Patents Assigned to Kansas State University Research Foundation
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Patent number: 11445674Abstract: The present disclosure relates to wheat plants having grain with high ?-glucan content, methods for constructing said wheat plants, grain therefrom and uses thereof. Wheat lines homozygous for the HvCslF6 gene from barley having five times the fiber content and an increased ?-glucan content of TA5790, TA5792, and TA5795 are disclosed.Type: GrantFiled: September 30, 2020Date of Patent: September 20, 2022Assignees: General Mills, Inc., Kansas State University Research FoundationInventors: Jesse Poland, Bernd Friebe, Titiana Danilova, Bikram S Gill, Eric Jackson
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Patent number: 11419677Abstract: An electrosurgical device (10) operable to deliver microwave energy to cause targeted tissue ablation is provided. The electrosurgical device (10) comprises an antenna (26), a reflector (30), and a dielectric material (34) disposed therebetween. The selection of the dielectric material (30) and the relative positioning of the antenna (26) and the reflector (30) provide impedance matching between the antenna (26) and a transmission line (12) so as to minimize heating along the length of the device (10) during use.Type: GrantFiled: December 1, 2015Date of Patent: August 23, 2022Assignee: Kansas State University Research FoundationInventors: Punit Prakash, Brogan McWilliams, Emily Frederick
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Patent number: 11371070Abstract: Described herein are antioxidant peptides and methods of producing the same. The antioxidant peptides are produced from cereal grain protein sources, which provide a number of advantages over more expensive antioxidant sources and synthetically-produced antioxidants. The antioxidant peptides are produced by reacting the cereal grain material with an enzyme capable of hydrolyzing proteins within the material, thereby forming hydrolysate peptides. The hydrolysate peptides are then selectively recovered to form an antioxidant peptide product. The antioxidant peptide product is useful in a number of applications, particularly as an ingredient in a food product to provide antioxidant properties to the food product.Type: GrantFiled: October 31, 2019Date of Patent: June 28, 2022Assignee: Kansas State University Research FoundationInventors: Yonghui Li, Shiwei Xu, Ruijia Hu
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Patent number: 11344055Abstract: The invention consists of novel compositions of food-grade coatings comprising mixtures containing propylene glycol as at least one active ingredient and containing at least one inert food-grade acceptable carrier for controlling food pests and pest infestations and reproduction on and/or in food. The invention further provides novel food containers and methods of applying coating compositions, including those of the invention, to foods and to food containers used to store, age, and/or cure the foods.Type: GrantFiled: November 11, 2016Date of Patent: May 31, 2022Assignees: Mississippi State University, Kansas State University Research FoundationInventors: Mark Wes Schilling, Yan Zhao, Yan Campbell, Thomas W. Phillips, Salehe Abbar, Barbara Amoah
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Patent number: 11346087Abstract: Inventive surfaces, and methods of using the same, are provided that exhibit improved water collection and frost formation properties over prior art surfaces. The inventive surfaces have a plurality of nanosized recessed areas formed therein. The geometries and patterns of the recessed areas are particularly designed to discourage water droplet coalescence on the surfaces. Due to these designs, the surfaces are capable of forming and maintaining smaller, as well as asymmetrical, droplets on the surfaces. As a result, a greater surface area of the inventive surfaces can be covered by water droplets, thereby increasing water recovery. In addition, the smaller, asymmetrical droplets lead to desirable frost layer characteristics under non-cryogenic freezing conditions.Type: GrantFiled: May 12, 2017Date of Patent: May 31, 2022Assignee: Kansas State University Research FoundationInventors: Amy Betz, Melanie Derby
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Patent number: 11318470Abstract: Microfluidic devices and nanobiosensors comprising a magnetic nanoparticle attached to a reporter molecule via a release unit for microfluidic-based detection of a target analyte in a biological sample. The nanobiosensors can be magnetically manipulated or guided through the microfluidics channels for incubation with the biological sample, concentration of the nanobiosensors, and detection of target analytes, without having to pump the entire initial sample through a microfluidic channel of the microfluidic device. The magnetic nanoparticles are separated from the reporter molecules before detection and can be re-used.Type: GrantFiled: November 17, 2017Date of Patent: May 3, 2022Assignee: Kansas State University Research FoundationInventors: Christopher T. Culbertson, Stefan H. Bossmann
