Patents Assigned to Kaohsiung Medical University
  • FREE RADICAL-INDUCED INTRACELLULAR DNA DAMAGE REDUCING REAGENT, MEDICAMENT OR HEALTH FOOD AND SKIN CARE PRODUCT OR COSMETIC, AND METHODS FOR PREPARING THE SAME
    Publication number: 20120189652
    Abstract: The invention provides a free radical-induced intracellular DNA damage reducing reagent, including: an effective amount of a Gracilaria sp. extract, serving as an active ingredient, wherein the free radical-induced intracellular DNA damage reducing reagent is capable of reducing free radical-induced intracellular DNA damage. The invention also provides a free radical-induced intracellular DNA damage reducing medicament or health food and a free radical-induced intracellular DNA damage reducing skin care product or cosmetic.
    Type: Application
    Filed: February 23, 2011
    Publication date: July 26, 2012
    Applicants: KAOHSIUNG MEDICAL UNIVERSITY, NATIONAL KAOHSIUNG MARINE UNIVERSITY
    Inventors: Jing-Iong Yang, Hsueh-Wei Chang, Chao-Neng Tseng, Jin-Ching Lee, Chih-yuan Lin, Chi-Chen Yeh
  • Theophylline Derivative Inhibits Osteoporosis
    Publication number: 20120184570
    Abstract: The theophylline derivative disclosed in the present invention is characterized by having the pharmaceutical functions of osteoporosis. The theophylline derivative protects against bone resorption and inflammatory mediator infiltration.
    Type: Application
    Filed: July 8, 2011
    Publication date: July 19, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Jwu-Lai Yeh, Ing-Jun Chen
  • BENZENOID COMPOUNDS OF ANTRODIA CINNAMOMEA, PREPARATION AND ANALYSIS METHOD THEREOF
    Publication number: 20120178945
    Abstract: Disclosed are a method for preparing an n-hexane extract of the fruiting body of Antrodia cinnamomea (AC), wherein the fruiting body of AC is sequentially extracted with the ethanol solution and the n-hexane solution to obtain the n-hexane extract containing at least one benzenoid compound. The amounts of 4,7-dimethoxy-5-(3-methylbut-3-en-1-ynyl)-6-methyl-1,3-benzodioxole, 4,7-dimethoxy-5-methyl-1,3-benzodioxole, antrocamphine A and the combination thereof in the at least one benzenoid compound are determined using chromatography, NMR and HPLC. In addition, the present invention is applicable on detecting the amounts of benzenoid compounds in the AC healthcare food/drug or the fruiting body of AC, and thus owns the industrial values.
    Type: Application
    Filed: January 9, 2012
    Publication date: July 12, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: YANG-CHANG WU, FANG-RONG CHANG, MEI-CHIN LU, YING-CHI DU, TUNG-YING WU, YU-MING HSU
  • METHODS FOR CONJUGATING NUCLEIC ACIDS WITH SMALL MOLECULES
    Publication number: 20120177573
    Abstract: A method for conjugating a nucleic acid with a molecule is provided. The method includes steps of (a) reacting the nucleic acid having a 5?-monophosphate with an activating agent in a first buffer to form a solution; (b) mixing an alcohol with the solution formed in the step (a) to obtain an intermediate; and (c) dissolving the intermediate in a second buffer containing an ethylenediaminetetraacetic acid (EDTA) and adding a nucleophile thereinto to react the intermediate with the nucleophile.
    Type: Application
    Filed: July 22, 2011
    Publication date: July 12, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Tzu-Pin Wang, Yi-Jhang Ciou
  • Hybrid Superparamagnetic Iron Oxide Nanoparticles And Polyethylenimine As A Magnetoplex For Gene Transfection
    Publication number: 20120157626
    Abstract: Disclosed are the nanoparticle and the method for the same, and the preparing method includes steps of mixing polyethylenimine (PEI) with the poly(acrylic acid)-bound iron oxide (PAAIO) to form a PEI-PAAIO polyelectrolyte complex (PEC) and mixing the PEI-PAAIO PEC with genetic material such as plasmid DNA to form the PEI-PAAIO/pDNA magnetic nanoparticle. The PEI-PAAIO/pDNA magnetoplex is highly water dispersible and suitable for long term storage, shows superparamagnetism, low cytotoxicity, high stability and nice transfection efficiency, and thus the PEI-PAAIO PEC can replace PEI as a non-viral gene vector.
