Abstract: The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties.
Type:
Grant
Filed:
December 12, 2011
Date of Patent:
November 27, 2012
Assignee:
Interface Biologics, Inc.
Inventors:
Sanjoy Mullick, Weilun Chang, Alexandra Piotrowicz, Jeannette Ho, Richard Witmeyer
Abstract: The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties.
Type:
Application
Filed:
May 7, 2012
Publication date:
August 30, 2012
Applicant:
Interface Biologics Inc.
Inventors:
Sanjoy Mullick, Richard Witmeyer, Paul Santerre, Weilun Chang
Abstract: The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties.
Type:
Application
Filed:
December 12, 2011
Publication date:
June 14, 2012
Applicant:
Interface Biologics Inc.
Inventors:
Sanjoy MULLICK, Weilun CHANG, Alexandra PIOTROWICZ, Jeannette HO, Richard WITMEYER
Abstract: The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties.
Type:
Grant
Filed:
July 19, 2011
Date of Patent:
May 15, 2012
Assignee:
Interface Biologics Inc.
Inventors:
Sanjoy Mullick, Richard Witmeyer, Paul Santerre, Weilun Chang
Abstract: The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties.
Type:
Grant
Filed:
December 14, 2007
Date of Patent:
December 6, 2011
Assignee:
Interface Biologics Inc.
Inventors:
Sanjoy Mullick, Richard Witmeyer, Paul Santerre, Weilun Chang
Abstract: The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties.
Type:
Application
Filed:
July 19, 2011
Publication date:
November 10, 2011
Applicant:
Interface Biologics Inc.
Inventors:
Sanjoy Mullick, Richard Witmeyer, Paul Santerre, Weilun Chang
Abstract: A pharmaceutically-active polymeric compound of the general formula (I), Y-[Yn-LINK B-X]m-LINK B??(I) wherein (i) X is a coupled biological coupling agent of the general formula (II) Bio-LINK A-Bio??(II) wherein Bio is a biologically active agent fragment or precursor thereof linked to LINK A through a hydrolysable covalent bond; and LINK A is a coupled central flexible linear first segment of <2000 theoretical molecular weight linked to each of said Bio fragments; (ii) Y is LINK B-OLIGO; wherein (a) LINK B is a coupled second segment linking one OLIGO to another OLIGO and an OLIGO to X or precursor thereof; and (b) OLIGO is a short length of polymer segment having a molecular weight of less than 5,000 and comprising less than 100 monomeric repeating units; (iii) m is 1-40; and (iv) n is selected from 2-50. The compounds are useful as biomaterials, particularly, providing antibacterial activity in vivo.
Abstract: The invention features the use of a matrix consisting of low molecular weight components for use as a self-eliminating coating for implantable medical devices. The matrix coatings can be used to enhance biocompatibility and to control the local delivery of biologically active agents.
Type:
Application
Filed:
October 17, 2008
Publication date:
May 5, 2011
Applicant:
Interface Biologics, Inc
Inventors:
Roseita Esfand, J. Paul Santerre, Mark J. Ernsting, Vivian Z. Wang, Sylvia Tjahyadi
Abstract: The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
Abstract: The invention features a method for treating a subject diagnosed with, or at risk of developing, a bacterial infection by administering to the subject a combination of biologically active agents.
Type:
Application
Filed:
April 7, 2009
Publication date:
March 11, 2010
Applicant:
Interface Biologics, Inc.
Inventors:
Frank LaRonde, Hanje Chen, Selva Sinnadurai
Abstract: The invention relates to graftable polymers comprising biologically active agents and the use of such polymers in the manufacture of shaped articles, such as implantable medical devices and catheters. The graftable polymers are covalently grafted to a surface via one or more grafting moieties incorporated into the pharmaceutically-active graftable polymer. The coated articles of the invention can further comprise tie-coats, and the ratio of polymer:tie coat can be used to adjust the rate of drug elution.
Abstract: The invention features alcohol and water repellent non-woven fabrics made from synthetic polymer fibers. The fibers comprise a surface modifier admixed with the synthetic polymer to impart alcohol and water repellency properties.
Type:
Application
Filed:
January 17, 2007
Publication date:
August 27, 2009
Applicant:
Interface Biologics, Inc.
Inventors:
Jeannette Ho, Richard Witmeyer, Paul J. Santerre