Patents Assigned to J. Craig Venter Institute
  • Compounds and methods for treating, detecting, and identifying compounds to treat apicomplexan parasitic diseases
    Patent number: 11964944
    Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
    Type: Grant
    Filed: June 2, 2022
    Date of Patent: April 23, 2024
    Assignees: The University of Chicago, J. Craig Venter Institute, Inc., The University of Sheffield, Institute for Systems Biology, The University of Leeds, The University of Strathclyde, The Government of the United States
    Inventors: Rima McLeod, Martin McPhillie, Colin W. G. Fishwick, Hernan Alejandro Lorenzi, Kai Wang, Taek-Kyun Kim, Yong Zhou, Leroy E. Hood, Ying Zhou, Kamal El Bissati, Mark Hickman, QiGui Li, Craig Roberts
  • Resolvin mimetic antibodies and uses thereof
    Patent number: 11351140
    Abstract: Provided herein are compositions comprising a resolvin mimetic. Such mimetics may comprise an anti-ERV1 antibody, such as a resolvimab, or biologically-active antibody fragment thereof. Also provided herein are methods for treating or preventing an inflammatory disorder in a subject in need thereof comprising the steps of administering a therapeutically effective amount of at least one resolvin mimetic.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: June 7, 2022
    Assignee: J. Craig Venter Institute
    Inventor: Marcelo Freire
  • Engineered microalgae with enhanced lipid production
    Patent number: 10988773
    Abstract: Described herein are engineered microalgae that exhibit enhanced lipid production during exponential growth. Such engineered microalgae are useful, for example, for the production of biofuels.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: April 27, 2021
    Assignee: J. Craig Venter Institute
    Inventors: Andrew Allen, Christopher L. Dupont
  • COMPOSITIONS AND METHODS FOR RESOLUTION OF INFLAMMATION
    Publication number: 20200163922
    Abstract: Provided herein are compositions comprising a resolvin mimetic. Such mimetics may comprise an anti-ERV1 antibody, such as a resolvimab, or biologically-active antibody fragment thereof. Also provided herein are methods for treating or preventing an inflammatory disorder in a subject in need thereof comprising the steps of administering a therapeutically effective amount of at least one resolvin mimetic.
    Type: Application
    Filed: May 17, 2018
    Publication date: May 28, 2020
    Applicant: J. Craig Venter Institute
    Inventors: Marcelo FREIRE, Thomas E. van DYKE
  • Nucleic acids and proteins from streptococcus groups A and B
    Patent number: 10428121
    Abstract: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: October 1, 2019
    Assignees: Novartis AG, J. Craig Venter Institute, Inc.
    Inventors: John Telford, Vega Masignani, Maria Scarselli, Guido Grandi, Herve Tettelin, Claire Fraser
  • Modified bat influenza viruses and their uses
    Patent number: 10272149
    Abstract: Vaccine compositions useful for vaccination against a target influenza strain, and method and kits for using the same. The vaccines comprise a live attenuated influenza virus that is synthetically constructed based upon a backbone platform derived from a bat influenza strain, and heterologous surface proteins HA and NA derived from the target influenza strain. The live attenuated virus is non-reassortant with native, circulating influenza strains, and can be used to create vaccines for humans and other animals.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: April 30, 2019
    Assignees: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION, J. CRAIG VENTER INSTITUTE
    Inventors: David Wentworth, Bin Zhou, Wenjun Ma, Jingjiao Ma
  • PROTEINS AND NUCLEIC ACIDS FROM MENINGITIS/SEPSIS-ASSOCIATED ESCHERICHIA COLI
    Publication number: 20180298064
    Abstract: Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunising against MNEC infections.
    Type: Application
    Filed: June 26, 2018
    Publication date: October 18, 2018
    Applicants: GlaxoSmithKline Biologicals SA, J. Craig Venter Institute, Inc.
    Inventors: Vega MASIGNANI, Danilo Gomes MORIEL, Francesco BERLANDA SCORZA, Nathalie NORAIS, Maria Rita FONTANA, Mariagrazia PIZZA, Laura SERINO, Hervé TETTELIN
  • Engineered microalgae with enhanced lipid production
    Patent number: 9868959
    Abstract: Described herein are engineered microalgae that exhibit enhanced lipid production during exponential growth. Such engineered microalgae are useful, for example, for the production of biofuels.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: January 16, 2018
    Assignee: J. Craig Venter Institute
    Inventors: Andrew Allen, Christopher Lee Dupont
  • Nucleic acids and proteins from groups A and B
    Patent number: 9840538
    Abstract: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: December 12, 2017
    Assignees: Novartis AG, J. Craig Venter Institute, Inc.
    Inventors: John Telford, Vega Masignani, Maria Scarselli, Guido Grandi, Herve Tettelin, Claire Fraser
  • bacteriophage and uses thereof
    Patent number: 9795642
    Abstract: Bacteriophages are provided that infect strains of Enterococcus faecalis, an opportunistic bacterial pathogen that causes human disease. Also provided are methods of treating Enterococcus faecalis by therapeutic administration of such bacteriophages.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: October 24, 2017
    Assignees: TEMPLE UNIVERSITY—Of The Commonwealth System of Higher Education, J. Craig Venter Institute, Inc.