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Patent number: 11279945Abstract: Isolated cDNA sequences encoding for highly conserved domains of plant viral pathogen genomes. The cDNA sequences are selected from the group consisting of those listed in Table I (SEQ ID NOs: 1-68). cDNA fusion constructs or chimeric transgene constructs comprising at least two different cDNA sequences selected from the list in Table I, and more specifically cDNA corresponding to at least two different viruses is described, along with methods of creating transgenic plants with broad-spectrum, durable resistance to multiple viral pathogens using these cDNA sequences.Type: GrantFiled: May 4, 2017Date of Patent: March 22, 2022Assignees: Kansas State University Research Foundation, Heartland Plant Innovations, Inc.Inventors: Dorith Rotenberg, Anna E. Whitfield, William W. Bockus, Forrest G. Chumley, Rodolfo Acosta-Leal
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Patent number: 11252957Abstract: Described herein are nucleic acid-peptide capsule complexes or nanoparticles comprising pre-formed peptide capsules and nucleic acids bound the exterior surface of the capsule, such that the wrap around the capsule membrane. The peptide capsules comprise bilayer membrane defining a liquid-receiving interior space and comprises a plurality of branched, amphipathic peptides. Method of making and using such complexes for delivering nucleic acids in vivo and in vitro are also described.Type: GrantFiled: August 31, 2017Date of Patent: February 22, 2022Assignee: Kansas State University Research FoundationInventors: John M. Tomich, Gerald Reeck, Luz Adriana Avila Flores, Raman Chandrasekar
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Patent number: 11254048Abstract: Additive manufacturing systems and methods used for creating 3D parts from continuous-fiber reinforced composites such as, e.g., carbon-fiber or glass-fiber pre-impregnated tape are provided. The systems and methods lay tape in successive layers and cut each layer according to a 2D slice of a 3D CAD file. During the placement of each piece of tape, a laser welds the tape to other tape, eliminating the need for post-processing of each layer. By utilizing tape instead of large fiber-reinforced sheets, the systems and methods described herein reduce waste compared to known manufacturing techniques.Type: GrantFiled: February 20, 2018Date of Patent: February 22, 2022Assignee: Kansas State University Research FoundationInventors: Dong Lin, Pedram Parandoush
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Patent number: 11235330Abstract: Polymer hydrogels and methods for selective retrieval of microbial targets from microwells and other cell culture devices. The methods use semi-permeable, photodegradable hydrogel membranes that permit exchange of nutrients and waste products but seals motile bacteria and other microbes within microwells. Light exposure can be used to degrade the hydrogel membrane in a targeted manner and release the microbes from targeted microwells for further study.Type: GrantFiled: October 5, 2018Date of Patent: February 1, 2022Assignee: Kansas State University Research FoundationInventors: Ryan R. Hansen, Thomas G. Platt, Andre Jacobus van der Vlies
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Patent number: 11208499Abstract: Water soluble, lipophilic starches are provided, which comprise a mixture of functionalized high and low molecular weight maltodextrin molecules. The starches may be formed by dispersing a granular starch in a liquid medium to form a slurry that is simultaneously cooked and subjected to enzyme hydrolysis. Following hydrolysis, the starch is functionalized with an organic acid anhydride reagent, such as octenylsuccinic anhydride. The organic acid anhydride substitution occurs randomly and at various locations within the maltodextrin molecules.Type: GrantFiled: December 27, 2019Date of Patent: December 28, 2021Assignee: Kansas State University Research FoundationInventors: Yong-Cheng Shi, Yanjie Bai, Zhenhua Sun
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Patent number: 11162143Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.Type: GrantFiled: April 21, 2021Date of Patent: November 2, 2021Assignees: The University of Kansas, Kansas State University Research FoundationInventor: Mei He
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Patent number: 11135010Abstract: An electrosurgical device (10) is provided that is operable to deliver microwave energy within a controlled angular expanse to cause targeted tissue ablation. The device (10) comprises a blocking or reflecting material such as cylindrical members (34) that are laterally spaced from the antenna (20) that is operable to emit the microwave energy. The reflecting material creates regions in and/or surrounding the device into which sensors (51), such as thermocouple wires, may be placed to monitor a condition associated with the device or the patient's body.Type: GrantFiled: May 22, 2020Date of Patent: October 5, 2021Assignees: Precision Microwave Inc., Kansas State University Research FoundationInventors: Austin Pfannenstiel, Hojjatollah Fallahi, Punit Prakash
