Abstract: Provided are novel 4- and 5-substituted 1,2,3-triazoles, and regioisomer mixtures thereof, modified polymers, wherein the substituted 1,2,3-triazoles are modified by reaction with a modifying polymer (maleic anhydride based polymer). Depending upon the ratio of the substituted 1,2,3-triazole to the maleic anhydride based polymer employed, the resulting modified polymers can provide maleic anhydride based polymers that are partially or fully reacted with the substituted 1,2,3-triazoles. The resulting modified polymers may be partially or fully opened to provide amic acids, carboxylic acids, carboxylic acidic salts, imides, or esters. The novel 4- or 5-substituted 1,2,3-triazoles, and regioisomer mixtures thereof, modified polymers can be converted to a wide variety of useful polymers and may be employed in a wide variety of compositions. An example of a modified polymer may be represented by the structure: formula: (1) wherein m, n, and q are defined herein.

Abstract: The present invention provides novel functionalized mixtures 4- and 5-vinyl substituted regioisomers of 1,2,3-triazoles via 1,3-dipolar cycloaddition. Functionalized alkyne moieties with a terminal alcoholic functionality are reacted with functionalized organic moieties with a terminal leaving group and an azide to provide an alcoholic functionalized mixture of 4- and 5-substituted regioisomers of 1,2,3-triazole moieties. The mixture may be converted to a wide variety of useful functionalized mixtures of 4- and 5-vinyl substituted regioisomers of 1,2,3-triazole moieties, which in turn can be converted to a wide variety of useful polymers The novel alcoholic functionalized mixtures of 4- and 5-substituted regioisomers can be separated by chromatography to provide the purified 4- and 5-alcoholic functionalized substituted 1,2,3-triazole moieties. The novel compounds of the invention can be employed in a wide variety of compositions (Formulae (I), (II)); wherein R1, R2, R3, and R4, are defined herein.

Abstract: Disclosed herein is an eco-friendly, non-aqueous and stable antimicrobial solution composition comprising (a) about 0.1 to 20.0 wt % of a Tropolone; and (b) about 80.0 to 99.9 wt % of bio-derived 1,3-propanediol and/or bio-derived sorbitan caprylate. Also disclosed is a process for preparing and method of using the composition. The composition is stable for at least two years at room temperature and can be employed in the fields of cosmetic, toiletry, personal care, household, cleaning, disinfecting, food, beverages, enzyme formulations, feminine care products, foot care products, pet care products, food ingredients, paints, coatings, metal working fluids, nutrients for plants, construction and/or laundry products.

Abstract: Disclosed herein is an eco-friendly, non-aqueous and stable antimicrobial solution composition comprising (a) about 0.1 to 20.0 wt % of a Tropolone; and (b) about 80.0 to 99.9 wt % of bio-derived 1,3-propanediol and/or bio-derived sorbitan caprylate. Also disclosed is a process for preparing and method of using the composition. The composition is stable for at least two years at room temperature and can be employed in the fields of cosmetic, toiletry, personal care, household, cleaning, disinfecting, food, beverages, enzyme formulations, feminine care products, foot care products, pet care products, food ingredients, paints, coatings, metal working fluids, nutrients for plants, construction and/or laundry products.

Abstract: The invention relates to an extract of cotton fibers, a cosmetic composition comprising, by way of an active principle, at least one extract of cotton fibers, formed by mono, di, tri and tetra saccharides, in a physiologically suitable medium. The invention also relates to a cosmetic treatment method for protecting keratin substrates, for reinforcing the skin's cutaneous barrier and/or for reinforcing protection of the hair and/or for enhancing keratin synthesis and/or for nourishing keratin substrates. The invention also relates to a method for producing an extract of cotton fibers and to the use thereof for the preparation of a cosmetic composition according to the invention.

