Abstract: Methods of treating cancer with particular doses of anti-ICOS antibodies are provided.
Type:
Application
Filed:
April 2, 2018
Publication date:
January 23, 2020
Applicant:
Jounce Therapeutics, Inc.
Inventors:
Jason Windham Reeves, Deborah Law, Christopher Harvey, Beth G. Trehu, Lauren Pepper MacKenzie, Amit Deshpande, Jennifer S. Michaelson, Igor Feldman, Sriram Sathyanarayanan
Abstract: Gene expression signatures correlating to ICOS expression levels are provided. Methods of treatment comprising determining ICOS expression levels using gene signatures in patients and administering anti-ICOS antibodies are also provided.
Type:
Application
Filed:
October 21, 2016
Publication date:
December 27, 2018
Applicant:
Jounce Therapeutics, Inc.
Inventors:
Jason Windham Reeves, Igor Feldman, Christopher Harvey, Sriram Sathyanarayanan, Heather Hirsch, Lauren Pepper MacKenzie, Amit Deshpande, Stephen Sazinsky, Jennifer S. Michaelson, Kutlu Gosku Elpek
Abstract: Provided herein are various embodiments relating to antibodies. Some of the embodiments include agonist antibodies that bind ICOS. Such antibodies can be used in methods to treat, for example, cancer.
Type:
Application
Filed:
June 20, 2018
Publication date:
December 13, 2018
Applicant:
Jounce Therapeutics, Inc.
Inventors:
Stephen Sazinsky, Jennifer S. Michaelson, Sriram Sathyanarayanan, Kutlu Goksu Elpek
Abstract: Provided herein are various embodiments relating to antibodies. Some of the embodiments include agonist antibodies that bind ICOS. Such antibodies can be used in methods to treat, for example, cancer.
Type:
Grant
Filed:
March 22, 2016
Date of Patent:
July 17, 2018
Assignee:
Jounce Therapeutics, Inc.
Inventors:
Stephen Sazinsky, Jennifer S. Michaelson, Sriram Sathyanarayanan, Kutlu Goksu Elpek
Abstract: Provided herein are various embodiments relating to antibodies. Some of the embodiments include antagonist antibodies that bind PD-1. Such antibodies can be used in methods to treat, for example, cancer.
Type:
Application
Filed:
November 1, 2017
Publication date:
May 3, 2018
Applicant:
Jounce Therapeutics, Inc.
Inventors:
George Robert Mabry, III, Stephen Sazinsky