Patents Assigned to Johns Hopkins
  • TUNABLE METASURFACE DEVICE
    Publication number: 20240204405
    Abstract: A metasurface device in the form of a unit cell may include a first metasurface sub-cell configured to exhibit a first resonant electromagnetic field (EMF) response and a second metasurface sub-cell configured to exhibit a second resonant EMF response. Each the two metasurface sub-cells may include a patterned layer and a variable impedance element operably coupled to the patterned layer. The variable impedance element may be configured to, in response to receipt of a control signal, change an impedance of the respective metasurface sub-cell based on the control signal to change the EMF response of the sub-cell. The first metasurface sub-cell and the second metasurface sub-cell may be disposed in a cascaded configuration such that first EMF response and the second EMF response couple to exhibit an integrated EMF response for the metasurface unit cell.
    Type: Application
    Filed: December 14, 2023
    Publication date: June 20, 2024
    Applicant: The Johns Hopkins University
    Inventors: Timothy A. Sleasman, David B. Shrekenhamer, Ra'id S. Awadallah, Robert S. Duggan
  • Processes for making niobium-based electrode materials
    Patent number: 12015150
    Abstract: Processes for preparing a niobate material are provided, in which the processes include the following steps: (i) providing a niobium-containing source; (ii) providing a transitional metal source (TMS), a post-transitional metal source (PTMS), or both; (iii) dissolving (a) the niobium-containing source, and (b) the TMS, the PTMS, or both in an aqueous medium to form an intermediate solution; (iv) forming an intermediate paste by admixing an inert support material with the intermediate solution; (v) optionally coating the intermediate paste on a support substrate; and (vi) removing the inert support material by subjecting the intermediate paste to a calcination process and providing a transition-metal-niobate (TMN) and/or a post-transition-metal-niobate (PTMN). Anodes including a TMN and/or PTMN are also provided.
    Type: Grant
    Filed: April 28, 2023
    Date of Patent: June 18, 2024
    Assignee: The Johns Hopkins University
    Inventors: Konstantinos Gerasopoulos, Dajie Zhang, Matthew W. Logan
  • Harmonic drive actuator gearhead
    Patent number: 12007009
    Abstract: A novel way of mounting a harmonic drive gearhead to a cylindrically shaped motor reduces the overall size of the actuator assembly. Specifically, the motor is mounted within the harmonic drive and its bearings, a space that is typically occupied by a harmonic drive component. This is made possible by redesigning the harmonic drive such that it is able to surround the motor and provide for a compact footprint for the actuator assembly.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: June 11, 2024
    Assignee: The Johns Hopkins University
    Inventors: Dan Stoianovici, Doru Petrisor
  • Safe sequencing system
    Patent number: 12006544
    Abstract: The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe-Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ?95% of them contain the identical mutation.
