Abstract: A male member (1) includes a tubular member (10) and a cover (20) covering at least a tip (11) of the tubular member. A lateral hole (14) that communicates with a flow path (13) is formed in an outer peripheral surface of the tubular member. The cover includes an outer peripheral wall (21) that can be deformed elastically by compression and a head part (23) that is provided at one end of the outer peripheral wall. The head part includes an interior cavity (24) into which the tubular member is inserted, and a slit (25) is formed in an innermost part (24a) of the interior cavity. In a state where the outer peripheral wall is not deformed by compression, an inner peripheral surface of the interior cavity contacts closely with the outer peripheral surface of the tubular member so as to block the lateral hole, and the tip of the tubular member and the innermost part of the interior cavity are spaced apart from each other.

Abstract: An antiadhesive material that is excellent in biocompatibility and bioabsorbability, as well as excellent strength in suturing and bonding, is provided. A reinforcing material 12 made of a biodegradable polymer is placed in a gelatin solution so that the reinforcing material 12 is impregnated with the solution, and the gelatin is caused to gelate and dried. By so doing, an antiadhesive material in which a gelatin film 11 and the reinforcing material 12 are integrated is obtained. The reinforcing material 12 preferably is arranged in a portion of the gelatin film 11 to be subjected to suturing, and preferably is arranged along a periphery of the gelatin film 11. The gelatin film 11 preferably is a cross-linked gelatin film, and the reinforcing material 12 preferably is a nonwoven fabric.

Abstract: A catheter lock solution which is a catheter lock preparation having a bacteriostatic property at physiological osmotic pressure without practically containing a bacteriostatic component such as a preservative, an antimicrobial agent, or an antibiotic and having high safety, characterized in that the preparation contains a weak acid having an acid dissociation constant (pKa) of 3.0 to 6.5 as a buffer, a pH of the solution is less than 6.0, preferably from 3.0 to about 5.5, an osmotic pressure ratio is from 0.5 to 3.0, and a pH change (variation) can be suppressed to less than the 6.0 with the weak acid, and a container containing the catheter lock solution.

Abstract: A hub (40) can be displaced between an initial position at which the hub is located on a front end side of an inner cavity of a shield (20) and an inner needle (50) penetrates an outer needle (30) and a retracted position at which the hub is located on a rear end side of the inner cavity of the shield and the inner needle is housed within the inner cavity of the shield. A stopper (170) includes an insertion portion (172) that is inserted into the inner cavity of the shield and a base portion (180) that is located on a rear end of the insertion portion. The base portion includes a roof portion (183) that exposes part of an outer circumferential face of a tube (60) connected to the hub and covers the remainder thereof, and a pair of grasping portions (185) that are arranged to sandwich the tube and can be elastically displaced so as to grip the tube.

Abstract: It is intended to provide a serum which contains a large amount of growth factors capable of efficiently promoting the growth of stem cells. A human serum for cell culture which shows a residual ratio of platelets remaining within 20 minutes after blood collection in relation to the whole amount of the platelets is 0% to 20%, and a release ratio of cell growth factors is 20% to 100%.

Abstract: A medical heat exchanger includes a thin tube bundle 2 in which a plurality of heat transfer thin tubes 1 for letting heat medium liquid flow therethrough are arranged and stacked, seal members 3a to 3c sealing the thin tube bundle while allowing both ends of the heat transfer thin tubes to be exposed and forming a blood channel 5 which allows blood to flow therethrough so that the blood comes into contact with each outer surface of the heat transfer thin tubes; a housing 4 containing the seal members and the thin tube bundle and provided with an inlet port 8 and an outlet port 9 of the blood positioned respectively at both ends of the blood channel; and a pair of heat transfer thin tube headers 6, 7 forming flow chambers 14a, 14b, 15a, 15b that respectively surround both ends of the thin tube bundle and having an inlet port 6a and an outlet port 7a of the heat medium liquid.

Abstract: A heat exchange module 12 is formed by stacking pipe groups obtained by fixing a plurality of pipes 1 with use of pipe array holding members 9a to 9d. Flow path forming members 50 are arranged on pipe groups in the uppermost and lowermost layers, and walls 51 and 52 are provided so as to protrude from the outer-side pipe array holding members and the inner-side pipe array holding members. Flow path members 63 are provided between the walls 51 and 52 adjacent to each other so as to allow through holes 53 and 54 to communicate with each other. The heat exchange module 12 is housed in the housing 2, and while rotating the housing 2, a resin material 24 is filled into a space enclosed by the two inner-side pipe array holding members of each pipe group in the housing 2, interstices around the pipes present between an opening 15a of the housing and the outer-side pipe array holding members, and interstices around the pipes present between an opening 15b of the housing and the outer-side pipe array holding members.