    Type: Application
    Filed: March 29, 2011
    Publication date: June 21, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Li-Fang Wang, Shuo-Li Sun, Yu-Lun Lo
  • ETHANOL EXTRACT OF ANTRODIA CAMPHORATA FOR INDUCING APOPTOSIS AND PREPARATION METHOD THEREOF
    Publication number: 20120141524
    Abstract: A preparation method for an ethanol extract of the fruiting body of Antrodia camphorata (EEAC) is provided. The preparation method includes steps of: (a) providing the fruiting body of A. camphorata (AC); (b) extracting the fruiting bodies with a first ethanol solution; and (c) obtaining EEAC. EEAC further can be sequentially extracted or fractioned by n-hexane, ethyl acetate and ethanol, and an n-hexane fraction (FC), an ethyl acetate fraction (FA) and an ethanol fraction (FB) respectively are generated. The growth inhibition and apoptosis induction of leukemia cell line HL 60 are effectively mediated by FA product, in which zhankuic acid A is the bioactive marker. The amount of triterpenoid in the fruiting body of AC can be determined by NMR and HPLC analysis.
    Type: Application
    Filed: February 16, 2012
    Publication date: June 7, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yang-Chang Wu, Mei-Chin Lu, Fang-Rong Chang, Ying-Chi Du, Tung-Ying Wu
  • PROCESSES FOR PREPARING AMINE SALTS OF SILDENAFIL-ANALOGUES AND USE THEREOF
    Publication number: 20120108604
    Abstract: A series of amine salts including a structure of formula (I) and formula (III) have provided. In formula I or formula (III), R1, Ra and RX are as defined in the specification. The amine complex salts disclosed in the present invention are characterized in a pro-drug active form and various pharmaceutical function.
    Type: Application
    Filed: March 10, 2011
    Publication date: May 3, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Ing-Jun Chen
  • METHOD FOR DETERMINING RISK FOR KIDNEY STONES DEVELOPING OR RECURRING AND METHOD FOR USING SINGLE-NUCLEOTIDE POLYMORPHISM RS12313273 AS BIOMARKER FOR DETERMINING DEVELOPMENT OR RECURRENCE OF KIDNEY STONE
    Publication number: 20120100539
    Abstract: The invention provides a method for determining a risk for kidney stones to develop in a subject, including: obtaining a biosample of the subject; detecting the presence of the single-nucleotide polymorphism rs12313273 (C/T) at position 30881 of the ORAI1 gene (SEQ ID No.: 1) in the biosample; and determining a risk for kidney stones to develop in the subject, wherein if the presence of a C allele of the single-nucleotide polymorphism rs12313273 (C/T) is detected, it indicates that the subject has an increased risk for kidney stones to develop.
    Type: Application
    Filed: October 20, 2011
    Publication date: April 26, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Wei-Chiao Chang, Yii-Her Chou, Suh-Hang Hank Juo, Mu-En Liu, Chen-Chia Chang, Yi-Ching Chiu
  • PHARMACEUTICAL COMPOSITIONS COMPRISING CHLOROPHENYL PIPERAZINE DERIVED COMPOUNDS AND USE OF THE COMPOUNDS IN PRODUCING MEDICAMENTS
    Publication number: 20120094985
    Abstract: The invention relates to a pharmaceutical composition for treating serotonergic neurotransmission related disease or condition, including an effective amount of a chlorophenylpiperazine derived compound of Formula (I), or the pharmaceutically acceptable salt thereof. The pharmaceutical composition is safe and does not have side effect on lethargy.
    Type: Application
    Filed: December 29, 2011
    Publication date: April 19, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Ing-Jun Chen
  • USE OF KMUP-3 FOR MYOCARDIAL INFARCTION
    Publication number: 20120095013
    Abstract: A pharmaceutical composition for improving a cardiac function is provided. The pharmaceutical composition comprises an effective amount of an active component being one of a KMUP-3 compound and a salt thereof.
