Patents Assigned to Kalypsys, Inc.
  • Bicyclic heteroaryl inhibitors of PDE4
    Patent number: 7745646
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: June 29, 2010
    Assignee: Kalypsys, Inc.
    Inventors: Steven Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20100120741
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Application
    Filed: September 10, 2009
    Publication date: May 13, 2010
    Applicants: Kalypsys, Inc., Alcon Research, Ltd
    Inventors: Allen J. Borchardt, Clay Beauregard, Travis Cook, Robert L. Davis, Daniel A. Gamache, John M. Yanni
  • ARYL-SUBSTITUTED HETEROCYCLIC PDE4 INHIBITORS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20100105729
    Abstract: Disclosed herein are potent and selective aryl-substituted heterocyclic compounds, useful as inhibitors of phosphodiesterase 4 (PDE4), compositions comprising the same, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of PDE4 activity are also provided, as well as methods for the treatment of inflammatory diseases and other diseases in which PDE4 or one of its isoforms may play a role.
    Type: Application
    Filed: September 20, 2007
    Publication date: April 29, 2010
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Guy Oshiro, Stewart A. Noble, James W. Malecha, Andrew K. Shiau
  • NOVEL METHOD OF PREPARATION OF 5-CHLORO-3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOLE AND (3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOL-5YL)-DIALKYL-AMINES
    Publication number: 20100094021
    Abstract: The present invention discloses a novel method for preparing 3-imidazol-1-yl-[1,2,4]thiadiazole derivatives, particularly to a method of preparing 5-halo-3-imidazol-1-yl-[1,2,4]thiadiazole, more particularly (3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-dialkyl-amines, that afford a high yield of pure product.
    Type: Application
    Filed: December 11, 2009
    Publication date: April 15, 2010
    Applicant: KALYPSYS, INC.
    Inventors: Mark R. Herbert, Russell D. Cousins, Hengyuan Lang, Timothy C. Gahman, Stewart A. Noble
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20100081646
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: August 19, 2009
    Publication date: April 1, 2010
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Clay Beauregard, Daniel A. Gamache, Mark R. Hellberg, Stewart A. Noble, Andrew K. Shiau, David J. Thomas, John M. Yanni
  • AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20100063047
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Application
    Filed: September 10, 2009
    Publication date: March 11, 2010
    Applicants: KALYPSYS, INC., ALCON RESEARCH, LTD
    Inventors: Allen J. Borchardt, Clay Beauregard, Robert L. Davis, Daniel A. Gamache, John M. Yanni
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20100022586
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PD E4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: July 6, 2007
    Publication date: January 28, 2010
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • NOVEL INHIBITORS OF RHO KINASE
    Publication number: 20090318485
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of Rho kinase for the treatment or prevention of disease.
    Type: Application
    Filed: July 20, 2007
    Publication date: December 24, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Allen J. Borchardt, Elisabeth M.M. Gardiner, Stewart A. Noble, Dana L. Siegel
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20090291950
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PD E4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: July 6, 2007
    Publication date: November 26, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • HETEROCYCLIC INHIBITORS OF PDE4
    Publication number: 20090275586
    Abstract: The present invention is directed to potent and selective heterocyclic compounds, useful as inhibitors of phosphodiesterase 4 (PDE4), compositions comprising the same, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of PDE4 activity are also provided, as well as methods for the treatment of inflammatory diseases and other diseases in which PDE4 or one of its isoforms may play a role.
    Type: Application
    Filed: September 20, 2007
    Publication date: November 5, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Guy Oshiro, Stewart A. Noble, James W. Malecha, Andrew K. Shiau
  • SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR
    Publication number: 20090264417
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: September 4, 2008
    Publication date: October 22, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steven P. Govek
  • SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR
    Publication number: 20090227599
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: March 3, 2009
    Publication date: September 10, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Sergio G. Duron, Andrew K. Lindstrom, Andrew K. Shiau, Boliang Lou, Steven P. Govek, David J. Thomas
  • AMINOQUINAZOLINE CANNABINOID RECEPTOR MODULATORS FOR TREATMENT OF DISEASE
    Publication number: 20090209536
    Abstract: The present invention relates to compounds and methods useful as modulators of CB2 for the treatment or prevention of disease states including, but not limited to pain, autoimmune disease, malabsorption syndrome, pulmonary disease, osteoporosis, muscle spasm in cancer, neuromuscular disorder, and atherosclerosis progression.
    Type: Application
    Filed: June 16, 2008
    Publication date: August 20, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Timothy Gahman, David Thomas, Hengyuan Lang, Mark Eben Massari
  • HETEROCYCLIC MODULATORS OF TGR5
    Publication number: 20090105124
    Abstract: Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of TGR5 activity in a human or animal subject are also provided for the treatment diseases mediated by TGR5.
    Type: Application
    Filed: August 18, 2008
    Publication date: April 23, 2009
    Applicant: Kalypsys, Inc.
    Inventors: Nicholas D. Smith, Joseph E. Payne, Timothy Z. Hoffman, Celine Bonnefous, Anothony B. Pinkerton, Dana L. Siegel
  • Sulfonyl-substituted bicyclic compounds as modulators of PPAR
    Patent number: 7517884
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: April 14, 2009
    Assignee: Kalypsys Inc.
    Inventors: James W. Malecha, Sergio G. Duron, Andrew K. Lindstrom
  • HETEROCYCLODIAZEPINE CANNABINOID RECEPTOR MODULATORS FOR TREATMENT OF DISEASE
    Publication number: 20090062253
    Abstract: The present invention relates to compounds and methods useful as modulators of CB2 for the treatment or prevention of disease states including, but not limited to pain, autoimmune disease, malabsorption syndrome, pulmonary disease, osteoporosis, muscle spasm in cancer, neuromuscular disorder, and atherosclerosis progression.
    Type: Application
    Filed: August 28, 2008
    Publication date: March 5, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Timothy C. Gahman, Cunxiang Zhao, Hengyuan Lang, Mark Eben Massari
  • HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE
    Publication number: 20090054304
    Abstract: The present invention relates to compounds useful as modulators of TGR5 and methods for the treatment or prevention of metabolic, cardiovascular, and inflammatory diseases.
    Type: Application
    Filed: August 8, 2008
    Publication date: February 26, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Mark R. Herbert, Anthony B. Pinkerton, Dana L. Siegel
  • Sulfonyl-substituted bicyclic compounds as modulators of PPAR
    Patent number: 7494999
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: February 24, 2009
    Assignee: Kalypsys, Inc
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steven P. Govek
  • QUINAZOLINONE MODULATORS OF TGR5
    Publication number: 20090035306
    Abstract: The present invention relates to quinazolinone compounds useful as modulators of TGR5 and methods for the treatment or prevention of metabolic, cardiovascular, and inflammatory diseases.
    Type: Application
    Filed: November 20, 2007
    Publication date: February 5, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Anthony B. Pinkerton, Ayman Kabakibi, Timothy Z. Hoffman, Dana L. Siegel, Stewart A. Noble
  • SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR
    Publication number: 20090029971
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: September 4, 2008
    Publication date: January 29, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steve P. Govek