    Inventors: Roy H. Stevens, Hongming Zhang, Derrick E. Fouts, Jessica DePew
  • Nucleic acids and proteins from streptococcus groups A and B
    Patent number: 9738693
    Abstract: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: August 22, 2017
    Assignees: Novartis AG, J. Craig Venter Institute, Inc.
    Inventors: John Telford, Vega Masignani, Maria Scarselli, Guido Grandi, Herve Tettelin, Claire Fraser
  • Modular energy recovering water treatment devices
    Patent number: 9505636
    Abstract: A modular device that is optimized for preliminary water treatment and energy generation and methods for operating the same are described.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: November 29, 2016
    Assignee: J. Craig Venter Institute
    Inventor: Orianna Bretschger
  • PROTEINS AND NUCLEIC ACIDS FROM MENINGITIS/SEPSIS-ASSOCIATED ESCHERICHIA COLI
    Publication number: 20160244489
    Abstract: Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunising against MNEC infections.
    Type: Application
    Filed: May 9, 2016
    Publication date: August 25, 2016
    Applicants: GlaxoSmithKline Biologicals SA, J. Craig Venter Institute, Inc.
    Inventors: Vega MASIGNANI, Danilo Gomes MORIEL, Francesco BERLANDA SCORZA, Nathalie NORAIS, Maria Rita FONTANA, Mariagrazia PIZZA, Laura SERINO, Herve TETTELIN
  • HAEMOPHILUS INFLUENZAE TYPE B
    Publication number: 20160024157
    Abstract: Polypeptides comprising various amino acid sequences derived from Haemophilus influenzae type b, including a number of lipoproteins. These can be used in the development of vaccines for preventing and/or treating bacterial meningitis. They may also be useful for diagnostic purposes, and as targets for antibiotics. Antibodies against the polypeptides are also disclosed, as are the coding nucleic acids.
    Type: Application
    Filed: October 6, 2015
    Publication date: January 28, 2016
    Applicants: GLAXOSMITHKLINE BIOLOGICALS SA, J. CRAIG VENTER INSTITUTE, INC.
    Inventors: Vega MASIGNANI, Rino RAPPUOLI, Herve TETTELIN
  • PROTEINS AND NUCLEIC ACIDS FROM MENINGITIS/SEPSIS-ASSOCIATED ESCHERICHIA COLI
    Publication number: 20140356389
    Abstract: Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunising against MNEC infections.
    Type: Application
    Filed: June 2, 2014
    Publication date: December 4, 2014
    Applicants: J. CRAIG VENTER INSTITUTE, INC., NOVARTIS VACCINES AND DIAGNOSTICS SRL
    Inventors: Vega MASIGNANI, Danilo Gomes MORIEL, Francesco BERLANDA SCORZA, Nathalie NORAIS, Maria Rita FONTANA, Mariagrazia PIZZA, Laura SERINO, Herve TETTELIN
  • Metaproteomic Method to Identify Secreted Pattern Recognition Molecules and Adhesive Antimicrobial Factors for Detection of Microbial Agents Eliciting Inflammation in the Human Host
    Publication number: 20140243220
    Abstract: Described herein are methods for analyzing complex host-microbial mixtures. The disclosed methods may be used to diagnosis or prognose in a subject an inflammatory disease, which is caused by or contributed to by microbes.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 28, 2014
    Applicant: J. Craig Venter Institute
    Inventor: Rembert Pieper
  • Proteins and nucleic acids from meningitis/sepsis-associated
    Patent number: 8758764
    Abstract: Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunising against MNEC infections.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: June 24, 2014
    Assignees: Novartis Vaccines and Diagnostics Srl, J. Craig Venter Institute
    Inventors: Vega Masignani, Danilo Gomes Moriel, Francesco Berlanda Scorza, Nathalie Norais, Maria Rita Fontana, Mariagrazia Pizza, Laura Serino, Herve Tettelin
  • ENGINEERED MICROALGAE WITH ENHANCED LIPID PRODUCTION
    Publication number: 20140162330
    Abstract: Described herein are engineered microalgae that exhibit enhanced lipid production during exponential growth. Such engineered microalgae are useful, for example, for the production of biofuels.
    Type: Application
    Filed: December 13, 2011
    Publication date: June 12, 2014
    Applicant: J. CRAIG VENTER INSTITUTE
    Inventors: Andrew Allen, Christopher Lee Dupont
  • PLEATED CATHODE ELECTRODE: HIGH SURFACE AREA, LIGHT-WEIGHT, MODIFIED PACKED-BED ELECTRODE FOR OXYGEN REDUCTION
    Publication number: 20140141286
    Abstract: Featured herein are oxygen reduction electrodes configured in an electrochemical system, such as a microbial fuel cell, comprising a cathode configured as a pleated sheet and an anode comprised of a conductive material.
    Type: Application
    Filed: August 16, 2013
    Publication date: May 22, 2014
    Applicant: J. Craig Venter Institute
    Inventors: Orianna Bretschger, Greg Wanger
  • antigens and compositions
    Patent number: 8524251
    Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: September 3, 2013
    Assignees: J. Craig Venter Institute, Inc., Novartis AG
    Inventors: Claire Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter