Patents Assigned to Intermune, Inc.
  • Methods of Administering Pirfenidone Therapy
    Publication number: 20110319453
    Abstract: The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
    Type: Application
    Filed: September 2, 2011
    Publication date: December 29, 2011
    Applicant: INTERMUNE, INC.
    Inventors: Williamson Z. Bradford, Javier Szwarcberg
  • Pirfenidone therapy and inducers of cytochrome P450
    Patent number: 8084475
    Abstract: The present invention relates to methods involving avoiding adverse drug interactions with pirfenidone and CYP inducers, such as smoking.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: December 27, 2011
    Assignee: Intermune, Inc.
    Inventors: Williamson Ziegler Bradford, Javier Szwarcberg
  • NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION
    Publication number: 20110312996
    Abstract: The embodiments provide compounds of the general Formulae VI, VII, VIII, IX, X, XI, XII, XIII, XIV, and XV as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Application
    Filed: May 16, 2011
    Publication date: December 22, 2011
    Applicant: InterMune, Inc.
    Inventors: Brad Buckman, John B. Nicholas, Vladimir Serebryany, Scott D. Seiwert
  • Macrocyclic inhibitors of hepatitis C virus replication
    Patent number: 8048862
    Abstract: The embodiments provide compounds of the general Formulae I, II, III, IV, V, VI, VII, and X, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: November 1, 2011
    Assignee: InterMune, Inc.
    Inventors: Scott D. Seiwert, Leonid Beigelman, Brad Buckman, Antitsa Dimitrova Stoycheva, Steven B. Porter, Williamson Ziegler Bradford, Vladimir Serebryany
  • Pirfenidone Treatment for Patients with Atypical Liver Function
    Publication number: 20110263656
    Abstract: Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone administration. The methods include administering to a patient pirfenidone at doses lower than the full target dosage for a time period, followed by administering to the patient pirfenidone at the full target dosage. The methods also include administering pirfenidone at the full target dose with no reduction and administering permanently reduced doses of pirfenidone.
    Type: Application
    Filed: November 9, 2009
    Publication date: October 27, 2011
    Applicant: INTERMUNE, INC.
    Inventors: Williamson Z. Bradford, Javier Szwarcberg
  • Pirfenidone/Toll-Like Receptor (TLR) Agonist Compounds and Methods of Treating Neutropenia
    Publication number: 20110218169
    Abstract: The invention disclosed herein relates to compositions and methods for treating subjects suffering from or at risk of developing neutropenia. In some embodiments, the methods comprise administering to a subject suffering from or at risk of developing neutropenia, an effective amount of pirfenidone and one or more toll-like receptor (TLR) agonists.
    Type: Application
    Filed: February 10, 2011
    Publication date: September 8, 2011
    Applicant: INTERMUNE, INC.
    Inventors: Roderick Phillips, Lawrence M. Blatt
  • Methods of administering pirfenidone therapy
    Patent number: 8013002
    Abstract: The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: September 6, 2011
    Assignee: Intermune, Inc.
    Inventors: Williamson Ziegler Bradford, Javier Szwarcberg
  • Capsule formulation of pirfenidone and pharmaceutically acceptable excipients
    Patent number: 7988994
    Abstract: A capsule formulation of pirfenidone is provided that includes pharmaceutically acceptable excipients. In one embodiment, this capsule formulation is capable of sustaining desirable pharmacokinetic responses in a patient. Further provided are methods of treating fibrotic conditions and other cytokine-mediated disorders by administering pirfenidone capsules of such formulation to a patient in need.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: August 2, 2011
    Assignee: Intermune, Inc.
    Inventors: Ramachandran Radhakrishnan, Ronald Vladyka, Kenneth Sultzbaugh
  • Use of Alpha-Glucosidase Inhibitors to Treat Alphavirus Infections
    Publication number: 20110177026
    Abstract: The present invention provides methods for treating a flavivirus infection, including hepatitis C virus (HCV) infection, in an individual suffering from a flavivirus infection. In some embodiments, the methods involve administering to an individual in need thereof an effective amount of an agent that inhibits enzymatic activity of a membrane-bound ?-glucosidase inhibitor. In other embodiments, the methods involve administering to an individual in need thereof effective amounts of an ?-glucosidase inhibitor and at least one additional therapeutic agent.
    Type: Application
    Filed: February 10, 2011
    Publication date: July 21, 2011
    Applicant: INTERMUNE, INC.
    Inventors: Lawrence M. Blatt, Hua Tan, Scott D. Seiwert
  • PIRFENIDONE THERAPY AND INDUCERS OF CYTOCHROME P450
    Publication number: 20110172277
    Abstract: The present invention relates to methods involving avoiding adverse drug interactions with pirfenidone and CYP inducers, such as smoking.
