Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
Type:
Grant
Filed:
June 28, 2012
Date of Patent:
July 14, 2015
Assignees:
Kalypsys, Inc., Alcon Laboratories, Inc.
Inventors:
Steven P. Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
Abstract: The present invention relates to salts, hydrates, and polymorphs of bicyclic heteroaryl compounds, and pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of diseases including allergic rhinitis.
Type:
Grant
Filed:
September 7, 2012
Date of Patent:
October 14, 2014
Assignee:
Kalypsys, Inc.
Inventors:
Pingyun Chen, Stephen A. R. Carino, Ricky Wayne Couch, Daniel S. Kinder, Beth A. Norton
Abstract: The present invention relates to substituted tetrazolo[1,5-a]pyrazine compounds for Formula IX: as well as pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
Type:
Grant
Filed:
March 10, 2011
Date of Patent:
October 29, 2013
Assignee:
Kalypsys Inc.
Inventors:
Allen Borchardt, Robert Davis, Stewart A. Noble
Abstract: Disclosed herein are new methods of treatment of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and other fibrotic diseases of the liver in a subject by modulating PPAR? with sulfonyl-substituted bicyclic compounds and compositions as pharmaceuticals.
Abstract: The present invention relates to salts, hydrates, and polymorphs of bicyclic heteroaryl compounds, and pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of diseases including allergic rhinitis.
Type:
Application
Filed:
September 7, 2012
Publication date:
September 19, 2013
Applicant:
KALYPSYS, INC.
Inventors:
Pingyun Chen, Stephen A.R. Carino, Ricky Wayne Couch, Daniel S. Kinder, Beth A. Norton
Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
Type:
Application
Filed:
June 28, 2012
Publication date:
July 11, 2013
Applicant:
KALYPSYS, INC.
Inventors:
Steven Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
Type:
Application
Filed:
November 7, 2011
Publication date:
May 9, 2013
Applicant:
KALYPSYS, INC.
Inventors:
Steven P. Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
Type:
Application
Filed:
February 10, 2012
Publication date:
February 21, 2013
Applicant:
KALYPSYS, INC.
Inventors:
Steven P. Govek, Clay Beauregard, Daniel A. Gamache, Mark R. Hellberg, Stewart A. Noble, Andrew K. Shiau, David J. Thomas, John M. Yanni
Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
Type:
Grant
Filed:
July 6, 2007
Date of Patent:
September 4, 2012
Assignee:
Kalypsys Inc.
Inventors:
Steven Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
Type:
Grant
Filed:
August 19, 2009
Date of Patent:
March 20, 2012
Assignee:
Kalypsys, Inc.
Inventors:
Steven P. Govek, Clay Beauregard, Daniel A. Gamache, Mark R. Hellberg, Stewart A. Noble, Andrew K. Shiau, David J. Thomas, John M. Yanni
Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
Type:
Application
Filed:
November 21, 2011
Publication date:
March 15, 2012
Applicants:
ALCON RESEARCH, LTD, KALYPSYS, INC.
Inventors:
Allen J. Borchardt, Clay Beauregard, Travis Cook, Robert L. Davis, Daniel A. Gamache, John M. Yanni
Abstract: The present invention relates to carbazole compounds, pharmaceutical compositions comprising them, and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
Type:
Grant
Filed:
June 11, 2009
Date of Patent:
December 20, 2011
Assignee:
Kalypsys, Inc
Inventors:
Mehmet Kahraman, Allen J. Borchardt, Robert L. Davis, Stewart A. Noble, James W. Malecha
Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
Type:
Application
Filed:
March 10, 2011
Publication date:
October 20, 2011
Applicant:
KALYPSYS, INC.
Inventors:
Allen Borchardt, Robert Davis, Clay Beauregard, Daniel Becker, Daniel Gamache, Stewart A. Noble, Mark Hellberg, Peter Klimko, Zhihai Qiu, Joseph Payne, John Yanni
Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
Type:
Application
Filed:
March 9, 2011
Publication date:
September 29, 2011
Applicant:
Kalypsys, Inc.
Inventors:
Allen Borchardt, Robert Davis, Clay Beauregard, Daniel Gamache, Mark Hellberg, Peter Klimko, John Yanni
Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
Type:
Application
Filed:
March 10, 2011
Publication date:
September 29, 2011
Applicant:
KALYPSYS, INC.
Inventors:
Allen Borchardt, Robert Davis, Stewart A. Noble
Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
Type:
Grant
Filed:
September 4, 2008
Date of Patent:
March 29, 2011
Assignee:
Kalypsys, Inc
Inventors:
Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen K. Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steve P. Govek
Abstract: Salt forms of potent modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
Type:
Grant
Filed:
October 23, 2006
Date of Patent:
January 4, 2011
Assignee:
KALYPSYS, Inc
Inventors:
Dennis A. Bennett, Stephan D. Parent, David T. Jonaitis
Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
Type:
Grant
Filed:
September 4, 2008
Date of Patent:
November 16, 2010
Assignee:
Kalypsys, Inc
Inventors:
Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D Bayne, Mehmet Kahraman, Boliang Lou, Steven P. Govek
Abstract: The present invention relates to compounds and methods useful as inhibitors of nitric oxide synthase. Certain compounds of the subject invention have the following structural formula: wherein T, X, and Y are independently selected from the group consisting of CR4, N, NR4, S, and O; U is selected from the group consisting of CR10 and N; V is selected from the group consisting of CR4 and N; W and W? are independently selected from the group consisting of CH2, CR7R8, NR9, O, N(O), S(O)q and C(O); n, m and p are independently an integer from 0 to 5; q is 0, 1, or 2; and other substituents are as defined herein. Other compounds of the subject invention have structural formulas as defined herein. Also disclosed herein are pharmaceutical compositions comprising the compounds of the subject invention.
Type:
Grant
Filed:
November 28, 2005
Date of Patent:
November 2, 2010
Assignee:
Kalypsys, Inc.
Inventors:
Timothy C. Gahman, Hengyuan Lang, Mark R. Herbert, Angelina M. Thayer, Christian A. Hassig, Stewart A. Noble, Russell D. Cousins, Hui Zhuang, Christopher R. Santos, Xiaohong Chen
Abstract: A plate lid for covering a multi-well plate for use in a high throughput screening (HTS) process. The lid includes a plate section dimensioned to cover the plate, a frame block positioned on the underside perimeter of the plate section to form a recessed center, a skirt section protruding from each edge of the frame block; and a gasket layer positioned on the frame block for sealing the peripheral surface of the multi-well plate.