Patents Assigned to John Hopkins University School of Medicine
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Publication number: 20090137427Abstract: Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. The enhanced rate of mutation can be further augmented using mutagens. Moreover, the hypermutability of mismatch repair deficient cells can be remedied to stabilize cells or mammals with useful mutations.Type: ApplicationFiled: October 19, 2007Publication date: May 28, 2009Applicant: The John Hopkins University School of MedicineInventors: Nicholas C. Nicolaides, Philip M. Sass, Luigi Grasso, Bert Vogelstein, Kenneth W. Kinzler
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Patent number: 7534432Abstract: Growth differentiation factor-8 (GDF-8) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-8 polypeptide and polynucleotide sequences.Type: GrantFiled: January 29, 2007Date of Patent: May 19, 2009Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Publication number: 20090124684Abstract: This invention provides methods and compositions for inducing weight loss and maintaining optimum weight comprising administering an agent that stimulates carnitine palmitoyl transferase-1 (CPT-1) activity to the patient in need, including human patients. These methods do not require inhibition of fatty acid synthesis. In particular, this invention provides methods for development of therapeutics that selectively enhance fatty acid oxidation, increase energy production, and reduce adiposity while preserving lean mass, through the pharmacological stimulation of CPT-1 activity. In a preferred mode, the agent is administered in an amount sufficient to increase fatty acid oxidation. In another preferred mode, the agent is administered in an amount sufficient to antagonize malonyl CoA inhibition of CPT-1. In yet another preferred mode, the agent is administered in an amount sufficient to increase malonyl CoA level.Type: ApplicationFiled: November 6, 2008Publication date: May 14, 2009Applicant: The Johns Hopkins University School of Medicine Licensing and Technology DevelopmentInventors: Jagan N. Thupari, Leslie E. Landree, Gabrielle Ronnett, Francis P. Kuhajda
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Patent number: 7524633Abstract: The present invention provides methods and kits useful for detecting neplasia by measuring the methylation level of biomarkers, especially the promoter region of GSTP1 for the detection of prostate adenocarcinoma.Type: GrantFiled: July 6, 2007Date of Patent: April 28, 2009Assignee: The Johns Hopkins University School of MedicineInventor: David Sidransky
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Patent number: 7521536Abstract: Glutamate Transporter Associated Proteins and nucleotide encoding Glutamate Transporter Associated Proteins are provided. Also provided is a method for identifying a compound that modulates a cellular response mediated by a Glutamate Transporter Associated Protein. A method is further provided for identifying a compound that inhibits an interaction between a Glutamate Transporter Associated Protein and a glutamate transporter protein. A method is provided for treating a disorder associated with glutamate transport.Type: GrantFiled: August 1, 2007Date of Patent: April 21, 2009Assignee: The Johns Hopkins University School of MedicineInventors: Jeffrey D. Rothstein, Mandy Jackson, Glen Lin, Robert Law, Irina Orlov
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Patent number: 7495075Abstract: Growth differentiation factor-16 (GDF-16) is disclosed along with its polynucleotide sequence and amino acid sequence Also disclosed are diagnostic and therapeutic methods of using the GDF-16 polypeptide and polynucleotide sequences.Type: GrantFiled: August 28, 2006Date of Patent: February 24, 2009Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Thanh Huynh, Suzanne Sebald
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Patent number: 7476661Abstract: The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.Type: GrantFiled: January 23, 2006Date of Patent: January 13, 2009Assignee: John Hopkins University School of MedicineInventors: Philip A. Beachy, James K. Chen, Anssi Jussi Nikolai Taipale
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Patent number: 7462457Abstract: The present invention related to methods and reagents for generating and using activating mutations of receptors and ion channels.Type: GrantFiled: August 30, 2001Date of Patent: December 9, 2008Assignee: Johns Hopkins University School of MedicineInventors: Philip A. Beachy, Jussi Taipale
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Patent number: 7459481Abstract: This invention provides methods and compositions for inducing weight loss and maintaining optimum weight comprising administering an agent that stimulates carnitine palmitoyl transferase-1 (CPT-1) activity to the patient in need, including human patients. These methods do not require inhibition of fatty acid synthesis. In particular, this invention provides methods for development of therapeutics that selectively enhance fatty acid oxidation, increase energy production, and reduce adiposity while preserving lean mass, through the pharmacological stimulation of CPT-1 activity. In a preferred mode, the agent is administered in an amount sufficient to increase fatty acid oxidation. In another preferred mode, the agent is administered in an amount sufficient to antagonize malonyl CoA inhibition of CPT-1. In yet another preferred mode, the agent is administered in an amount sufficient to increase malonyl CoA level.Type: GrantFiled: October 2, 2006Date of Patent: December 2, 2008Assignee: The Johns Hopkins University School of Medicine Licensing And Technology DevelopmentInventors: Jagan N. Thurpari, Leslie E. Landree, Gabrielle Ronnett, Francis P. Kuhajda
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Patent number: 7427476Abstract: A novel T-type calcium channel (CACNA1G) is provided, as are polynucleotides encoding the same. CACNA1G has been implicated in cellular proliferative disorders. More specifically, it has been observed that the methylation state of specific regions within CpG islands associated with the CACNA1G gene correlates with a number of cancerous phenotypes involving a variety of tissue and cell types. Also provided are methods for detecting cellular proliferative disorders by determining the methylation state of genes or regulatory regions associated therewith, including CACNA1G, as well as kits containing reagents for performing invention methods.Type: GrantFiled: August 30, 2004Date of Patent: September 23, 2008Assignee: The Johns Hopkins University School of MedicineInventor: Jean-Pierre Issa