    Type: Application
    Filed: January 8, 2010
    Publication date: July 14, 2011
    Applicant: INTERMUNE, INC.
    Inventors: Williamson Z. Bradford, Javier Szwarcberg
  • METHODS OF ADMINISTERING PIRFENIDONE THERAPY
    Publication number: 20110166186
    Abstract: The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 7, 2011
    Applicant: INTERMUNE, INC.
    Inventors: Williamson Z. Bradford, Javier Szwarcberg
  • NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION
    Publication number: 20110152246
    Abstract: The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Application
    Filed: December 16, 2010
    Publication date: June 23, 2011
    Applicant: InterMune, Inc.
    Inventors: Brad Buckman, John B. Nicholas, Vladimir Serebryany, Scott D. Seiwert
  • Altering Pharmacokinetics of Pirfenidone Therapy
    Publication number: 20110136876
    Abstract: The invention relates to methods for reducing adverse events in patients receiving pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) therapy.
    Type: Application
    Filed: February 16, 2011
    Publication date: June 9, 2011
    Applicant: INTERMUNE, INC.
    Inventors: Cynthia Y. Robinson, Jeffery S. Loutit, Michelle M. Freemer
  • NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION
    Publication number: 20110129444
    Abstract: The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Application
    Filed: September 24, 2010
    Publication date: June 2, 2011
    Applicant: INTERMUNE, INC
    Inventors: BRAD BUCKMAN, John B. Nicholas, Vladimir Serebryany, Scott Seiwert
  • Novel Inhibitors of Hepatitis C Virus Replication
    Publication number: 20110110890
    Abstract: The embodiments provide compounds of the general Formula I and compound 105S, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Application
    Filed: November 8, 2010
    Publication date: May 12, 2011
    Applicant: INTERMUNE, INC.
    Inventors: Leonid Beigelman, Guangyi Wang, Brad Buckman, Antitsa Dimitrova Stoycheva
  • Use of ?-glucosidase inhibitors to treat alphavirus infections
    Patent number: 7932267
    Abstract: The present invention provides methods for treating a flavivirus infection, including hepatitis C virus (HCV) infection, in an individual suffering from a flavivirus infection. In some embodiments, the methods involve administering to an individual in need thereof an effective amount of an agent that inhibits enzymatic activity of a membrane-bound ?-glucosidase inhibitor. In other embodiments, the methods involve administering to an individual in need thereof effective amounts of an ?-glucosidase inhibitor and at least one additional therapeutic agent.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: April 26, 2011
    Assignee: Intermune, Inc.
    Inventors: Lawrence M. Blatt, Hua Tan, Scott Seiwert
  • Peptide inhibitors of hepatitis C virus replication
    Patent number: 7932277
    Abstract: The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula II, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: April 26, 2011
    Assignees: InterMune, Inc., Array Biopharma Inc.
    Inventors: Scott Seiwert, Steven W. Andrews, Leonid Beigelman, Lawrence M. Blatt, Brad Buckman, Kevin R. Condroski, Yutong Jiang, Robert J. Kaus, April L. Kennedy, Timothy S. Kercher, Michael A. Lyon, Bin Wang
  • THERAPEUTIC ANTIVIRAL PEPTIDES
    Publication number: 20110082182
    Abstract: Disclosed herein are compounds represented by a formula: Therapeutic methods, compositions, medicaments, and dosage forms related thereto are also disclosed.
    Type: Application
    Filed: September 30, 2010
    Publication date: April 7, 2011
    Applicant: INTERMUNE, INC.
    Inventors: Brad Buckman, Vladimir Serebryany, Scott Seiwert, Leonid Beigelman, Antitsa Stoycheva
  • NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION
    Publication number: 20110081315
    Abstract: The embodiments provide compounds of the general Formulae I, Ia, II, III, IV, V, VI-1, VI-2, VII, VIII, IX, X, XI, and XII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Application
    Filed: September 24, 2010
    Publication date: April 7, 2011
    Applicant: INTERMUNE, INC.
    Inventors: Brad Buckman, John B. Nicholas, Leonid Beigelman, Vladimir Serebryany, Antitsa Dimitrova Stoycheva, Timothy Thrailkill, Scott Seiwert
  • Methods of administering pirfenidone therapy
    Patent number: 7910610
    Abstract: The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: March 22, 2011
    Assignee: Intermune, Inc.
    Inventors: Williamson Ziegler Bradford, Javier Szwarcberg