Patents Assigned to John Hopkins University School of Medicine
  • Growth differentiation factor-9
    Publication number: 20040152143
    Abstract: Growth differentiation factor-9 (GDF-9) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-9 polypeptide and polynucleotide sequences.
    Type: Application
    Filed: November 7, 2003
    Publication date: August 5, 2004
    Applicant: The John Hopkins University School of Medicine
    Inventor: Se-Jin Lee
  • Immediate early genes and methods of use therefor
    Publication number: 20040152658
    Abstract: The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.
    Type: Application
    Filed: March 2, 2004
    Publication date: August 5, 2004
    Applicants: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE, BASF-LYNX BIOSCIENCE AG, LYNX THERAPEUTICS, INC.
    Inventors: Paul F. Worley, Anthony Lanahan, Bernhard Goetz, Holger Hiemisch, Rohini Kuner, Sigrid Scheek, Karoly Nikolich, Eugene Zhukovsky
  • Growth differentiation factor, lefty-2
    Publication number: 20040146891
    Abstract: Growth differentiation factor, Lefty-2, is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the Lefty-2 polypeptide and polynucleotide sequences.
    Type: Application
    Filed: October 10, 2003
    Publication date: July 29, 2004
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Se-Jin Lee, Thanh Huynh, Suzanne Sebald
  • Beta secretase transgenic organisms and methods of use thereof
    Publication number: 20040132680
    Abstract: The invention provides transgenic non-human animals, such as transgenic rodents and transgenic non-human mammalian cells harboring a transgene which eliminates the expression of a &bgr;-secretase BACE1. Also provided are methods of diagnosing neurodegenerative diseases including Alzheimer's Disease as well as methods of identifying agents which modulate or treat Alzheimer's Disease and related pathology.
    Type: Application
    Filed: September 4, 2003
    Publication date: July 8, 2004
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Philip C. Wong, Huaibin Cai, Donald L. Price
  • Growth differentiation factor-7
    Publication number: 20040127696
    Abstract: The present invention provides antibodies that bind to the growth differentiation factor-7.
    Type: Application
    Filed: January 14, 2004
    Publication date: July 1, 2004
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Se-Jin Lee, Thanh Huynh
  • Aberrantly methylated genes as markers of breast malignancy
    Patent number: 6756200
    Abstract: The invention is directed to a method of diagnosing a cell proliferative disorder of breast tissue by determining the methylation status of nucleic acids obtained from a subject. Aberrant methylation of several genes including TWIST, HOXA5, NES-1, retinoic acid receptor beta (RAR&bgr;), estrogen receptor (ER), cyclin D2, WT-1, 14.3.3 sigma, and combinations of such genes serve as markers of breast malignancy.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: June 29, 2004
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Saraswati Sukumar, Ella Evron, William C. Dooley, Nicoletta Sacchi, Nancy Davidson
  • Fibroblast growth factor homologous factors (FHFs) and methods of use
    Publication number: 20040102379
    Abstract: The invention provides fibroblast growth factor homologous factor (FHF) polypeptides and nucleic acid molecules that encode them. Also included in the invention are diagnostic and therapeutic methods using FHF polypeptides and nucleic acids.
    Type: Application
    Filed: October 20, 2003
    Publication date: May 27, 2004
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Jeremy Nathans, Philip M. Smallwood
  • Method for identifying an agent that affects a hedgehog signaling pathway
    Patent number: 6733971
    Abstract: The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: May 11, 2004
    Assignees: Baylor College of Medicine, The Johns Hopkins University School of Medicine
    Inventors: Philip A. Beachy, Ming-Jer Tsai, Sophia Tsai, Venkatesh Krishnan, Chien-Huan Chen
  • Growth differentiation factor-11
    Publication number: 20040088747
    Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is provided. Also provided are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue and bone tissue.
    Type: Application
    Filed: June 10, 2003
    Publication date: May 6, 2004
    Applicant: THE JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • Modulation of hedgehog-mediated signaling pathway
    Publication number: 20040082036
    Abstract: The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
    Type: Application
    Filed: October 1, 2003
    Publication date: April 29, 2004
    Applicants: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE, BAYLOR COLLEGE OF MEDICINE
    Inventors: Philip A. Beachy, Ming-Jer Tsai, Sophia Tsai, Venkatesh Krishnan, Chien-Huan Chen
  • Methods to identify growth differentiation factor (GDF) receptors
    Publication number: 20040077053
    Abstract: The present invention provides receptors for the growth differentiation factor (GDF) family of growth factors and methods of identifying such receptors. Also included are methods of identifying antibodies which bind to the receptors, peptide fragments of the receptor which inhibit GDF binding, GDF receptor-binding agents capable of blocking GDF binding to the receptor. The receptors of the invention allow the identification of antagonists or agonists useful for agricultural and human therapeutic purposes.
