Abstract: The present disclosure relates to a copper-phosphorus-zinc-tin brazing sheet and a preparation method and use thereof. The copper-phosphorus-zinc-tin brazing sheet includes a copper core layer, CuP alloy layers respectively arranged on two sides of the copper core layer, and at least two SnZn alloy layers respectively arranged on the other sides of the two CuP alloy layers away from the copper core layer.
Type:
Grant
Filed:
February 14, 2023
Date of Patent:
May 6, 2025
Assignee:
ZHENGZHOU RESEARCH INSTITUTE OF MECHANICAL ENGINEERING CO., LTD.
Abstract: A heat exchanger includes a main body portion and a cover. The main body portion includes a heat exchange core, a collecting pipe portion and a first mounting shell. The collecting pipe portion includes a first collecting pipe portion and a second collecting pipe portion. Both the first collecting pipe portion and the second collecting pipe portion are provided with mounting end plates. Two ends of the first mounting shell are hermetically connected to the mounting end plates by brazing. The first mounting shell encloses part of the heat exchange core in a circumferential direction. Two ends of the cover are hermetically connected to the mounting end plates by bonding. The cover and the first mounting shell are arranged in an enclosing manner in the circumferential direction. The heat exchanger improves stability and reliability. A manufacture method of the heat exchanger is also disclosed.
Type:
Grant
Filed:
March 15, 2024
Date of Patent:
May 6, 2025
Assignee:
HANGZHOU SANHUA RESEARCH INSTITUTE CO., LTD.
Abstract: The present invention discloses a nanobody targeting IL-6R? protein and uses thereof, wherein the heavy chain variable region of the nanobody comprises three complementary determining regions, CDR1, CDR2, and CDR3, wherein CDR1 has an amino acid sequence as shown in SEQ ID NO. 2, CDR2 has an amino acid sequence as shown in SEQ ID NO. 3, and CDR3 has an amino acid sequence as shown in SEQ ID NO. 4. With high affinity to IL-6R? protein and high stability and water solubility, the nanobody can be used in the development of pharmaceutical compositions for the treatment of IL-6-mediated related diseases or conditions, as well as in the development of reagents or kits for the detection of IL-6R?, which can provide potentially highly effective antibodies for the study of IL-6-mediated related diseases, and provide new therapeutic strategies and targets for autoimmune diseases or tumors.
Type:
Grant
Filed:
April 22, 2024
Date of Patent:
May 6, 2025
Assignee:
INSTITUTE OF HEALTH AND MEDICINE, HEFEI COMPREHENSIVE NATIONAL SCIENCE CENTER
Abstract: The three-state spintronic device includes: a bottom electrode, a magnetic tunnel junction and a top electrode from bottom to top. The magnetic tunnel junction includes: a spin-orbit coupling layer, a ferromagnetic free layer, a barrier tunneling layer, a ferromagnetic reference layer, three local magnetic domain wall pinning centers and domain wall nucleation centers. An antisymmetric exchange interaction is modulated, and the magnetic domain wall pinning centers are embedded in an interface between a heavy metal and the ferromagnetic free layer. The magnetic domain wall nucleation centers are at two ends of the ferromagnetic free layer. A current pulse flows through the spin-orbit coupling layer to generate a spin current and the spin current is injected into the ferromagnetic free layer. Under a control of all-electrical controlled, an effective field of a spin-orbit torque drives domain wall to move and displace.
Type:
Grant
Filed:
January 21, 2021
Date of Patent:
May 6, 2025
Assignee:
INSTITUTE OF MICROELECTRONICS, CHINESE ACADEMY OF SCIENCES
Inventors:
Huai Lin, Guozhong Xing, Zuheng Wu, Long Liu, Di Wang, Cheng Lu, Peiwen Zhang, Changqing Xie, Ling Li, Ming Liu
Abstract: An apparatus for saturating a buffer material includes a jig for fixing and supporting a buffer material to prevent an increase of a volume of the buffer material. The jig is provided to surround at least a portion of the buffer material. The apparatus further includes a case having a space in which the jig supporting the buffer material is accommodated, a supply unit configured to supply water vapor into the case to adjust a saturation level of the buffer material, and a control unit configured to control the supply unit to stop the supply of water vapor when the saturation level of the buffer material reaches a preset critical saturation level.
