Patents Assigned to Jouveinal
  • Patent number: 4933331
    Abstract: 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thioacetate-17-butyrate and 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thiopropionate-17-butyrate, are anti-inflammatory agents.
    Type: Grant
    Filed: November 4, 1985
    Date of Patent: June 12, 1990
    Assignee: Jouveinal, S.A.
    Inventors: Gilbert G. Aubard, Agnes G. Grouhel, Jean-Louis Junien, Claude P. Roux, Dieran R. Torossian
  • Patent number: 4929614
    Abstract: Benzodiazepines of formula ##STR1## in which R.sub.1 is H of halogen, R.sub.2 is H or halogen, Ar is indolyl, phenyl, naphthyl, indolyl monosubstituted with a halogen or with a methoxy or phenyl mono-, di- or trisubstituted with a halogen or with a methoxy or with a trifluoromethyl group, and n is 2 or 3; and their optical isomers.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: May 29, 1990
    Assignee: Jouveinal S.A.
    Inventors: Alain P. Calvet, Jean-Louis Junien, Ives R. Pascal, Xavier B. Pascaud, Francois J. Roman
  • Patent number: 4861765
    Abstract: A 21-substituted thiosteroid represented by the general formula ##STR1## wherein R.sup.1 represents an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 5 or 6 carbon atoms, a phenyl group, or a benzyl group which may have a substituent on the benzene ring,R.sup.2 represents an alkanoyl group having 2 to 6 carbon atoms,R.sup.3 represents a hydrogen atom or a methyl group,X represents a hydrogen or halogen atom, andthe dotted line between 1- and 2-positions represents an optional bond. These compounds are useful an anti-inflammatory agents.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: August 29, 1989
    Assignee: Jouveinal
    Inventors: Morihiro Mitsukuchi, Tomoyuki Ikemoto, Yoshiaki Watanabe, Kaoru Sota
  • Patent number: 4816490
    Abstract: A method of reducing hyperlipemia in warm-blooded animals by administration of an effective amount of 2-[(3,4-dimethoxy-benzoyl)-methyl]-2-hydroxy-1,3-dioxoIndone.
    Type: Grant
    Filed: December 17, 1987
    Date of Patent: March 28, 1989
    Assignee: Jouveinal S.A.
    Inventor: Guy Petibon
  • Patent number: 4761400
    Abstract: Lactulose-based laxative composition which is in the form of a jelly with a viscosity at 20.degree. C. measured on the Brookfield viscosimeter between 15,000 and 30,000 centipoises, a refractive index at 20.degree. C. between 1.430 and 1.445 and a pH between 3 and 4.
    Type: Grant
    Filed: January 6, 1986
    Date of Patent: August 2, 1988
    Assignee: Jouveinal S.A.
    Inventors: Bernard J. M. Doat, Jean-Francois J. Letavernier, Gilbert G. Aubard, Jean B. Llull, Alain P. Calvet, Jean-Louis Junien
  • Patent number: 4734428
    Abstract: Aminoethyl imidazole of formula: ##STR1## in which R.sub.1 is a lower alkyl, R.sub.2 is a phenyl or phenoxy radical, optionally substituted by a halogen atom or a lower alkoxy radical, R.sub.3,R.sub.4 and R.sub.5 are a hydrogen atom or a lower alkyl radical and x, y and z have the value 0 or 1, but the values of y and z cannot be the same, together with their acid addition salts with acids.Cytoprotective medicament.
    Type: Grant
    Filed: June 10, 1986
    Date of Patent: March 29, 1988
    Assignee: Jouveinal S.A.
    Inventors: Gilbert G. Aubard, Jacques Bure, Agnes G. Grouhel, Jean-Louis Junien, Veronique J. Lelievre, Xavier B. Pascaud, Claude P. Roux
  • Patent number: 4177268
    Abstract: The present invention relates a method for the alleviation of inflammation which comprises administering to a host a therapeutically effective amount of a dexamethasone derivative of the formula ##STR1## in which R represents an alkyl radical comprising a number of carbons atoms between 4 and 9 or a para-fluoro-phenyl radical.The product used in this method has a considerable local anti-inflammatory activity.
