Abstract: 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thioacetate-17-butyrate and 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thiopropionate-17-butyrate, are anti-inflammatory agents.
Type:
Grant
Filed:
November 4, 1985
Date of Patent:
June 12, 1990
Assignee:
Jouveinal, S.A.
Inventors:
Gilbert G. Aubard, Agnes G. Grouhel, Jean-Louis Junien, Claude P. Roux, Dieran R. Torossian
Abstract: Benzodiazepines of formula ##STR1## in which R.sub.1 is H of halogen, R.sub.2 is H or halogen, Ar is indolyl, phenyl, naphthyl, indolyl monosubstituted with a halogen or with a methoxy or phenyl mono-, di- or trisubstituted with a halogen or with a methoxy or with a trifluoromethyl group, and n is 2 or 3; and their optical isomers.
Type:
Grant
Filed:
April 14, 1989
Date of Patent:
May 29, 1990
Assignee:
Jouveinal S.A.
Inventors:
Alain P. Calvet, Jean-Louis Junien, Ives R. Pascal, Xavier B. Pascaud, Francois J. Roman
Abstract: A 21-substituted thiosteroid represented by the general formula ##STR1## wherein R.sup.1 represents an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 5 or 6 carbon atoms, a phenyl group, or a benzyl group which may have a substituent on the benzene ring,R.sup.2 represents an alkanoyl group having 2 to 6 carbon atoms,R.sup.3 represents a hydrogen atom or a methyl group,X represents a hydrogen or halogen atom, andthe dotted line between 1- and 2-positions represents an optional bond. These compounds are useful an anti-inflammatory agents.
Type:
Grant
Filed:
June 23, 1986
Date of Patent:
August 29, 1989
Assignee:
Jouveinal
Inventors:
Morihiro Mitsukuchi, Tomoyuki Ikemoto, Yoshiaki Watanabe, Kaoru Sota
Abstract: A method of reducing hyperlipemia in warm-blooded animals by administration of an effective amount of 2-[(3,4-dimethoxy-benzoyl)-methyl]-2-hydroxy-1,3-dioxoIndone.
Abstract: Lactulose-based laxative composition which is in the form of a jelly with a viscosity at 20.degree. C. measured on the Brookfield viscosimeter between 15,000 and 30,000 centipoises, a refractive index at 20.degree. C. between 1.430 and 1.445 and a pH between 3 and 4.
Type:
Grant
Filed:
January 6, 1986
Date of Patent:
August 2, 1988
Assignee:
Jouveinal S.A.
Inventors:
Bernard J. M. Doat, Jean-Francois J. Letavernier, Gilbert G. Aubard, Jean B. Llull, Alain P. Calvet, Jean-Louis Junien
Abstract: Aminoethyl imidazole of formula: ##STR1## in which R.sub.1 is a lower alkyl, R.sub.2 is a phenyl or phenoxy radical, optionally substituted by a halogen atom or a lower alkoxy radical, R.sub.3,R.sub.4 and R.sub.5 are a hydrogen atom or a lower alkyl radical and x, y and z have the value 0 or 1, but the values of y and z cannot be the same, together with their acid addition salts with acids.Cytoprotective medicament.
Type:
Grant
Filed:
June 10, 1986
Date of Patent:
March 29, 1988
Assignee:
Jouveinal S.A.
Inventors:
Gilbert G. Aubard, Jacques Bure, Agnes G. Grouhel, Jean-Louis Junien, Veronique J. Lelievre, Xavier B. Pascaud, Claude P. Roux
Abstract: The present invention relates a method for the alleviation of inflammation which comprises administering to a host a therapeutically effective amount of a dexamethasone derivative of the formula ##STR1## in which R represents an alkyl radical comprising a number of carbons atoms between 4 and 9 or a para-fluoro-phenyl radical.The product used in this method has a considerable local anti-inflammatory activity.
Type:
Grant
Filed:
January 4, 1977
Date of Patent:
December 4, 1979
Assignee:
Jouveinal S.A.
Inventors:
Dieran R. Torossian, Gilbert G. Aubard, Jacky M. Legeai
Abstract: The present invention relates to new esters of the 21-thiol-steroids, having the general formula given at (I) below, and also to a method of preparation of these new esters. ##STR1## in which: R.sub.1 represents an alkyl radical comprising a number of carbon atoms between 4 and 9, or the para-fluoro-phenyl radical;R.sub.2 represents hydroxyl or the ketone function.The esters of the invention have a considerable anti-inflammatory activity but also have small systemic effects and are applied especially to the local treatment of inflammatory illnesses.
Type:
Grant
Filed:
January 4, 1977
Date of Patent:
July 4, 1978
Assignee:
Jouveinal S.A.
Inventors:
Dieran Robert Torossian, Gilbert Gustave Aubard, Jacky Marcel Legeai
Abstract: The present invention relates to new esters of the 21-thiol-steroids, having the general formula given at (I) below, and also to a method of preparation of these new esters. ##STR1## in which: R.sub.1 represents an alkyl radical comprising a number of carbon atoms between 4 and 9, or the para-fluoro-phenyl radical;R.sub.2 represents hydroxyl or the ketone function.The esters of the invention have a considerable anti-inflammatory activity but also have small systemic effects and are applied especially to the local treatment of inflammatory illnesses.
Type:
Grant
Filed:
January 4, 1977
Date of Patent:
July 4, 1978
Assignee:
Jouveinal S.A.
Inventors:
Dieran Robert Torossian, Gilbert Gustave Aubard, Jacky Marcel Legeai
Abstract: The present invention relates to new esters of the 21-thiol-steroids, having the general formula given at (I) below, and also to a method of preparation of these new esters: ##STR1## in which: R.sub.1 represents an alkyl radical comprising a number of carbon atoms between 4 and 9, or a para-fluoro-aryl radical;R.sub.2 represents an atom of hydrogen or a methyl radical;R.sub.3 represents a hydroxyl radical of a ketone function;R.sub.4 represents an atom of hydrogen or an atom of fluorine;R.sub.5 and R.sub.6 each represent an atom of hydrogen or a second bond between the carbon atoms C-1 and C-2.A method of preparation of the above new esters comprises the operation of condensation of:Derivatives of the general formula below, in which R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.
Abstract: Method for percutaneous treatment of edemas of humans to reduce their swelling, by percutaneous application of a pharmaceutical preparation comprising an active element consisting of acetazolamide in a concentration of between 1 to 50% incorporated in a vehicle which is compatible with percutaneous administration.
Type:
Grant
Filed:
January 27, 1975
Date of Patent:
October 12, 1976
Assignee:
Jouveinal S.A.
Inventors:
Claude P. Roux, Dieran Robert Torossian
Abstract: Pharmaceutical preparation and method for percutaneous treatment of edemas, with the pharmaceutical preparation comprising an active element consisting of acetazolamide in a concentration of between 1 to 50% incorporated in a vehicle which is compatible with percutaneous administration.
Type:
Grant
Filed:
May 24, 1971
Date of Patent:
January 20, 1976
Assignee:
Jouveinal, S.A.
Inventors:
Claude Paul Roux, Dieran Robert Torossian