    Type: Grant
    Filed: November 27, 2023
    Date of Patent: June 11, 2024
    Assignee: The Johns Hopkins University
    Inventors: Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Isaac A. Kinde
  • CVS transplantation for treatment of bacterial vaginosis
    Patent number: 12005089
    Abstract: Methods and materials for treating bacterial vaginosis (“BV”) are provided. Cervicovaginal secretions (“CVS”) from a woman with vaginal microbiota dominated (>50%) by one of the species of lactobacillus typically found in the human vagina, e.g. Lactobacillus crispatus, L. iners, L. gasseri, L jensenii, is transplanted to women with BV as a method for restoring beneficial vaginal microbial communities and/or increasing resistance to sexually transmitted disease. Efficacy can be enhanced, or the properties of the endogenous CVS improved, through administration of an acidifying agent such as lactic acid. The examples demonstrate the role of healthy CVS in disease resistance, and the effect of pH on CVS properties. The examples also describe the collection and transplantation of healthy beneficial CVS into women at risk for, or after treatment for, BV.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: June 11, 2024
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Laura Ensign, Richard Cone, Justin Hanes
  • Device and methods for color corrected OCT imaging endoscope/catheter/capsule to achieve high-resolution
    Patent number: 12004718
    Abstract: The present invention is directed to an achromatic capsule endoscope with diffractive optics. A micromotor (or a broadband rotary joint) and a custom 800 nm SD-OCT system make ultrahigh-resolution 3D volumetric imaging over a large area possible. The diffractive microlens is used directly with other miniature lens including but not limited to a GRIN lens, making the capsule endoscope design simpler and cost effective. Preliminary ex vivo 3D intraluminal imaging was performed with the distal-scanning capsule endoscope in conjunction with a home-built broadband spectral-domain OCT system, demonstrating the performance of the diffractive capsule.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: June 11, 2024
    Assignee: The John Hopkins University
    Inventor: Xingde Li
  • Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration
    Patent number: 12007395
    Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and (c) correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: June 11, 2024
    Assignee: The Johns Hopkins University
    Inventors: Jennifer E. Van Eyk, Allen Dale Everett, Zhicheng Jin
  • SURFACE ENHANCED RAMAN SPECTROSCOPY METHOD OF PATHOGEN DETECTION AND SUBSTRATE FOR THE SAME
    Publication number: 20240183784
    Abstract: A surface-enhanced Raman spectroscopy (SERS) substrate, including a substrate base; and a plurality of metal insulator metal (MIM) nanostructures disposed on the substrate base, wherein an average distance between the plurality of MIM nanostructures disposed on the substrate base is from about 1 nm to about 10 nm, and a method of detecting at least one pathogen using the SERS substrate.
    Type: Application
    Filed: April 11, 2022
    Publication date: June 6, 2024
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Kam Sang KWOK, Debadrita PARIA, Ishan BARMAN, David H. GRACIAS
  • METHOD AND SYSTEM FOR A CONFIDENCE-BASED SUPERVISED-AUTONOMOUS CONTROL STRATEGY FOR ROBOTIC-ASSISTED SURGERY
    Publication number: 20240180646
    Abstract: A computer system, a computer-readable medium, and a computer-implemented method for robot-assisted suturing is disclosed. The computer-implemented method includes determining, by a suture planner algorithm executed by a hardware processor, a desired location for a suture for a potential suture location on a treatment area on a patient and determining which sutures from the suture planner algorithm can be done autonomously and which sutures may require human intervention to be performed.
    Type: Application
    Filed: March 28, 2022
    Publication date: June 6, 2024
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Hamed SAEIDI, Axel KRIEGER, Michael KAM, Simon LEONARD, Justin OPFERMANN
  • Tubing-free, sample-to-droplet microfluidic system and chip
    Patent number: 11998912
    Abstract: A tubing-free, sample-to-droplet microfluidic system includes a tubing-free, sample-to-droplet microfluidic chip; a valve control system connected to the tubing-free, sample-to-droplet microfluidic chip; a vacuum system fluidly connected to the tubing-free, sample-to-droplet microfluidic chip; and a droplet formation pressure system fluidly connected to the tubing-free, sample-to-droplet microfluidic chip. A microfluidic chip for a tubing-free, sample-to-droplet microfluidic system includes a tubing-free, sample-to-droplet interface section; a droplet mixing section in fluid connection with the tubing-free, sample-to-droplet interface section to received droplets therefrom; an incubation section in fluid connection with the droplet mixing section to receive droplets therefrom; and a detection section in fluid connection with the incubation section to receive droplets therefrom.
    Type: Grant
    Filed: September 27, 2022
    Date of Patent: June 4, 2024
    Assignee: The Johns Hopkins University
    Inventors: Tza-Huei Jeff Wang, Kuangwen Hsieh, Yi-Fan Frank Hsieh, Aniruddha Mrithinjay Kaushik, Fangchi Shao, Pengfei Zhang
  • Self-assembling antiviral prodrugs
    Patent number: 11998609
    Abstract: Disclosed are therapeutic self-assembling molecules including a peptide sequence conjugated to one or more antiviral therapeutics to form a peptide-based antiviral prodrug capable of self-assembly into supramolecular structures with varying morphology in aqueous solutions, which can be injected subcutaneously or intramuscularly for the long-acting treatment of chronic viral infections.
