Abstract: The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a monohydric alcohol or an amide wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. Anti-inflammatory lipid mediators can be selected from the group consisting of polyunsaturated fatty acids (e.g.

Abstract: The present invention relates to improved contact lens packages and methods of use and manufacture/assembly. A contact lens package may include a cavity that houses a contact lens, packaging solution, and an absorbent member. In one aspect, the absorbent member may be configured for transitioning between an expanded state and a compressed state, and the absorbent member may be in the compressed state when the package is in an unopened state.

Abstract: Provided are imidazolium zwitterion polymerizable compounds and their applications in ophthalmic devices and packaging solutions. The zwitterionic polymerizable compounds are of formula I: wherein R1, R2, R3, L1, L2, and Pg are as described herein.

Abstract: Tunable apodized multiple-focus ophthalmic devices and methods characterized by a lens with multiple optical zones each with an optical power optimized for one or more focal lengths and a tunable apodization mask positioned within at least a portion of the optical zone(s). Upon a desired change of focus for the wearer, an optical transmission characteristic of the tunable apodization mask may be varied. The tunable apodization mask may take the form of an electrochromic device or another suitable material.

Abstract: A system, method and computer program product for estimating future axial elongation of an individual's eye as a way to predict and track refractive error progression of an individual. The method includes: receiving, via a computer interface, data relating to refractive change in a prior pre-determined time period for the individual from a reference timepoint; receiving data representing an age of the individual and data representing a current axial length value of the eye as measured at the reference timepoint; calculating, by said processor, a future axial elongation of the eye as a function of the age of the individual, the current axial length value of the eye as measured at the reference timepoint, and the refractive change in the prior pre-determined time period; generating, an output indication of said computed axial elongation of the eye, and using said output indication to select a myopia control treatment for said individual.

Abstract: Provided is a method for manufacturing photoabsorbing contact lenses and photoabsorbing contact lenses produced thereby. The method comprises: (a) providing a mold assembly comprised of a base curve and a front curve, the base curve and the front curve defining and enclosing a cavity therebetween, the cavity containing a reactive mixture, wherein the reactive mixture comprises at least one polymerizable monomer, a photoinitiator which absorbs at an activating wavelength, and a photoabsorbing compound which displays absorption at the activating wavelength; and (b) curing the reactive mixture to form the photoabsorbing contact lens by exposing the reactive mixture to radiation that includes the activating wavelength, wherein the radiation is directed at both the base curve and the front curve of the mold assembly, and wherein the radiation's radiant energy at the base curve is greater than the radiation's radiant energy at the front curve.

Abstract: Provided are amino acid based polymerizable compounds and their applications in ophthalmic devices. The amino acid based polymerizable compounds are of formula I: wherein R, R1, and R2 are as described herein.

Abstract: A contact lens package includes a base having a proximal end and a distal end, a solution well between the proximal end and the distal end, a contact lens support in the solution well, a top opening between the proximal end and the distal end and over the contact lens support, and a via through a wall of the base adjacent the well, the via providing a fluid exit for solution within well. A removable lid overlying the top opening may be removably affixed over the top opening such that a user may remove the lid to access the contact lens. Using this package, fluid can be drained away from the contact lens in the package before removal from the package by a user, thus providing good adhesion between a user's finger or applicator and the lens over prior packaging.

Abstract: A system of contact lenses includes at least two contact lenses, each lens having a visual correction for a non-rotationally symmetric eye aberration. Each lens has a different level or degree of a stabilization that is characterized by a thickness differential between a thickness of a stabilization zone and a thickness of a non-stabilization zone.

Abstract: Described are visible light absorbing compounds. The compounds absorb various visible light wavelengths, such as in the region of 500 to 625 nm, and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

Abstract: The present invention relates to borate and phosphate containing compositions, especially eye care compositions, achieving physiologically compatible pH and tonicity as well as good bacteriostatic properties. Methods of using the compositions of the present invention are also disclosed.

Abstract: An automated product locker includes a housing and a drawer configured to be slidably stowable within the housing. The defines a storage area for storing product. Visual indicators on the product locker indicate respective positions, i.e., locations of the product within the storage area, so that desired products may located by the user. Upon withdrawal or closure of a door by a user, a machine vision system, such as a camera, may capture information about the product and inventory the product based, at least in part, on the information identified from images of the product obtaining by the machine vision system.

Abstract: A method for quality control of contact lens packages comprises receiving a first data set comprising a plurality of images of a contact lens package having physically implanted defects; receiving a second data set comprising a plurality of images of a contact lens package having digitally implanted defects; testing and training, on the first and second data set, a model to determine a validated one or more quality control models; capturing image data of a package of a contact lens; analyzing, based on the validated one or more quality control models, the image data; and causing, based on the analyzing, output of a quality control metric indicative of at least an accept or reject condition of the package.

Abstract: A primary package for holding contact lenses is disclosed. It is primarily made from a nucleated polypropylene resin. It has been determined that the nucleated polypropylene resin should be formulated with a polypropylene base resin with greater than 99% polypropylene homopolymer and a primary and secondary stabilizer, which also contains a catalyst acid scavenger; at least one nucleator/clarifier; and at least one catalyst acid scavenger.

Abstract: A method or use of a contact lens, includes applying to at least one eye of a contact lens wearer the contact lens that is a free radical reaction product of a reactive mixture that includes one or more polymerizable compounds suitable for making the contact lens; and a high energy visible (HEV) light absorbing compound; and improving, by the contact lens, at least one clinical attribute comprising overall preference of the contact lens while using computer screens and digital devices as observed by the contact lens wearer, comfort at the end of the day, CLUE Comfort score, CLUE Vision score.

Abstract: A contact lens having an electronic system is described herein to provide lens accommodation using a distance measurement determined from an ultrasound time of flight signal. In at least one embodiment, the contact lens includes an ultrasound module, a system controller, a timing circuit, and an actuator. In at least one embodiment, the ultrasound module includes at least one transducer configured to emit a sound pressure wave outwardly and receive a reflected sound pressure wave from an object. A timer may track an elapsed time between generation and detection of the sound pressure wave by the at least one transducer to determine the distance to the object. In at least one embodiment, lens accommodation is further achieved using a communication link between a pair of contact lenses to determine a convergence angle based on independent distance measurements generated by each contact lens.

Abstract: Described are polymerizable high energy light absorbing compounds of formula I: Wherein Y, Pg, R2, R3, R4, R5, and R6 are as described herein. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

Abstract: Disclosed herein are compositions and methods comprising a composition for light filtering. An example composition comprises a plurality of metal nanoparticles, at least a portion of the plurality of metal nanoparticles having an anisotropic shape; and a stabilizing mechanism disposed to selectively couple with at least a portion of the plurality of metal nanoparticles, wherein the composition exhibits a peak light filtering value in the range of about 600 nm to about 850 nm.