Abstract: Peptide compounds of the general formula (I) R1-(AA)n-X1—X2-Arg-Glu-Met-Asn-Trp-X3-(AA)p-R2 modulating the survivin protein are described. Furthermore, cosmetic or pharmaceutical compositions, including at least one peptide of the general formula (I), in a physiologically acceptable medium are described. Additionally, methods for treating the cutaneous signs of ageing and photo-ageing, treating the skin against external aggressions, and limiting hair loss and/or stimulating hair growth are described.

Abstract: What is described herein is a synergistic matrix composite for making a stable microemulsion in water of an active ingredient comprising a first matrix composition including by wt. (a) 5-30% of a C8-C18 N-alkyl pyrrolidone, (b) optionally, 5-60% of a water insoluble organic solvent soluble therein, (c) 30-70% of a non-ionic emulsifier, and (d) 1-15% of an EO/PO/EO copolymer, and, (e) optionally, 1-5% of a surface active buffering agent, e.g. a branched alkyl ethoxylated phosphate ester, a second matrix composition comprising a polar polymeric material, e.g. polyethylene glycol, and/or a neutralized derivatized vegetable oil, e.g. maleated linseed oil, which composite is capable of loading a higher amount of said active than either composition alone.

Abstract: A stable and high loading ternary solid dispersion composition comprising (a) about 50% wt. to about 90% wt. of amorphous Efavirenz; (b) about 10% wt. to about 50% wt. of polyvinyl pyrrolidone (PVP), a first polymer; (c) about 1% wt. to about 30% wt. of a water-soluble second polymer; and (d) optionally about 0.1% wt. to about 50% wt. of at least one pharmaceutically acceptable excipient. Also discloses a high loading ternary composition comprising (a) a solid dispersion composition comprising (i) about 50% wt. to about 90% wt. of amorphous Efavirenz; (ii) about 10% wt. to about 50% wt. of polyvinyl pyrrolidone, a first polymer; (b) about 1% wt. to about 30% wt. of a water-soluble second polymer blended with solid dispersion of composition of (a); and (c) optionally about 0.1% wt. to about 50% wt. of at least one pharmaceutically acceptable excipient.

Abstract: The present application provides an aqueous, stable, VOC-free microemulsion based antimicrobial disinfectant and/or cleaning concentrate composition capable of inhibiting or killing gram(+), gram(?) and methicillin-resistant Staphylococcus aureus (MRSA) comprising (i) a water-soluble matrix composite made of (a) water-soluble polymer, and (b) water-soluble surfactant; (ii) a blend of antimicrobial agents comprising (a) at least one compound selected from phenols, halogenated phenols, derivatives of phenols, derivatives of halogenated phenols, bis -phenols, cresols, resorcinols, halogenated hydroxyl diphenylethers, anilides or combinations thereof; and (b) at least one compound derived from essential oils; and (iii) optionally, one or more additives. Also, there is described a method of use and process for preparing the composition.

Abstract: The invention relates to a cosmetic and/or pharmaceutical composition comprising, in a physiologically suitable medium, a carob peptide extract (Ceratonia siliqua L.) as an active agent for promoting aquaporin expression. The present invention also relates to the use of a carob peptide extract (Ceratonia siliqua L.), as an active agent for promoting aquaporin expression, in a cosmetic composition for improving the moisturization and the barrier function of the epidermis and for stimulating skin regeneration. The invention also relates to the use of this novel active agent for preparing a pharmaceutical, in particular dermatological, composition for regulating and/or stimulating aquaporin activity. The invention also relates to a cosmetic treatment method for preventing or combating dryness of the skin and mucous membranes and the manifestations of skin aging.

Abstract: A peptidic hydrolyzate enriched in bioactive peptides is disclosed that is a proteasome activator. Cosmetic and pharmaceutical compositions are disclosed that include the peptidic hydrolyzate enriched in bioactive peptides in a physiologically acceptable medium. Also disclosed are methods for depigmenting, lightening and/or whitening the skin and treating hyperpigmentation blemishes as well as cutaneous signs due to photo-aging by administering the cosmetic compositions or pharmaceutical compositions.

Abstract: Provided are novel 4- and 5-substituted 1,2,3-triazoles, and regioisomer mixtures thereof, modified polymers, wherein the substituted 1,2,3-triazoles are modified by reaction with a modifying polymer (maleic anhydride based polymer). Depending upon the ratio of the substituted 1,2,3-triazole to the maleic anhydride based polymer employed, the resulting modified polymers can provide maleic anhydride based polymers that are partially or fully reacted with the substituted 1,2,3-triazoles. The resulting modified polymers may be partially or fully opened to provide amic acids, carboxylic acids, carboxylic acidic salts, imides, or esters. The novel 4- or 5-substituted 1,2,3-triazoles, and regioisomer mixtures thereof, modified polymers can be converted to a wide variety of useful polymers and may be employed in a wide variety of compositions. An example of a modified polymer may be represented by the structure: formule: (1) wherein m, n, and q are defined herein.

Abstract: A process for reducing the intensity of the intrinsic bitter taste of a water soluble active which comprises dry mixing of said active with ?-cyclodextrin.

Abstract: A cosmetic or pharmaceutical composition that includes a peptide hydrolyzate which is enriched in soothing bioactive peptide in a physiologically acceptable medium is described. Methods for applying such compositions to the skin are also described, in particular where the active principle activates 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) reductase in skin cells to treat skin irritations.

Abstract: Disclosed are novel ultraviolet-absorbing compounds produced by two embodiments. By a first embodiment, the ultraviolet-absorbing compound is derived from at a first reactant being a UV absorber comprising a carbon-nitrogen triple bond and a second reactant having amine functionality. By a second embodiment, the ultraviolet-absorbing compound is derived from a first reactant being a UV absorber comprising amine functionality and a second reactant comprising a carbon-nitrogen triple bond. In both embodiments of the invention, the second reactant may be a small molecule, a monomer, a macromolecule, a biomolecule, or a polymer. The invention's ultraviolet-absorbing compounds are directed toward formulations and applications that serve to protect against UV radiation in any art.

Abstract: A peptidic hydrolyzate enriched in bioactive peptide, capable of reinforcing the skin barrier function and stimulating epidermal differentiation is described. Additionally, a cosmetic and/or pharmaceutical composition that includes a physiologically acceptable medium and the peptidic hydrolyzate as active principle are described. The cosmetic composition activates the HMG-CoA reductase in the cutaneous cells and treats the cutaneous signs of aging and photo-aging.

Abstract: Peptide compounds of the following general formula (I): R1-(AA)n-X1-X2-X3-Lys-Lys-Gln-Lys-Trp-X4-(AA)p-R2 are disclosed herein. The peptide compounds can be used as Telomeric repeat-binding factor 2 (TRF2) protein-modulating compounds and have a preventive action on deoxyribonucleic acid (DNA) double-strand breaks. In addition, cosmetic compositions that include at least one peptide of general formula (I) in a physiologically acceptable medium are disclosed along with methods for preventing and/or treating cutaneous signs of aging and photoaging.

Abstract: This invention relates to new peptides activating extracellular matrix protein synthesis in the skin. This invention also relates to a cosmetic composition comprising such peptides as an active agent and the use of such a composition for increasing the extracellular matrix protein expression, delaying the appearance of or reducing wrinkles, sagging and loss of skin volume, and dehydration of the skin. The invention finally relates to cosmetic care methods intended to delay or treat cutaneous signs of aging and photoaging.

Abstract: Described is a class of symmetrical and asymmetrical N-alkyl lactam ethers. One preferred ether is bis-N-ethyl pyrrolidone ether. Preferred compositions and uses of the ethers are in performance chemicals, personal care, and pharmaceutical fields, where they function a variety of roles, including as a solvent, solubilizer, freezing point depressor, diluent, extracting agent, cleaning agent, degreaser, absorbent and/or dispersion agent.

Abstract: This invention provides a process of making a stable aqueous dispersion including concentrated, finely divided particles of a water insoluble biocide active, which comprises grinding the biocide in water in the presence of a non-ionic polymeric dispersant and optionally a co-dispersant, and compositions prepared by this process.

Abstract: This invention relates to peptide compounds of general formula (I) R1-(AA)n-X1—X2—X3-Asp-Leu-Lys-Lys-X4—X5-(AA)p-R2. Said peptide compounds have an action on the SCF/c-Kit signaling pathway and thus make it possible to protect skin pigment structures from external stresses. In addition, this invention relates to a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in a physiologically acceptable medium, and its use for attenuating age-related pigmentation defects and the effects of photoaging on the skin. The invention finally relates to various cosmetic treatment methods using said peptides according to the invention.

Abstract: Sun-care products are described that protect from UV radiation and do not turn white when applied to wet skin. The sun-care product may comprise (A) a cosmetically-acceptable, substantially non-aqueous vehicle, and (B) a UV active, wherein said non-aqueous vehicle comprises alcohol in an amount of 50% (w/w) or less based on the weight of the sun-care product and an ester wherein said non-aqueous vehicle comprises at least 10%>by weight esters based on the total weight of the non-aqueous vehicle and said sun-care product is substantially non-whitening upon application to wet skin.

Abstract: UV-absorbing compounds are disclosed that are derived from at least: (a) a UV absorber having at least one hydroxyl group, primary amine group, or secondary amine group, (b) a coupling agent having anhydride functionality, and (c) a graft host comprising an unsaturated fatty acid. These compounds absorb, scatter, deflect, or scatter ultraviolet radiation in a variety of personal care and performance chemical applications. R? and R?? are alkyl or alkenyl groups that naturally occur in oil.

Abstract: The present invention relates to a polymerizable polymer formed from an N-vinyl amide monomer and containing a polymerizable functionality. In one approach, a dual functional monomer may be employed. In the case where the dual functional monomer incorporates glycidyl methacrylate, a third polymerizable monomer is also included. In a second approach, a monomer with polymerizable functionality can be grafted onto a pre-existing, suitable N-vinyl amide co-polymeric material, yielding a co-polymer comprising a polymerizable functionality. where x+y+z+a=100.

Abstract: Carotenoid compositions of enhanced solubility and bioavailability are described that contain at least one carotenoid with at least one solubility-enhancing polymer. In one embodiment, the carotenoid is a provitamin A carotenoid such as ?-carotene. In another embodiment the carotenoid is a non-provitamin A carotenoid such as lycopene or lutein. Described methods to produce the bioenhanced products include dry blending and solvent spray drying. In accordance with certain embodiments of the invention, the method includes the steps of providing a mixture comprising the carotenoid, a solubility-enhancing polymer and a solvent and removing the solvent to produce an amorphous form of the carotenoid. Products made by the invention's compositions and methods include pharmaceuticals, nutraceuticals, cosmetic, and personal care products for man and animal.