    Type: Grant
    Filed: January 4, 1977
    Date of Patent: December 4, 1979
    Assignee: Jouveinal S.A.
    Inventors: Dieran R. Torossian, Gilbert G. Aubard, Jacky M. Legeai
  • Patent number: 4098803
    Abstract: The present invention relates to new esters of the 21-thiol-steroids, having the general formula given at (I) below, and also to a method of preparation of these new esters. ##STR1## in which: R.sub.1 represents an alkyl radical comprising a number of carbon atoms between 4 and 9, or the para-fluoro-phenyl radical;R.sub.2 represents hydroxyl or the ketone function.The esters of the invention have a considerable anti-inflammatory activity but also have small systemic effects and are applied especially to the local treatment of inflammatory illnesses.
    Type: Grant
    Filed: January 4, 1977
    Date of Patent: July 4, 1978
    Assignee: Jouveinal S.A.
    Inventors: Dieran Robert Torossian, Gilbert Gustave Aubard, Jacky Marcel Legeai
  • Patent number: 4098804
    Abstract: The present invention relates to new esters of the 21-thiol-steroids, having the general formula given at (I) below, and also to a method of preparation of these new esters. ##STR1## in which: R.sub.1 represents an alkyl radical comprising a number of carbon atoms between 4 and 9, or the para-fluoro-phenyl radical;R.sub.2 represents hydroxyl or the ketone function.The esters of the invention have a considerable anti-inflammatory activity but also have small systemic effects and are applied especially to the local treatment of inflammatory illnesses.
    Type: Grant
    Filed: January 4, 1977
    Date of Patent: July 4, 1978
    Assignee: Jouveinal S.A.
    Inventors: Dieran Robert Torossian, Gilbert Gustave Aubard, Jacky Marcel Legeai
  • Patent number: 4014909
    Abstract: The present invention relates to new esters of the 21-thiol-steroids, having the general formula given at (I) below, and also to a method of preparation of these new esters: ##STR1## in which: R.sub.1 represents an alkyl radical comprising a number of carbon atoms between 4 and 9, or a para-fluoro-aryl radical;R.sub.2 represents an atom of hydrogen or a methyl radical;R.sub.3 represents a hydroxyl radical of a ketone function;R.sub.4 represents an atom of hydrogen or an atom of fluorine;R.sub.5 and R.sub.6 each represent an atom of hydrogen or a second bond between the carbon atoms C-1 and C-2.A method of preparation of the above new esters comprises the operation of condensation of:Derivatives of the general formula below, in which R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.
    Type: Grant
    Filed: May 28, 1974
    Date of Patent: March 29, 1977
    Assignee: Jouveinal S.A.
    Inventors: Dieran Robert Torossian, Gilbert Gustave Aubard, Jacky Marcel Gerard Legeai
  • Patent number: 3985892
    Abstract: Method for percutaneous treatment of edemas of humans to reduce their swelling, by percutaneous application of a pharmaceutical preparation comprising an active element consisting of acetazolamide in a concentration of between 1 to 50% incorporated in a vehicle which is compatible with percutaneous administration.
    Type: Grant
    Filed: January 27, 1975
    Date of Patent: October 12, 1976
    Assignee: Jouveinal S.A.
    Inventors: Claude P. Roux, Dieran Robert Torossian
  • Patent number: 3934016
    Abstract: Pharmaceutical preparation and method for percutaneous treatment of edemas, with the pharmaceutical preparation comprising an active element consisting of acetazolamide in a concentration of between 1 to 50% incorporated in a vehicle which is compatible with percutaneous administration.
    Type: Grant
    Filed: May 24, 1971
    Date of Patent: January 20, 1976
    Assignee: Jouveinal, S.A.
    Inventors: Claude Paul Roux, Dieran Robert Torossian