Patents Assigned to Kabushiki Kaisha Hayashibara Seibutsu
  • Pharmaceutical composition for ophthalmic use
    Patent number: 6555526
    Abstract: An ophthalmic pharmaceutical composition comprising trehalose as an effective ingredient and a pharmaceutically-acceptable carrier. The pharmaceutical composition is a safe, long-term continuously-administrable, therapeutic and/or prophylactic agent for the ophthalmologic clinical symptoms and signs in Sjögren syndrome.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: April 29, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Toshihiko Matsuo, Masashi Kurimoto, Hiroshi Yamauchi
  • Hedgehog protein
    Publication number: 20030059838
    Abstract: Disclosed are a novel hedgehog protein, i.e., a Desert hedgehog protein of human origin including mature and precursor forms, a DNA encoding the protein, a monoclonal antibody recognizing the protein, a process for producing the protein, and a method for detecting the protein. The hedgehog protein is useful in establishment of hybridomas which produce antibodies recognizing the protein, and the monoclonal antibody is useful in detection and purification of the protein. The hedgehog protein, DNA, and monoclonal antibody of this invention have efficacy in elucidation of hereditary morphological abnormalities in humans to establish their treatments and diagnoses.
    Type: Application
    Filed: May 17, 2002
    Publication date: March 27, 2003
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Toshio Ariyasu, Shuji Nakamura, Kunzo Orita
  • Polypeptides having L-asparaginase activity
    Patent number: 6537547
    Abstract: Disclosed are polypeptides which originate from mammal, having L-asparaginase activity. The polypeptides are easily prepared by applying recombinant DNA techniques to DNAs encoding the polypeptides and they exert satisfactory effects in the treatment and/or the prevention for diseases caused by tumor cells dependent on L-asparagine, and cause no substantial serious side effects even when administered to humans in relatively-high dose.
    Type: Grant
    Filed: June 5, 1997
    Date of Patent: March 25, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Takeshi Ario, Madoka Taniai, Kozo Yamamoto, Masashi Kurimoto
  • Espression enhancer for protein synthesis inhibitory genes
    Publication number: 20030039629
    Abstract: The objects of the present invention are to reveal a specific combination of human interferon-&agr; subtypes that remarkably enhances the expression of protein synthesis inhibitory genes, and to provide an expression enhancer comprising as effective ingredients interferon-&agr; subtypes in such a combination and uses thereof. The above objects are solved by providing an expression enhancer for protein synthesis inhibitory genes which comprises as effective ingredients interferon-&agr;2 and interferon-&agr;8 subtypes of human interferon-&agr;, and uses thereof including pharmaceuticals.
    Type: Application
    Filed: September 26, 2001
    Publication date: February 27, 2003
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Yoshiaki Yanai, Osamu Sano, Masashi Kurimoto
  • Cyanine dyes
    Patent number: 6525181
    Abstract: The object of the present invention is to provide organic dye compounds which exert satisfactory optical absorption properties and thermal resistance when used in high density optical recording media. The above object is solved by specific trimethine cyanine dyes, light absorbents and optical recording media which comprise the cyanine dyes, and preparations for the cyanine dyes comprising either reacting a benzoindolium compound having a compatible leaving group with a pyrazinoimidazolium compound having a reactive methyl group; or reacting a benzoindolium compound having a reactive methyl group with a pyrazinoimidazolium compound having a compatible leaving group.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: February 25, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Chiaki Kasada, Katsumi Orita, Kentaro Yano, Toshio Kawata, Shigeo Yasui
  • Physiologically active extract obtained from indigo plant polygonum tinctorium
    Patent number: 6524625
    Abstract: A physiologically active extract comprising an ethyl acetate-soluble ingredient of an indigo plant, which is obtainable by soaking a raw indigo plant in an organic solvent used for extraction. The ethyl acetate-soluble ingredient includes tryptanthrin, 3,5,4′-trihydroxy-6,7-methylenedioxy-flavone, kaempferol, 3,5,7,4′-tetrahydroxy-6-methoxy-flavone, gallic acid, caffeic acid, indirubin, pheophorbide a, and methylpheophorbide a.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: February 25, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyuto
    Inventors: Hajime Aga, Shigeyuki Arai, Shigeharu Fukuda, Toshio Kunikata, Masashi Kurimoto
  • Monoclonal antibody specific to polypeptide which induces interferon-G&ggr; production
    Patent number: 6509449
    Abstract: A monoclonal antibody which is specific to a polypeptide having a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing. The monoclonal antibody is obtainable from hybridomas and can be used for the purification and detection of the polypeptide. The polypeptide strongly induces the IFN-&ggr; production by immunocompetent cells with only a small amount, and dose not cause serious side effects even when administered to human in a relatively-high dose.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: January 21, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Toshio Kunikata, Mutsuko Taniguchi, Keizo Kohno, Masashi Kurimoto
  • Polypeptides having interferon-&ggr; inducing activity
    Patent number: 6476197
    Abstract: Disclosed are created stable polypeptides which are capable of inducing the production of interferon-gamma by immunocompetent cells. The present polypeptides contain specific amino acid sequences usually derived from the wild-type polypeptides, being capable of the production of interferon-gamma, by replacing the cysteine(s) with different amino acid(s). The present polypeptides possess a stability and an activity of inducing the production of IFN-&ggr; by immunocompetent cells, both of which are significantly higher than those of the wild-type polypeptides. In addition to the activity, the present polypeptides can exhibit remarkable activities of inducing the formation of killer cells and enhancing thier cytotoxicities. The present polypeptides are easily obtainable by the process according to the present invention using recombinant DNA techniques.
