Patents Assigned to Kabushiki Kaisha Hayashibara Seibutsu
  • Reduction inhibitory agent for active-oxygen eliminating activity
    Publication number: 20040058592
    Abstract: A reduction inhibitory agent for active-oxygen eliminating activity which comprises trehalose as an effective ingredient, a method for inhibiting the reduction of active-oxygen eliminating activity which comprises incorporating either trehalose or the reduction inhibitory agent into plant edible products and/or plant antioxidants, and a composition where the reduction of active-oxygen eliminating activity of the plant edible products and/or plant antioxidants is satisfactorily inhibited by the method.
    Type: Application
    Filed: September 26, 2003
    Publication date: March 25, 2004
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Hajime Aga, Takashi Shibuya, Shigeharu Fukuda, Toshio Miyake
  • Method for estimating therapeutic efficacy of tumor necrosis factor
    Publication number: 20040053288
    Abstract: Disclosed is a method for estimating the therapeutic efficacy of physiologically active substances or antitumor agents, particularly, tumor necrosis factor (TNF-&agr;) in the treatment of cancers. The method comprises a step of evaluating the expression level of a TNF-&agr;-related gene in a cancer cell.
    Type: Application
    Filed: April 9, 2003
    Publication date: March 18, 2004
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Yoshiaki Yanai, Shigeto Yamamoto, Kozo Yamamoto, Hakuo Ikegami
  • Cyanine dye
    Patent number: 6683188
    Abstract: The present invention provides organic dye compounds having their absorption maxima in a region ranging from the ultraviolet region to a relatively short wavelength visible region and uses thereof. The present invention provides specific monomethine cyanine dyes, light absorbents and optical recording media comprising the monomethine cyanine dyes, and a process for producing the monomethine cyanine dyes which comprises a step of reacting a quaternary ammonium salt of nitrogen atom-containing heterocyclic compound having a reactive methyl group with a quaternary ammonium salt of nitrogen atom-containing heterocyclic compound having an appropriate leaving group.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: January 27, 2004
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Chiaki Kasada, Yasushi Aizawa, Toshio Kawata, Shigeo Yasui
  • Physiologically active complex
    Publication number: 20040001802
    Abstract: Disclosed is a physiologically active complex which comprises a proteinaceous part with TNF activity and a high molecular part bound artificially to the N-terminus of the proteinaceous part. The proteinaceous part in the complex has the amino acid sequence of SEQ ID NO:2 where Xaa is a member selected from the group consisting of asparagine, alanine, arginine, serine, threonine, proline, methionine, and leucine; while the high molecular part in the complex is a homopolymer of polyethylene glycol, copolymer of polyethylene glycol, or a derivative thereof.
    Type: Application
    Filed: January 31, 2003
    Publication date: January 1, 2004
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Tadanori Mayumi, Yasuo Tsutsumi, Shinsaku Nakagawa, Hakuo Ikegami
  • Crystalline alpha-D-glucosyl alpha-D-galactoside, saccharide composition comprising the same, process for producing the same, and uses thereof
    Publication number: 20030228404
    Abstract: A crystalline &agr;-D-glucosyl &agr;-D-galactoside which has a melting point of 119-123° C.; a saccharide composition comprising the same; a process for producing the same or the saccharide composition comprising the same, which comprises (i) crystallizing &agr;-D-glucosyl &agr;-D-galactoside from its solution and (ii) collecting the grown crystalline &agr;-D-glucosyl &agr;-D-galactoside; a method for converting amorphous &agr;-D-glucosyl &agr;-D-galactoside to crystalline &agr;-D-glucosyl &agr;-D-galactoside in the presence of moisture; and a composition comprising the crystalline &agr;-D-glucosyl &agr;-D-galactoside or the saccharide composition comprising the same.
    Type: Application
    Filed: June 6, 2003
    Publication date: December 11, 2003
    Applicant: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Tomoyuki Nishimoto, Michio Kubota, Shigeharu Fukuda
  • Formazan metal complex
    Patent number: 6645594
    Abstract: The present invention provides organic compounds which improve the light resistance of organic dye compounds without substantially deteriorating their preferable light properties when applied to them, and have satisfactory solubility in organic solvents and compatibility with organic dye compounds.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: November 11, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kentaro Yano, Katsumi Orita, Toshio Kawata, Shigeo Yasui
  • Inhibitory agent for protein denaturation, kneaded meat with suppressed freezing-denaturation, process thereof, and process of fish and meat paste products
    Patent number: 6641853
    Abstract: Disclosed is an inhibitory agent for kneaded meat and process for producing fish and meat paste products, especially, kamabokos, and fish sausages. The inhibitory agent comprises (i) a member selected from sorbitol, trehalose, mixture thereof, and another saccharide(s) containing sorbitol and/or trehalose; and (ii) a pH-controlling agent which adjusts a kneaded meat to an alkaline pH. The agent effectively inhibits the protein denaturation of kneaded meat, and fish- and meat-paste products without using a phosphate.