Abstract: Personal care compositions comprising a polymer-bound UV absorber are described that provide enhanced properties, including customizable UV spectrum protection, broad-spectrum UV spectrum protection, water resistance, and labile UV stabilization. The polymer comprises anhydride functionality, such as maleic anhydride or a derivative thereof, and the UV absorber contains at least one hydroxyl, primary amine, or secondary amine group. The personal care compositions may be used to treat and/or protect against burns, cancers, erythema, lentigo (“liver spots”), keratotic lesions, wrinkles, and cellular changes of the skin; and/or color changes, embrittlement, lack of luster, tangles, split ends, and/or unmanageability of the hair.

Abstract: A stable, aqueous suspension concentrate which includes a solid polymeric dispersant comprising one or more anionic polymeric dispersing agents, optionally a co-dispersant which preferably is a homopolymer and/or a copolymer of a heterocyclic vinyl lactam, preferably in a wt. ratio of 0.1:1 to 1:0.1, a UV-labile, water-insoluble biocide active, and a UV-blocker or UV-absorber to stabilize said active upon storage and/or exposure to sunlight or UV radiation.

Abstract: The invention relates to peptidic compounds of general formula (I) R1-(AA)n-X1-X2-Ile-Gln-Ala-Cys-Arg-Gly-X3-(AA)p-R2 as caspase-14 activators. The invention also relates to a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in a physiologically acceptable medium, and to the use of said composition for preventing and/or repairing damage to deoxyribonucleic acid, for preventing and/or treating cutaneous signs of ageing and photo-ageing, and for improving the skin barrier function. The invention further relates to a cosmetic treatment method for preventing and/or treating cutaneous signs of ageing and photo-ageing, and for preventing and/or repairing damage caused by ultraviolet radiation.

Abstract: The present invention relates to the use of a composition comprising at least one peptidic fava bean extract as an active agent capable of limiting hair loss, and/or stimulating its growth. Moreover, the composition is intended, on one hand, to modulate the Clock, Perl and Bmal1 genes in the dermal papilla cells, and, on the other hand, to restore the circadian rhythm and resynchronize the biological clock of said cells. Finally, the present invention relates to several methods of non-therapeutic cosmetic treatment using said composition.

Abstract: What is described herein is an environment-friendly, highly aqueous solution of 1,2-benzisothiazolin-3-one (BIT) which is free from volatile organic compounds (VOC's), glycols, derivatives of glycols, glycerols and/or derivatives of glycerols. The composition comprises: (i) about 0.1% to about 30% by wt. of BIT; (ii) about 5% to about 15% by wt. of neutralizing agent; (iii) about 50% to about 85% by wt. of water; and (iv) about 0.1% to about 5% by wt. of chelating agent. The aqueous solution of BIT may further comprise at least one water soluble form of a co-biocide. The composition is efficient in protecting aqueous media against microbial attack in various industrial applications.

Abstract: The present invention provides novel 4- and 5-substituted 1,2,3-triazole moieties, with at least one remote polymerizable moiety. The novel mixtures of 4- and 5-substituted regioisomers of 1,2,3-triazole moieties can be separated by chromatography to provide the purified 4- and 5-substituted 1,2,3-triazole moieties. The novel mixtures of 4- and 5-substituted regioisomers of 1,2,3-triazole moieties, and the purified 4- and 5-substituted 1,2,3-triazole moieties, with at least one remote polymerizable moiety, can be converted to a wide variety of useful polymers. The novel compounds of the invention can be employed in a wide variety of compositions. E, Q, Z, X, a, and R1-R4, in the structures below, are defined herein.

Abstract: Functional additives for cleansing compositions exhibiting enhanced anti soil-re-deposition and/or dye transfer inhibitory properties comprising polymers in the form of homopolymers, copolymers or terpolymers synthesized from at least one hydrophobic monomer. Examples of hydrophobic monomers include N-vinyl caprolactam, vinyl acetate, vinyl esters, acrylated glycols, methacrylamide, C1 to C12 alkyl- and C1 to C12 dialkylacrylamide, C1 to C12 alkyl- and C1 to C12 dialkylmethacrylamide, C1 to C12 alkyl aery late, C1 to C12 alkyl methacrylate, 4-butyl phenyl maleimide, octyl acrylamide.