Abstract: A method for preparing serum and a serum preparation apparatus is provided that can give a large amount of serum with high culture efficiency regardless of freshness of blood used. In a method for preparing serum from blood containing at least platelets, a platelet processing step is provided in which platelet membrane in the blood is destroyed. After the platelet processing step, a deposition step for depositing thermolabile protein in blood and a removal step for removing the thermolabile protein, which has been deposited in the deposition step, are preferably provided.

Abstract: A connector (1) that can be connected to a first container and a second container (20) to transfer a liquid between the first container and the second container (20) includes a first connecting portion (3) that is engageable with the first container and a second connecting portion (4) that is engageable with the second container (20). The second connecting portion (4) is integrally provided with an engagement portion that is engageable with the second container (20) and a needle-like portion (7) for piercing into the second container (20). Thus, it is possible to prevent a container from falling off during liquid transfer. Also, since the needle-like portion (7) is integral with the second connecting portion (4), connection to the second container (20) is facilitated.

Abstract: The present invention provides a separation container capable of preventing contamination with unnecessary components and efficiently separating a separation subject.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: A device for measuring oral cavity pressure includes the following: a pressure measuring probe 1 having a configuration in which a balloon 4 made of an elastic material is supported by a balloon base 5; a communicating member having an inner bore that communicates with the inside of the balloon via the balloon base to transmit the air pressure in the balloon; and a pressure detecting unit 8 that is connected to the rear end of the communicating member and detects the transmitted air pressure. The balloon includes a pressure receiving portion 4a that forms a cavity and a balloon tubular portion 4b that communicates with the inside of the pressure receiving portion, and the balloon is joined to the front end portion of the balloon base with the balloon tubular portion. The balloon base has a rib 5c that protrudes outward along the outer circumferential direction of the front end portion on the balloon side.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: The present invention provides a method for controlling the proliferation and differentiation of cord blood-derived hematopoietic stem cells with excellent safety when proliferating them by culturing. The hematopoietic stem cells are inoculated into a medium containing a sonicated liquid component of cord blood. The proliferation and differentiation of the cord blood hematopoietic stem cells can be inhibited in the presence of the sonicated liquid component of cord blood. On the contrary, the proliferation of cord blood hematopoietic stem cells can be accelerated by inoculating the hematopoietic stem cells into a medium containing a non-sonicated liquid component of cord blood. Thus, according to the present invention, by using serum derived from cord blood, it is possible to regulate the inhibition of the proliferation and differentiation of cord blood hematopoietic stem cells and the acceleration of the proliferation of the same as desired.

Abstract: The present invention provides a method for controlling the proliferation and differentiation of cord blood-derived hematopoietic stem cells with excellent safety when proliferating them by culturing. The hematopoietic stem cells are inoculated into a medium containing a sonicated liquid component of cord blood. The proliferation and differentiation of the cord blood hematopoietic stem cells can be inhibited in the presence of the sonicated liquid component of cord blood. On the contrary, the proliferation of cord blood hematopoietic stem cells can be accelerated by inoculating the hematopoietic stem cells into a medium containing a non-sonicated liquid component of cord blood. Thus, according to the present invention, by using serum derived from cord blood, it is possible to regulate the inhibition of the proliferation and differentiation of cord blood hematopoietic stem cells and the acceleration of the proliferation of the same as desired.

Abstract: The present invention is a peritoneal function testing method characterized by using a ratio MTACun/MTACc calculated using MTACun and MTACc as an index for a peritoneal function test, where MTACun is an overall mass transfer-area coefficient for urea nitrogen and MTACc is an overall mass transfer-area coefficient for creatinine. The use of MTACun/c of the present invention in this way enables examination of the future peritoneal function of a patient (a mechanism of deterioration in peritoneal function). To be specific, MTACun and MTACc can be obtained by computing Pyle-Popovich model. In addition, the peritoneal function testing method may further calculate a permeability coefficient for cell pores (LPSC) and an overall permeability coefficient (LPS) from Three-Pore Theory model while obtaining a ratio LPSC/LPS calculated using the LPSC and the LPS, and may use the LPSC/LPS ratio and the MTACun/MTACc ratio as indexes for the peritoneal function test.

Abstract: A peritoneal function testing method uses a ratio of MTACun/MTACc, calculated using MTACun and MTACc, as an index for a peritoneal function test, wherein MTACun is an overall mass transfer-area coefficient for urea nitrogen and MTACun is an overall mass transfer-area coefficient for creatinine. The use of MTACun/MTACc enables examination of the future peritoneal function of a patient (a mechanism of deterioration in peritoneal function). To be specific, MTACun and MTACc can be obtained by computing a Pyle-Popovich model. In addition, the peritoneal function testing method further calculates a permeability coefficient for cell pores (LpSC) and an overall permeability coefficient (LPS) from a Three-Pore Theory model while obtaining a ratio of LPSC/LPS calculated using the LPSC and the LPS. The LPSC/LPS ratio and the MTACun/MTACc ratio can be used as indexes for the peritoneal function test.