    Type: Grant
    Filed: January 10, 2000
    Date of Patent: November 4, 2003
    Assignees: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenyuojo, Aoba Kasei Kabushiki Kaisha
    Inventors: Teruo Kowata, Mitsutake Sato, Takeo Shimomura, Masami Yamashita
  • Pharmaceutical composition for ophtalmic use
    Publication number: 20030186931
    Abstract: An ophthalmic pharmaceutical composition comprising trehalose as an effective ingredient and a pharmaceutically-acceptable carrier. The pharmaceutical composition is a safe, long-term continuously-administrable, therapeutic and/or prophylactic agent for the ophthalmologic clinical symptoms and signs in Sjögren syndrome.
    Type: Application
    Filed: March 24, 2003
    Publication date: October 2, 2003
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Toshihiko Matsuo, Masashi Kurimoto, Hiroshi Yamauchi
  • Cyanine dyes
    Publication number: 20030181727
    Abstract: The present invention provides organic dye compounds having their absorption maxima in a region ranging from the ultraviolet region to a relatively short wavelength visible region and uses thereof. The present invention provides specific monomethine cyanine dyes, light absorbents and optical recording media comprising the monomethine cyanine dyes, and a process for producing the monomethine cyanine dyes which comprises a step of reacting a quaternary ammonium salt of nitrogen atom-containing heterocyclic compound having a reactive methyl group with a quarternary ammonium salt of nitrogen atom-containing heterocyclic compound having an appropriate leaving group.
    Type: Application
    Filed: May 16, 2003
    Publication date: September 25, 2003
    Applicant: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenky
    Inventors: Chiaki Kasada, Yasushi Aizawa, Toshio Kawata, Shigeo Yasui
  • 4-cyanocoumarin derivatives and uses thereof
    Publication number: 20030176520
    Abstract: 4-Cyanocoumarin derivatives which have a distinct sensitivity to visible light, distinct luminescent ability, and satisfactory applicability for photochemical polymerization, dye lasers, and organic electroluminescent elements. Since most of the derivatives have a fluorescent maximum wavelength of 600 to 650 nm, particularly, 610 to 630 nm, they are extremely useful as luminescent agents for organic EL elements which emit visible light in a red-color region, and can be quite useful as luminescent agents in organic EL elements and laser-active substances in dye lasers, as well as luminous bodies as lighting sources for lighting devices, and information displays for visually displaying information.
    Type: Application
    Filed: January 21, 2003
    Publication date: September 18, 2003
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Yoshio Taniguchi, Toshiki Koyama, Chihaya Adachi, Tomoyasu Saitou, Makoto Satsuki, Akira Shinpo, Sadaharu Suga, Shizuo Tokito, Hisayoshi Fujikawa, Koji Noda, Atsushi Miura, Yasunori Taga
  • DNA which encodes trehalase and uses thereof
    Publication number: 20030166596
    Abstract: Disclosed are a DNA which encodes murine trehalase, a polypeptide expressed by the DNA, and a transgenic- and knockout-animals which have been genetically engineered with the DNA. The DNA comprises a part or the whole of the nucleotide sequence of SEQ ID NO:1.
    Type: Application
    Filed: June 25, 2002
    Publication date: September 4, 2003
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Yoshiaki Yanai, Harumi Ariyasu, Tsunetaka Ohta, Masashi Kurimoto
  • Monoclonal antibody for human IL-18 receptor
    Patent number: 6600022
    Abstract: Disclosed are a receptor protein which recognize a novel cytokine, i.e., interleukin-18, a monoclonal antibody specific to the protein, and uses thereof. The receptor protein is useful as pharmaceutical to treat and prevent autoimmune and allergic disease because it suppresses and regulates excessive immunoreaction. The monoclonal antibody specifically reacts with interleukin-18 receptor, exhibiting efficacy in purification, detection and inhibition of interleukin-18 receptor.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: July 29, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kakuji Torigoe, Shimpei Ushio, Toshio Kunikata, Masashi Kurimoto
  • Polypeptides
    Publication number: 20030133919
    Abstract: Disclosed are a polypeptide (including that in soluble form) as receptor for a novel cytokine, i.e., interleukin-18, a DNA encoding the polypeptide, and the uses of the polypeptide including pharmaceutical and neutralizer to interleukin-18. Pharmaceuticals with the polypeptide is useful to treat and prevent autoimmune and allergic disease because it suppresses and regulates excessive immunoreaction.
    Type: Application
    Filed: January 23, 2003
    Publication date: July 17, 2003
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Kakuji Torigoe, Takanori Okura, Masashi Kurimoto
  • Monoclonal antibody specific to polypeptide which induces interferon-gamma production
    Publication number: 20030129184
    Abstract: A monoclonal antibody which is specific to a polypeptide having a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing. The monoclonal antibody is obtainable from hybridomas and can be used for the purification and detection of the polypeptide. The polypeptide strongly induces the IFN-&ggr; production by immunocompetent cells with only a small amount, and dose not cause serious side effects even when administered to human in a relatively-high dose.