Type:
Grant
Filed:
July 23, 2021
Date of Patent:
May 6, 2025
Assignee:
KOREA ATOMIC ENERGY RESEARCH INSTITUTE
Inventors:
Seok Yoon, Seung-Hun Park, Geon Young Kim, Dong Keun Cho
Abstract: A molecular marker combination linked to quantitative traits of tea plant (+)-catechin content, including a SNP site 1, a SNP site 2, a SNP site 3, a SNP site 4, a SNP site 5, a SNP site 6, a SNP site 7 and a SNP site 8, which are located in tea genomes Scaffold4239:309117, Scaffold3614: 66549, Scaffold349: 3413816, Scaffold1989: 2316385, Scaffold451: 940283, Scaffold3727:442660, Scaffold115:803980 and Scaffold920:281727, respectively, and genotypes thereof are extremely significantly correlated with the (+)-catechin content is provided. A detection method for detecting each site, and one or more molecular marker site is used to evaluate the tea plant (+)-catechin content.
Type:
Grant
Filed:
May 13, 2024
Date of Patent:
May 6, 2025
Assignee:
TEA RESEARCH INSTITUTE, GUANGDONG ACADEMY OF AGRICULTURAL SCIENCES
Inventors:
Kaixing Fang, Hualing Wu, Xiaohui Jiang, Hongjian Li, Qiushuang Wang, Dandan Qin, Chendong Pan, Bo Li
Abstract: Embodiments relate to a Brillouin distributed optical fiber sensor including a first light source to output a first light having a modulated intensity at a preset frequency, an optical modulation unit to generate Brillouin probe light and Brillouin pump light using the first light and apply the Brillouin probe light and the Brillouin pump light to one end and the other end of a test optical fiber, respectively, a second light source to apply a second light with a frequency that is different from a frequency of the first light to one end of the test optical fiber in a direction opposite to the Brillouin pump light, and an optical detection unit to detect Brillouin scattered light generated by interaction between the Brillouin pump light and the Brillouin probe light in the test optical fiber.
Type:
Grant
Filed:
November 24, 2021
Date of Patent:
May 6, 2025
Assignee:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Gukbeen Ryu, Wookjin Jeong, Sang Bae Lee, Wonsuk Lee, In Soo Kim, Jongbum Kim, Kwan Il Lee
Abstract: A manufacturing method for an electron source according to the present disclosure includes steps of: (A) cutting out a chip from a block of an electron emission material, (B) fixing a first end portion of the chip to a distal end of a support needle, and (C) sharpening a second end portion of the chip. The step (A) includes forming first and second grooves which constitute first and second surfaces of the chip in the block by irradiating a surface of the block with an ion beam. The first end portion of the chip includes the first surface and the second surface with the surfaces forming an angle ? of 10 to 90°. The step (B) includes forming a joint between the distal end of the support needle and the first end portion of the chip.
Type:
Grant
Filed:
June 23, 2022
Date of Patent:
May 6, 2025
Assignees:
Denka Company Limited, NATIONAL INSTITUTE FOR MATERIALS SCIENCE
Inventors:
Hiromitsu Chatani, Daisuke Ishikawa, Jie Tang, Tadakatsu Ohkubo, Shuai Tang, Jun Uzuhashi, Kazuhiro Hono
Abstract: Provided herein are non-naturally occurring variants of the hepatitis B virus (HBV) Core protein, the HBV polymerase N-terminal domain, and the HBV polymerase C-terminal domain, as well as immunogenic fragments thereof. Fusion proteins comprising the HBV variants fused to a herpes simplex virus (HSV) glycoprotein (gD) sequence, as well as methods of using the fusion proteins, are also provided.
Type:
Grant
Filed:
October 24, 2023
Date of Patent:
May 6, 2025
Assignees:
Virion Therapeutics, LLC, The Wistar Institute
Inventors:
Hildegund C J Ertl, Colin Stephen Magowan
Abstract: An electronic system for transmitting and receiving internal data through an optical channel. The electronic system may include a light emitter configured to generate a first optical signal, a first device configured to receive the first optical signal and including a transmitter configured to output a second optical signal representing a transmission value based on the first optical signal, a second device including a first receiver configured to receive the second optical signal from the first device and output a third optical signal by adjusting a light intensity of the second optical signal, and configured to read the transmission value based on the light intensity of the second optical signal, and a third device including a second receiver configured to receive the third optical signal from the second device, and configured to read the transmission value based on a light intensity of the third optical signal.
Type:
Grant
Filed:
May 22, 2023
Date of Patent:
May 6, 2025
Assignees:
SAMSUNG ELECTRONICS CO., LTD., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Hanyeoreum Bae, Myoungsoo Jung, Jie Zhang
Abstract: An apparatus for generating broadcast signal frame according to an embodiment of the present invention includes a combiner configured to generate a multiplexed signal by combining a core layer signal and an enhanced layer signal; a power normalizer configured to reduce power of the multiplexed signal to a power level corresponding to the core layer signal; a time interleaver configured to generate a time-interleaved signal by performing time-interleaving that is applied to both the core layer signal and the enhanced layer signal; and a frame builder configured to generate a broadcast signal frame including a preamble for signaling start position information and size information for each of Physical Layer Pipes (PLPs). In this case, the Physical Layer Pipes include a core layer physical layer pipe corresponding to the core layer signal and an enhanced layer physical layer pipe corresponding to the enhanced layer signal.
Type:
Grant
Filed:
August 11, 2022
Date of Patent:
May 6, 2025
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Bo-Mi Lim, Sung-Ik Park, Sun-Hyoung Kwon, Jae-Young Lee, Heung-Mook Kim, Nam-Ho Hur
Abstract: Disclosed are compositions and methods for ex vivo expansion of tumor infiltrating lymphocytes for use in adoptive cell therapy (ACT). Also disclosed are compositions and method for identifying an agent for ex vivo expansion of tumor infiltrating lymphocytes for use in ACT. Also disclosed are methods for treating cancer using tumor-infiltrating lymphocytes expanded by the disclosed methods.
Type:
Grant
Filed:
May 24, 2022
Date of Patent:
May 6, 2025
Assignees:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., UNIVERSITY OF SOUTH FLORIDA
Inventors:
Amod A. Sarnaik, Shari Pilon-Thomas, Mark McLaughlin, Hao Liu
Abstract: Systems, methods, and other embodiments described herein relate to estimating scaled depth maps by sampling variational representations of an image using a learning model. In one embodiment, a method includes encoding data embeddings by a learning model to form conditioned latent representations using attention networks, the data embeddings including features about an image from a camera and calibration information about the camera. The method also includes computing a probability distribution of the conditioned latent representations by factoring scale priors. The method also includes sampling the probability distribution to generate variations for the data embeddings. The method also includes estimating scaled depth maps of a scene from the variations at different coordinates using the attention networks.
Type:
Grant
Filed:
October 13, 2023
Date of Patent:
May 6, 2025
Assignees:
Toyota Research Institute, Inc., Toyota Jidosha Kabushiki Kaisha
Inventors:
Vitor Campagnolo Guizilini, Igor Vasiljevic, Dian Chen, Adrien David Gaidon, Rares A. Ambrus
Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.
Type:
Grant
Filed:
October 27, 2022
Date of Patent:
May 6, 2025
Assignees:
FUDAN UNIVERSITY, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, SHANGHAI MIRACOGEN INC.
Inventors:
Ke Yu, Jingkang Shen, Tao Meng, Lanping Ma, Xuesai Zhang, Qingrou Li, Qing Lin
Abstract: The present invention relates to a novel enzyme capable of producing multi-hydroxy derivatives from polyunsaturated fatty acids and a method for producing multi-hydroxy derivatives of polyunsaturated fatty acids using the same.
