Abstract: The present invention provides a method for controlling the proliferation and differentiation of cord blood-derived hematopoietic stem cells with excellent safety when proliferating them by culturing. The hematopoietic stem cells are inoculated into a medium containing a sonicated liquid component of cord blood. The proliferation and differentiation of the cord blood hematopoietic stem cells can be inhibited in the presence of the sonicated liquid component of cord blood. On the contrary, the proliferation of cord blood hematopoietic stem cells can be accelerated by inoculating the hematopoietic stem cells into a medium containing a non-sonicated liquid component of cord blood. Thus, according to the present invention, by using serum derived from cord blood, it is possible to regulate the inhibition of the proliferation and differentiation of cord blood hematopoietic stem cells and the acceleration of the proliferation of the same as desired.

Abstract: The present invention provides a communication member for a medical container capable of allowing communication between the inside and the outside of a container body containing a liquid in a state of being fixed to the container body. The communication member includes: a valve 2 having an insertion hole 2a; a tubular body 3 supporting the valve 2; and a closing film 4 for closing a bore of the tubular body 3 in the bore and in the vicinity of the valve 2. The tubular body 3 and the closing film 4 are molded integrally. A groove 4a that passes through the center of the closing film 4 is formed on either a surface of the closing film 4 on the valve 2 side or a surface opposite to the valve side.

Abstract: An intestinal anastomotic surgery aid 1 is constituted with a cylindrical portion 40 for covering the proximal end side of an engaging rod 28, and a cover portion 41 that extends from the cylindrical portion 40 towards the distal end side of the engaging rod 28. The proximal end part of the cylindrical portion 40 is inserted to a recessed portion 26 of a device main body 21 to be held to the device main body 21. The anus-side piece of the intestine is tied with a suture to be held to the outer face of the cylindrical portion 40.

Abstract: In a breathable structure, a luer lock cap has a low melting point, and a through-hole to be covered with a breathable film. The breathable film is a two-layered film, in which a second film having a low melting point adheres to a porous first film having water repellency. An auxiliary film body is a two-layered film with an outer shape larger than that of the breathable film, in which a fourth film having a higher melting point adheres to a third film having a low melting point. The breathable film is connected to the auxiliary film body with the second film being heat-laminated to the third film. The auxiliary film body is connected to the luer cap lock with an outer edge portion of the third film being heat-laminated to the luer cap lock.

Abstract: A heat exchange module 12 is formed by stacking pipe groups obtained by fixing a plurality of pipes 1 with use of pipe array holding members 9a to 9d. Flow path forming members 50 are arranged on pipe groups in the uppermost and lowermost layers, and walls 51 and 52 are provided so as to protrude from the outer-side pipe array holding members and the inner-side pipe array holding members. Flow path members 63 are provided between the walls 51 and 52 adjacent to each other so as to allow through holes 53 and 54 to communicate with each other. The heat exchange module 12 is housed in the housing 2, and while rotating the housing 2, a resin material 24 is filled into a space enclosed by the two inner-side pipe array holding members of each pipe group in the housing 2, interstices around the pipes present between an opening 15a of the housing and the outer-side pipe array holding members, and interstices around the pipes present between an opening 15b of the housing and the outer-side pipe array holding members.

Abstract: A spout (4) that is attached to a pouch-like bag and through which the contents filled in the bag are discharged, the spout includes: a tubular portion (49) in which a through hole (12) is formed and from a leading end of which the contents are discharged; and a rib (20) that extends from the inner circumferential surface of the tubular portion (9) towards the central axis side (13) of the through hole (12). A hole (21) surrounded by the edge of the extended rib (20) is formed in the part where the rib (20) is formed. This configuration makes it easy to secure the strength of the rib (20) and is advantageous in preventing breakage and deformation of the rib (20). Thus, accidental insertion of connecting needles can be prevented with more certainty.

Abstract: It is intended to provide a method of producing thermally fused synthetic resin members for medical use which makes it possible that, in the case of thermally fusing synthetic resin members for medical use, for example, a relatively soft thermoplastic tube constituting an AVF needle with another part being harder than the tube such as a needle base (hub) of a wing needle, or a part provided with a fitting connector being harder than the tube (for example, a blood circuit, an extension tube, an infusion set or the like), the connecting parts of the thermoplastic tube member and the other member harder than the thermoplastic tube member can be quickly and uniformly thermal-fused and the production process can be automatically and continuously performed while keeping a high productivity; and a production apparatus therefor.

Abstract: A connector (1) that can be connected to a first container and a second container (20) to transfer a liquid between the first container and the second container (20) includes a first connecting portion (3) that is engageable with the first container and a second connecting portion (4) that is engageable with the second container (20). The second connecting portion (4) is integrally provided with an engagement portion that is engageable with the second container (20) and a needle-like portion (7) for piercing into the second container (20). Thus, it is possible to prevent a container from falling off during liquid transfer. Also, since the needle-like portion (7) is integral with the second connecting portion (4), connection to the second container (20) is facilitated.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: A weight sensor includes an arm having an end fixed to a pillar and a free end; a filtrate holder, a replacement fluid holder, and a dialysate holder provided at three locations of the arm along a longitudinal direction of the arm to hold respective substances; a first strain value sensor, a second strain value sensor, and a third strain value sensor each of which detects a strain value of the arm corresponding to a total weight of the substances held by the holders ranging from a holder proximate to the free end to a corresponding holder; and a weight calculation unit that calculates the total and each of the weights from the obtained detection results.

Abstract: A medical port includes a disc-shaped valve 1 in which an insertion hole is formed in a central portion 1a, a base seat 7 that supports the valve from a lower surface side, and a cover 2 that has a fitting hole exposing an upper surface of the central portion of the valve and covers at least a peripheral edge of the valve from the upper surface side, the fitting hole being formed so that when an inserting body has been inserted into the insertion hole, a fit between the inserting body and the fitting hole can cause the inserting body to be locked against the cover. An annular protrusion 1d is formed in the valve 1, the annular protrusion being continuous in the circumferential direction, and formed in the valve 1 so that in the state in which the inserting body is locked against the cover, the annular protrusion is in contact with an outer circumferential surface of a leading end portion of the inserting body.

Abstract: A spout (4) that can be attached to a liquid container and through which contents with which the liquid container is filled are discharged, the spout including: a tubular portion (9) in which a through hole (12) is formed and from a leading end of which the content is discharged; and ribs (20) that partition the through hole (12). When the tubular portion (9) is seen from the leading end side, the through hole (12) is divided into at least three parts by the ribs (20). Thus, the strength of the ribs (20) is easily secured, which is advantageous in preventing breakage or deformation of the ribs (20), and also erroneous piercing with a connecting needle is reliably prevented.

Abstract: A conduit tube (90) that communicates with an intracardiac blood inflow port (50) and a liquid medicine injection port (72) and allows blood from the intracardiac blood inflow port and a liquid medicine from the liquid medicine injection port to flow into a cardiotomy section (2) is inserted from above downward in the cardiotomy section 2. A blood flow channel (93) for the flow of blood and a liquid medicine flow channel (95) for the flow of a liquid medicine are formed independently of each other in the conduit tube. With respect to the vertical direction, the lower end of a blood conduit tube portion (94) that forms the blood flow channel is located at a lower position than the lower end of a liquid medicine conduit tube portion (96) that forms the liquid medicine flow channel. This prevents the generation of negative pressure in the liquid medicine flow channel due to the flow of blood. It also reduces the resistance to the inflow of a liquid medicine into the cardiotomy section.

Abstract: A cardiotomy section (2) includes a filter (10) and a defoamer (20) arranged inside the filter. A lower end (11a) of the filter is sealed or folded in an approximately straight line or in a curve, and the defoamer is annularly arranged along the inner peripheral surface of the filter, as viewed from above. A conduit tube (90) that introduces intracardiac blood is inserted from above downward in the cardiotomy section. A lower end of the conduit tube is located at the same level as or at a lower level than the lower end of the defoamer, with respect to the vertical direction. In a projection view of a lower end face of the defoamer with respect to a horizontal plane, (Ru2?2×Tu)/(Ru1?2×Tu)?0.24 is satisfied, where Ru1 is the outer dimension of the annularly arranged defoamer in a major axial direction, Ru2 is the outer dimension thereof in a minor axial direction, and Tu is the thickness of the defoamer. This achieves a blood reservoir equipped with a cardiotomy section having high defoaming performance.

Abstract: According to the present invention, there is provided a hemodiafiltration apparatus capable of easily and efficiently removing medium to large molecule solutes at a low cost. Provided is a hemodialysis apparatus which uses a hemodialyzer accommodating a hollow yarn membrane in hemodiafiltration to cause a dialysis fluid to flow from a dialysis fluid circuit side to a blood circuit side by forceful back-filtration via the hemodialyzer, and to cause a fluid in the blood circuit to reflux to a dialysis fluid circuit side by filtration via the hemodialyzer, the hemodialysis apparatus being characterized in that a flux operation of the fluid from the dialysis fluid side to the blood circuit side by the back-filtration, and a reflux operation of the fluid from the blood circuit side to the dialysis fluid circuit side by the filtration are repeated intermittently and for at least a plurality of times.

Abstract: The present invention provides a method for purifying a polymer, by which a reduction in molecular weight of the polymer can be suppressed, and a residual catalyst in the polymer can be reduced effectively. The polymer containing the residual catalyst is brought into contact with an organic solvent containing an organic acid that has a pKa in the range of 2 to 3.9. Thus, the catalyst remaining in the polymer can be reduced, and the polymer can be purified. The organic acid can be, for example, lactic acid.

Abstract: A fluid control device is characterized in that the device is structured of a hollow first fluid path (21) and second fluid path (22), a housing portion (1) formed between the first fluid path and the second fluid path and having a hollow portion with a cross-sectional area larger than cross-sectional areas of both fluid paths, and a valve member (3) that has a main body (31) and a projection portion (32) that are installed in an opening portion where the first fluid path is connected to the hollow portion and that is formed of an elastic material. The fluid control device enables the circulation of liquid when the pressure of liquid flowing from the first fluid path toward the second fluid path is more than a predetermined level. The fluid control device enables accurate and safe measurement of pressure including blood pressure, and, when flushing operation of an infusion circuit etc.