Patents Assigned to IRM LLC
  • Methods and compositions for modulating herpesviral replication and transcription activator
    Publication number: 20050123904
    Abstract: This invention provides novel polypeptides that modulate activities of the replication and transcription activator (RTA) of Kaposi's sarcoma-associated herpesvirus (KSHV). The invention also provides methods for screening modulators of RTA activities. The methods comprise first screening test agents for modulators of an RTA-modulatory polypeptide and then further screening the identified modulating agents for modulators of RTA activities. The invention further provides methods and pharmaceutical compositions for treating diseases and conditions associated with infections of gammaherpesviruses.
    Type: Application
    Filed: August 17, 2004
    Publication date: June 9, 2005
    Applicant: IRM LLC
    Inventors: Josephine Harada, Christian Nelson, Sumit Chanda
  • Multi-well container positioning devices and related systems and methods
    Publication number: 20050118060
    Abstract: The present invention provides positioning devices the include one or more container stations that each comprise a support surface that is structured to position at least one multi-well container. Container stations are tiered relative to one another and/or rotationally coupled to support structures of the positioning devices. The invention also relates to systems and methods that include the positioning devices described herein.
    Type: Application
    Filed: August 3, 2004
    Publication date: June 2, 2005
    Applicant: IRM, LLC
    Inventor: Douglas Evans
  • Methods and compositions for modulating cell proliferation
    Publication number: 20050118663
    Abstract: This invention provides methods for identifying novel SHMT modulators. The methods comprise first screening test agents for modulators of p38 activity and then further screening the identified modulating agents for modulators of SHMT enzyme activity. The invention further provides methods and pharmaceutical compositions for modulating cellular proliferation and for treating tumors using the novel SHMT modulators.
    Type: Application
    Filed: July 30, 2004
    Publication date: June 2, 2005
    Applicant: IRM LLC
    Inventors: Kavita Shah, Sungjoon Kim
  • Methods for the preparation of rhodamine
    Publication number: 20050113584
    Abstract: Method for preparing rhodamine on a solid support and, in particular, methods for the economical preparation of rhodamine NHS ester are disclosed.
    Type: Application
    Filed: July 14, 2004
    Publication date: May 26, 2005
    Applicant: IRM LLC
    Inventors: Robert Damoiseaux, Jennifer Harris
  • Inhibitors of cathepsin S
    Publication number: 20050113356
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: August 18, 2004
    Publication date: May 26, 2005
    Applicant: IRM LLC
    Inventors: Hong Liu, Arnab Chatterjee, David Tully, Phillip Alper, Badry Bursulaya, Jianhua Guo, David Woodmansee, Daniel Mutnick, Donald Karanewsky, Yun He
  • Non-pressure based fluid transfer in assay detection systems and related methods
    Publication number: 20050112783
    Abstract: The present invention relates generally to sample assaying systems that include non-pressure-based fluid transfer probes. The non-pressure-based fluid transfer probes of the invention are typically utilized to transfer fluidic samples to sample assay containers or other supports for sample detection or imaging. The invention also provides various additional components that are optionally included in these systems, including container positioning devices, container storage components, and robotic devices among others. Pin tools and methods of assaying fluidic samples that utilize the systems of the invention are also provided.
    Type: Application
    Filed: August 3, 2004
    Publication date: May 26, 2005
    Applicant: IRM, LLC
    Inventors: Douglas Evans, Nick Callamaras
  • Multi-well containers, systems, and methods of using the same
    Publication number: 20050112033
    Abstract: The invention provides multi-well containers that include membranes for performing various processes, including analytical and synthetic processes. Related systems, kits, and methods are also provided.
    Type: Application
    Filed: September 3, 2004
    Publication date: May 26, 2005
    Applicant: IRM, LLC
    Inventors: Kanyin Zhang, Douglas Evans
  • Inhibitors of cathepsin S
    Publication number: 20050107368
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: August 18, 2004
    Publication date: May 19, 2005
    Applicant: IRM LLC
    Inventors: Hong Liu, Phillip Alper, Donald Karanewsky
  • Methods and compositions for inducing apoptosis in cancer cells
    Publication number: 20050079172
    Abstract: Anti-DR4 or Anti-DR5 antibody agonists, combined with apoptosis-inducing agents, synergistically induce apoptosis in cancer cells.
    Type: Application
    Filed: November 25, 2003
    Publication date: April 14, 2005
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Marc Nasoff, Quinn Deveraux, Deborah Knee, Pedro Aza-Blanc, Garret Hampton, Klaus Wagner
  • Method and apparatus for performing multiple processing steps on a sample in a single vessel
    Patent number: 6869792
    Abstract: A method is provided which comprises: performing a plurality of fermentations, each fermentation in a different sample vessel; and performing a further processing step on the plurality of fermented samples where the sample is retained in the same sample vessel as the fermentation during the processing step.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: March 22, 2005
    Assignee: IRM, LLC
    Inventor: Robert Charles Downs
  • Material removal and dispensing devices, systems, and methods
    Publication number: 20050058577
    Abstract: The present invention provides material removal heads and devices for noninvasively removing materials from the wells of multi-well plates. The material removal heads of the invention are structured to prevent cross-contamination among wells of multi-well plates as materials are removed from the plates. The invention also provides dispense heads and devices that include angled dispensers. Related systems, kits, and methods are additionally provided.
    Type: Application
    Filed: April 7, 2004
    Publication date: March 17, 2005
    Applicant: IRM, LLC
    Inventors: Kenneth Micklash, Robert Downs, Jim Chang, James Mainquist
  • Methods and compositions for inhibiting herpesviral replication
    Publication number: 20050058991
    Abstract: This invention provides methods of screening for compounds that inhibit herpesviral transcription and replication. The methods comprise screening test compounds for ability to enhance the activity of homeodomain transcription factor PDX1 in repressing transcription of herpesviral genes (e.g., the IE gene of cytomegalovirus). Transcriptional repression by PDX1 can be monitored using an expression vector comprising a reporter gene operably linked to a PDX1-binding, upstream transcription regulatory sequence of the herpesvirus. The invention further provides methods and pharmaceutical compositions for stimulating PDX1-mediated transcriptional repression in a subject and for treating diseases and conditions associated with herpesviral infection.
    Type: Application
    Filed: July 7, 2004
    Publication date: March 17, 2005
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Sheng-Hao Chao, Jeremy Caldwell
  • Modulators of transmembrane protease serine 6
    Publication number: 20050054027
    Abstract: This invention provides novel methods for identifying modulators of transmembrane protease serine 6 (TMPRSS6). The methods comprise screening test agents for ability to modulate proteolysis of a pathogenic toxin substrate or a synthetic peptide substrate of TMPRSS6. The methods can further comprise screening the identified modulating agents for ability to inhibit infections of pathogens. Also provided in the invention are methods and pharmaceutical compositions for treating infections of pathogens whose toxins are proteolytically activated by TMPRSS6.
    Type: Application
    Filed: September 3, 2004
    Publication date: March 10, 2005
    Applicant: IRM LLC
    Inventors: Jennifer Harris, Aaron Shipway
  • Inhibitors of cathepsin S
    Publication number: 20050049244
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: June 10, 2004
    Publication date: March 3, 2005
    Applicant: IRM LLC
    Inventors: Hong Liu, David Tully, Phillip Alper, Robert Epple, Arnab Chatterjee, Michael Roberts
  • Methods and compositions for modulating NF-AT transcription factor
    Publication number: 20050048585
    Abstract: This invention provides novel NF-AT-modulatory polypeptides. The invention also provides methods for screening modulators of NF-AT. The methods comprise first screening test agents for modulators of an NF-AT-modulatory polypeptide and then further screening the identified modulating agents for modulators of NF-AT. The invention further provides methods and pharmaceutical compositions for modulating NF-AT bioactivities in a cell and for treating diseases and conditions mediated by abnormal NF-AT activities.
    Type: Application
    Filed: December 10, 2003
    Publication date: March 3, 2005
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Suhaila White, Sumit Chanda, Jeremy Caldwell
  • Solution phase sythesis of arylbenzoxazoles
    Patent number: 6861533
    Abstract: This invention provides methods for the solution-phase synthesis of arylbenzoxazoles. The methods involve condensation of aminophenols with benzaldehydes to form a Schiff base. The Schiff base is then induced to undergo oxidative cyclization in the presence of DDQ. The resulting arylbenzoxazoles can be separated from the reduced DDQ byproduct by treatment of reaction mixture with a strongly basic ion exchange resin.
    Type: Grant
    Filed: November 19, 2002
    Date of Patent: March 1, 2005
    Assignee: IRM LLC
    Inventors: Junbiao Chang, Shifeng Pan
  • Methods and compositions for modulating erythropoietin expression
    Publication number: 20050037390
    Abstract: This invention provides novel Epo-modulating polypeptides. The invention also provides methods for screening modulators of Epo expression. The methods comprise first screening test agents for modulators of an Epo-modulating polypeptide and then further screening the identified modulating agents for modulators of Epo expression. The invention further provides methods and pharmaceutical compositions for modulating Epo expression in cells and for treating diseases and conditions due to Epo deficiency.
    Type: Application
    Filed: June 4, 2004
    Publication date: February 17, 2005
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Fred King, Sumit Chanda, Jeremy Caldwell, John Hogenesch
  • Compounds that induce neuronal differentiation in embryonic stem cells
    Publication number: 20050038049
    Abstract: The invention provides a novel class of compounds and compositions that are useful in the treatment or prevention of diseases or disorders associated with kinases, particularly GSK-3?, c-Abl, HER-1, HER-2, KDR, Flt-3, c-Raf-1, PDGFR-?, c-Kit, Flt-4, Flt-1, Tek, c-src, CDK1, PDK1, FGFR-1, FGFR-2, Fer, MAP3K13, EPHA7 and c-Met kinases. The invention further relates to the use of the compounds of the invention as potent inducers of neurogenesis in embryonic stem cells.
    Type: Application
    Filed: April 22, 2004
    Publication date: February 17, 2005
    Applicants: THE SCRIPPS RESEARCH INSTITUTE, IRM LLC
    Inventors: Sheng Ding, Tom Wu, Nathanael Gray, Peter Schultz
  • Novel use of liver X receptor agonists
    Publication number: 20050036992
    Abstract: This invention provides novel methods for modulating expression of glut4 and other genes involved in glucose metabolism, and methods for treating or ameliorating diabetes and related diseases. The methods comprise administering to cells in a subject an effective amount of an LXR agonist and thereby modulating expression of those genes that are important for glucose uptake or gluconeogenesis. The modulation will lead to increased uptake of glucose by cells in the subject and/or reduced glucose output in the liver, and accordingly ameliorate symptoms associated with, e.g., type II diabetes.
    Type: Application
    Filed: December 22, 2003
    Publication date: February 17, 2005
    Applicants: IRM LLC, The Regents of the University of California
    Inventors: Enrique Saez, Peter Tontonoz, Bryan Laffitte, Jing Li
  • Novel compounds and compositions as protein kinase inhibitors
    Publication number: 20050014753
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated tyrosine kinase activity, particularly diseases associated with the activity of PDGF-R, c-Kit and Bcr-abl.
    Type: Application
    Filed: April 1, 2004
    Publication date: January 20, 2005
    Applicant: IRM LLC
    Inventors: Qiang Ding, Taebo Sim, Guobao Zhang, Francisco Adrian, Nathanael Gray