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Patent number: 11135163Abstract: Peptide hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and optionally albumin. The peptide comprises (consists of) a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, hemostatic agents, as well as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.Type: GrantFiled: August 22, 2018Date of Patent: October 5, 2021Assignee: Kansas State University Research FoundationInventors: Xiuzhi S. Sun, Hongzhou Huang, Tiffany L. Carter, Mark L. Weiss
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Publication number: 20210298827Abstract: A novel monitoring method evaluates tissue ablation progress. An antenna in a distal portion of an ablation applicator sends and receives electrical information from the target tissue during ablation. The information is used to determine ablation progress. A related ablation monitoring system includes a power monitor and processor operable to evaluate ablation progress based on reflected electrical properties during the ablation. The invention has particular benefits when used in endoscopic-based microwave ablation.Type: ApplicationFiled: January 26, 2018Publication date: September 30, 2021Applicant: Kansas State University Research FoundationInventors: Punit Prakash, Austin Pfannenstiel
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Patent number: 11122758Abstract: Wheat lines comprising homoeologous pairing promoter genes from chromosome 5Mg from Ae. geniculata and methods of inducing homoeologous recombination in plant breeding from these lines.Type: GrantFiled: October 7, 2017Date of Patent: September 21, 2021Assignee: Kansas State University Research FoundationInventors: Bikram S. Gill, Bernd Friebe, Dal-Hoe Koo
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Publication number: 20210251689Abstract: A tissue ablation system includes an antenna, a microwave energy source, measurement apparatus including a signal generator and a detector, a controller, and a switch assembly arranged to alternatively electrically couple the antenna to the microwave energy source or to the measurement apparatus, wherein the controller is configured to cause the switch assembly to alternate between assessment mode and ablation mode, and wherein the controller is configured to control the delivery of ablative microwave energy during an ablation mode based at least in part on a difference between a then-current broadband reflection coefficient spectrum and a previously measured broadband reflection coefficient spectrum obtained by delivery of a spectrum of individual non-ablative microwave signals and detecting the reflection of same during respective assessment modes.Type: ApplicationFiled: June 12, 2019Publication date: August 19, 2021Applicants: HOLOGIC, INC., KANSAS STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Punit Prakash, Hojjatollah Fallahi, Jessica T. Schenck, Eric A. Frattura
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Patent number: 11090378Abstract: The present disclosure provides the complete nucleotide sequence for porcine parainfluenza virus 1. Immunogenic compositions comprising portions of the nucleotide sequence and proteins expressed therefrom are also provided.Type: GrantFiled: January 4, 2017Date of Patent: August 17, 2021Assignee: Kansas State University Research FoundationInventor: Ben Hause
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Patent number: 11072799Abstract: Methods and recombinant vectors for increasing resistance to Fusarium head blight (FHB) infection in plants. Exogenous Fhb1 nucleic acids are described to generate transgenic plants having increased resistance to FHB relative to a control plant. The nucleotide sequence of the exogenous nucleic acid comprises SEQ ID NO:1, 2, 4, 5, or 6; has at least 95% sequence identity to SEQ ID NO:1, 2, 4, 5, or 6; encodes a protein comprising the amino acid sequence of SEQ ID NO: 3, 7, 8, or 9; or encodes a protein having at least 95% amino acid identity to SEQ ID NO: 3, 7, 8, or 9.Type: GrantFiled: July 8, 2019Date of Patent: July 27, 2021Assignees: Kansas State University Research Foundation, Regents of The University Of MinnesotaInventors: Bikram Gill, Nidhi Rawat, Eduard Akhunov, Michael Pumphrey, James A. Anderson, Sixin Liu
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Patent number: 11066677Abstract: The present disclosure describes genetically-modified plants having enhanced tolerance to multiple abiotic stressors, such as extreme temperatures (heat or cold) and/or drought. Abiotic stress tolerance is enhanced by ectopic expression of a heterologous glutaredoxin. Abiotic stress tolerance (particularly drought) is also enhanced by inhibited function, activity, or expression of an endogenous glutaredoxin. Methods of producing such genetically-modified plants are also disclosed.Type: GrantFiled: June 9, 2017Date of Patent: July 20, 2021Assignees: Kansas State University Research Foundation, Baylor College of MedicineInventors: Sunghun Park, Frank White, Jungeun Park, Kendal Hirschi, Ning-Hui Cheng