Abstract: A parasite analysis system includes a pressure vessel configured to store a biological sample, an imaging cell connected to the pressure vessel, and a waste depository connected to the imaging cell. An input valve controls whether biological sample can flow from the pressure vessel into the imaging cell and an output valve controls whether biological sample can flow from the imaging cell into the waste depository. The parasite analysis system also includes a camera that captures a chronological set of images of a portion of the biological sample in the imaging cell and an image analysis system that analyzes the chronological set of images to generate an estimate of a number of parasites in the portion of the biological sample. Estimates for multiple portions of the biological sample may be generated and sampling techniques used to estimate the number of parasites in the entire biological sample.
Type:
Grant
Filed:
July 18, 2018
Date of Patent:
August 6, 2019
Assignee:
Intervet Inc.
Inventors:
Pavel Vácha, Petr Jankuj, Richard J. Marhoefer, Václav Belák, Jind{hacek over (r)}ich Soukup, Brunhilde Schölzke, Britta von Oepen
Abstract: A soft chewable pharmaceutical product for delivery of a pharmaceutically acceptable active ingredient to an animal comprising pamoic acid or a pharmaceutically acceptable salt and a process for the manufacture of such soft chewable pharmaceutical product.
Type:
Application
Filed:
March 8, 2019
Publication date:
July 4, 2019
Applicant:
Intervet Inc.
Inventors:
Susi Alteheld, Stefan Fuchs, Carina Hang, Jürgen Lutz
Abstract: A composition for oral administration of a bioactive agent to aquatic or terrestrial species includes particles each of which includes a bioactive agent dispersed in oil droplets, the oil droplets being dispersed in a matrix including an enteric coating polymer, wherein the particles each further include a mucoadhesive polymer. Methods of making and using the composition are also provided.
Abstract: The invention relates to a composition and a method for manufacturing semi-dry or dry particles containing a mucoadhesive polymer and a bioactive agent such as, but not limited to, an Immunogenic Substance (e.g., a vaccine), that allows the oral or nasal administration and delivery of the bioactive agent essentially unaltered to mucosal surfaces in the animal, including an aquatic animal.
Abstract: The present invention relates to methods of treating or preventing arthropod infestations of poultry animals and methods of controlling arthropod infestations in poultry animal's environment by administering an isoxazoline compound of formula (I) via drinking water.
Type:
Application
Filed:
March 5, 2019
Publication date:
June 27, 2019
Applicant:
Intervet Inc.
Inventors:
Anja Regina Heckeroth, Hartmut Zoller, Annie Flochlay-Sigognault, Bruno Huyghe
Abstract: The present invention regards a new and Improved HVT-vectored ND-IBD vaccine, comprising a recombinant HVT comprising the VP2 gene from IBDV and the F gene from NDV to a target animal. The recombinant HVT can be used in a vaccine for poultry, which displayed good viral vector replication, effective expression of the NDV F- and IBDV VP2 genes, improved immunoprotection against ND and IBD, and improved genetic stability over prior art constructs.
Type:
Grant
Filed:
December 23, 2015
Date of Patent:
June 4, 2019
Assignee:
Intervet Inc.
Inventors:
Iwan Verstegen, Paulus Jacobus Antonius Sondermeijer, Paul Vermeij
Abstract: The present invention relates to a vaccine comprising Open Reading Frame 2 (ORF2) protein of Swine Hepatitis E virus (HEV) and a pharmaceutically acceptable carrier, for use in the protection of anti-HEV MDA-positive piglets against HEV fecal shedding.
Type:
Application
Filed:
May 24, 2017
Publication date:
May 23, 2019
Applicant:
Intervet Inc.
Inventors:
Paul Vermeij, Ad Groof De, Carla Christina Schrier, Wannes Vogels
Abstract: The present invention relates to immortalised chicken embryonic epithelial kidney cells, to cell cultures comprising such immortalised cells, to vaccines comprising such cells, to methods for the replication of avian viruses on such cells, and to methods for the preparation of such cells and such vaccines.
Abstract: A process to prepare a compound of Formula (I) wherein R3, R4 and R5 are each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.
Type:
Application
Filed:
January 4, 2019
Publication date:
May 9, 2019
Applicant:
Intervet Inc.
Inventors:
Michael Berger, Stephan Veit, Hans Peter Niedermann, Tobias Kappesser, Alfred Stutz
Abstract: A process for selective transvinylation of a reactant carboxylic acid with a reactant vinyl ester to give a product vinyl ester and the corresponding acid of the reactant vinyl ester in the presence of one or more ruthenium catalysts, wherein a) the reactant vinyl ester, the reactant carboxylic acid and the ruthenium catalyst are supplied to a reactor, wherein b) the molar ratio of reactant vinyl ester to reactant carboxylic acid is 1:3 to 3:1, and c) the transvinylation reaction is conducted, d) on completion of the transvinylation reaction, the reactant vinyl ester and the corresponding acid are separated from the reaction mixture by distillation, e) the product vinyl ester is separated by distillation from the bottom product of the distillation, and f) the remaining reaction mixture is recycled into the reactor.
