Abstract: The present disclosure relates to compact isochronous sector-focused cyclotrons having reduced dimensions and weight compared with state of the art cyclotrons of same energies. In one implementation, a cyclotron may include two pole magnets facing each other in a chamber defined by a yoke having base plates and flux return yokes forming a lateral wall of the chamber. The magnet poles may include between three and eight hill sectors alternating with a same number of valley sectors distributed about a central axis. The lip of the abyssal opening may be positioned at a distance from the corresponding valley peripheral edge. The flux return yoke may have a thickness in the portions facing valley sectors, such that the ratio of the product of the distance times the thickness to the square of the distance of the peripheral edge to the central axis is less than 5%.

Abstract: The method of the invention comprises the steps of: providing a reference ion beamlet; determining in a phantom (60) a distribution of a linearly-superposable quantity representing a linearly-superposable effect induced by said reference ion beamlet; approximating an ion beam (10) as a weighted superposition of ion beamlets (15), said weighted superposition comprising weight coefficients, at least one ion beamlet (15) being obtained by applying a roto-translation operation to said reference ion beamlet; determining a roto-translated distribution of a linearly-superposable quantity by roto-translating said distribution of a linearly-superposable quantity with said roto-translation operation; determining said physical and/or radiobiological quantities by performing a weighted superposition comprising said weight coefficients, and said roto-translated distribution of a linearly-superposable quantity.

Abstract: Cyclotron for accelerating charged particles around an axis, comprising an electromagnet with an upper pole and a lower pole, producing a magnetic field in the direction of said axis; a Dee electrode assembly and a counter Dee electrode assembly separated from each other by a gap for accelerating said charged particles and a pair of ion sources located in a central region of the cyclotron. Said ion sources are located at a distance of said axis such that the particles emitted from the first ion source pass between said first and second ion sources after a path of half a turn, and radially outwards of the second ion source after a path of three half-turns, and reciprocally.

Abstract: The present invention is related to an apparatus for transporting a charged particle beam. The apparatus may include means for scanning the charged particle beam on a target, a dipole magnet arranged upstream of the means for scanning, at least three quadrupole lenses arranged between the dipole magnet and the means for scanning and means for adjusting the field strength of said at least three quadrupole lenses in function of the scanning angle of the charged particle beam. The apparatus can be made at least single achromatic.

Abstract: The disclosure is related to an apparatus and method for charged hadron therapy verification. The apparatus comprises a collimator comprising a plurality of collimator slabs of a given thickness, spaced apart so as to form an array of mutually slit-shaped openings, configured to be placed at a right angle to the beam line, so as to allow the passage of prompt gammas from the target, the collimator being defined at least by three geometrical parameters being the width and depth of the slit-shaped openings and a fill factor. The disclosure is also related to a method for charged hadron therapy verification with a multi-slit camera.

Abstract: The present disclosure relates to an accessory holder attachable to or integrated in the nozzle of an apparatus for particle beam irradiation treatment. The accessory may be an aperture piece, a range shifter or any other element that can be placed in the beam path between the outer end of the nozzle and the irradiated target. The accessory holder may be equipped with first displacement means for moving the accessory away from or towards the nozzle, thereby moving the accessory forwards and backwards in the direction of the beam and second displacement means for moving the accessory into or out of the beam path. Measurements or treatment steps may be performed with and without the accessory in the beam path, without interrupting the treatment.

Abstract: Disclosed embodiments include an electron accelerator, having a resonant cavity having an outer conductor and an inner conductor; an electron source configured to generate and to inject a beam of electrons transversally into the resonant cavity; a radio frequency (RF) source coupled to the resonant cavity and configured to: energize the resonant cavity with an RF power at a nominal RF frequency, and generate an electric field into said resonant cavity that accelerates the electrons of the electron beam a plurality of times into the cavity and according to successive and different transversal trajectories; and at least one deflecting magnet configured to bend back the electron beam that emerges out of the cavity and to redirect the electron beam towards the cavity.

