Patents Assigned to Intermune, Inc.
  • LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS
    Publication number: 20130072449
    Abstract: Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.
    Type: Application
    Filed: August 14, 2012
    Publication date: March 21, 2013
    Applicant: InterMune, Inc.
    Inventors: Brad O. Buckman, John B. Nicholas, Kumaraswamy Emayan, Scott D. Seiwert
  • Granulate formulation of pirfenidone and pharmaceutically acceptable excipients
    Patent number: 8383150
    Abstract: A capsule formulation of pirfenidone is provided that includes pharmaceutically acceptable excipients. In one embodiment, this capsule formulation is capable of sustaining desirable pharmacokinetic responses in a patient. Further provided are methods of treating fibrotic conditions and other cytokine-mediated disorders by administering pirfenidone capsules of such formulation to a patient in need.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: February 26, 2013
    Assignee: Intermune, Inc.
    Inventors: Ramachandran Radhakrishnan, Ronald Vladyka, Kenneth Sultzbaugh
  • PIRFENIDONE THERAPY AND INDUCERS OF OF CYTOCHROME P450
    Publication number: 20130045997
    Abstract: The present invention relates to methods involving avoiding adverse drug interactions with pirfenidone and CYP inducers, such as smoking.
    Type: Application
    Filed: December 3, 2010
    Publication date: February 21, 2013
    Applicant: INTERMUNE, INC
    Inventors: Williamson Z. Bradford, Javier Szwarcberg
  • Method of Administering Pirfenidone Therapy
    Publication number: 20130030024
    Abstract: The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
    Type: Application
    Filed: December 3, 2010
    Publication date: January 31, 2013
    Applicant: INTERMUNE ,INC.
    Inventors: Williamson Z. Bradford, Javier Szwarcberg
  • Methods of administering pirfenidone therapy
    Patent number: 8318780
    Abstract: The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: November 27, 2012
    Assignee: Intermune, Inc.
    Inventors: Williamson Ziegler Bradford, Javier Szwarcberg
  • Compounds and methods for treating inflammatory and fibrotic disorders
    Patent number: 8304413
    Abstract: Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: November 6, 2012
    Assignee: Intermune, Inc.
    Inventors: Karl Kossen, Scott D. Seiwert, Vladimir Serebryany, Donald Ruhrmund, Leonid Beigelman, Luca Francesco Mario Raveglia, Stefania Vallese, Ivana Bianchi, Tao Hu
  • Macrocyclic inhibitors of hepatitis C virus replication
    Patent number: 8299021
    Abstract: The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: October 30, 2012
    Assignee: InterMune, Inc.
    Inventors: Lawrence M Blatt, Scott D Seiwert, Steven W Andrews, Pierre Martin, Andreas Schumacher, Bradley Barnett, C. Todd Eary, Robert Kaus, Timothy Kercher, Weidong Liu, Michael Lyon, Paul Nichols, Bin Wang, Tarek Sammakia, April Kennedy, Yutong Jiang
  • METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM
    Publication number: 20120258924
    Abstract: Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.
    Type: Application
    Filed: June 20, 2012
    Publication date: October 11, 2012
    Applicant: INTERMUNE, INC.
    Inventors: Lawrence M. Blatt, Scott D. Seiwert, Leonid Beigelman, Ramachandran Radhakrishnan, Karl Kossen, Vladimir Serebryany
  • NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION
    Publication number: 20120208995
    Abstract: The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Application
    Filed: April 19, 2012
    Publication date: August 16, 2012
    Applicants: Array BioPharma, Inc., InterMune, Inc.
    Inventors: Lawrence M. Blatt, Scott D. Seiwert, Steven W. Andrews, Pierre Martin, Andreas Schumacher, Bradley Barnett, C. Todd Eary, Robert Kaus, Timothy Kercher, Weidong Liu, Michael Lyon, Paul Nichols, Bin Wang, Tarek Sammakia, April Kennedy, Yutong Jiang
  • NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION
    Publication number: 20120101032
    Abstract: The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IV, IVa, V, Va, VI and VIa, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Application
    Filed: October 21, 2011
    Publication date: April 26, 2012
    Applicant: INTERMUNE, INC.
    Inventors: Brad BUCKMAN, Vladimir SEREBRYANY, John B. NICHOLAS, Scott SEIWERT
  • SUBSTITUTED PROLINE INHIBITORS OF HEPATITIS C VIRUS REPLICATION
    Publication number: 20120095211
    Abstract: The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IIIb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods.