Abstract: A cosmetic composition having a synergistic TRF2 protein activation system consisting essentially of a combination of a peptidic soybean and yeast extract in a physiologically acceptable medium is disclosed and protecting or treating damage to the DNA of skin cells associated with aging by applying the cosmetic composition thereto, typically topically. The peptidic soybean and yeast extract is obtained by hydrolyzing at least 80% of soybeans by weight of the total weight of raw materials and at most 20% of yeast by weight of the total weight of raw materials.

Abstract: Peptide compounds of general formula (I) R1-(AA)n-X1—X2—X3-Asp-Leu-Lys-Lys-X4—X5-(AA)p-R2, cosmetic or pharmaceutical compositions comprising at least one peptide compound of general formula (I) in a physiologically acceptable medium, and methods for cosmetic treatment of skin are disclosed. The peptide compounds of general formula (I) were demonstrated to be agents making it possible to influence the pigmentation of the skin and skin appendages, by ensuring optimal transfer of the melanosomes to the keratinocytes, so as to make the skin tone uniform owing to an effect on the SCF/c-Kit signaling pathway. The compounds, compositions, and methods treat or attenuate age-related pigmentation defects and the effects of photoaging on the skin.

Abstract: The present invention provides a method for measuring a two-dimensional distribution of ionizing radiation doses with high spatial resolution. The method comprises exposing radiation sensitive film to a pattern of ionizing radiation to form a measurement film, exposing areas of radiation sensitive film to a plurality of known doses of the ionizing radiation to form a calibration film(s), scanning all the exposed films together with an unexposed radiation sensitive film at a single time to produce a digital image, measuring those areas of the digital image corresponding to the unexposed film and the calibration film(s) exposed to different known doses, associating the measured responses in the areas to the known doses and using the association to convert the values in the scanned image corresponding to the measurement film from scanner response values to dose values. In a preferred embodiment, all of the radiation sensitive films are the same type of film.

Abstract: Described herein are multifunctional polymers comprising a first repeating unit having at least one pseudo-cationic moiety, a second repeating unit having at least a hydrophobic moiety, and a third repeating unit, where the weight-average molecular weight is less than about 10,000 Da. In one embodiment the polymers exhibit antimicrobial activity. Also provided are compositions formulated with the multifunctional polymers, and a method of providing antimicrobial activity.

Abstract: Carbamate and thiocarbamate compounds are described that comprise a polymerizable moiety and one or more free hydroxyl and/or thiol groups. Polymers may be obtained by polymerizing these carbamate and/or thiocarbamate compounds. The carbamate and thiocarbamate compounds, as well as the polymers they produce may be formulated into adhesive, agricultural, biocide, cleaning, coating, encapsulation, membrane, oilfield, performance chemical, and personal care compositions.

Abstract: A method of attenuating hair loss includes applying to the hair a composition having an effective amount of a hair-loss attenuating peptide hydrolysate and a cosmetically acceptable carrier.

Abstract: A peptide of general formula (I): R1-(AA)nX1-X2-Arg-Arg-Gly-X3-X4-(AA)p-R2, and cosmetic and pharmaceutical compositions are disclosed that include at least one peptide of general formula (I), in a physiologically suitable medium. Also disclosed are methods for activating human transglutaminase to reinforce the skin barrier function and to stimulate epidermal regeneration and differentiation or for cosmetic treatment to treat signs of skin ageing, which include administering a composition containing the peptide of general formula (I) as an active ingredient.

Abstract: A stable ternary solid dispersion composition with enhanced physical stability and/or bioavailability comprising: (a) about 1% wt. to about 50% wt. of one or more poorly soluble active pharmaceutical ingredient (API) which belongs to Biopharmaceutics Classification System (BCS) class II and/or IV; (b) about 11% wt. to about 50% wt. of at least one water-soluble polymer; and (c) about 20% wt. to about 99% wt. of crosslinked polyvinylpyrrolidone (crospovidone, a water-insoluble polymer). The solid dispersion is capable of inhibiting crystallization of API in solid state and/or aqueous gastrointestinal tract (GIT) medium. Also disclosed is a method of preparation of such solid dispersion composition by fusion or solvent or fusion-solvent method.