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Patent number: 7412276Abstract: A method of performing brain therapy may include placing a subject in a main magnetic field, introducing into the subject's brain a combination imaging and therapeutic probe, the probe including a magnetic resonance imaging antenna and an electrical energy application element, acquiring a first magnetic resonance image from the antenna of the combination probe, acquiring a second magnetic resonance image from a surface coil, combining the first and second magnetic resonance images to produce a composite image, positioning the combination probe within the brain with guidance from at least one of the images, and delivering electrical energy to the brain from the electrical energy application element of the combination probe thus positioned.Type: GrantFiled: March 2, 2004Date of Patent: August 12, 2008Assignee: Johns Hopkins University School of MedicineInventors: Henry R. Halperin, Ronald D. Berger, Ergin Atalar, Elliot R. McVeigh, Albert C. Lardo, Hugh Calkins, Joao Lima
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Patent number: 7399848Abstract: Disclosed are polynucleotides encoding growth differentiation factor-8 (GDF-8) useful for increasing the muscle mass in chickens.Type: GrantFiled: November 23, 2004Date of Patent: July 15, 2008Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 7393682Abstract: The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can specifically hybridize to such polynucleotides. The present invention also provides an isolated polynucleotide encoding a mature myostatin peptide.Type: GrantFiled: November 7, 2000Date of Patent: July 1, 2008Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 7390483Abstract: The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell line, and a method of using such a composition.Type: GrantFiled: February 23, 2006Date of Patent: June 24, 2008Assignee: Johns Hopkins University School of MedicineInventors: Hyam I. Levitsky, Ivan Borrello
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Patent number: 7384753Abstract: Growth differentiation factor-11 (GDF-11) is disclosed along with its polynucleotide sequence and amino acid sequence. The invention provides a method for identifying a compound that affects GDF-11 activity or gene expression.Type: GrantFiled: June 10, 2003Date of Patent: June 10, 2008Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 7385086Abstract: This invention provides compounds and methods for treating, with said compound, a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SOn-Z-CO—Y, where R is an alkyl groups having 6-20 carbon atoms, unsaturated hydrocarbon groups having 6-20 carbon atoms, or alkyl groups having 6-20 carbon atoms interrupted by at least one aromatic ring; Z is —CH2—, —CH2CH2—, —NH—NH—, —O—, ——NH—, —O—NH—, —CH2—NH—, —CH2—O—, —NH—O—, —NH—CH2—, —O—CH2—, and —CH?CH—; Y is —NH2, —O—CH2—C6H5, —CO—CO—O—CH3, and —O—CH3; and n is 1 or 2. It has been discovered that these compounds treat microbially-based infections caused by corynebacteria, nocardiae, rhodococcus, and mycobacteria. These compounds may be used to treat mycobacterial cells, such as Mycobacteria tuberculosis, drug resistant M. tuberculosis, M. avium intracellulare, M. leprae, M. paratuberculosis, and pathogenic Mycobacteria sp.Type: GrantFiled: January 27, 2004Date of Patent: June 10, 2008Assignee: The Johns Hopkins University School of MedicineInventors: Craig A. Townsend, James D. Dick, Gary R. Pasternack, Francis P. Kuhajda, Nicole M. Parrish
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Publication number: 20080132464Abstract: The invention is directed to a method of prophylactically or therapeutically treating choroidal neovascularization, wherein the method comprises directly administering to the eye a therapeutic factor or a nucleic acid sequence that encodes a therapeutic factor, which he expressed to produce the therapeutic factor, to selectively induce apoptosis of endothelial cells associated with neovascularization of the choroid such that choroidal neovascularization is treated prophylactically or therapeutically. The invention also provides a method of prophylactically or therapeutically treating ocular neovascularization, wherein the method comprises directly administering to the eye a nucleic acid sequence encoding a therapeutic factor to promote apoptosis of endothelial cells associated with neovascularization, such that the nucleic acid is expressed thereby producing the therapeutic factor to treat ocular neovascularization prophylactically or therapeutically.Type: ApplicationFiled: November 12, 2007Publication date: June 5, 2008Applicant: JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINEInventors: Peter A. Campochiaro, Peter Gehlbach
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Patent number: 7381528Abstract: Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a predisposition for increased muscle mass as compared to subjects having wild-type myostatin. Increased muscle mass is particularly desirable for identification of animals used to produce food products, including bovine, porcine, ovine, avian and piscine species.Type: GrantFiled: September 11, 2003Date of Patent: June 3, 2008Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 7378498Abstract: A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.Type: GrantFiled: December 10, 2004Date of Patent: May 27, 2008Assignee: The Johns Hopkins University School of MedicineInventors: Paul F. Worley, Jian Cheng Tu, Bo Xiao, Daniel Leahy, Jutta Beneken, Anthony A. Lanahan, Paul R. Brakeman
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Patent number: 7371067Abstract: The invention provides a system for virtually designing a medical device conformed for use with a specific patient. Using the system, a three-dimensional geometric model of a patient-specific body cavity or lumen is reconstructed from scanned volume images such as obtained x-rays, magnetic resonance imaging (MRI), computer tomography (CT), ultrasound (US), angiography or other imaging modalities. Knowledge of the physical properties of the cavity/lumen is obtained by determining the relationship between image density and the stiffness or elasticity of tissues in the body cavity or lumen and is used to model interactions between a simulated device and a simulated body cavity or lumen.Type: GrantFiled: March 5, 2002Date of Patent: May 13, 2008Assignees: The Johns Hopkins University School of Medicine, Agency for Science, Technology & Research (A*Star)Inventors: James H. Anderson, William R. Brody, Chee-Kong Chui, Yiyu Cai, Yaoping Wang, Wieslaw L. Nowinski