    Type: Application
    Filed: September 20, 2011
    Publication date: April 19, 2012
    Applicant: InterMune, Inc.
    Inventors: Brad Buckman, John B. Nicholas, Vladimir Serebryany, Scott D. Seiwert
  • NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION
    Publication number: 20120094897
    Abstract: The embodiments provide compounds of the general Formulae I, and II, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Application
    Filed: September 14, 2011
    Publication date: April 19, 2012
    Applicant: InterMune, Inc.
    Inventors: Brad Buckman, John B. Nicholas, Vladimir Serebryany, Scott D. Seiwert
  • Pirfenidone Therapy and Inducers of Cytochrome P450
    Publication number: 20120088801
    Abstract: The present invention relates to methods involving avoiding adverse drug interactions with pirfenidone and CYP inducers, such as smoking.
    Type: Application
    Filed: December 15, 2011
    Publication date: April 12, 2012
    Applicant: INTERMUNE, INC.
    Inventors: Williamson Z. Bradford, Javier Szwarcberg
  • PIRFENIDONE TREATMENT FOR PATIENTS WITH ATYPICAL LIVER FUNCTION
    Publication number: 20120077850
    Abstract: Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone administration. The methods include administering to a patient pirfenidone at doses lower than the full target dosage for a time period, followed by administering to the patient pirfenidone at the full target dosage. The methods also include administering pirfenidone at the full target dose with no reduction and administering permanently reduced doses of pirfenidone.
    Type: Application
    Filed: December 6, 2011
    Publication date: March 29, 2012
    Applicant: INTERMUNE, INC.
    Inventors: Williamson Z. Bradford, Javier Szwarcberg
  • METHODS OF TREATING ATRIAL FIBRILLATION WITH P38 INHIBITOR COMPOUNDS
    Publication number: 20120046321
    Abstract: The invention disclosed herein relates generally to compounds and methods useful in treating or preventing atrial fibrillation (AF).
    Type: Application
    Filed: September 26, 2011
    Publication date: February 23, 2012
    Applicant: INTERMUNE, INC.
    Inventors: Jeff Olgin, Susan Eisenberg, Lawrence M. Blatt, Scott D. Seiwert, Karl Kossen
  • Compounds and methods for inhibiting hepatitis C viral replication
    Patent number: 8119592
    Abstract: Macrocyclic compounds having the structures described herein are useful for inhibiting replication of the hepatitis C virus (HCV). In preferred embodiments, the compounds are active against both the NS3 protease and the NS3 helicase of HCV.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: February 21, 2012
    Assignee: InterMune, Inc.
    Inventors: Leonid Beigelman, Scott D. Seiwert, Lawrence Blatt, Steven Andrews, Julia Haas
  • Methods of Administering Pirfenidone Therapy
    Publication number: 20120015985
    Abstract: The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
    Type: Application
    Filed: September 26, 2011
    Publication date: January 19, 2012
    Applicant: INTERMUNE, INC.
    Inventors: Williamson Z. Bradford, Javier Szwarcberg
  • Method for Synthesizing Pirfenidone
    Publication number: 20120016133
    Abstract: A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone.
    Type: Application
    Filed: September 26, 2011
    Publication date: January 19, 2012
    Applicant: INTERMUNE, INC.
    Inventors: Sabine M. Pyles, Michael Cyr, Ramachandran Radhakrishnan
  • Granulate Formulation of Pirfenidone and Pharmaceutically Acceptable Excipients
    Publication number: 20120015984
    Abstract: A capsule formulation of pirfenidone is provided that includes pharmaceutically acceptable excipients. In one embodiment, this capsule formulation is capable of sustaining desirable pharmacokinetic responses in a patient. Further provided are methods of treating fibrotic conditions and other cytokine-mediated disorders by administering pirfenidone capsules of such formulation to a patient in need.
    Type: Application
    Filed: June 16, 2011
    Publication date: January 19, 2012
    Applicant: INTERMUNE, INC.
    Inventors: Ramachandran Radhakrishnan, Ronald Vladyka, Kenneth Sultzbaugh
  • METHODS OF TREATING HIV PATIENTS WITH ANTI-FIBROTICS
    Publication number: 20120014917
    Abstract: The invention relates to methods of treating patients infected with human immunodeficiency virus (HIV) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof.
    Type: Application
    Filed: September 26, 2011
    Publication date: January 19, 2012
    Applicants: University of Minnesota, INTERMUNE, INC.
    Inventors: Karl Kossen, Timothy Schacker, Ashley T. Haase