Abstract: An example method for facilitating the generation of a control field for a quantum system is provided. The example method may include receiving quantum system experiment input parameters and generating a set of coefficients defining a plurality of controls. The plurality of controls may be provided as a weighted sum of basis functions that include discrete prolate spheroidal sequences. The example method may further include applying a gradient based optimization, synthesizing the plurality of controls, and configuring a waveform generator with the plurality of controls to enable the waveform generator to generate the control field.

Abstract: Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The viruses labeled with alkyne-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

Abstract: A term-based encrypted retrieval privacy (TERP) data retrieval system performs data retrieval from a data repository server. The system includes a client processor included with a data requesting client and a server processor included with the data repository server. The client processor determines a vector forest that is shared with the data repository server, which includes forest vectors assigned with a respective vector ID, and generates a query including an encrypted ciphertext table that cross-references the vector IDs with a corresponding ciphertext entry. The server processor receives the query, and selects a given document from the data repository server that has assigned thereto at least one nearest neighbor vector among the forest vectors. The server processor compares a nearest neighbor vector ID of the nearest neighbor vector to the vector IDs included in the encrypted ciphertext table, and generates an encoded search result based on the encrypted ciphertext entries.

Abstract: Compositions for the treatment of colorectal cancer target bacterial biofilms in the gastrointestinal tract. Methods of treatment include one or more agents which target bacteria and the bacterial biofilms.

Abstract: The present disclosure relates generally to the field of medical devices and establishing access to body passageways. In particular, the present disclosure relates to devices, systems and methods to facilitate entry of a guidewire or other endoscopic accessory tool into and/or through patient-specific anatomies. For example, the devices, systems and methods of the present disclosure may rotate a proximal end of a guidewire to transmit mechanical motion to the distal end of the guidewire to facilitate atraumatic access to tortuous or otherwise restricted anatomies.

Abstract: Provided herein are tissue-specific differential methylated regions (T-DMRs) and cancer-related differential methylated regions (C-DMRs) and methods of use thereof. In one embodiment of the invention, there are provided methods of detecting a cell proliferative disorder by detecting altered methylation in one or more DMRs identified herein. In another embodiment of the invention, there are provided methods of determining clinical outcome by detecting altered methylation in one or more DMRs identified herein.

Abstract: The present invention is directed to multiple aperture devices (MADs) for beam shaping in x-ray imaging. Two or more of these binary filters can be placed in an x-ray beam in series to permit a large number of x-ray fluence profiles. However, the relationship between particular MAD designs and the achievable fluence patterns is complex. The present invention includes mathematical and physical models that are used within an optimization framework to find optimal MAD designs. Specifically, given a set of target fluence patterns, the present invention finds, for example, a dual MAD design that is a “best fit” in generating the desired fluence patterns. This process provides a solution for both the design of MAD filters as well as the control actuation that is required (relative motion between MADs) that needs to be specified as part of the operation of a MAD-based fluence field modulation system.

Abstract: Described are methods for treating or preventing a neurological disease in a subject. The methods include administering a suppressor of hemichannel permeability to a subject having or prone of getting a neurological disease. The methods include the treatment and prevention of amyotrophic lateral sclerosis (ALS).

Abstract: Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce.

Abstract: The present invention is directed to spatial-spectral filtering for multi-material CT decomposition. The invention includes a specialized filter that spectrally shapes an x-ray beam into a number of beamlets with different spectra. The filter allows decomposition of an object/anatomy into different material categories (including different biological types: muscle, fat, etc. or exogenous contrast agents that have been introduced: e.g iodine, gadolinium, etc.). The x-ray beam is spectrally modulated across the face of the detector using a repeating pattern of filter materials. Such spatial-spectral filters allow for collection of many different spectral channels using “source-side” control. However, in contrast to other spectral techniques that provide mathematically complete projection data, spatial-spectral filtered data is sparse in each spectral channel—making traditional projection-domain or image-domain material decomposition difficult to apply.