Abstract: The present disclosure relates to a particle therapy system for irradiating a target with a scanning beam technique. In one implementation, the system includes an irradiation planning device with a planning algorithm configured to associate a particle beam energy E(i) to each spot of the irradiation plan and organize the spots in a sequence of spots according to energy. The system may further include a control system configured for controlling in parallel, from spot to spot, a variation of an output energy of a beam generator, a variation of a magnetic field of one or more electromagnets of a beam transport system and a variation of a magnetic field of the scanning magnet.

Abstract: The present invention relates to a dosimetry device (10) for determining a spatial distribution of a quantity of radiation incident on the dosimetry device. The device comprises a segmented electrode assembly (12) comprising an electrically non-conducting substrate (13) having a plurality of electrode elements (14) provided thereon, surrounded by ground electrodes. The device further comprises an electrically conducting sheet (16) comprising a protrusion (17) arranged such as to define a plurality of ionization chamber cavities (18) between the segmented electrode assembly (12) and the electrically conducting sheet (16). The device also comprises a voltage applying means (28) for applying a voltage difference between the electrically conducting sheet (16) and the plurality of electrode elements (14) and a routing means (25) for routing a plurality of ionization currents corresponding to the plurality of electrode elements (14) to a processing means.

Abstract: A method for determining a water equivalent depth between an entrance point and a reference point is disclosed. The method may comprise sending to a charged particle beam detector placed at a reference point within or beyond a body a charged particle beam whose energy is modulated between a minimum and maximum energy value, acquiring the time dependent response of said charged particle beam detector, determining from said time dependent response a value of a statistical parameter, providing a calibration curve expressing a relationship between values of said statistical parameter and water equivalent depths, and extracting from this calibration curve the water equivalent depth corresponding to the value of the statistical parameter determined from the time dependent response of the charged particle beam detector placed at the reference point.

Abstract: The present invention relates to a pulsed beam particle accelerator which can be used for particle radiation therapy. More particular, a device and method are provided to control the number of particles within a beam pulse. The particle accelerator comprises means for varying the number of particles within each beam pulse of said pulsed ion beam from a minimum value to a maximum value as function of the value of a beam control parameter. For each particle irradiation the required number of particles for each beam pulse is controlled by defining a value for said beam control parameter based on calibration data.

Abstract: The present invention relates to a dosimetry device for an energy particle beam from a source and including at least two ionization chambers, each of which includes a collector electrode and a polarization electrode, said electrodes in each ionization chamber being separated by a gap including a fluid, an energy beam from a single source passing through said ionization chambers, the device being characterized in that said ionization chambers have different charge collection efficiency factors. Said calculation algorithm for the dose rate deposited by said beam is based on the measurement of an output signal in each ionization chamber of the device and on a ?gain? factor related to a first ionization chamber, said ?gain? factor being theoretically predetermined on the basis of said intrinsic and/or extrinsic parameters of said ionization chambers.

Abstract: The present invention relates to an apparatus for producing a radioisotope by irradiating a target fluid comprising a precursor of said radioisotope with a particle beam produced by a particle accelerator, the apparatus comprising: —a housing comprising a target cavity for receiving said target fluid, said housing having an opening for allowing the passage of the said particle beam into the said cavity; —a dual foil flange for closing said opening of the target cavity, said dual foil flange comprising: —a standoff comprising a central hole; —a first and a second foil able to allow the passage of the said particle beam and located respectively on a first side and a second side of the said standoff, covering the said central hole and forming a cooling cavity; —a first flange and a second flange for sealing respectively the said first and second foil on said standoff; —at least an inlet channel and at least an outlet channel, for flowing a cooling fluid through the cavity of the dual foil flange; —guiding means

Abstract: The invention is related to a method for monitoring a range of a particle beam in a target. The method is using gamma detectors for detecting prompt gammas produced in the target. The time differences between the time of detecting a gamma quantum and a time of emission of a particle or a bunch of particles from the radiation device are determined. A statistical distribution of those time difference is used to deduce information related to the range of the beam. The invention is also related to an apparatus for monitoring a range based on measured time profiles of detected prompt gammas.