    Type: Grant
    Filed: December 1, 1997
    Date of Patent: November 5, 2002
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kozo Yamamoto, Iwao Okamoto, Masashi Kurimoto
  • Osteoclastgenic inhibitory agent
    Publication number: 20020150555
    Abstract: An osteoclastgenic inhibitory agent which comprises an interleukin-18 and/or its functional equivalent. The agent can be arbitrarily used as an ingredient for cell culture and agents for regulating bone resorption and for osteoclast-related diseases, directed to treat and/or prevent hypercalcemia, osteoclastoma, osteoporosis, etc.
    Type: Application
    Filed: March 19, 2002
    Publication date: October 17, 2002
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Matthew Todd Gillispie, Nicole Joy Horwood, Nobuyuki Udagawa, Masashi Kurimoto
  • Pyran derivatives
    Patent number: 6455579
    Abstract: Disclosed are pyran derivatives, which have distinctive sensitivity to visible light and distinctive luminous ability. The derivatives are useful in photopolymerization, electroluminescence, and dye lasers, and are obtainable through a step of reacting a compound having a 4-cyanomethylene-2-methyl-4H-pyran skeleton with a compound having a 3-formylcoumarin skeleton.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: September 24, 2002
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Makoto Satsuki, Akira Shinpo, Yasuyo Ooga, Sadaharu Suga, Atsushi Oda, Hiroshi Tada, Yoshikazu Sakaguchi
  • Anti-HIV infection agents and method for treating HIV infection
    Patent number: 6455555
    Abstract: The present invention relates to agents for anti-HIV infection, which contain, as an active ingredient, at least one photosensitizing dye selected from the group consisting of the compounds of the formulae (I) and (II): wherein R1, R2 and R3 are the same or different and each represents alkyl group having 1 to 4 carbon atoms, R4, R5 and R6 are the same or different and each represents alkyl group having 5 to 10 carbon atoms, and X− represents a physiologically acceptable monovalent anion. The present invention also relates to a method for treating or preventing HIV infection diseases, which includes administering the photosensitizing dye. A daily dose of the photosensitizing dye is usually 2 to 100 &mgr;g, and preferably 5 to 40 &mgr;g, per kg body weight.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: September 24, 2002
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Yoshinori Nakagawa, Takehiro Niiyama, Satoshi Tsuboi
  • Hard candy with a relatively-high moisture and hardness, and process of the same
    Patent number: 6455096
    Abstract: A hard candy with a relatively-high moisture and hardness, and process of the same. The levels of moisture and hardness are respectively from about 3.5% to about 10%, and at least 4.0 kg as a penetration strength when measured by a rheometer. The hard candy is characteristic of a relatively-high transparency, insubstantial stickiness to the teeth, and lesser stimulation to the teeth.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: September 24, 2002
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Naohiko Katagiri, Satoshi Iritani, Toshio Miyake
  • Method for preparing inclusion packaged product
    Patent number: 6449925
    Abstract: An inclusion package product is produced by coating a base sheet with a solution of and inclusion article; drying the solution coated onto the base sheet; and placing an overlapping sheet onto the base sheet and sealing prescribed sections of the base sheet to the overlapping sheet to surround the area coated with the solution.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: September 17, 2002
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kyoichi Otsu, Naoko Yamashita, Yoshiji Okumura, Toshio Miyake
  • Peptide
    Publication number: 20020128450
    Abstract: Disclosed are artificially produced peptide capable of neutralizing the biological activities of IL-18, which comprises a part or the whole of the variable regions in anti interleukin 18 antibody, including single chain variable region fragments and humanized antibodies, a process of producing the peptide, and uses thereof. The peptide is useful as pharmaceutical to treat and prevent diseases such as autoimmune diseases and inflammatory diseases, where the biological activities of interleukin-18 are involved.
