Patents Assigned to J. Craig Venter Institute
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Patent number: 8491918Abstract: Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis.Type: GrantFiled: October 13, 2011Date of Patent: July 23, 2013Assignees: J. Craig Venter Institute, Inc., Novartis AGInventors: Rino Rappuoli, Claire Fraser, Mariagrazia Pizza, Maria Scarselli, Davide Serruto, Hervé Tettelin
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Publication number: 20130178377Abstract: Described herein are highly accurate metaproteomic based methods for diagnosing urogenital and kidney infections, which are easy to perform and that also provide information regarding the extent of the infection, the causative agent(s) and the nature of the host response.Type: ApplicationFiled: December 27, 2012Publication date: July 11, 2013Applicant: J. Craig Venter InstituteInventor: J. Craig Venter Institute
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Publication number: 20130129740Abstract: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.Type: ApplicationFiled: August 30, 2012Publication date: May 23, 2013Applicants: J. Craig Venter Institute, Novartis Vaccines and Diagnostics, Inc.Inventors: John Telford, Vega Masignani, Maria Scarselli, Guido Grandi, Hervé Tettelin, Claire Fraser
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Patent number: 8431139Abstract: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.Type: GrantFiled: May 16, 2006Date of Patent: April 30, 2013Assignees: Novartis Vaccines and Diagnostics, Inc., J. Craig Venter InstituteInventors: John Telford, Vega Masignani, Maria Scarselli, Guido Grandi, Herve Tettelin, Claire Fraser
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Publication number: 20120207778Abstract: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences.Type: ApplicationFiled: February 16, 2012Publication date: August 16, 2012Applicants: J. CRAIG VENTER INSTITUTE, INC., NOVARTIS VACCINES AND DIAGNOSTICS S.R.L.Inventors: John Telford, Vega Masignani, Immaculada Margarit Y Ros, Guido Grandi, Claire Fraser, Hervé Tettelin
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Publication number: 20120164166Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: ApplicationFiled: January 26, 2012Publication date: June 28, 2012Applicants: NOVARTIS AG, J. CRAIG VENTER INSTITUTE, INC.Inventors: Claire Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
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Publication number: 20120156236Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: ApplicationFiled: January 26, 2012Publication date: June 21, 2012Applicants: NOVARTIS AG, J. CRAIG VENTER INSTITUTE, INC.Inventors: Claire FRASER, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
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Publication number: 20120148616Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: ApplicationFiled: January 26, 2012Publication date: June 14, 2012Applicants: NOVARTIS AG, J. CRAIG VENTER INSTITUTE, INC.Inventors: Claire FRASER, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
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Publication number: 20120135024Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: ApplicationFiled: March 23, 2011Publication date: May 31, 2012Applicants: NOVARTIS AG, J. CRAIG VENTER INSTITUTE, INC.Inventors: Claire FRASER, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
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Publication number: 20120128707Abstract: The invention provides proteins and nucleic acid sequences from Streptococcus Pneumoniae, together with a genome sequence. These are useful for the development of vaccines, diagnostics, and antibiotics.Type: ApplicationFiled: October 5, 2010Publication date: May 24, 2012Applicants: J. CRAIG VENTER INSTITUTE, NOVARTIS VACCINES AND DIAGNOSTICS SRLInventors: VEGA MASIGNANI, HERV¿ TETTELIN, CLAIRE FRASER
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Publication number: 20120093868Abstract: Polypeptides comprising various amino acid sequences derived from Haemophilus influenzae type b, including a number of lipoproteins. These can be used in the development of vaccines for preventing and/or treating bacterial meningitis. They may also be useful for diagnostic purposes, and as targets for antibiotics. Antibodies against the polypeptides are also disclosed, as are the coding nucleic acids.Type: ApplicationFiled: December 21, 2011Publication date: April 19, 2012Applicants: J. CRAIG VENTER INSTITUTE, INC., NOVARTIS VACCINES AND DIAGNOSTICS SRLInventors: Vega MASIGNANI, Rino Rappuoli, Herve Tettelin
