Patents Assigned to Kabushiki Kaisha Hayashibara Seibutsu
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Patent number: 7521567Abstract: The objectives of this invention are to extend the range of choosing materials to use in the preparation of photopolymerizable compositions by providing a novel organic compound which absorbs a visible light; or to provide an orgamc material which is useful as host compound in organic electroluminescent devices, as well as its uses: The objectives are attainable by providing an aromatic tertiary amine compound bearing within the same molecule one or more specific atomic groups, a luminescent agent directed to use in organic electroluminescent devices comprising it, and an organic electroluminescent device using such amine compound, as well as its uses.Type: GrantFiled: July 7, 2004Date of Patent: April 21, 2009Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Makoto Fujiwara, Natsuko Sonoda, Makoto Satsuki, Sadaharu Suga, Hisayoshi Fujikawa, Koji Noda, Yasunori Taga
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Publication number: 20090098061Abstract: The objective of the invention is to provide a solution for tissue adhesion prevention and a method for tissue adhesion prevention that are applicable to general surgery and in which covering condition during surgery is stable and convenient. The invention is the solution for tissue adhesion prevention of which the active ingredient is trehalose. Also, it contains at least one or more among antioxidants, chelates, antiseptics, hemostatics, anti-inflammatory agents, and polysaccharides, mucopolysaccharides, salts of polysaccharides and salts of mucopolysaccharides having lubricating properties. This solution for tissue adhesion prevention is provided as any form of perfusion fluid, spray fluid, solution for spray or vaporization administration, foam-like aerosol preparation, injection solution for intravenous fluids, intravenous fluid.Type: ApplicationFiled: June 8, 2006Publication date: April 16, 2009Applicants: Cellex K.K., KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO, THE UNIVERSITY OF TOKYOInventors: Shigeki Suzuki, Yoshikatsu Miwa, Nobuo Sasaki, Yuiichi Tei
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Patent number: 7514158Abstract: A method for producing a coumarin compound represented by Formula 1, which comprises a step of reacting a coumarin compound represented by Formula 1 with a compound having an aldehyde group and an activated methylene group; luminous agents for organic EL elements and organic EL elements which all comprise the coumarin compound; and displaying panels and information displaying apparatuses using the organic EL elements: ø(Z)m??Formula 1 wherein in Formula 1, ø is an aromatic ring, heterocycle, or a combination thereof, each Z is the same or a different coumarin group represented by Formula 2; and m is an integer of two or more;Type: GrantFiled: December 10, 2002Date of Patent: April 7, 2009Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Makoto Satsuki, Makoto Fujiwara, Natsuko Ishida, Sadaharu Suga, Hisayoshi Fujikawa, Hisato Takeuchi, Yasunori Taga
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Publication number: 20090088390Abstract: The present invention provides a polypeptide inducing the production of an antibody in permucosal administration in the presence of no immunological adjuvant, a composition containing the polypeptide, and use thereof. The present invention solves the above object by providing a polypeptide inserted with a cell attachment motif of a cell adhesive molecule to the peptide which has an amino acid sequence of multiagretope type T cell epitope at the amino terminal side of an inserted linker peptide, and an amino acid sequence of a B cell epitope at the carboxyl terminal side of the inserted linker peptide, a composition containing the polypeptide, and use thereof.Type: ApplicationFiled: June 9, 2008Publication date: April 2, 2009Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventor: Toshiki NISHIZAWA
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Publication number: 20090081401Abstract: An optical recording medium which comprises a substrate and a recording layer provided on the substrate by using an organic dye compound having absorption maximum in a region with wavelengths longer than that of a writing light used, and which records information by allowing to irradiate the recording layer with the writing light to act on the organic dye compound to form a pit on the substrate.Type: ApplicationFiled: September 17, 2008Publication date: March 26, 2009Applicant: Kabushiki Kaisha, Hayashibara, Seibutsu, Kagaku KenkyInventors: Fumio Matsui, Yasushi Aizawa, Dai Matsuura
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Publication number: 20090075908Abstract: The present invention has an object to provide an agent for strengthening calcium-containing tissues, which can be safely applied; and its use: The present invention solves the object by providing an agent for strengthening calcium-containing tissues, which comprises one or more flavones, flavonols, flavanones, flavanonols, anthocyanidins, flavanols, chalcones, and aurones.Type: ApplicationFiled: September 15, 2008Publication date: March 19, 2009Applicant: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyInventors: Masaki Miyake, Shimpei Ushio, Kanso Iwaki, Masashi Kurimoto
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Publication number: 20090076278Abstract: The present invention provides novel organic compounds, which absorb the light in the ultra violet and the infrared regions, have improved light tolerance and solubility in solvents, and have thermal tolerance suitable for uses to which the organic compounds are applied, and provides uses of the same. The above objects are solved by providing indolenine compounds and methine dyes, which have a bis-indolenine skeleton composed of two indolenine rings linked together at their respective C-3 positions via a divalent linking group, and by providing optical recording media containing the methine dyes.Type: ApplicationFiled: November 7, 2006Publication date: March 19, 2009Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Yasufumi Dan-Oh, Masahiko Toki, Kentaro Yano, Yasushi Aizawa