    Type: Application
    Filed: August 8, 2001
    Publication date: September 12, 2002
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Yoshihiro Nishida, Takanori Okura, Tadao Tanimoto, Masashi Kurimoto
  • Agent for anti-osteoporosis
    Patent number: 6440446
    Abstract: An orally or parenterally administrable agent for anti-osteoporosis, comprising trehalose as an effective ingredient and optionally another ingredients, that exerts a satisfactory therapeutic/prophylactic effect on osteoporosis with lesser side effects.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: August 27, 2002
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Chiyo Yoshizane, Yasushi Nishizaki, Shigeyuki Arai, Masashi Kurimoto
  • Protein which induces interferon-&ggr; production by immunocompetent cell
    Patent number: 6441138
    Abstract: A protein of human cell origin, which induces the IFN-&ggr; production by immunocompetent cells and has the amino acid sequence of SEQ ID NO:1 near at the N-terminus. It can be produced from human cells such as lymphoblasts, lymphocytes, monoblasts, monocytes, myeloblasts, myelocytes, granulocytes and macrophages, and used for preventing and/or treating IFN-&ggr; susceptive diseases.
    Type: Grant
    Filed: January 3, 2001
    Date of Patent: August 27, 2002
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kenji Akita, Yoshiyuki Nukada, Mitsukiyo Fujii, Tadao Tanimoto, Masashi Kurimoto
  • Polypeptides having L-asparaginase activity
    Patent number: 6436396
    Abstract: Disclosed are polypeptides which originate from mammal, having L-asparaginase activity. The polypeptides are easily prepared by applying recombinant DNA techniques to DNAs encoding the polypeptides and they exert satisfactory effects in the treatment and/or the prevention for diseases caused by tumor cells dependent on L-asparagine, and cause no substantial serious side effects even when administered to humans in relatively-high dose.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: August 20, 2002
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Takeshi Ario, Madoka Taniai, Kozo Yamamoto, Masashi Kurimoto
  • Method and composition for improving the aftertaste of sucrose
    Patent number: 6432470
    Abstract: A method for improving the aftertaste of sucrose without lowering the sweetening power of sucrose, which comprises incorporating trehalose into sucrose in an amount of 2-12% to the sucrose, on a dry solid basis. The method produces saccharide compositions and food products having improved aftertaste of sucrose without lowering the sweetening power of sucrose.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: August 13, 2002
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hiroto Chaen, Masakazu Mitsuhashi, Toshio Miyake
  • Cyanine dyes
    Patent number: 6413607
    Abstract: The present invention provides organic dye compounds which exert excellent recording characteristics in high-density optical recording media, and uses thereof. The present invention solves the objects of the present invention by providing non-symmetric trimethine cyanine dyes having a specific structure and properties, light absorbents and optical recording media comprising the cyanine dyes, and a process for preparing the cyanine dye comprising a step of reacting either 3,3-dimethyl-5-nitroindolium compounds or 3,3-dimethyl-5-sulfonamideindolium compounds, which have a reactive methyl group or an appropriate leaving group, with 3,3-dimethylbezoindolium compounds, which have a reactive methyl group or an appropriate leaving group.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: July 2, 2002
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Chiaki Kasada, Yoshie Hata, Toshio Kawata, Shigeo Yasui
  • Process for producing a pharmaceutical composition containing a protein which induces interferon-&ggr; production by an immunocompetent cell
    Patent number: 6403079
    Abstract: A protein of human cell origin, which induces the IFN-&ggr; production by immunocompetent cells and has the amino acid sequence of SEQ ID NO:1 near at the N-terminus. It can be produced from human cells such as lymphoblasts, lymphocytes, monoblasts, monocytes, myeloblasts, myelocytes, granulocytes and macrophages, and used for preventing and/or treating IFN-&ggr; susceptive diseases.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: June 11, 2002
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kenji Akita, Yoshiyuki Nukada, Mitsukiyo Fujii, Tadao Tanimoto, Masashi Kurimoto