Abstract: The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating current (AC) for clinically significant durations at selected therapeutic frequencies through the cardiac tissue to a subject experiencing arrhythmia. Methods are also provided to minimize or eliminate pain during defibrillation.

Abstract: A computer-implemented method, a computer system, and a non-transitory computer readable medium are provided that perform a method for determining an auscultation quality metric (AQM). The computer-implemented method includes obtaining an acoustic signal representative of pulmonary sounds from a patient; determining a plurality of derived signals from the acoustic signal; performing a regression analysis on the plurality of derived signals; and determining the AQM from the regression analysis.

Abstract: The invention of the instant application discloses spirocyclic guanidine compounds of general formula (I), shown below, and their use in methods of treating cancer

Abstract: Methods and systems for connection-driven generation of robotic user interfaces and modification of robotic properties include detecting a connection of a robotic peripheral to a robot; obtaining a peripheral property set corresponding to the robotic peripheral, wherein the peripheral property set includes one or more properties of the robotic peripheral; modifying, based on the peripheral property set, a robotic property set that includes one or more properties of the robot to provide a modified robotic property set; generating, during runtime, a robotic graphical user interface (“RGUI”) dynamically based on the peripheral property set, wherein the RGUI provides at least one user-accessible interface to control the robot and the robotic peripheral; and controlling, based on the modified robotic property set, the robot and the robotic peripheral in response to user input received via the RGUI.

Abstract: Prodrugs of mebendazole and methods for their use in treating a disease, disorder, or disorder, including cancer, are disclosed.

Abstract: An electrode includes at least one of sulfur (S) or selenium (Se), and a functionalized metal organic framework (R-MOF), the functionalized metal organic framework (R-MOF) having a functional group (R) attached to an organic portion of a metal organic framework (MOF). The functionalized metal organic framework (R-MOF) is adapted to react with at least one of electrochemically accessible sulfur (S) or selenium (Se) to capture at least one of lithium polysulfide or sodium polysulfide via covalent attachment of sulfur (S) or selenium (Se), respectively, to the functional group (R) of the functionalized metal organic framework (R-MOF).

Abstract: A closed-loop implantable neurostimulator system for mitigating chronic pain, the closed-loop implantable neurostimulator system including a neuromodulation device comprising one or more electrodes configured to measure a physiological signal of a subject and deliver an electrical stimulation signal to a target area in the subject and a controller, in communication with the one or more electrodes, comprising a processor and a computer-readable memory storing a trained healthy computer model, the controller configured to analyze the physiological signal that is measured using the trained healthy computer model to identify a corrective electrical stimulation signal that, when delivered by the one or more electrodes to the target area, reduces pathological neuronal events in the target area while preserving acute pain response.

Abstract: Provided herein are methods of detecting a ophthalmologic genetic disease in a subject that include matching properties of captured images and/or videos with properties of an ocular pathology model that is trained on a plurality of reference images and/or videos of ocular cells of reference subjects, which properties of the ocular pathology model are indicative of the pathology. Related systems and computer program products are also provided.

Abstract: An attachment for a drill includes an inner housing configured to be coupled to the drill. The attachment also includes an outer housing positioned at least partially around the inner housing. The attachment also includes a vertical guide coupled to or integral with the inner housing. The attachment also includes a horizontal guide coupled to or integral with the outer housing. The attachment also includes a guide adapter configured to move along the vertical guide and the horizontal guide. The inner housing and the vertical guide are configured to move vertically with respect to the outer housing and the guide adapter, and the inner housing and the guide adapter are configured to move laterally with respect to the horizontal guide and the outer housing.

Abstract: Compounds with the following structures and their analogs are provided. Compositions that include these structures can be used to inhibit glucose transporters and stop or decrease the proliferation of cancer, treat possible organ rejection and treat autoimmune disease.