    Type: Grant
    Filed: November 7, 2022
    Date of Patent: June 4, 2024
    Assignee: The Johns Hopkins University
    Inventors: Honggang Cui, Charles Williams Flexner, Maya Monroe, Han Wang
  • Qubit devices comprising one or more polycrystalline or single crystalline spin-triplet superconductors
    Patent number: 11995516
    Abstract: A qubit device may include a closed loop comprising one or more polycrystalline spin-triplet superconductors. The closed loop may maintain a half-quantum magnetic flux in a ground state. A qubit device may include a closed loop comprising one or more single crystalline spin-triplet superconductors connected by one or more s-wave superconductors. The closed loop may maintain a half-quantum magnetic flux in a ground state.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: May 28, 2024
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Yufan Li, Xiaoying Xu, Chia-Ling Chien
  • Machine learning model to adjust C-arm cone-beam computed tomography device trajectories
    Patent number: 11992348
    Abstract: A device may receive an X-ray image captured by a C-arm CBCT device at a particular position defined by a six-degree of freedom pose relative to an anatomy, and may process the X-ray image, with a machine learning model, to determine a predicted quality of next possible X-ray images provided by the C-arm CBCT device. The device may utilize the machine learning model, to identify a particular X-ray image, of the next possible X-ray images, with a greatest predicted quality and to update the six-degree of freedom pose based on the particular X-ray image. The device may provide, to the C-arm CBCT device, data that identifies the updated six-degree of freedom pose to cause the C-arm CBCT device to adjust to a new position based on the updated six-degree of freedom pose.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: May 28, 2024
    Assignee: The Johns Hopkins University
    Inventors: Mathias Unberath, Jan-Nico Zaech
  • Silicon carbide magnetometer and associated material formation methods
    Patent number: 11993864
    Abstract: A method for forming a silicon carbide material with a plurality of negatively charged silicon mono-vacancy defects includes irradiating a silicon carbide sample, annealing the irradiated silicon carbide sample in an annealing operation, and quenching the annealed silicon carbide sample. Quenching may include heating the annealed silicon carbide sample to a maximum temperature and quenching the annealed silicon carbide sample to form the silicon carbide sample with the plurality of negatively charged silicon mono-vacancy defects.
    Type: Grant
    Filed: November 2, 2021
    Date of Patent: May 28, 2024
    Assignee: The Johns Hopkins University
    Inventors: John B. Abraham, Brian D. Clader, Robert Osiander, Cameron A. Gutgsell, Dalibor J. Todorovski, Scott A. Sperling, Jacob E. Epstein, Timothy M. Sweeney, Elizabeth A. Pogue, Tyrel M. McQueen
  • Compositions and methods useful for the prevention of malaria and dengue virus transmission
    Patent number: 11992015
    Abstract: The present invention relates to the fields of malaria and dengue virus. More specifically, the present invention provides compositions and methods useful for the treatment and prevention of malaria and dengue virus. In particular embodiments, a composition comprises mosquito nectar feed and Chromobacterium sp_Panamam (Csp_P).
