Abstract: According to the application, by measuring mass spectra of urine samples and/or serum samples in a healthy group, a negative control group, a positive control group and a treatment group of a drug to be evaluated, the mass spectra of the samples of the treatment group of the drug to be evaluated and the mass spectra of the samples of the negative control group are compared to calculate a difference between peak areas of characteristic fragment particle peaks of metabolic markers in the samples of the treatment group of the drug to be evaluated and in the samples of the negative control group, and a difference value is used to evaluate multidrug resistance of the drug to be evaluated. The larger the difference value is, the larger a callback value is, and the better an effect of reversing the tumor multidrug resistance is.

Abstract: Disclosed is an ultralow loss hollow-core antiresonant fiber, which includes an outer layer structure, a hollow-core area and a plurality of closed cavities. The radial section of the inner surface of the outer layer structure is a circle with a first radius. In the circumferential direction of the inner surface of the outer layer structure, the plurality of the closed cavities are spaced from one another and are distributed uniformly and circumferentially. Each closed cavity includes: an outermost wall serving as a first thin wall, and the radial section of the outermost wall is a fan shape or a circle with a second radius. Each closed cavity further includes: second thin walls located in the inner space surrounded by the inner surface of the outermost wall, and the end surfaces of the second thin walls are annular thin-walled structures with thin-walled spacers arranged in the centers.

Abstract: The present disclosure provides an online monitoring and source apportionment method for atmospheric particles containing heavy metals, and belongs to the technical field of online quantification and source tracing of atmospheric particles containing heavy metals. The single particle aerosol mass spectrometer and X-ray fluorescence spectrometer are combined to quickly determine the concentration, time series, chemical compositions and mixing state of atmospheric particles containing heavy metals from both qualitative and quantitative perspectives. A heavy metal-containing particle mass concentration limit system is incorporated into the X-ray fluorescence spectrometer. Once the mass concentration of a particle containing heavy metals exceeds the standard, the aerosol mass spectrometer can immediately receive this alert through the information transmission system.

Abstract: The present invention discloses a respirator for measuring a respiratory rate of a biofilm. The respirator includes a body, a carbon dioxide absorption tube and a perforated partition disposed in an interior of the body. The perforated partition divides the interior of the body into an oxygen mass-transfer stir zone provided with a stirring device and a biofilm reaction zone for placing MBBR fillers. The carbon dioxide absorption tube is provided with an air vent and contains a solution capable of absorbing CO2. The perforated partition has a first hole corresponding to a middle portion and a lower portion of the perforated partition and acting as a liquid-exchange channel, and a second hole corresponding to an upper portion of the perforated partition and acting as a gas-exchange channel, and the oxygen mass-transfer stir zone is communicated with the biofilm reaction zone through the liquid-exchange channel and the gas-exchange channel.

Abstract: An electrical readout optical sensor, includes a back metal electrode layer, a semiconductor layer, and a metal or metalloid layer; wherein the semiconductor layer is a main body portion and is divided into a first surface and a second surface; the first surface is provided with a groove structure, and forms a grating; the back metal electrode layer covers the second surface of the semiconductor layer; the metal or metalloid layer covers the first surface of the semiconductor layer, and forms a phototube for generating a photocurrent signal having a wide wavelength range and high linearity. An optical sensing structure of narrowband light absorption and a photoelectric conversion structure having a wide wavelength range are directly integrated, and the portable high-precision optical sensing ability is implemented by means of an output mode of a photocurrent.

Abstract: A composite nanoparticle, a preparation method thereof and preparation method of a composite nano preparation using thereof, wherein the composite nanoparticle is a polymer-lipid nanoparticle encapsulating psoralen, isopsoralen and paclitaxel simultaneously, and the preparation method thereof comprises the following steps of: S1. dissolving soybean lecithin and DSPE-PEG2000 in an aqueous phase, subjected to blending and preheating; and S2. dissolving psoralen, isopsoralen, paclitaxel and PLGA in an oleic phase, subjected to blending and injecting into the aqueous phase of S1 to obtain a mixture, and then heating and blending the mixture to obtain the composite nanoparticle.

Abstract: An optical fiber sensing apparatus, system, and method capable of in operando and/or in situ monitoring a state of charge (SOC) of an energy storage device such as a capacitor or a battery is provided. The apparatus comprises an optical fiber having a surface plasmon resonance (SPR)-stimulating structure, exemplarily including a tilted grating in a core, and a SPR-active layer coating a cladding, of the optical fiber. The apparatus is configured such that when arranged in a close proximity with an electrode of the energy storage device, SPR waves are stimulated upon receiving an actuating light. Through analysis of signals of the SPR waves, the SOC of the energy storage device can be determined. The apparatus can also be utilized to capture non-SPR optical waves, analysis of which can further derive information such as temperature, pressure, strain, etc. of the energy storage device and/or be used for calibration.

Abstract: A composition, and a crocins active site extracted from Gardenia jasminoides Ellis, mainly comprising the following ingredients: crocetin di-?-D-gentiobioside, crocetin-?-D-glucopyranosyl-?-D-gentiobioside, crocetin di-?-D-glucopyranoside, 13Z-crocetin di-?-D-gentiobioside, neocrocin B, crocetin mono-?-D-gentiobioside, 13Z-crocetin-8-O-?-D-gentiobioside, 13Z-crocetin-8?-O-?-D-gentiobioside, and crocetin mono-?-D-glucopyranoside. Pharmacological experiment results show that the crocins active site can effectively improve learning and memory injuries in mice induced by scopolamine and amyloid ? protein.