Abstract: The invention is related to a method and apparatus for verifying the beam range in a target irradiated with a charged hadron beam, such as a proton beam. The beam range is the location of the Bragg peak in the target, being the location where the largest portion of the dose is delivered. The method utilizes a prompt gamma camera provided with a slit-shaped opening, so as to be able to produced a 1-dimensional profile of the dose distribution along the beam line. The camera is mounted with the slit oriented perpendicularly to the beam line. The method comprises the steps of calculating a position of the camera with respect to a target, for a plurality of beam energies and spots to be irradiated. The method further comprises the steps of verifying the beam range for said plurality of spots, and delivering a value representative of the difference between the estimated beam range and the actual beam range. The apparatus of the invention is provided with a positioning module for positioning the camera.

Abstract: A variable rotating capacitor or RotCo 5 that can be connected via a transmission line 3 to the dee 2 of a synchrocyclotron 1 so as to adjust a resonant frequency of the synchrocyclotron as a function of time and which comprises a cylindrical rotor 10 and a cylindrical stator 20 that are coaxial with the Z axis. The rotor comprises a plurality of circumferentially-distributed rotor electrodes 11 extending parallel to its rotation axis Z. The stator comprises a plurality of circumferentially-distributed stator electrodes 21 extending parallel to the rotation axis Z. Each stator electrode 21 consists of a single metal plate and all said plates are distributed over one and the same stator circumference 25. This makes it possible for the RF currents in the electrodes to be better distributed and thus reduces the local overheating. The present invention also relates to a synchrocyclotron comprising such a RotCo.

Abstract: The present invention relates to an RF system (1) able to generate a voltage for accelerating charged particles in a synchrocyclotron, the RF system (1) including a resonant cavity (2) comprising a conducting enclosure (5) within which are placed a conducting pillar (3) of which a first end is linked to an accelerating electrode (4) able to accelerate the charged particles, a rotary variable capacitor (10) coupled between a second end opposite from the first end of the pillar (3) and the conducting enclosure (5), the said capacitor (10) comprising fixed electrodes (11) and a rotor (13) comprising mobile electrodes (12), the fixed electrodes (11) and the mobile electrodes (12) forming a variable capacitance able to vary a resonant frequency of the resonant cavity (2) in a cyclic manner over time, an exterior layer of the rotor (13) having a conductivity of greater than 20,000,000 S/m at 300 K.

Abstract: A gantry structure (16) designed for pivoting about an axis of rotation (18) and for delivering a hadron beam on a target comprises a beam delivery line (24) receiving the hadron beam in a direction essentially parallel to the axis of rotation (18), deviating it away from said axis of rotation (18) and delivering it so that the axis of the beam intersects the axis of rotation (18). The beam delivery line (24) is a self-supporting structure supported by a pivotable support arm (32) in proximity of the center of gravity of the beam delivery line (24). A counterweight (42) is supported by a support arm extension (40) on the other side of the axis of rotation (18) for compensating the moment of force due to the weight of the beam delivery line (24) and the support arm (32).

Abstract: A magnet structure for use in a circular ion accelerator, such as e.g. a synchrocyclotron comprises a cold-mass structure including superconducting magnetic coils (20, 25), at least one dry cryocooler unit (10, 11, 12, 13) coupled with the cold-mass structure for cooling the latter and a magnetic yoke structure (30) with a return yoke (35) configured radially around said coils (20, 25). The return yoke (35) comprises an opening in which said dry cryocooler unit (10, 11, 12, 13) is received so as to be in thermal contact with said cold-mass structure.

Abstract: The invention concerns methods for adjusting the position of a main coil assembly in a cyclotron with respect to a median plane (M) and/or to a central axis (Z) of the cyclotron.