Type:
Grant
Filed:
March 8, 2024
Date of Patent:
May 6, 2025
Assignee:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
Inventors:
Jeong Woo Seo, Jong Jae Yi, Sun Yeon Heo, Young Bae Kim, Chul Ho Kim, Baek Rock Oh, Jung Hyun Ju, Hack Sun Choi
Abstract: System, methods, and other embodiments described herein relate to communicating a recommended speed through feedback on a combined pedal for acceleration or braking. In one embodiment, a control system includes a pedal coupled to a first device having a throttle sensor for a vehicle and a first actuator that generates throttle feedback by applying force to the pedal. The control system also includes the pedal being coupled to a second device having a brake activation sensor for the vehicle and a second actuator that generates braking feedback, the first actuator triggers a rotation of the pedal that initiates a braking command through the brake activation sensor according to a recommended speed computed using vehicle data.
Abstract: A low-friction long-life ultra-lattice composite coating as well as a preparation method and use thereof are provided. The ultra-lattice composite coating includes a titanium transition layer, a TiNx bearing layer, a TiNx/MoS2 gradient transition layer, a MoS2/Me gradient transition layer and a MoS2/Me ultra-lattice layer which are successively formed on the surface of a matrix; wherein, in a direction gradually far away from the matrix, the content of MoS2 in the TiNx/MoS2 gradient transition layer is increasing, and the content of MoS2 in the MoS2/Me gradient transition layer is decreasing. The ultra-lattice composite coating has excellent mechanical property and tribological performance, with a vacuum friction coefficient being below 0.02 and a friction life exceeding 4×106 revolutions, which can meet the requirements on ultra-low friction and ultra-long service life for aerospace vehicles.
Type:
Grant
Filed:
December 11, 2023
Date of Patent:
May 6, 2025
Assignee:
NINGBO INSTITUTE OF MATERIALS TECHNOLOGY AND ENGINEERING, CHINESE ACADEMY OF SCIENCES
Abstract: The present invention provides an induction type oil debris signal monitoring and identification system, which comprises an induction type oil debris sensor, used to detect small electromagnetic changes in the oil and output a monitoring signal after processing through a signal processing circuit; a bubble and debris classification and identification network module, used to analyze whether an abnormal amplitude signal in the monitoring signal contains bubbles or not so as to prevent the bubbles from being c as debris, and a two-level debris signal analysis network module, used to analyze the monitoring signal and determine the size and the quantity of debris.
Type:
Grant
Filed:
June 21, 2024
Date of Patent:
May 6, 2025
Assignees:
Nanjing University of Aeronautics and Astronautics (NUAA), Nanjing University of Aeronautics and Astronautics Shenzhen Research Institute
Abstract: Described herein are concepts, system and techniques which provide a means to construct robust high-field superconducting magnets using simple fabrication techniques and modular components that scale well toward commercialization. The resulting magnet assembly—which utilizes non-insulated, high temperature superconducting tapes (HTS) and provides for optimized coolant pathways—is inherently strong structurally, which enables maximum utilization of the high magnetic fields available with HTS technology. In addition, the concepts described herein provide for control of quench-induced current distributions within the tape stack and surrounding superstructure to safely dissipate quench energy, while at the same time obtaining acceptable magnet charge time. The net result is a structurally and thermally robust, high-field magnet assembly that is passively protected against quench fault conditions.
Type:
Grant
Filed:
September 28, 2023
Date of Patent:
May 6, 2025
Assignees:
Massachusetts Institute of Technology, Commonwealth Fusion Systems LLC
Inventors:
Brian Labombard, Robert S. Granetz, James Irby, Rui Vieira, William Beck, Daniel Brunner, Jeffrey Doody, Martin Greenwald, Zachary Hartwig, Philip Michael, Robert Mumgaard, Alexey Radovinsky, Shunichi Shiraiwa, Brandon N. Sorbom, John Wright, Lihua Zhou