    Type: Application
    Filed: December 24, 2002
    Publication date: July 10, 2003
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Toshio Kunikata, Mutsuko Taniguchi, Keizo Kohno, Masashi Kurimoto
  • Method for inhibiting trimethylamine formation
    Patent number: 6576281
    Abstract: Disclosed are a method for inhibiting trimethylamine formation per se from raw fishery products by incorporating trehalose and/or maltitol, an agent having trehalose and/or maltitol as effective ingredients to inhibit trimethylamine formation per se from raw fishery products, and an edible fishery product with satisfactory flavor and taste obtained by using the method or the agent.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: June 10, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hiroto Chaen, Kazuyuki Oku, Toshio Miyake
  • Inclusion packaged product and preparation of the same
    Patent number: 6576307
    Abstract: An easily-handleable inclusion packaged product having thin-leaf inclusion articles which are prevented from contacting with external atmosphere to give a satisfactorily sanitation. The product can be produced by the steps of (1) coating a solution of an inclusion article on a base sheet, (2) drying the coated solution, and (3) sealing prescribed sections of the base sheet and an overlapping sheet by laminating the overlapping sheet on the base sheet to surround the area coated with the solution.
    Type: Grant
    Filed: November 28, 1997
    Date of Patent: June 10, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kyoichi Otsu, Naoko Yamashita, Yoshiji Okumura, Toshio Miyake
  • Process for producing high 2-O-&agr;-D-glucopyranosyl-L-ascorbic acid
    Patent number: 6576446
    Abstract: Disclosed is a process for producing a high &agr;G-AA content product, which comprises the steps of: contacting a solution as a material solution, containing &agr;G-AA, L-ascorbic acid, and a saccharide(s), with an anion exchange resin packed in a column to adsorb the &agr;G-AA and L-ascorbic acid on the anion exchanger; washing the anion exchanger with water to remove the saccharide(s) therefrom; feeding to the column an aqueous solution, as an eluent, of an acid and/or a salt with a concentration of less than 0.5 N to fractionate a fraction rich in 2-O-&agr;-D-glucopyranosyl-L-ascorbic acid and a fraction rich in L-ascorbic acid; and collecting the former fraction.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: June 10, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hiroshi Yamasaki, Koichi Nishi, Toshio Miyake
  • 4-cyanocoumarin derivatives and uses thereof
    Patent number: 6573380
    Abstract: 4-Cyanocoumarin derivatives which have a distinct sensitivity to visible light, distinct luminescent ability, and satisfactory applicability for photochemical polymerization, dye lasers, and organic electroluminescent elements. Since most of the derivatives have a fluorescent maximum wavelength of 600 to 650 nm, particularly, 610 to 630 nm, they are extremely useful as luminescent agents for organic EL elements which emit visible light in a red-color region, and can be quite useful as luminescent agents in organic EL elements and laser-active substances in dye lasers, as well as luminous bodies as lighting sources for lighting devices, and information displays for visually displaying information.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: June 3, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Yoshio Taniguchi, Toshiki Koyama, Chihaya Adachi, Tomoyasu Saitou, Makoto Satsuki, Akira Shinpo, Sadaharu Suga, Shizuo Tokito, Hisayoshi Fujikawa, Koji Noda, Atsushi Miura, Yasunori Taga
  • DNA encoding polypeptides having interferon-gamma inducing activity
    Publication number: 20030092130
    Abstract: Disclosed are created stable polypeptides which are capable of inducing the production of interferon-gamma by immunocompetent cells. The present polypeptides contain specific amino acid sequences usually derived from the wild-type polypeptides, being capable of the production of interferon-gamma, by replacing the cysteine(s) with different amino acid(s). The present polypeptides possess a stability and an activity of inducing the production of IFN-&ggr; by immunocompetent cells, both of which are significantly higher than those of the wild-type polypeptides. In addition to the activity, the present polypeptides can exhibit remarkable activities of inducing the formation of killer cells and enhancing thier cytotoxicities. The present polypeptides are easily obtainable by the process according to the present invention using recombinant DNA techniques.
    Type: Application
    Filed: October 1, 2002
    Publication date: May 15, 2003
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Kozo Yamamoto, Iwao Okamoto, Masashi Kurimoto
  • Polypeptides that bind interleukin-18 (IL-18)
    Patent number: 6559298
    Abstract: Disclosed are a polypeptide (including that in soluble form) as receptor for a novel cytokine, i.e., interleukin-18, a DNA encoding the polypeptide, and the uses of the polypeptide including pharmaceutical and neutralizer to interleukin-18. Pharmaceuticals with the polypeptide is useful to treat and prevent autoimmune and allergic disease because it suppresses and regulates excessive immunoreaction.
    Type: Grant
    Filed: April 24, 2000
    Date of Patent: May 6, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kakuji Torigoe, Takanori Okura, Masashi Kurimoto