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Publication number: 20080241904Abstract: A novel process for producing isomaltose and uses thereof and comprising the steps of contacting saccharides, which have a glucose polymerization degree of at least two and ?-1,4 glucosidic linkage as a linkage at the non-reducing end, with an ?-isomaltosylglucosaccharide-forming enzyme, in the presence or the absence of ?-isomaltosyl-transferring enzyme to form a-isomaltosylglucosaccharides, which have a glucose polymerization degree of at least three, ?-1,6 glucosidic linkage as a linkage at the non-reducing end, and ?-1,4 glucosidic linkage as a linkage other than the non-reducing end, and/or to form cyclo{?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-(1?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-(1?}; contacting the saccharides so formed with isomaltose-releasing enzyme to release isomaltose; and collecting the released isomaltose; and uses thereof.Type: ApplicationFiled: July 12, 2007Publication date: October 2, 2008Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Michio Kubota, Tomoyuki Nishimoto, Takanobu Higashiyama, Hikaru Watanabe, Shigeharu Fukuda, Toshio Miyake
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Publication number: 20080221045Abstract: An object of the present invention is to provide a means for improving hepatic function of mammals including humans to normal condition. The present invention achieves the above object by providing a hepatic function-improving agent comprising ?-glucosyl-hesperidin as an effective ingredient.Type: ApplicationFiled: November 21, 2005Publication date: September 11, 2008Applicant: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Hitoshi Mitsuzumi, Mika Takami, Yoshikatsu Miwa, Hiroto Chaen, Toshio Miyake
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Publication number: 20080214499Abstract: The object of the present invention is to provide a lipid-regulating agent or a composition for regulating the amount of lipids comprising the agent. The present invention solves the above object by providing a lipid-regulating agent comprising a cyclic tetrasaccharide and/or its saccharide-derivative(s) and a composition for regulating the amount of lipids comprising the lipid-regulating agent.Type: ApplicationFiled: February 19, 2008Publication date: September 4, 2008Applicant: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Kazuyuki Oku, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
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Patent number: 7419727Abstract: This invention has an objective to improve durability at elevated temperature in organic electroluminescent devices using coumarin derivatives as dopant in a luminescent layer. This invention attains the above objective by providing in the organic electroluminescent devices formed by laminating an anode, a hole injection layer, a hole transportation layer, a luminescent layer, an electron transportation layer and a cathode in this order, the luminescent layer which comprises as dopant the green light-emitting coumarin derivative and hole- and electron-transporting substances as host; said coumarin derivative consisting of a plurality of coumarin groups bound to an aromatic ring, heterocycle, or any combination thereof, and exhibiting a glass transition point of 150° C. or higher or a melting point of 297° C. or higher.Type: GrantFiled: February 12, 2004Date of Patent: September 2, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Kazushige Kojima, Kojiro Tachi, Hisayoshi Fujikawa, Koji Noda, Masahiko Ishii, Yasunori Taga, Makoto Satsuki, Makoto Fujiwara, Natsuko Ishida, Sadaharu Suga
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Patent number: 7414038Abstract: The object of the present invention is to provide an embolizing material which is easily handleable and stable in quality and is solved by providing an embolizing material comprising an ester derivative of a polysaccharide having a weight-average molecular weight of 10,000-500,000 daltons and an average substitution degree of acyl group of over two; an embolizing agent for arteriovenous aneurysm, which comprises the embolizing material and an appropriate physiologically acceptable water-soluble organic acid; and a method of producing an embolizing agent, which comprises a step of dissolving the embolizing material in an appropriate physiologically acceptable water-soluble organic solvent.Type: GrantFiled: October 5, 2001Date of Patent: August 19, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Kazushi Kinugasa, Shinya Mandai
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Patent number: 7405048Abstract: A monoclonal antibody which is specific to a polypeptide having a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing. The monoclonal antibody is obtainable from hybridomas and can be used for the purification and detection of the polypeptide. The polypeptide strongly induces the IFN-? production by immunocompetent cells with only a small amount, and dose not cause serious side effects even when administered to human in a relatively-high dose.Type: GrantFiled: December 24, 2002Date of Patent: July 29, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Toshio Kunikata, Mutsuko Taniguchi, Keizo Kohno, Masashi Kurimoto