Abstract: The present invention relates to methods of treating or preventing arthropod infestations of poultry animals and methods of controlling arthropod infestations in poultry animal's environment by administering an isoxazoline compound of formula (I) via drinking water.
Type:
Grant
Filed:
December 19, 2014
Date of Patent:
April 30, 2019
Assignee:
Intervet Inc.
Inventors:
Anja Regina Heckeroth, Hartmut Zoller, Annie Flochlay-Sigognault, Bruno Huyghe
Abstract: A soft chewable pharmaceutical product for delivery of a pharmaceutically acceptable active ingredient to an animal comprising pamoic acid or a pharmaceutically acceptable salt and a process for the manufacture of such soft chewable pharmaceutical product.
Type:
Application
Filed:
May 17, 2018
Publication date:
April 25, 2019
Applicant:
Intervet Inc.
Inventors:
Rainer Roepke, Carsten Schmidt, Susi Alteheld, Carina Hang
Abstract: A soft chewable pharmaceutical product for delivery of a pharmaceutically acceptable active ingredient to an animal comprising pamoic acid or a pharmaceutically acceptable salt and a process for the manufacture of such soft chewable pharmaceutical product.
Type:
Application
Filed:
May 17, 2018
Publication date:
April 25, 2019
Applicant:
Intervet Inc.
Inventors:
Rainer Roepke, Carsten Schmidt, Susi Alteheld, Carina Hang, Stefan Fuchs, Jürgen Lutz
Abstract: The present invention pertains to a vaccine comprising non live Lawsonia intracellularis antigen and a pharmaceutically acceptable carrier for use in a method to reduce in a pig the shedding of Lawsonia intracellularis bacteria associated with subclinical infection with Lawsonia intracellularis, by systemic administration of the vaccine to the pig.
Abstract: The present invention pertains to a vaccine comprising in combination non-replicating immunogen of porcine circo virus type 2 and non-replicating immunogen of Mycoplasma hyopneumoniae and an adjuvant containing a nano-emulsion of mineral oil in water, for use in prophylactically treating an animal against an infection with porcine circovirus type 2 (PCV2) and an infection with Mycoplasma hyopneumoniae by administration of the vaccine into the dermis of the animal.
Type:
Application
Filed:
March 22, 2017
Publication date:
April 11, 2019
Applicant:
Intervet Inc.
Inventors:
Melanie Sno, Maarten Hendrik Witvliet, Vicky Fachinger
Abstract: The present invention pertains to a vaccine comprising in combination non-replicating immunogen of porcine circo virus type 2 and live attenuated PRRS virus for use in prophylactically treating an animal against an infection with porcine circovirus type 2 (PCV2) and an infection with PRRS virus by administration of the vaccine into the dermis of the animal.
Type:
Application
Filed:
March 22, 2017
Publication date:
April 4, 2019
Applicant:
Intervet Inc.
Inventors:
Melanie Sno, Maarten Hendrik Witvliet, Vicky Fachinger
Abstract: The present invention pertains to a vaccine for use in prophylactically treating an animal against an infection with porcine circovirus type 2 (PCV2) and an infection with PRRS virus, the vaccine comprising in combination non-replicating immunogen of porcine circovirus type 2 and live attenuated PRRS virus, wherein the vaccine additionally comprises albumin.
Type:
Application
Filed:
March 22, 2017
Publication date:
March 28, 2019
Applicant:
Intervet Inc.
Inventors:
Melanie Sno, Pieter Gelder Van, Vicky Fachinger, Chen Shu-hui Tan
Abstract: A new solid dosage form formulation and manufacturing process incorporating zilpaterol HCl is presented. This formulation is an animal feed premix with improved content uniformity and is manufactured by a simple method that uses a supersaturated solution of zilpaterol that is incorporated into a solid carrier matrix.
Type:
Grant
Filed:
July 20, 2016
Date of Patent:
March 19, 2019
Assignee:
Intervet Inc.
Inventors:
Keith Freehauf, Brian Carrillo, Jiyue Zhang
Abstract: The present invention is drawn to liquid stable poultry vaccines that comprise a live avian virus. The invention is also drawn to the manufacture of such vaccines and methods of vaccinating animal subjects with these vaccines.
Type:
Application
Filed:
September 14, 2018
Publication date:
January 10, 2019
Applicant:
Intervet Inc.
Inventors:
Zhisong Qiao, Stephanie Cook, Kevin O'Connell, Ian Tarpey
Abstract: The invention relates to certain methods for the determination of an antigen content of a first antigen in a mixture comprising two or more antigens. The invention also relates to a potency test for an antigen in a combination vaccine. The method allows the determination of the antigen content in a mixture additionally comprising antibodies that are capable of binding with the antigen.
Type:
Application
Filed:
September 12, 2018
Publication date:
January 10, 2019
Applicant:
Intervet Inc.
Inventors:
Michelle Allen, Mark Garrett, Urs Peter Bruderer, Martinus Antonius Johannes Thijssen