    Type: Grant
    Filed: July 29, 2021
    Date of Patent: May 28, 2024
    Assignee: The Johns Hopkins University
    Inventors: George Dimopoulos, Sarah M. Short, Jose L. Ramirez
  • MOTION CORRECTION FOR DIGITAL SUBTRACTION ANGIOGRAPHY
    Publication number: 20240164738
    Abstract: An angiography system includes a table supporting a subject, configured to: receive, from a 2D X-ray imaging system, contrast-enhanced 2D data of a region of the subject's body, a contrast-enhanced 2D data corresponding to a position and orientation of the X-ray imaging system relative to the region; receive, from a three dimensional (3D) X-ray imaging system, 3D data of the region acquired prior to administration of the contrast agent; generate, from the 3D data, a 2D mask of the region with simulated noncontrast-enhanced 2D data that corresponds to the position and orientation of the X-ray imaging system relative to the region; generate a vasculature image of the region by subtracting the contrast-enhanced 2D data from the 2D mask; and provide the vasculature image on the display.
    Type: Application
    Filed: March 22, 2022
    Publication date: May 23, 2024
    Applicant: The Johns Hopkins University
    Inventors: Jeffrey H. SIEWERDSEN, Alejandro SISNIEGA
  • Immunoswitch nanoparticles for reprogrammed T cell responses
    Patent number: 11986538
    Abstract: The presently disclosed subject matter relates to immunoswitch particles that switch off immunosuppressive pathways on tumor cells or immunosuppressive molecules induced by tumor cells in the tumor microenvironment, or virus infected cells or immunosuppressive molecules induced by virus infected cells in the microenvironment surrounding the virus infected cells, while simultaneously switching on co-stimulatory or co-inhibitory pathways on T cells, as well as method for converting immunosuppressive signals in cells, tissues, and subjects into stimulatory signals, and immunotherapy-based methods for treating cancer and chronic viral infections.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: May 21, 2024
    Assignee: The Johns Hopkins University
    Inventors: Alyssa K. Kosmides, Jonathan P. Schneck
  • Compositions and methods for enhancing an immune response
    Patent number: 11987606
    Abstract: The disclosure features compounds comprising an antigen portion, a soluble Major Histocompatibility Complex (MHC) molecule portion (e.g., all or an antigen-binding portion of a soluble MHC class I molecule), and a dynamic anchor portion (e.g., an agent, such as Annexin V, that binds to phosphatidylserine). The featured compounds are useful for a variety of therapeutic applications, including, e.g., enhancing a T cell response to an antigen of interest or enhancing a T cell-driven immune response by a subject to an antigen of interest (e.g., a cancer antigen or a microbial antigen).
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: May 21, 2024
    Assignee: The Johns Hopkins University
    Inventors: Tzyy-Choou Wu, Chih-Ping Mao, Chien-Fu Hung
  • SYSTEMS AND METHODS FOR ASSESSING SURGICAL SKILL
    Publication number: 20240161652
    Abstract: A method includes determining one or more metrics of a surgical task being performed by a surgeon based at least partially upon a type of the surgical task being performed and a video of the surgical task being performed. The method also includes determining a surgical skill of the surgeon during the surgical task based at least partially upon the video, the one or more metrics, or a combination thereof.
    Type: Application
    Filed: March 22, 2022
    Publication date: May 16, 2024
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Satyanarayana S. VEDULA, Shameema SIKDER, Gregory D. HAGER, Tae Soo KIM, Chien-Ming HUANG, Anand MALPANI, Kristen H. PARK, Bohua WAN
  • SUPERLATTICE STRUCTURES FOR THERMOELECTRIC DEVICES
    Publication number: 20240162112
    Abstract: Example superlattice structures and methods for thermoelectric devices are provided. An example structure may include a plurality of superlattice periods. Each superlattice period may include a first material layer disposed adjacent to a second material layer. For each superlattice period, the first material layer may be formed of a first material and the second material layer may be formed of a second material. The plurality of superlattice periods may include a first superlattice period and a second superlattice period. A thickness of a first material layer of the first superlattice period may be different than a thickness of a first material layer of the second superlattice period.
    Type: Application
    Filed: January 26, 2024
    Publication date: May 16, 2024
    Applicant: The Johns Hopkins University
    Inventors: Rama Venkatasubramanian, Jonathan M. Pierce, Dezsi Geza