data including environment information of the virtual machine.

Abstract: Vehicle systems are disclosed. A vehicle system includes one or more sensors, a steering wheel, an accelerator pedal, a steering wheel actuator, an accelerator pedal actuator, and a controller. The controller is communicatively coupled to the one or more sensors and the steering sensitivity adjusting unit. The controller includes at least one processor and at least one memory module storing computer readable and executable instructions that, when executed by the processor, cause the controller to detect an object based on output from the one or more sensors, and send to the steering sensitivity adjusting unit an instruction for adjusting a sensitivity of the steering wheel in response to detecting the object.