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Patent number: 7402375Abstract: The present invention provides organic dye compounds having their absorption maxima in a region ranging from the ultraviolet region to a relatively short wavelength visible region and uses thereof. The present invention provides specific monomethine cyanine dyes, light absorbents and optical recording media comprising the monomethine cyanine dyes, and a process for producing the monomethine cyanine dyes which comprises a step of reacting a quaternary ammonium salt of nitrogen atom-containing heterocyclic compound having a reactive methyl group with a quaternary ammonium salt of nitrogen atom-containing heterocyclic compound having an appropriate leaving group.Type: GrantFiled: May 16, 2003Date of Patent: July 22, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Chiaki Kasada, Yasushi Aizawa, Toshio Kawata, Shigeo Yasui
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Patent number: 7384636Abstract: The present invention provides a polypeptide inducing the production of an antibody in permucosal administration in the presence of no immunological adjuvant, a composition containing the polypeptide, and use thereof. The present invention solves the above object by providing a polypeptide inserted with a cell attachment motif of a cell adhesive molecule to the peptide which has an amino acid sequence of multiagretope type T cell epitope at the amino terminal side of an inserted linker peptide, and an amino acid sequence of a B cell epitope at the carboxyl terminal side of the inserted linker peptide, a composition containing the polypeptide, and use thereof.Type: GrantFiled: March 29, 2004Date of Patent: June 10, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventor: Toshiki Nishizawa
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Patent number: 7375225Abstract: 4-Cyanocoumarin derivatives which have a distinct sensitivity to visible light, distinct luminescent ability, and satisfactory applicability for photochemical polymerization, dye lasers, and organic electroluminescent elements. Since most of the derivatives have a fluorescent maximum wavelength of 600 to 650 nm, particularly, 610 to 630 nm, they are extremely useful as luminescent agents for organic EL elements which emit visible light in a red-color region, and can be quite useful as luminescent agents in organic EL elements and laser-active substances in dye lasers, as well as luminous bodies as lighting sources for lighting devices, and information displays for visually displaying information.Type: GrantFiled: January 21, 2003Date of Patent: May 20, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Yoshio Taniguchi, Toshiki Koyama, Chihaya Adachi, Tomoyasu Saitou, Makoto Satsuki, Akira Shinpo, Sadaharu Suga, Shizuo Tokito, Hisayoshi Fujikawa, Koji Noda, Atsushi Miura, Yasunori Taga
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Publication number: 20080113938Abstract: The present invention has an object to provide an accelerator for mineral absorption and a composition containing the accelerator. The object is solved by providing an accelerator for mineral absorption comprising cyclic tetrasaccharide and/or saccharide derivatives thereof and a composition containing the accelerator.Type: ApplicationFiled: December 20, 2007Publication date: May 15, 2008Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Kazuyuki OKU, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
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Patent number: 7354694Abstract: The present invention provides styryl dyes which have absorption maxima at a wavelength of 400 nm or less and are sensitive to a laser beam with a wavelength of 450 nm or less, light absorbents and optical recording media which comprise the styryl dyes, and a process for producing the styryl dyes which comprises reacting with an aldehyde compound a quaternary ammonium salt of nitrogen atom containing heterocyclic compound having an active methyl or active methylene group.Type: GrantFiled: November 24, 2000Date of Patent: April 8, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyukoInventors: Chiaki Kasada, Toshio Kawata, Kentaro Yano, Shigeo Yasui
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Publication number: 20080032350Abstract: The object of the present invention is to provide an ?-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an ?-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the ?-1,6 glucosidic linkage as a linkage at the non-reducing end and the ?-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the ?-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the ?-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; ?-isomaltosyl-transferring method using the enzyme; method for forming ?-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{66)-?-D-glucopyranosyl-(163)-?-D-glucopyranosyl-Type: ApplicationFiled: May 9, 2007Publication date: February 7, 2008Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Michio Kubota, Keiji Tsusaki, Takanobu Higashiyama, Shigeharu Fukuda, Toshio Miyake
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Publication number: 20080003651Abstract: The object of the present invention is to provide an ?-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an ?-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the ?-1,6 glucosidic linkage as a linkage at the non-reducing end and the ?-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the ?-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the ?-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; ?-isomaltosyl-transferring method using the enzyme; method for forming ?-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{66)-?-D-glucopyranosyl-(163)-?-D-glucopyranosyl-Type: ApplicationFiled: May 9, 2007Publication date: January 3, 2008Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Michio Kubota, Keiji Tsusaki, Takanobu Higashiyama, Shigeharu Fukuda, Toshio Miyake