Patents Assigned to IRM LLC
  • Azolopyrimidines as Inhibitors of Cannabinoid 1 Activity
    Publication number: 20090247556
    Abstract: The invention provides compounds of formula (Ia), (Ic), (Ig) and (Ik), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).
    Type: Application
    Filed: March 30, 2007
    Publication date: October 1, 2009
    Applicant: IRM LLC
    Inventors: Xiaohui He, Kunyong Yang, Hong Liu, David Archer Ellis
  • Methods and compositions for modulating T lymphocytes
    Patent number: 7595148
    Abstract: This invention provides novel methods and compositions for modulating T cell differentiation and T cell responses. The modulators are identified by screening test compounds for ability to modulate an inositol 1,4,5-trisphosphate 3-kinase (IP3K). The IP3K modulators can be further examined for their activity in modulating development of progenitor T cells (e.g., CD4+/CD8+ double positive T cells) into mature CD4+ or CD8+ single positive T cells. Pharmaceutical compositions comprising these T cell modulators can be administered to a subject to modulate T cell immune responses, to suppress inflammations, and to treat disease conditions such as autoimmune diseases, graft rejection or allergies.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: September 29, 2009
    Assignee: IRM LLC
    Inventors: Michael P. Cooke, Karsten Sauer, Tim Wiltshire, Lisa Tarantino, Colin Fletcher, Ben Wen
  • Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors
    Patent number: 7592349
    Abstract: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: September 22, 2009
    Assignees: IRM LLC, Novartis AG
    Inventors: Valentina Molteni, Shuli You, Juliet Nabakka, Yi Liu, Xiaolin Li, Donatella Chianelli, Jon Loren, Xiaodong Liu, Shifeng Pan, Donald S. Karanewsky, Pascal Furet, Vito Guagnano
  • Compounds and compositions as protein kinase inhibitors
    Patent number: 7589101
    Abstract: The invention provides a novel class of compounds of formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the AbI, Bcr-AbI, Aurora-A, SGK, Tie-2, Trk-B, FGFR3, c-kit, b-RAF, c-RAF, DYRK2, Fms, Fyn and PDGFRalpha and PDGFR&bgr; kinases.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: September 15, 2009
    Assignees: IRM LLC, The Scripps Research Institute
    Inventors: Barun Okram, Pingda Ren, Nathanael S. Gray
  • Immunosuppressant Compounds and Compositions
    Publication number: 20090221547
    Abstract: The present invention relates to immunosuppressants, processes for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction. This application relates to compounds selected from Formula (Ia), (Ib), (Ic) and (Id).
    Type: Application
    Filed: August 22, 2006
    Publication date: September 3, 2009
    Applicant: IRM LLC
    Inventors: Wenqi Gao, Yongqin Wan, Jiqing Jiang, Yi Fan, Nathanael S. Gray, Shifeng Pan
  • Sample deposition method and system
    Patent number: 7578206
    Abstract: A method and system to deposit rapidly, accurately and efficiently liquid droplets onto a sample plate. A liquid from which the droplet is formed contains sample molecules, matrix molecules or a mixture of both sample and matrix molecules. A sample plate is positioned with respect to a position below a portion of the liquid, such as a droplet. A power supply forms an electric field between the sample plate and the liquid, which pulls the droplet to a target location on the sample plate. A plurality of capillary columns is provided for simultaneous or successive multiple depositions via application of one or more high voltage pulses between the liquid sample array and a sample plate.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: August 25, 2009
    Assignee: IRM LLC
    Inventors: Ansgar Brock, Christopher M. Shaw, Robert C Downs
  • Bicyclic compounds and compositions as PDF inhibitors
    Patent number: 7579363
    Abstract: This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: August 25, 2009
    Assignee: IRM LLC
    Inventors: Valentina Molteni, Xiaohui He, Yun He, Andreas Kreusch, Juliet Nabakka, Kunyong Yang
  • COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS
    Publication number: 20090209573
    Abstract: The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
    Type: Application
    Filed: October 28, 2005
    Publication date: August 20, 2009
    Applicants: IRM LLC, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Xu Wu, Sheng Ding, Peter G. Schultz
  • COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS
    Publication number: 20090203666
    Abstract: The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
    Type: Application
    Filed: May 4, 2007
    Publication date: August 13, 2009
    Applicant: IRM LLC
    Inventors: Wenqi Gao, Jiqing Jiang, Yongqin Wan, Dai Cheng, Dong Han, Xu Wu, Shifeng Pan
  • Immunosuppressant compounds and compositions
    Patent number: 7572811
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: August 11, 2009
    Assignee: IRM LLC
    Inventors: Shifeng Pan, Thomas Marsilje, Wenshuo Lu, Wenqi Gao, Nathanael Schiander Gray, Yun He, Yahua Liu, Yuan Mi, Yongping Xie
  • Compounds and compositions as protein kinase inhibitors
    Patent number: 7569593
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, lck, SAPK2?, p38, TGF?, KDR, c-Kit, b-RAF, c-RAF, FLT1 and FLT4 kinases.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: August 4, 2009
    Assignee: IRM LLC
    Inventors: Nathanael Schiander Gray, Jiqing Jiang, Yi Liu, Ruo Steensma
  • COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS
    Publication number: 20090192203
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
    Type: Application
    Filed: November 7, 2006
    Publication date: July 30, 2009
    Applicant: IRM LLC
    Inventors: Robert Epple, Christopher Cow, Mihai Azimioara, Ross Russo, Yongping Xie, Xing Wang
  • Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors
    Patent number: 7563894
    Abstract: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: July 21, 2009
    Assignees: IRM LLC, Novartis AG
    Inventors: Valentina Molteni, Shuli You, Juliet Nabakka, Yi Liu, Xiaolin Li, Donatella Chianelli, Jon Loren, Xiaodong Liu, Shifeng Pan, Donald S. Karanewsky, Pascal Furet, Vito Guagnano
  • METHODS AND COMPOSITIONS FOR TREATING HYPERALGESIA
    Publication number: 20090175882
    Abstract: This invention provides compounds which specifically inhibit TRPA1 but not other members of the thermoTRP ion channel family. Also provided in the invention are methods of using TRPA1-specific inhibitors to treat or alleviate pains mediated by noxious mechanosensation.
    Type: Application
    Filed: February 21, 2007
    Publication date: July 9, 2009
    Applicants: IRM LLC, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Ardem Patapoutian, Timothy J. Jegla
  • METHODS AND COMPOSITIONS FOR MODULATING FOXO1 ACTIVITY AND INSULIN SIGNALING
    Publication number: 20090156523
    Abstract: The invention provides methods for modulating insulin signaling pathway and methods for treating insulin resistance. The methods employ agents which modulate FOXO1 subcellular localization. The invention also provides methods of screening for compounds that modulate insulin signaling related activities such as gluconeogenesis and cell proliferation.
    Type: Application
    Filed: July 11, 2006
    Publication date: June 18, 2009
    Applicant: IRM LLC
    Inventors: Charles Cho, Sumit Chanda, Peter G. Schultz
  • INHIBITORS OF CATHEPSIN S
    Publication number: 20090137570
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: January 28, 2009
    Publication date: May 28, 2009
    Applicant: IRM LLC
    Inventors: Hong LIU, Arnab K. CHATTERJEE, David C. TULLY, Phillip B. ALPER, Badry BURSULAYA, Jianhua GUO, David H. WOODMANSEE, Daniel MUTNICK, Donald S. KARANEWSKY, Yun HE
  • SPIRO IMIDOZOLE DERIVATIVES AS PPAR MODULATORS
    Publication number: 20090137610
    Abstract: The invention provides compounds (Ia), (Ib) and (Ic), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
    Type: Application
    Filed: January 25, 2007
    Publication date: May 28, 2009
    Applicant: IRM LLC
    Inventors: Robert Epple, Ross Russo, Mihai Azimioara, Christopher Cow, Valentina Molteni, Xiaolin Li, Donatella Chianelli
  • COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS
    Publication number: 20090137591
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR?.
    Type: Application
    Filed: February 3, 2006
    Publication date: May 28, 2009
    Applicant: IRM LLC
    Inventors: Christopher Cow, Robert Epple, Xing Wang, Yongping Xie, Hans Martin Seidel
  • Compounds and Compositions as Protein Kinase Inhibitors
    Publication number: 20090137555
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases and disorders associated with kinase activity, particularly diseases associated with the activity of CDK1, CDK2, CDK4, CDK5, GSK3?, Bcr-abl, Flt-3, c-Kit, PDGFR?, Src, Mek1 and CK1.
    Type: Application
    Filed: August 6, 2008
    Publication date: May 28, 2009
    Applicant: IRM LLC
    Inventors: Yongqin Wan, Nathanael S. Gray
  • IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS
    Publication number: 20090131400
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Application
    Filed: July 25, 2008
    Publication date: May 21, 2009
    Applicant: IRM LLC
    Inventors: Yuan Mi, Shifeng Pan, Nathanael Schiander Gray, Wenqi Gao, Yi Fan, Tao Jiang