Patents Assigned to INSTITUTE
  • Patent number: 10968434
    Abstract: An exosome active formulation for inhibiting endothelial cell migration, and a preparation method and use thereof include the following steps: isolating primary umbilical vein endothelial cells and performing cell culture and passage; adding anisodamine to a culture medium of the subcultured endothelial cells to pretreat the endothelial cells, and then replacing the culture medium with a new endothelial cell culture medium and adding TNF-? to continue the culture of the endothelial cells; extracting exosomes from the TNF-? containing endothelial cell culture medium obtained after the endothelial cells are cultivated; and identifying the exosomes. The exosome active formulation for inhibiting endothelial cell migration prepared by the preparation method of this disclosure and its use in the antitumor drugs.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: April 6, 2021
    Assignee: INSTITUTE OF MICROCIRCULATION (OF THE CHINESE ACADEMY OF MEDICAL SCIENCES & PEKING UNION MEDICAL COLLEGE)
    Inventors: Honggang Zhang, Bingwei Li, Qiuju Zhang, Ruijuan Xiu
  • Patent number: 10968567
    Abstract: A method for preparing ?-cellulose, a spinning composition, and a fiber material are provided. The method for preparing ?-cellulose includes providing a coffee residue; subjecting the coffee residue to a decolorization treatment, obtaining a white powder; reacting the white powder with an alkaline solution, obtaining a mixture; filtering the mixture to produce a filter cake; and baking the filter cake to obtain ?-cellulose.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: April 6, 2021
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Shi-Kuang Hwang, Tien-Ching Lu, Kai-Jen Hsiao, Jing-Wen Tang
  • Patent number: 10967515
    Abstract: An apparatus for remotely controlling field robots, includes: an interface unit; a work command generator generating a work command signal for operating field robots; an autonomous command generator which generates an autonomous operation command signal for controlling an operation of a second field robot when a user selects a following mode and the work command generator generates a work command signal for a first field robot to correspond to the following mode, or generates an autonomous operation command signal for controlling operations of the first field robot and the second field robot in order to operate an object of work when the user selects an object mode and the work command generator generates a work command signal for the object of work to correspond to the object mode; and a communication unit transmitting the generated autonomous operation command signal to the first field robot and the second field robots.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: April 6, 2021
    Assignee: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Seung Yeol Lee, Dae Jin Kim, Sung Hoon Eom, Jeon Il Moon
  • Patent number: 10972264
    Abstract: A method is provided that protects electronic Identity information based on key derived operation. The method includes using an electronic Identity server to send an application derived identifier of the application and user electronic Identity code to a host security module that randomly generates an application master key, encrypts the application derived identifier with the application master key, and gets an application encryption key. The host security module encrypts the user electronic Identity code with the application encryption key, and gets an encryption document. The electronic Identity server codes the encryption document and an application identity code, and gets an application electronic Identity code. The electronic Identity server uses the application electronic Identity code as the user identifier.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: April 6, 2021
    Assignee: THE THIRD INSTITUTE OF THE MINISTRY OF PUBLIC SECURITY
    Inventors: Xiang Zou, Minghui Yang, Lishun Ni, Yixin Xu, Jun Huang
  • Patent number: 10972131
    Abstract: A low density parity check (LDPC) encoder, an LDPC decoder, and an LDPC encoding method are disclosed. The LDPC encoder includes first memory, second memory, and a processor. The first memory stores an LDPC codeword having a length of 16200 and a code rate of 2/15. The second memory is initialized to 0. The processor generates the LDPC codeword corresponding to information bits by performing accumulation with respect to the second memory using a sequence corresponding to a parity check matrix (PCM).
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: April 6, 2021
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Sung-Ik Park, Heung-Mook Kim, Sun-Hyoung Kwon, Nam-Ho Hur
  • Patent number: 10966986
    Abstract: The present invention features improved Compounds, especially (I) methods of identifying patients having Cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3L1) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein).
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: April 6, 2021
    Assignees: BAYER PHARMA AKTIENGESELLSCHAFT, THE BROAD INSTITUTE, INC., DANA-FARBER CANCER INSTITUTE INC.
    Inventors: Timothy A. Lewis, Alex Burgin, Monica Schenone, Xiaoyun Wu, Heidi Greulich, Matthew Meyerson, Luc De Waal, Antje Margret Wengner, Knut Eis, Philip Lienau, Ulrike Sack, Martin Lange
  • Patent number: 10968216
    Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: April 6, 2021
    Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFT, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: Stefan Nikolaus Gradl, Duy Nguyen, Knut Eis, Judith Günther, Timo Stellfeld, Andreas Janzer, Sven Christian, Thomas Mueller, Sherif El Sheikh, Han Jie Zhou, Changjia Zhao, David B. Sykes, Steven James Ferrara, Kery Liu, Simon Anthony Herbert, Claudia Merz, Michael Niehues, Carl Friedrich Nising, Martina Schäfer, Katja Zimmermann, Jörg Knäblein, Kai Thede, Thomas Faupel
  • Patent number: 10972325
    Abstract: Disclosed is a technique related to a method and apparatus for generating a preamble and a data frame for wireless communication, and to a synchronization estimation method using the preamble. According to the technique, a method for generating a frame for wireless communication is disclosed, wherein the method comprises: a step of generating a modified sequence using a first base sequence for synchronization estimation; and a step of allocating the first base sequence and the modified sequence to the frequency domain of a first timeslot to generate a preamble. The modified sequence includes a complex conjugated sequence of the first base sequence or a sequence having a code different from that of the first base sequence.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: April 6, 2021
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Kapseok Chang, Wooyong Lee, Hyun-Kyu Chung
  • Patent number: 10970617
    Abstract: An acceleration and compression method for a deep convolutional neural network based on quantization of a parameter provided by the present application comprises: quantizing the parameter of the deep convolutional neural network to obtain a plurality of subcode books and respective corresponding index values of the plurality of subcode books; acquiring an output feature map of the deep convolutional neural network according to the plurality of subcode books and respective corresponding index values of the plurality of subcode books. The present application may implement the acceleration and compression for a deep convolutional neural network.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: April 6, 2021
    Assignee: INSTITUTE OF AUTOMATION CHINESE ACADEMY OF SCIENCES
    Inventors: Jian Cheng, Jiaxiang Wu, Cong Leng, Hanqing Lu
  • Patent number: 10969859
    Abstract: A system comprising a display provided with zones, a token, a proximity sensor for detecting the proximity of a token to one zone and a processor to register in a memory an association upon the detection of the proximity of the token to the zone. The association is logged as a set of data comprising the data of which a representation is made on the zone in the proximity of which the token has been brought. The processor is programmed to update a log file with the logged association. The processor performs an operation in accordance with the content of the log file.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: April 6, 2021
    Assignee: LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)
    Inventors: Annie Guerriero, Valérie Maquil
  • Patent number: 10971929
    Abstract: The present invention provides a chip ESD protection circuit, includes an integrated circuit layer and a conductive layer. A first ground bonding pad that is connected to a first ground wire of a first power domain is disposed on each of the first power domain and a second power domain in the integrated circuit layer. The first ground bonding pads are bonded to the conductive layer. A second power clamping unit is disposed on the second power domain. A first end of the second power clamping unit is connected to a second power wire of the second power domain, and a second end thereof is connected to the first ground wire or a second ground wire of the second power domain. According to the chip ESD protection circuit, the ESD protection capability of a chip can be improved. The occupied area of the chip is reduced.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: April 6, 2021
    Assignee: CHINA ELECTRONIC TECHNOLOGY CORPORATION, 24TH RESEARCH INSTITUTE
    Inventors: Yan Wang, Tao Liu, Guang-Bing Chen, Yu-Xin Wang, Dong-Bing Fu, Yu-Jun Yang, Liang Chen, Yang Pu
  • Patent number: 10967377
    Abstract: A multi-well plate allows for improvement in accuracy of experiments or tests. The present invention relates to a multi-well plate comprising: a top portion placed in a horizontal direction; a bottom portion opposing the top portion in a direction crossing the horizontal direction; and wells each recessed from the top portion toward the bottom portion, wherein the wells are horizontally arranged in a matrix with rows and columns, and each well has an opening formed at the top portion, and a peripheral wall extending from a periphery of the opening to the bottom portion. In the multi-well plate, at least two wells respectively include marks each containing at least one symbol, and each mark is placed at an opening peripheral wall end portion close to the corresponding opening.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: April 6, 2021
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventor: Yoshio Kato
  • Patent number: 10970229
    Abstract: An apparatus includes a first processor to execute a user-level application to operate in a virtual address, and a co-processor to execute a computing kernel associated with user-level application elements to be performed on the co-processor. The computing kernel is to operate in the virtual address. A memory includes physical addresses, and a partition used to map the virtual address associated with the first processor and to map the virtual address associated with the co-processor. A packet processor manages communications between the first processor and the co-processor. The packet processor receives packets from the first processor, with the packets including memory addresses identifying code and data of the computing kernel. The packet processor stores the packets in a queue associated with the user-level application, and outputs the packets to the co-processor, such that the co-processor is enabled to execute the computing kernel.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: April 6, 2021
    Assignees: STMICROELECTRONICS (GRENOLBE 2) SAS, TECHNOLOGICAL EDUCATIONAL INSTITUTE OF CRETE
    Inventors: Antonio-Marcello Coppola, Georgios Kornaros, Miltos Grammatikakis
  • Patent number: 10966999
    Abstract: Provided herein are the 3?3? cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: April 6, 2021
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Ondrej Pav, Tomas Jandusik, Ivan Rosenberg, Radim Nencka
  • Patent number: 10971276
    Abstract: The present invention relates to a composition for removing a radionuclide, including: a first polymer including a hydroxy group; a second polymer into which a boronic acid group is introduced as a functional group; and an adsorbent for removing the radionuclide, and a method for removing a radionuclide using the same.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: April 6, 2021
    Assignee: KOREA ATOMIC ENERGY RESEARCH INSTITUTE
    Inventors: Yang Hee-Man, ChanWoo Park, Lee Kune-Woo, Ilgook Kim, In-Ho Yoon, BumKyoung Seo
  • Patent number: 10969374
    Abstract: The invention relates to a device and method for laboratory ice jam and ice dam radar measurement tests, the device includes a non-metal water tank, a truss spans the top of the non-metal water tank, the truss is connected with a radar plate parallel to a surface of water through a lifting mechanism, a measuring radar is provided on the radar plate, a permeable measuring barrel soaked in the water is provided below the radar plate, a barrel bottom of the permeable measuring barrel is a permeable plate capable of rising and falling, model ice blocks are provided in the permeable measuring barrel, and a handle capable of shaking the truss upwards, downwards, leftwards and rightwards is provided on the truss.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: April 6, 2021
    Assignee: CHINA INSTITUTE OF WATER RESOURCES AND HYDROPOWER RESEARCH
    Inventors: Hui Fu, Xinlei Guo, Tao Wang, Yongxin Guo, Jiazhen Li, Ping Ji, Jiajia Pan, Jinzhi Lu
  • Patent number: 10968308
    Abstract: Provided are a preparation method of an epoxy compound having an alkoxysilyl group in which an increase in the epoxy equivalent weight (EEW) of the epoxy compound is minimized because alkoxysilylation occurs through a simple one-step reaction using a hydroxyl group formed during the synthesis of the epoxy compound, an epoxy compound having an alkoxysilyl group prepared by the method, a composition comprising the same, and a use thereof. The method includes the reaction of an epoxy compound having a hydroxyl group with an isocyanate alkoxysilane in the presence of amine-based base catalyst, wherein the epoxy compound having an alkoxysilyl group has a mole ratio of [epoxide group]:[alkoxysilyl group] of n:1 ranging from 2:1 to 10:1, and an EEW increase of the epoxy compound having an alkoxysilyl group is less than 260/n. The epoxy compound has good physical properties when being cured.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: April 6, 2021
    Assignee: KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGY
    Inventors: Hyun Aee Chun, Yun Ju Kim, Sook Yeon Park, Su Jin Park
  • Patent number: 10968313
    Abstract: The present invention relates to an amino polymer, its main chain is attached via a —O— group to a structure represented by the following formula (I). The present invention also relates to a process for producing said amino polymer and to its use as fuel oil detergent. Compared with the prior art, the fuel oil detergent of the present invention has the advantages such as a lower manufacturing cost and an improved deposit formation inhibition performance. In formula (I), groups and values are defined as described in the description.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: April 6, 2021
    Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, RESEARCH INSTITUTE OF PETROLEUM PROCESSING, SINOPEC
    Inventors: Xin Cheng, Jianrong Zhang, Zuoxin Huang, Qinghua Duan
  • Patent number: 10966738
    Abstract: Devices, systems and methods for ocular ultrasound are provided having therapeutic and/or diagnostic applications. In one aspect, an ocular probe is disclosed that is uniquely configured for use in the eye on the basis of shape and frequency. The ocular probe may be multi-functional, providing sensor, optical or other functionality in additional to ultrasound energy.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: April 6, 2021
    Assignee: DOHENY EYE INSTITUTE
    Inventor: Mark S. Humayun
  • Patent number: 10968109
    Abstract: A method for synthesizing a mordenite (MOR) molecular sieve with a modulatable location and distribution of B acid sites, and a product thereof and the use thereof. Provided is a method for synthesizing a mordenite MOR molecular sieve with acid sites located at an 8-membered ring “side pocket” in communication with a 12-membered ring pore channel in the presence or absence of an inorganic base. The method includes introducing an additional reagent and an optional fluorinating reagent which have different structures and charge densities into a synthetic gel, and the B acid sites of the obtained MOR zeolite are located at an 8-membered ring “side pocket” in communication with a 12-membered ring pore channel A catalyst product obtained exhibits an excellent performance in terms of adsorption and catalysis. The synthesis method has broad industrial application, particularly being applied to catalysts for the carbonylation reaction of dimethyl ether.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: April 6, 2021
    Assignee: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Linying Wang, Peng Tian, Zhongmin Liu, Hongyi Yang, Xuebin Zhao, Beibei Gao, Yuyan Qiao