Abstract: Provided herein are various embodiments relating to antibodies. Some of the embodiments include antagonist antibodies that bind PD-1. Such antibodies can be used in methods to treat, for example, cancer.
Type:
Grant
Filed:
June 7, 2022
Date of Patent:
February 20, 2024
Assignee:
Jounce Therapeutics, Inc.
Inventors:
George Robert Mabry, III, Stephen Sazinsky
Abstract: Methods of treating infectious diseases, such as a viral diseases, and methods of enhancing the effectiveness of a vaccine against an infectious disease, such as a viral disease, with an ICOS agonist, such as an anti-ICOS agonist antibody, are provided.
Type:
Application
Filed:
April 19, 2021
Publication date:
May 18, 2023
Applicant:
Jounce Therapeutics, Inc.
Inventors:
Christopher Harvey, Richard Murray, Robert Huebner
Abstract: Provided herein are various embodiments relating to antibodies. Some of the embodiments include antagonist antibodies that bind PD-1. Such antibodies can be used in methods to treat, for example, cancer.
Type:
Application
Filed:
June 7, 2022
Publication date:
January 19, 2023
Applicant:
Jounce Therapeutics, Inc.
Inventors:
George Robert Mabry, III, Stephen Sazinsky
Abstract: Methods of treating cancer with particular doses of anti-ICOS antibodies are provided.
Type:
Application
Filed:
December 14, 2021
Publication date:
September 8, 2022
Applicant:
Jounce Therapeutics, Inc.
Inventors:
Jason Windham Reeves, Deborah Law, Christopher Harvey, Elizabeth G. Trehu, Lauren Pepper MacKenzie, Amit Deshpande, Jennifer S. Michaelson, Igor Feldman, Sriram Sathyanarayanan
Abstract: Provided herein are various embodiments relating to antibodies. Some of the embodiments include antagonist antibodies that bind PD-1. Such antibodies can be used in methods to treat, for example, cancer.
Type:
Grant
Filed:
April 10, 2020
Date of Patent:
July 12, 2022
Assignee:
Jounce Therapeutics, Inc.
Inventors:
George Robert Mabry, III, Stephen Sazinsky
Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.
Type:
Grant
Filed:
July 14, 2020
Date of Patent:
June 14, 2022
Assignee:
Jounce Therapeutics, Inc.
Inventors:
Heather B. Cohen, Lauren Pepper Mackenzie, Donald Raymond Shaffer, Jeffrey Yan-Fei Smith
Abstract: Gene expression signatures correlating to ICOS expression levels are provided. Methods of treatment comprising determining ICOS expression levels using gene signatures in patients and administering anti-ICOS antibodies are also provided.
Type:
Application
Filed:
February 5, 2021
Publication date:
November 4, 2021
Applicant:
Jounce Therapeutics, Inc.
Inventors:
Jason Windham Reeves, Igor Feldman, Christopher Harvey, Sriram Sathyanarayanan, Heather Hirsch, Lauren Pepper MacKenzie, Amit Deshpande, Stephen Sazinsky, Jennifer S. Michaelson, Kutlu Goksu Elpek
Abstract: Provided herein are various embodiments relating to antibodies. Some of the embodiments include agonist antibodies that bind ICOS. Such antibodies can be used in methods to treat, for example, cancer.
Type:
Application
Filed:
September 16, 2020
Publication date:
June 10, 2021
Applicant:
Jounce Therapeutics, Inc.
Inventors:
Stephen Sazinsky, Jennifer S. Michaelson, Sriram Sathyanarayanan, Kutlu Goksu Elpek
Abstract: Gene expression signatures correlating to ICOS expression levels are provided. Methods of treatment comprising determining ICOS expression levels using gene signatures in patients and administering anti-ICOS antibodies are also provided.
Type:
Grant
Filed:
October 21, 2016
Date of Patent:
April 6, 2021
Assignee:
Jounce Therapeutics, Inc.
Inventors:
Jason Windham Reeves, Igor Feldman, Christopher Harvey, Sriram Sathyanarayanan, Heather Hirsch, Lauren Pepper MacKenzie, Amit Deshpande, Stephen Sazinsky, Jennifer S. Michaelson, Kutlu Goksu Elpek
Abstract: Provided herein are various embodiments relating to antibodies. Some of the embodiments include antagonist antibodies that bind PD-1. Such antibodies can be used in methods to treat, for example, cancer.
Type:
Application
Filed:
April 10, 2020
Publication date:
December 24, 2020
Applicant:
Jounce Therapeutics, Inc.
Inventors:
George Robert Mabry, III, Stephen Sazinsky
Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
July 28, 2020
Assignee:
Jounce Therapeutics, Inc.
Inventors:
Heather B. Cohen, Lauren Pepper Mackenzie, Yasmin Ramsay, Donald Raymond Shaffer, Jeffrey Yan-Fei Smith
Abstract: Provided herein are various embodiments relating to antibodies. Some of the embodiments include antagonist antibodies that bind PD-1. Such antibodies can be used in methods to treat, for example, cancer.
Type:
Grant
Filed:
November 1, 2017
Date of Patent:
May 19, 2020
Assignee:
Jounce Therapeutics, Inc.
Inventors:
George Robert Mabry, III, Stephen Sazinsky
Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
April 14, 2020
Assignee:
Jounce Therapeutics, Inc.
Inventors:
Heather B. Cohen, Lauren Pepper Mackenzie, Yasmin Ramsay, Donald Raymond Shaffer, Jeffrey Yan-Fei Smith, Kristin Shanea O'Malley, Kevin Patrick Guay
Abstract: Provided herein are various embodiments relating to antibodies. Some of the embodiments include agonist antibodies that bind ICOS. Such antibodies can be used in methods to treat, for example, cancer.
Type:
Grant
Filed:
June 20, 2018
Date of Patent:
February 25, 2020
Assignee:
Jounce Therapeutics, Inc.
Inventors:
Stephen Sazinsky, Jennifer S. Michaelson, Sriram Sathyanarayanan, Kutlu Goksu Elpek