    Type: Application
    Filed: June 6, 2003
    Publication date: April 22, 2004
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Se-Jin Lee, Alexandra McPherron
  • Nucleic acid molecule encoding homer 1B protein
    Patent number: 6720175
    Abstract: A method is provided for identifying a compound that modulates a cellular response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: April 13, 2004
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Paul F. Worley, Jian Cheng Tu, Bo Xiao, Daniel Leahy, Jutta Beneken, Anthony A. Lanahan, Paul R. Brakeman
  • Growth differentiation factor-6
    Publication number: 20040067556
    Abstract: Growth differentiation factor-6 (GDF-6) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-6 polypeptide and polynucleotide sequences.
    Type: Application
    Filed: October 23, 2003
    Publication date: April 8, 2004
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Se-Jin Lee, Thanh Huynh
  • Growth differentiation factor-6
    Patent number: 6713302
    Abstract: Growth differentiation factor-6 (GDF-6) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-6 polypeptide and polynucleotide sequences.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: March 30, 2004
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Thanh Huynh
  • Antimicrobial compounds
    Patent number: 6713654
    Abstract: This invention provides methods for treating a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SOn—Z—CO—Y, where R is an alkyl group having 6-20 carbons; Z is a radical selected from —CH2—, —O—, and —NH—, two of these radicals coupled together, or —CH2═CH2—; Y is —NH2, O—CH2—C6H5, —CO—CO—O—CH3, or O—CH3; and n is 1 or 2. It has been discovered that these compounds inhibit growth of microbial cells which synthesize &agr;-substitued, &bgr;-hydroxy fatty acids, particularly corynemycolic acid, nocardic acid, and mycolic acid. These compounds may be used to inhibit growth of mycobacterial cells, such as Mycobacterium tuberculosis, drug-resistant M. tuberculosis, M. avium intracellulare, and M. leprae.
    Type: Grant
    Filed: August 28, 2000
    Date of Patent: March 30, 2004
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Craig A. Townsend, James D. Dick, Gary R. Pasternack, Francis P. Kuhajda, Nicole M. Parrish
  • Methods of diagnosing and treating hepatic cell proliferative disorders
    Patent number: 6709818
    Abstract: Provided are methods and compositions useful for the diagnosis, prognosis and treatment of hepatic cellular proliferative disorders. The methods include the modulation or analysis of hypemethylated glutathione-S-transferase nuleic acid sequence in hepatic samples and biological fluids.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: March 23, 2004
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: William G. Nelson, Xiaohui Lin, Julia C. Tchou, Jila Bakker
  • Growth differentiation factor-8
    Publication number: 20040055027
    Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the animal is provided. Also provided are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-8. The animals so treated are characterized by increased muscle tissue and bone content.
    Type: Application
    Filed: June 17, 2003
    Publication date: March 18, 2004
    Applicant: The Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • Methods for detection of mutations in myostatin variants
    Publication number: 20040048307
    Abstract: Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a predisposition for increased muscle mass as compared to subjects having wild-type myostatin. Increased muscle mass is particularly desirable for identification of animals used to produce food products, including bovine, porcine, ovine, avian and piscine species.
    Type: Application
    Filed: September 11, 2003
    Publication date: March 11, 2004
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • Growth differentiation factor-12
    Publication number: 20040043025
    Abstract: Growth differentiation factor-12 (GDF-12) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-12 polypeptide and polynucleotide sequences.
    Type: Application
    Filed: September 17, 2003
    Publication date: March 4, 2004
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Se-Jin Lee, Aurora F. Esquela
  • Immediate early genes and methods of use therefor
    Patent number: 6699660
    Abstract: The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.
    Type: Grant
    Filed: February 5, 1999
    Date of Patent: March 2, 2004
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Paul F. Worley, Anthony Lanahan, Bernhard Goetz, Holger Hiemisch, Rohini Kuner, Sigrid Scheek, Karoly Nikolich, Eugene Zhukovsky