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Publication number: 20120070457Abstract: Polypeptides comprising Neisseria meningitidis amino acid sequences. Over 36000 meningococcal polypeptide sequences are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be usedin medicine for treating or preventing disease and/or infection caused by N. meningitidis, such as meningococcal meningitis.Type: ApplicationFiled: September 8, 2011Publication date: March 22, 2012Applicants: J. CRAIG VENTER INSTITUTE, INC., NOVARTIS AGInventors: Sean C. Daugherty, Julie C. Dunning Hotopp, David R. Riley, Samuel V. Angiuoli, Heather Huot Creasy, Todd H. Creasy, Herve Tettelin, Duccio Medini, Emilio Siena, Sonia Budroni, Maria Scarselli
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Patent number: 8137673Abstract: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.Type: GrantFiled: May 16, 2006Date of Patent: March 20, 2012Assignees: Novartis Vaccines and Diagnostics, Inc., J. Craig Venter InstituteInventors: John Telford, Vega Masignani, Maria Scarselli, Guido Grandi, Herve Tettelin, Claire Fraser
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Publication number: 20120027801Abstract: Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis.Type: ApplicationFiled: October 13, 2011Publication date: February 2, 2012Applicants: J. CRAIG VENTER INSTITUTE, INC., NOVARTIS AGInventors: Rino Rappuoli, Claire Fraser, Mariagrazia Pizza, Maria Scarselli, Davide Serruto, Hervé Tettelin
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Patent number: 8039007Abstract: Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis.Type: GrantFiled: June 29, 2007Date of Patent: October 18, 2011Assignees: J. Craig Venter Institute, Inc., Novartis AGInventors: Rino Rappuoli, Claire Fraser, Mariagrazia Pizza, Maria Scarselli, Davide Serruto, Hervé Tettelin
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Patent number: 8025890Abstract: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.Type: GrantFiled: May 16, 2006Date of Patent: September 27, 2011Assignees: Novartis Vaccines and Diagnostics, Inc., J. Craig Venter InstituteInventors: John Telford, Vega Masignani, Maria Scarselli, Guido Grandi, Herve Tettelin, Claire Fraser
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Patent number: 7988979Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: GrantFiled: January 11, 2008Date of Patent: August 2, 2011Assignees: J. Craig Venter Institute, Inc., Novartis AGInventors: Claire M. Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Maria Rosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulo Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, Craig Venter
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Publication number: 20100311602Abstract: The present invention relates, e.g., to a method for isolating a DNA molecule of interest in a form suitable for sequencing at least a portion of the DNA by a high throughput sequencing method, comprising (a) digesting a double-stranded (ds) DNA molecule with two different restriction enzymes, A and B, to generate a ds form of the DNA molecule of interest, which is bounded by the two restriction enzyme cleavage products, and (b) attaching to each end of the DNA molecule of interest an adaptor molecule which comprises at one end a restriction enzyme cleavage site that is compatible with the restriction enzyme A or the restriction enzyme B cleavage product, and which also comprises a sequence and/or element that allows the DNA of interest to be sequenced with a high throughput sequencing apparatus.Type: ApplicationFiled: October 15, 2007Publication date: December 9, 2010Applicant: J. Craig Venter Institute, Inc.Inventors: Samuel Levy, Susanne Goldberg, Karen Beeson
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Publication number: 20100047768Abstract: The present invention relates, e.g., to a method for amplifying the genome of a single virus particle from a mixture of virus particles, comprising (a) subjecting the mixture of virus particles to flow cytometry and identifying a sorted sample that putatively contains a single virus particle, (b) imbedding the sorted sample comprising the putative single viral particle in a solid matrix (e.g., low melting agarose); (c) visualizing the embedded virus particle (e.g., by EFM and/or confocal microscopy) to confirm that a single particle is embedded; and (d) exposing the nucleic acid from the visualized, embedded single, discrete viral particle (e.g., by alkali treatment) and amplifying the genomic viral nucleic acid in situ (e.g., by MDA).Type: ApplicationFiled: August 18, 2009Publication date: February 25, 2010Applicant: J. Craig Venter Institute, Inc.Inventors: Shannon Williamson, Lisa Zeigler, Thomas Ishoey
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Patent number: 7612192Abstract: The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.Type: GrantFiled: August 11, 2004Date of Patent: November 3, 2009Assignees: Novartis Vaccines & Diagnostics, Inc., J. Craig Venter InstituteInventors: Claire Marie Fraser, Erin Kathleen Hickey, Jeremy D. Peterson, Herve Tettelin, Craig Ventor, Vega Masignani, Cesira Galeotti, Marirosa Mora, Giulio Ratti, Maria Scarselli, Vincenzo Scarlato, Rino Rappuoli, Mariagrazia Pizza, Guido Grandi