Patents Assigned to JSR Life Sciences Corporation
  • Publication number: 20180360033
    Abstract: Provided is a polymer having antimicrobial and disinfecting properties against a wide range of kinds of germs. A polymer, including: a polymer chain having a repeating unit represented by the following formula (1); and a partial structure (excluding the polymer chain) derived from a compound containing a group represented by —NH—. [In formula (1), R1 represents a hydrogen atom or a methyl group, Z represents a group forming an organic ammonium salt, —NR5R6 (where R5 and R6 each independently represent a hydrogen atom, or a substituted or unsubstituted hydrocarbon group), or a substituted or unsubstituted nitrogen-containing heterocyclic group, and X represents a single bond, or a divalent linking group.
    Type: Application
    Filed: December 13, 2016
    Publication date: December 20, 2018
    Applicants: JSR CORPORATION, JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES, JSR LIFE SCIENCES CORPORATION
    Inventors: Hidenori NARUSE, Atsushi ITOU, Shigeru IKAWA, Tsutomu SHIMOKAWA, Masato SUZUKI, Mari MATSUI, Satowa SUZUKI, Keigo SHIBAYAMA, Kazuhiro IKKYUU
  • Publication number: 20180356561
    Abstract: Provided is a gel that has excellent surface hydrophilicity, lubricity and antifouling property, and that is useful as, for example, a contact lens material. A gel including: a polymer a having 2.5 to 95 mass % of the following repeat unit (A), and 2.5 to 95 mass % of the following repeat unit (B), and a polymer b obtained through polymerization of a hydrophilic monomer with a crosslinking agent.
    Type: Application
    Filed: June 7, 2016
    Publication date: December 13, 2018
    Applicants: JSR CORPORATION, JSR Life Sciences Corporation
    Inventors: Satoshi HYUGAJI, Kazuhiro ISO, Kiyoshi SUDA, Naoki HAYASHI
  • Patent number: 10139401
    Abstract: To provide a solid-phase carrier that has extremely low nonspecific adsorption of biological substances such as proteins, peptides, nucleic acids and cells, and is capable of maintaining the activity of bound ligands at a high level; and a method for capturing a target substance using the solid-phase carrier.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: November 27, 2018
    Assignees: JSR CORPORATION, JSR Life Sciences Corporation
    Inventors: Hirokazu Kai, Eiji Takamoto, Kouji Tamori
  • Patent number: 10139402
    Abstract: A method for separating a vesicle having a lipid bilayer membrane from a biological sample, includes forming a complex of a vesicle and a solid phase carrier by bringing the biological sample containing the vesicle having the lipid bilayer membrane into contact with the solid phase carrier to which a ligand for recognizing a surface antigen present on a surface of the vesicle is bound. The complex is washed. The forming is performed in the presence of a nonionic surfactant which does not comprise an aromatic group to reduce an aggregation of the complex.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: November 27, 2018
    Assignees: JSR CORPORATION, JSR Life Sciences Corporation
    Inventors: Hiroya Fujii, Motoaki Mizuuchi, Tetsuji Yamaguchi, Hiroki Abe
  • Publication number: 20180291424
    Abstract: Provided is a method capable of reducing non-specific adsorption onto a solid phase carrier, and capable of selectively and efficiently separating a vesicle having a lipid bilayer membrane. A method of separating a vesicle having a lipid bilayer membrane includes: a complex forming step of forming a complex of a vesicle having a lipid bilayer membrane and a solid phase carrier to which a ligand which recognizes a surface antigen present on a surface of the vesicle is bound, by bringing a biological sample containing the vesicle into contact with the solid phase carrier; and a washing step of washing the complex, in which at least any one of the complex forming step and the washing step is performed under an environment having a salt concentration of from 0.15 M to 2 M.
    Type: Application
    Filed: May 20, 2016
    Publication date: October 11, 2018
    Applicants: JSR CORPORATION, JSR LIFE SCIENCES CORPORATION
    Inventors: Hiroki ABE, Hiroya FUJII, Kimiko UCHIDA
  • Publication number: 20180284109
    Abstract: This invention relates to a method of producing a probe-bound carrier, a probe-bound carrier and a method of detecting or separating a target substance. The method of producing a probe-bound carrier includes: step 1 of mixing a carrier having tosyl groups and a probe; and step 2 of reducing the amount of tosyl groups on a surface of a carrier, in which a proportion of area S2 that is occupied by one tosyl group on a surface of the carrier obtained in the step 2 with respect to area S1A that is occupied by one tosyl group on a surface of the carrier used in the step 1 (S2/S1A×100%) is not less than 140%.
    Type: Application
    Filed: March 27, 2018
    Publication date: October 4, 2018
    Applicants: JSR CORPORATION, JSR LIFE SCIENCES CORPORATION, JSR Micro, Inc., JSR Micro N.V.
    Inventors: Yuuichi Ueya, Yasuhito Satou
  • Publication number: 20180244911
    Abstract: The present invention relates to: a composition; a contact lens coating agent; a method of producing a contact lens; and a contact lens. The composition contains: a polymer which includes a repeating unit (A) having an HLB value of 14 or higher and a repeating unit (B) having an HLB value of 1 to less than 14; and a cationic group-containing bactericidal compound.
    Type: Application
    Filed: September 7, 2016
    Publication date: August 30, 2018
    Applicants: JSR CORPORATION, JSR LIFE SCIENCES CORPORATION
    Inventors: Kazuhiro ISO, Satoshi HYUUGAJI
  • Publication number: 20180223024
    Abstract: The present invention relates to: a polymer composition; an article; a medical device; an article production method; and a cell cluster production method. The polymer composition contains a polymer having the following repeating units (A) and (B) and is one selected from the group consisting of a medical device composition, a cell adhesion inhibitor, and a silicone substrate treatment composition: (A) a hydrophilic repeating unit; and (B) a repeating unit which has a polyoxyalkylene group in a side chain whose terminal is constituted by an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group having 6 to 30 carbon atoms.
    Type: Application
    Filed: August 4, 2016
    Publication date: August 9, 2018
    Applicants: JSR CORPORATION, JSR LIFE SCIENCES CORPORATION
    Inventor: Satoshi HYUUGAJI
  • Publication number: 20180222939
    Abstract: To provide an affinity support in which a binding property of a ligand to a target substance is improved. The affinity support contains a solid phase support and a protein ligand, wherein the protein ligand is represented by formula (1): R—R1 (1) wherein R represents a linker binding to the solid phase support, which contains a polyproline, and R1 represents a protein showing an affinity to immunoglobulin, and the R is bound to a C terminal or an N terminal of an amino acid sequence in R1.
    Type: Application
    Filed: July 27, 2016
    Publication date: August 9, 2018
    Applicants: JSR CORPORATION, JSR LIFE SCIENCES CORPORATION
    Inventors: Takashi ICHII, Satoshi NAKAMURA, Jun-ichi YASUOKA, Kaori ITAYA, Tomonori SHIOTANI
  • Publication number: 20180217294
    Abstract: A method for producing a medical device, and a medical device are provided, and the production method includes a step of heating a device together with a solution containing a polymer having the following repeating unit (A) and the following repeating unit (B), or a step of bringing a device into contact with a heated product of a solution containing a polymer having the following repeating unit (A) and the following repeating unit (B): (A) a hydrophilic repeating unit; and (B) a repeating unit having a polyoxyalkylene group in a side chain, the terminal of the side chain being composed of an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group having 6 to 30 carbon atoms.
    Type: Application
    Filed: July 26, 2016
    Publication date: August 2, 2018
    Applicants: JSR CORPORATION, JSR LIFE SCIENCES CORPORATION
    Inventors: Satoshi HYUUGAJI, Kazuhiro ISO
  • Publication number: 20180203004
    Abstract: A solid-phase support, formed by binding a chain polymer at least to the surface, wherein the chain polymer is a block polymer comprising a first block constituted from repetitions of a hydrophilic structural unit and a second block constituted from repetitions of a structural unit having a reactive functional group, a content ratio of the number of moles “a” of the reactive functional group contained in the chain polymer and the number of moles “b” of the whole structural unit contained in the chain polymer, (a/b), is from 0.03 to 0.25, and a density of the chain polymer occupying the surface of the solid-phase support is 0.1 polymers/nm2 or more.
    Type: Application
    Filed: March 13, 2018
    Publication date: July 19, 2018
    Applicants: JSR CORPORATION, JSR Life Sciences Corporation
    Inventor: Yuuichi UEYA
  • Patent number: 9958445
    Abstract: A solid-phase support, formed by binding a chain polymer at least to the surface, wherein the chain polymer is a block polymer comprising a first block constituted from repetitions of a hydrophilic structural unit and a second block constituted from repetitions of a structural unit having a reactive functional group, a content ratio of the number of moles “a” of the reactive functional group contained in the chain polymer and the number of moles “b” of the whole structural unit contained in the chain polymer, (a/b), is from 0.03 to 0.25, and a density of the chain polymer occupying the surface of the solid-phase support is 0.1 polymers/nm2 or more.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: May 1, 2018
    Assignees: JSR CORPORATION, JSR LIFE SCIENCES CORPORATION
    Inventor: Yuuichi Ueya
  • Publication number: 20180105560
    Abstract: Provided is an affinity chromatography carrier that maintains high immunoglobulin-binding capacity and high alkali resistance. An immunoglobulin-binding protein including at least one modified immunoglobulin-binding domain, the modified immunoglobulin-binding domain being a polypeptide consisting of an amino acid sequence of an immunoglobulin-binding domain selected from the group consisting of the B domain, Z domain, C domain, and variants thereof of Staphylococcus aureus protein A, in which at least one amino acid residue is inserted between positions corresponding to the 3-position and position 4 of the amino acid sequence of the B domain, Z domain or C domain.
    Type: Application
    Filed: March 24, 2016
    Publication date: April 19, 2018
    Applicants: JSR CORPORATION, JSR LIFE SCIENCES CORPORATION
    Inventors: Jun-ichi YASUOKA, Takashi ICHII, Satoshi NAKAMURA, Tomonori SHIOTANI, Kaori ITAYA
  • Publication number: 20170292947
    Abstract: Provided is a solid phase carrier which has high water dispersibility, allows facilitated binding of a ligand to a reactive functional group, and exhibits suppressed non-specific adsorption, and with which, in the case of using the solid phase carrier by having a ligand bound thereto, for example, detection of a target substance can be carried out with high sensitivity and low noise.
    Type: Application
    Filed: September 7, 2015
    Publication date: October 12, 2017
    Applicants: JSR CORPORATION, JSR Life Sciences Corporation
    Inventor: Yuuichi UEYA
  • Publication number: 20170145051
    Abstract: Provided is an affinity chromatography carrier that suppresses nonspecific adsorption of impurities, suppresses a decrease in dynamic binding capacity due to long-term storage, and has high storage stability. The affinity chromatography carrier includes a solid support including a copolymer including (M-1) more than 20 parts by mass and 99.5 parts by mass or less of a structural unit derived from an epoxy group-containing monovinyl monomer with respect to and (M-2) 0.5 to 80 parts by mass of a structural unit derived from a polyvinyl monomer with respect to all structural units; ring-opened epoxy groups obtained by subjecting the epoxy groups to the ring-opening ; and a ligand coupled to the solid support, and is such that after a certain column vessel is packed with the affinity chromatography carrier and then purged with a 2 M NaCl-containing 20 mM sodium phosphate buffer with a pH of 7.5, allowing the column to stand at 40° C. for 7 days increases pH in the column by at most 2.
    Type: Application
    Filed: June 25, 2015
    Publication date: May 25, 2017
    Applicants: JSR CORPORATION, JSR Life Sciences Corporation
    Inventors: Masaki MOMIYAMA, Sachiko TSUDA, Tomoya NORINOBU
  • Publication number: 20170146528
    Abstract: To provide a solid-phase carrier to which impurities are hard to nonspecifically adsorb. A solid-phase carrier, formed by binding a chain polymer, wherein the chain polymer comprises a random polymer structure containing a first structural unit having a reactive functional group, and a second structural unit having no reactive functional group or having a reactive functional group having a reactivity lower than that of the reactive functional group of the first structural unit, and the content ratio of the number of moles “a” of the reactive functional group contained in the first structural unit to the number of moles “b” of the entire structural unit contained in the chain polymer, (a/b), is from 0.01 to 0.7.
    Type: Application
    Filed: March 4, 2015
    Publication date: May 25, 2017
    Applicants: JSR CORPORATION, JSR LIFE SCIENCES CORPORATION
    Inventor: Yuuichi UEYA
  • Publication number: 20170138936
    Abstract: To provide a solid-phase carrier that has extremely low nonspecific adsorption of biological substances such as proteins, peptides, nucleic acids and cells, and is capable of maintaining the activity of bound ligands at a high level; and a method for capturing a target substance using the solid-phase carrier.
    Type: Application
    Filed: February 10, 2015
    Publication date: May 18, 2017
    Applicants: JSR CORPORATION, JSR Life Sciences Corporation
    Inventors: Hirokazu KAI, Eiji TAKAMOTO, Kouji TAMORI
  • Publication number: 20170058237
    Abstract: Provided is a lens solution which has excellent lipid detergency, exhibits high hydrophilization performance, and exhibits an excellent lipid adhesion preventive effect and an excellent lubricity-imparting effect when the solution is used to coat a lens. Disclosed is a lens solution containing a polymer having 2.5% to 95% by mass of the following repeating unit (A) and 2.5% to 95% by mass of the following repeating unit (B): (A) a hydrophilic repeating unit; and (B) a repeating unit having a polyoxyalkylene group in a side chain and having the end of the side chain formed from an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group.
    Type: Application
    Filed: February 6, 2015
    Publication date: March 2, 2017
    Applicants: JRS CORPORATION, JSR Life Sciences Corporation
    Inventors: Kazuhiro ISO, Satoshi HYUGAJI
  • Publication number: 20170043320
    Abstract: There are provided a solid-phase carrier and a carrier for affinity refining that exhibit high dynamic binding capacity when a ligand is immobilized, have excellent antifouling properties, and are unlikely to have non-specific adsorption of impurities. The solid-phase carrier has a functional group capable of fixing a ligand and is characterized by having a group having a sulfinyl group, a sulfide group, an oxy group or an imino group, and a hydroxyl group, a thiol group, an amino group, a carboxy group, a sulfate group, a phosphate group or an alkanoyl group.
    Type: Application
    Filed: November 27, 2014
    Publication date: February 16, 2017
    Applicants: JSR CORPORATION, JSR LIFE SCIENCES CORPORATION
    Inventors: Masaki MOMIYAMA, Sachiko TSUDA, Yusuke OKANO, Tomonori SHIOTANI, Yuko KAWADA, Ryou TSUDA, Hiroshi KAWAI
  • Publication number: 20170010270
    Abstract: The present invention relates to a method for assaying soluble GPC3 protein in a test sample, comprising using two different antibodies binding to different epitopes present in the N-terminal region of GPC3 protein.
    Type: Application
    Filed: June 25, 2014
    Publication date: January 12, 2017
    Applicants: CHUGAI SEIYAKU KABUSHIKI KAISHA, JSR CORPORATION, JSR LIFE SCIENCES CORPORATION
    Inventors: Toshihiko OHTOMO, Jun AMANO, Hideki ADACHI, Tsukasa SUZUKI, Motoaki MIZUUCHI, Tetsuji YAMAGUCHI, Seiki WAKUI