Abstract: A sensing apparatus for detecting at least one target molecule in a gaseous medium is provided, comprising an optical fiber having a core with a tilted grating, and a coating assembly. The coating assembly has a composite film layer having an outer surface in direct contact with the gaseous medium, and contains at least two compositions mixed with one another therein, which include one or more surface plasmon resonance (SPR)-active compositions and one or more reacting compositions that are reversibly reactive to the at least one target molecule. Depending on different reacting compositions, the sensing apparatus can detect various target gas molecules such as hydrogen, ammonia, methane, and formaldehyde, etc. The sensing apparatus has relatively fast response time and high resistance to deactivation. A sensing system based on the sensing apparatus, a manufacturing method of the sensing apparatus, and a detection method using the sensing system, are further provided.

Abstract: Disclosed are a method for preparing a linseed polysaccharide having antiviral activity and immunological activity, food and healthare products and methods of treatment using the linseed polysaccharide. The method comprises the steps of: using the linseeds as raw materials, pulverizing the linseeds, separating the husks from the kernels of the linseeds, extracting by the microwave-assisted hot water extraction, deproteinizing by the Sevage method, carrying out ethanol precipitation, and freeze-drying to obtain the linseed crude polysaccharides, then carrying out ion-exchange column chromatography, Sephadex gel column chromatography, and ultra-filtration so as to obtain the linseed triple-helix polysaccharides.

Abstract: A sensing apparatus for detecting at least one target molecule in a gaseous medium is provided, comprising an optical fiber having a core with a tilted grating, and a coating assembly. The coating assembly has a composite film layer having an outer surface in direct contact with the gaseous medium, and contains at least two compositions mixed with one another therein, which include one or more surface plasmon resonance (SPR)-active compositions and one or more reacting compositions that are reversibly reactive to the at least one target molecule. Depending on different reacting compositions, the sensing apparatus can detect various target gas molecules such as hydrogen, ammonia, methane, and formaldehyde, etc. The sensing apparatus has relatively fast response time and high resistance to deactivation. A sensing system based on the sensing apparatus, a manufacturing method of the sensing apparatus, and a detection method using the sensing system, are further provided.

Abstract: A sensing apparatus, system, and use method for selective detection of a target molecule in a gaseous medium with a limit of detection of less than 50 ppm are provided. The sensing apparatus comprises an optical fiber having a core with a tilted grating, and a coating assembly that is both active to surface plasmon resonance (SPR) and reversibly reactive to the target molecule to allow for repeated detection. Upon a compatible light propagating in the optical fiber, surface plasmon waves at an interface between the coating assembly and the medium can be generated to thereby derive information of the target molecule. Signals from core mode optical waves can additionally be used as inherent reference to remove influences of fluctuations from environmental factors and input power level. There is at least one range of concentrations for the target molecule allowing for linear measurement. Multiplexing of a plurality of sensing apparatuses is also disclosed.

Abstract: Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells; and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals.

Abstract: The invention discloses a non-fluorescent imaging optical sectioning method and device based on annular off-axis illumination focal plane conjugation.

Abstract: The present invention relates to dicaffeoyl spermidine cyclized derivatives and a preparation method and use thereof. Biological activity experiments show that the dicaffeoyl spermidine cyclized derivatives of the present invention have anti-Senile dementia activity and antioxidant activity, and their activity are even better than that of a positive control drug, thus suitable for the prevention and treatment of neurodegenerative diseases such as Senile dementia.

Abstract: The present invention provides a new kind of vinca alkaloid derivatives, new applications thereof and preparation methods therefor. The vinca alkaloid derivatives comprise hydrazinolyzed vinca alkaloids and vinca alkaloid dipeptide derivative. The hydrazinolyzed vinca alkaloids are the compounds obtained from the reaction of vinca alkaloids or salts thereof with hydrazinolyzed hydrate; and the vinca alkaloid dipeptide derivatives are the compounds obtained from the condensation of hydrazinolyzed vinca alkaloids with N-benzyloxycarbonylglycyl proline. The present invention provides the uses of the vinca alkaloids derivatives or the pharmaceutical compositions thereof in anti-tumor, preventing or treating diabetic retinopathy, rheumatoid arthritis and serving as angiogenesis inhibitors or vascular disrupting agents.

Abstract: Provided are a series of crocins compounds and related pharmacological applications thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasminoides Ellis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (H2O2) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by H2O2 and L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.

Abstract: The present invention relates to dicaffeoyl spermidine cyclized derivatives and a preparation method and use thereof. Biological activity experiments show that the dicaffeoyl spermidine cyclized derivatives of the present invention have anti-Senile dementia activity and antioxidant activity, and their activity are even better than that of a positive control drug, thus suitable for the prevention and treatment of neurodegenerative diseases such as Senile dementia.

Abstract: Disclosed is a method for synthesizing diglyceride using a bubble column reactor. The method comprises the steps of: an immobilized enzyme is placed on the bearing mechanism of the bubble column reactor; a hot bath mechanism is actuated to heat the reactor body to 55-75° C.; glycerol, fatty acid and water are added into a feed chute, preheated to 55-75° C.

Abstract: Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells; and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals.