Patents Assigned to IRM LLC
  • Site-Specific Labeling of Proteins for Nmr Studies
    Publication number: 20080171317
    Abstract: Methods of producing and/or analyzing spectroscopically labeled proteins, e.g., proteins site-specifically labeled with NMR active isotopes, spin-labels, chelators for paramagnetic metals, and the like, are provided. The labeled proteins are produced in translation systems including orthogonal aminoacyl tRNA synthetase/tRNA pairs. Methods for assigning NMR resonances, e.g., methods using isotopically labeled proteins, are also provided.
    Type: Application
    Filed: September 21, 2005
    Publication date: July 17, 2008
    Applicants: THE SCRIPPS RESEARCH INSTITUTE, IRM, LLC
    Inventors: Alexander Deiters, Bernhard H. Geierstanger, Peter G. Schultz
  • DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
    Publication number: 20080167308
    Abstract: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 10, 2008
    Applicants: IRM LLC, A DELAWARE LIMITED LIABILITY COMAPNY, NOVARTIS, AG
    Inventors: Valentina Molteni, Xiaolin Li, Donatella Chianelli, Juliet Nabakka, Jon Loren, Xiaodong Liu, Shifeng Pan, Yi Liu, Donald S. Karanewsky, Pascal Furet, Vito Guagnano, Shuli You
  • Transient receptor potential channel TRPV3 and its use
    Patent number: 7396910
    Abstract: This invention provides novel genes and polypeptides of the transient receptor potential channel family, and use of these genes and polypeptides for the treatment of pain and identification of agents useful in the treatment of pain.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: July 8, 2008
    Assignees: IRM LLC, Novartis AG
    Inventors: Stuart Bevan, Pamposh Ganju, Peter McIntyre, Ardem Patapoutian, Andrea Peier, Chuanzheng Song
  • High throughput processing system and method of using
    Patent number: 7390458
    Abstract: Briefly, the present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work perimeters to facilitate robotic transfer of sample holders from one work perimeter to another area. Each work perimeter typically includes a plurality of defined station locations, with each station location positioned to be accessible by the robot associated with that area. In addition, each station location is typically configured to receive a device, such as an automated instrument or a holding nest. Device components are arranged at selected station locations according to specific application requirements to provide a flexible, robust, reliable, and accurate high throughput processing system.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: June 24, 2008
    Assignee: IRM LLC
    Inventors: Kristina Marie Burow, Jeremy S. Caldwell, Robert Charles Downs, Scott Allan Lesley, James Kevin Mainquist, Andrew J. Meyer, Daniel G. Sipes, Mark Richard Weselak
  • DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
    Publication number: 20080139597
    Abstract: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 12, 2008
    Applicants: IRM LLC, A DELAWARE LIMITED LIABILITY COMAPNY, NOVARTIS, AG
    Inventors: Valentina Molteni, Xiaolin Li, Donatella Chianelli, Jon Loren, Juliet Nabakka, Xiaodong Liu, Shifeng Pan, Yi Liu, Donald S. Karanewsky, Pascal Furet, Vito Guagnano, Shuli You
  • DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
    Publication number: 20080139559
    Abstract: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 12, 2008
    Applicants: IRM LLC, A DELAWARE LIMITED LIABILITY COMAPNY, NOVARTIS
    Inventors: Valentina Molteni, Shuli You, Juliet Nabakka, Yi Liu, Xiaolin Li, Donatella Chianelli, Jon Loren, Xiaodong Liu, Shifeng Pan, Donald S. Karanewsky, Pascal Furet, Vito Guagnano
  • Inhibitors of cathepsin S
    Patent number: 7384970
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: June 10, 2008
    Assignee: IRM LLC
    Inventors: Hong Liu, Phil Alper, Arnab Chatterjee, David Tully, Badry Bursulaya, David Woodmansee, Robert Epple, Jennifer Leslie Harris, Jun Li
  • Compounds and Compositions as Protein Kinase Inhibitors
    Publication number: 20080113986
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders than involve abnormal activation of the Abl, Bcr-abl, Bmx, c-RAF, CSK, Fes, FGFR3, Flt3, GSK3?, IR, JNK1? 1, JNK2? 2, Lck, MKK4, MKK6, p70S6K, PDGFR?, Rsk1, SAPK2?, SAPK2?, Syk and Trk? kinases.
    Type: Application
    Filed: June 23, 2005
    Publication date: May 15, 2008
    Applicant: IRM LLC
    Inventors: Pingda Ren, Xia Wang, Nathanael Gray, Yi Liu, Taebo Sim
  • Compounds and compositions as protein kinase inhibitors
    Patent number: 7371750
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: May 13, 2008
    Assignee: IRM LLC
    Inventors: Taebo Sim, Hyun Soo Lee, Pingda Ren, Qiang Ding, Guobao Zhang, Yi Liu, Xia Wang, Tetsuo Uno, Bing Li, Lintong Li, Nathanael Schiander Gray, Shuli You
  • COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
    Publication number: 20080108616
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, SAPK2? and SAPK2? kinases.
