Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.
Type:
Grant
Filed:
October 27, 2022
Date of Patent:
May 6, 2025
Assignees:
FUDAN UNIVERSITY, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, SHANGHAI MIRACOGEN INC.
Inventors:
Ke Yu, Jingkang Shen, Tao Meng, Lanping Ma, Xuesai Zhang, Qingrou Li, Qing Lin
Abstract: The present invention relates to a novel enzyme capable of producing multi-hydroxy derivatives from polyunsaturated fatty acids and a method for producing multi-hydroxy derivatives of polyunsaturated fatty acids using the same.
Type:
Grant
Filed:
March 8, 2024
Date of Patent:
May 6, 2025
Assignee:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
Inventors:
Jeong Woo Seo, Jong Jae Yi, Sun Yeon Heo, Young Bae Kim, Chul Ho Kim, Baek Rock Oh, Jung Hyun Ju, Hack Sun Choi
Abstract: System, methods, and other embodiments described herein relate to communicating a recommended speed through feedback on a combined pedal for acceleration or braking. In one embodiment, a control system includes a pedal coupled to a first device having a throttle sensor for a vehicle and a first actuator that generates throttle feedback by applying force to the pedal. The control system also includes the pedal being coupled to a second device having a brake activation sensor for the vehicle and a second actuator that generates braking feedback, the first actuator triggers a rotation of the pedal that initiates a braking command through the brake activation sensor according to a recommended speed computed using vehicle data.
Abstract: A standard circuit for far-end crosstalk of a CAT 6A, including a first network connector and a second network connector. The first network connector includes a first transmitted signal pair and a first received signal pair. The second network connector is connected to the first network connector, and includes a second transmitted signal pair and a second received signal pair. The second transmitted signal pair is connected to the first transmitted signal pair. A first load is connected in series between the second received signal pair. A standard for far-end crosstalk of the CAT 6A is also provided.
Abstract: Disclosed herein is an apparatus and method for federated learning based on group key management. The apparatus receives learning group participation request information from a learning node that intends to participate in a federated learning group, updates a group key required for the learning node to participate in federated learning using a key material generated by hashing the learning group participation request information, decrypts an encrypted local variable received from the learning node and thereby updates the same to a global variable, and transmits the global variable to the learning node after encrypting the same using the updated group key.
Type:
Application
Filed:
January 18, 2024
Publication date:
May 1, 2025
Applicant:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Hyun-Jin KIM, Jong-Geun PARK, Jong-Hoon LEE
Abstract: A hydrogen leakage monitoring system is disposed on a vehicle body of a vehicle. The hydrogen leakage monitoring system includes a speed sensor, an inclination sensor, a hydrogen concentration sensor and a processor. The speed sensor is configured to sense a vehicle speed. The inclination sensor is configured to sense an inclination angle of the vehicle body. The hydrogen concentration sensor is configured to sense an actual hydrogen leakage value of a hydrogen device. The processor is configured to obtain the inclination degree value according to the vehicle speed and the inclination angle, obtain a hydrogen leakage threshold according to the inclination degree value, and initiate a corresponding process based on the actual hydrogen leakage value being greater than the hydrogen leakage threshold.
Type:
Application
Filed:
January 3, 2024
Publication date:
May 1, 2025
Applicant:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: Liquid Crystal Elastomer (LCE) fibers, an apparatus for manufacturing, and a method for using the apparatus are provided. LCE fibers formed from each of a plurality of resin recipes can undergo reversible temperature driven actuation of the fiber. Each of the resin recipes forms a fiber having a different actuation temperature. The apparatus includes: an extrusion device, a drawing bobbin, a coating basin, a collector bobbin, a first plurality of curing devices, and a second plurality of curing devices, to transform a resin recipe into a LCE fiber. In operation, the extrusion device extrudes the resin through to the first plurality of curing devices for a partial cure. Once in contact with drawing bobbin the resin is coated in a fluid, and then pull through the second plurality of curing devices for a final cure by collector bobbin, where it can be collected and post-processed.
Type:
Application
Filed:
October 25, 2024
Publication date:
May 1, 2025
Applicant:
Massachusetts Institute of Technology
Inventors:
Jack Forman, Ozgun Kilic Afsar, Sarah Nicita, Rosalie Hsin-Ju Lin, Cedric Honnet, Neil Gershenfeld, Hiroshi Ishii
Abstract: A method for improving gas storage capacity of a natural gas hydrate based on a crystal regulation and control principle is provided. A II structure was formed on the basis that a thermodynamic additive slightly soluble or insoluble in water was added to a hydrate generation system to compromise the hydrate generation conditions, and a crystal structure of the hydrate generated in the system was then regulated and controlled to be a I-type methane hydrate by controlling temperature and pressure. Therefore, the method for improving gas storage capacity of a natural gas hydrate is provided to creatively and fundamentally solve the problem of low gas storage capacity in the thermodynamic additive system.
Type:
Application
Filed:
November 14, 2023
Publication date:
May 1, 2025
Applicant:
GUANGZHOU INSTITUTE OF ENERGY CONVERSION, CHINESE ACADEMY OF SCIENCES
Abstract: A film thickness measurement device includes a spectroscopic ellipsometer, and the spectroscopic ellipsometer includes a projection module and a light receiving module. The projection module is configured to project a multi-wavelength polarized light onto a thin film. The projection module includes a light source and a polarization state generator. The light receiving module includes a polarization analyzer and an optical detector. The polarization analyzer is configured to screen out a multi-wavelength polarized reflection light according to reflection of the multi-wavelength polarized light by the thin film. The optical detector is configured to receive the multi-wavelength polarized reflection light. The optical detector includes at least one optical splitting unit, at least two optical filtering units and at least two optical detection units.
Type:
Application
Filed:
December 13, 2023
Publication date:
May 1, 2025
Applicant:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: A computer-implemented system, computer-implemented method, and computer-program product includes receiving a natural language query from a user for executing an analytical task; generating an analytical large language model (LLM) prompt based on the natural language query and, in response to generating the analytical LLM prompt, orchestrating an LLM-directed workflow for handling the natural language query by: automatically prompting, using the analytical LLM prompt, an analytical task-oriented LLM to generate a structured query for querying a data catalog application; querying the data catalog application using the structured query generated by the analytical task-oriented LLM; obtaining query results from the data catalog application, where the query results include metadata associated with at least one element accessible to the data catalog application; prompting the analytical task-oriented LLM to identify a given analytical task associated with a given analytical agent; and automatically executing, by t
Abstract: The present disclosure relates to a real-time chemical screening method using hepatic organoids fluorescently labeled with cytochrome P450 1A1 enzyme. The method for screening an AHR modulator or a hazardous chemical using CYP1A1 fluorescently labelled human pluripotent stem cell line-derived hepatic organoids according to the present disclosure enables the detection of substances that induce CYP1A1 regulation with higher sensitivity than when using the conventional human pluripotent stem cell line-derived hepatocytes by using hepatic organoids that can mimic the human body, and thus can be usefully utilized for early screening of new toxic or carcinogenic compounds while replacing animal testing.
Type:
Application
Filed:
October 25, 2024
Publication date:
May 1, 2025
Applicant:
Korea Research Institute of Chemical Technology
Inventors:
Hyemin KIM, Han-Jin PARK, Ji-Woo KIM, Haneul NOH
Abstract: There is provided a multi-modal knowledge-based conversation data generation and additional information labeling system. A conversation data generation method according to an embodiment includes: receiving input of a user utterance; searching pieces of text knowledge related to the user utterance; searching images related to the user utterance; receiving input of an answer to the user utterance referring to the searched text knowledge and images; and collecting the user utterances, the pieces of text knowledge, the images, and the answer to the user utterances as conversation data. Accordingly, open domain knowledge-based conversation data may be established by using both images and texts, and an image may be used as utterance and information acquired from the image may be used as utterance, so that AI conversation data similar to actual conversations can be established.
Type:
Application
Filed:
October 25, 2024
Publication date:
May 1, 2025
Applicant:
Korea Electronics Technology Institute
Inventors:
San KIM, Sa Im SHIN, Jin Yea JANG, Byung Gill JOE
Abstract: A beamforming chip and a radio frequency signal calibration method are provided. The beamforming chip includes a plurality of phase and gain controlling circuits and a calibration circuit. Each phase and gain controlling circuit is configured to change a phase and an amplitude of a received radio frequency input signal to generate a coupling signal. The calibration circuit is coupled to each phase and gain controlling circuit, and configured to select two of the coupling signals, wherein one is a first selected coupling signal before calibration and another one is a second selected coupling signal before calibration. The calibration takes the first selected coupling signal as a reference target to calibrate the phase and the amplitude gain of the second selected coupling signal until there are a minimum phase difference and a closest amplitude between the second selected coupling signal and the reference target.
Type:
Application
Filed:
November 26, 2023
Publication date:
May 1, 2025
Applicant:
Industrial Technology Research Institute
Abstract: An electrical appliance status analysis device and method are provided. Based on the correlation between appliance status sequence data and electricity meter sequence data, appliances are categorized into high-correlation appliances and low-correlation appliances. For high-correlation appliances, training is conducted using the first-type model directly based on the appliance status sequence data and electricity meter sequence data. For low-correlation appliances, features are extracted to produce appliance status feature data and electricity meter feature data, which are then combined with user information feature data to train a second-type model. This method remains applicable at low sampling frequencies. Even when the data sampling rate is below 1 Hz, the resulting appliance status analysis models provide accurate analysis results, addressing the limitations of NILM technology in analyzing data with low sampling frequency.
Abstract: The present application relates to an apparatus and method for evaluating XR-based upper limb motion control and motion control ability, the apparatus including a head mount display (HMD) configured to be worn on a user's head part and including a display for providing visual feedback information capable of monitoring a visual cue and a repetitive motion of muscle synergy or a direction and magnitude of a force that are contents for XR (eXtended Reality)-based multi-joint rehabilitation training of an upper limb, a measurement part, a synergy evaluation part, a visual cue control part and a composite biofeedback part.
Type:
Application
Filed:
December 26, 2023
Publication date:
May 1, 2025
Applicant:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Song Joo LEE, Hyung Min KIM, Kyung-Mi PARK, Keun Tae KIM, Duguma Teshome Gemechu, Ji-Yoon LEE, Olga Valerevna KIM
Abstract: A light-sensing device senses incident light of a predetermined wavelength and includes a photodiode substrate having a P-N junction structure and a first surface and a second surface facing each other; a metal layer formed on the first surface of the photodiode substrate; and a functional layer formed on the metal layer, and increasing an absorption rate of the metal layer with respect to light of the predetermined wavelength.
Type:
Application
Filed:
October 30, 2024
Publication date:
May 1, 2025
Applicant:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Abstract: Compositions comprising fused aromatic systems and associated electrodes, electrochemical cells, and charge storage devices are generally described. Preferably, the aromatic comprising a bis-tetraamino-benzoquinone molecule and/or a tautomer, oligomer, and/or polymer thereof. Alternatively, the aromatic composition comprises an active material comprising a fused aromatic system comprising carbon atoms, hydrogen atoms, and a plurality of heteroatoms each replacing a carbon atom.
Type:
Application
Filed:
January 26, 2022
Publication date:
May 1, 2025
Applicant:
Massachusetts Institute of Technology
Inventors:
Mircea Dinca, Harish Banda, Tianyang Chen
Abstract: Disclosed is a Lactobacillus plantarum strain WSH048, where the Lactobacillus plantarum strain WSH048 has the effects of repairing UV damage, relieving inflammation and preventing skin photoaging. The Lactobacillus plantarum strain WSH048 is Lactobacillus plantarum, with strain No. as WSH048, which was preserved at China General Microbiological Culture Collection Center (CGMCC) on Aug. 20, 2021 with the preservation No. as CGMCC No. 23159. The present disclosure further provides the screening method of Lactobacillus plantarum strain WSH048 and the preparation method of its fermented product. Lactobacillus plantarum strain WSH048 of the present disclosure, having the effects of repairing UV damage, relieving inflammation and preventing skin photoaging, can effectively solve the problems of side effect and expensive price from the current skin inflammation-relieving measures.
Type:
Application
Filed:
June 2, 2022
Publication date:
May 1, 2025
Applicants:
Nanjing Ascend Biotechnology Institute Co., Ltd., NANJING HUASHI NEW MATERIAL CO., LTD