    Type: Application
    Filed: January 7, 2008
    Publication date: May 8, 2008
    Applicant: IRM LLC
    Inventors: Qiang Ding, Nathanael Gray, Bing Li, Yi Liu, Tetsuo Uno
  • INHIBITORS OF CATHEPSIN S
    Publication number: 20080108595
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Applicant: IRM LLC
    Inventors: Hong Liu, Arnab Chatterjee, David Tully, Phillip Alper, Badry Bursulaya, Jianhua Guo, David Woodmansee, Daniel Mutnick, Donald Karanewsky, Yun He
  • Systems and methods for sorting samples
    Patent number: 7364907
    Abstract: Methods and systems for sorting compounds and compound holders into batches for subsequent processing are provided.
    Type: Grant
    Filed: November 7, 2003
    Date of Patent: April 29, 2008
    Assignee: IRM LLC
    Inventors: Mark R. Weselak, Brad Backes, Jared Ek
  • Methods of identifying modulators of human retrovirus replication
    Patent number: 7364842
    Abstract: This invention relates to the discovery that the transcription factors Pbx1 and HMG I are involved in retrovirus, e.g., HIV, replication. Thus, the invention provides methods of identifying modulators of these proteins. Such modulators can be used as reagents in in vitro assays to modulate expression of retroviral sequences and may be used to inhibit HIV replication in vivo.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: April 29, 2008
    Assignee: IRM, LLC
    Inventors: Sheng Hao Chao, Jeremy S. Caldwell
  • Transient receptor potential channel TRPM8 and its use
    Publication number: 20080076136
    Abstract: This invention provides novel genes and polypeptides of the transient receptor potential channel family, and use of these genes and polypeptides for the treatment of pain and identification of agents useful in the treatment of pain.
    Type: Application
    Filed: March 21, 2006
    Publication date: March 27, 2008
    Applicants: IRM LLC, Novartis AG
    Inventors: Stuart Bevan, Pamposh Ganju, Peter McIntyre, Ardem Patapoutian, Andrea Peier, Chuanzheng Song
  • Methods and compositions for modulating activator protein 1
    Patent number: 7344833
    Abstract: This invention provides novel AP-1 modulatory polypeptides. The invention also provides methods for screening modulators of AP-1 transcription factor activities. The methods comprise first screening test agents for modulators of an AP-1-modulatory polypeptide and then further screening the identified modulating agents for modulators of AP-1 transcription factor activities. The invention further provides methods and pharmaceutical compositions for modulating AP-1 transcription factor activities in a cell and for treating diseases and conditions mediated by abnormal cellular proliferation.
    Type: Grant
    Filed: November 5, 2003
    Date of Patent: March 18, 2008
    Assignee: IRM LLC
    Inventors: Sumit Chanda, Suhaila White, John B. Hogenesch, Jeremy S. Caldwell
  • Compounds and compositions as protein kinase inhibitors
    Patent number: 7338957
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, SAPK2? and SAPK2? kinases.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: March 4, 2008
    Assignee: IRM LLC
    Inventors: Qiang Ding, Nathanael Schiander Gray, Bing Li, Yi Liu, Tetsuo Uno
  • Sweet taste receptors
    Patent number: 7335487
    Abstract: This invention provides novel genes and polypeptides of the sweet receptor family, methods for production of the polypeptides, methods for screening compounds that specifically bind to and/or modulate the activity of these polypeptides; and antibodies specific for the polypeptides.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: February 26, 2008
    Assignees: IRM LLC, The Scripps Research Institute
    Inventors: Jiayu Liao, Sheng Ding, Peter G. Schultz
  • ANTAGONISTS OF PROTEASE ACTIVATED RECEPTOR-1 (PAR1)
    Publication number: 20080044424
    Abstract: The present invention provides antibodies or antigen-binding molecules that specifically recognize and antagonize human PAR1 receptor. Also provided in the invention are polynucleotides and vectors that encode such molecules and host cells that harbor the polynucleotides or vectors.
    Type: Application
    Filed: July 17, 2007
    Publication date: February 21, 2008
    Applicant: IRM LLC
    Inventors: Steve Cohen, Marc Nasoff
  • Capacity altering device, holder, and methods of sample processing
    Patent number: 7329393
    Abstract: This invention provides capacity altering devices that facilitate the processing of samples whose volume exceeds the capacity of external sample processing regions (e.g., sample tubes or wells). The invention also provides holders that can be used with such devices, e.g., to allow centrifugation of the devices and/or to minimize handling of the external processing regions. Methods of processing samples, particularly samples whose volume exceeds the capacity of the external processing regions, and methods of collecting compounds in external processing regions are another feature of the invention.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: February 12, 2008
    Assignee: IRM LLC
    Inventors: Bradley J. Backes, Jim Chang, John Isbell, James K. Mainquist, Christopher M. Shaw
  • High throughput incubation devices
    Patent number: 7329394
    Abstract: The invention provides an efficiently automated incubation device that reduces the number of powered moving parts in the device and the amount of air transfer between environments that are internal and external to the device.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: February 12, 2008
    Assignee: IRM LLC
    Inventors: Mark R. Weselak, Robert C. Downs