    Type: Application
    Filed: April 12, 2011
    Publication date: April 19, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Ing-Jun Chen
  • Method for gender identification of eagles with probe-based real-time PCR and the sequences used for gender identification of eagles
    Patent number: 8158358
    Abstract: A method for gender identification of eagles includes: providing a DNA of an eagle; performing a probe-based real-time PCR using the DNA as a template, a universal primer pair P2/P8 as a primer pair and a first probe and a second probe as probes, wherein the 5? ends of the first probe and the second probe are labeled with a first fluorescent dye and a second fluorescent dye, respectively, and the first probe is a sequence with about 15-38 nucleotides in length of SEQ ID No. 1 and the second probe is a sequence with about 15-44 nucleotides in length of SEQ ID No. 2; and analyzing a result of the PCR, wherein if the result is positive for both the first and the second fluorescent dye, the eagle is a female, and if the result is positive for only the first fluorescent dye, the eagle is a male.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: April 17, 2012
    Assignee: Kaohsiung Medical University
    Inventors: Hsueh-Wei Chang, Chien-Chung Cheng, De-Leung Gu, San-Hua Su
  • METHOD FOR PREPARING A COUMARIN COMPOUND, CHROMENE COMPOUND, AND METHOD FOR PREPARING A CHROMENE COMPOUND
    Publication number: 20120088923
    Abstract: Disclosed herein is a method for preparing a coumarin compound of formula (F), in which R1, R2, and R3 are independently H, C1˜C7 alkoxy, C1˜C7 alkyl, phenoxy, benzyloxy, or a halogen atom; R4 is an alkyl group; and Ar is an optionally substituted aryl group, the method including: treating a chromene compound having the following formula (E) with an acid in the presence of water. A chromene compound of formula (E) and a method for preparing the chromene compound of formula (E) are also disclosed.
    Type: Application
    Filed: October 11, 2010
    Publication date: April 12, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Eng-Chi Wang, Jui-Chi Tsai, Sie-Rong Li, Po-Yuan Chen
  • Isoxazole derivatives and pharmaceutical compositions comprising the same
    Patent number: 8138184
    Abstract: An isoxazole derivative is provided. The isoxazole derivative has following formula: wherein R1, R2, R3, R4 and R5, independently, include hydrogen, hydroxy or C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy. The invention also provides a pharmaceutical composition for treatment of osteoporosis and cancer including an isoxazole derivative or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: March 20, 2012
    Assignee: Kaohsiung Medical University
    Inventors: Cherng-Chyi Tzeng, Yeh-Long Chen, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang, Yin-Chih Fu
  • POLY(LACTIC-GLYCOLIC)ACID CROSS LINKED ALENDRONATE (PLGA-ALN) A SHORT TERM CONTROLLED RELEASE SYSTEM FOR STEM CELL DIFFERENTIATION AND DRUG DELIVERY
    Publication number: 20120045831
    Abstract: The present invention relates to a bisphosphonates and synthetic polymeric carriers to form a sustained release system. The present invention also provides a method for preparing a sustained release system, comprising activation of the synthetic polymeric carriers and the cross linking reaction. The present invention further provides methods for enhancing stem cell differentiation into osteogenic lineage and chondrogenic lineage, which comprise culturing a population of stem cells in specific micro-environments.
    Type: Application
    Filed: August 20, 2010
    Publication date: February 23, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Mei-Ling Ho, Je-Ken Chang, Rajalakshmanan Eswaramoorthy, Shun-Cheng Wu
  • METHOD FOR DETERMINING A RISK, FOR A SUBJECT, OF SUFFERING FROM ATOPIC DERMATITIS OR SEVERITY OF ATOPIC DERMATITIS FOR A SUBJECT SUFFERING FROM ATOPIC DERMATITIS AND METHOD FOR USING A SINGLE-NUCLEOTIDE POLYMORPHISM RS12313273 AS A BIOMARKER FOR DETERMINING THE DEVELOPMENT OR SEVERITY OF ATOPIC DERMATITIS
    Publication number: 20120028827
    Abstract: The invention provides a method for determining a risk, for a subject, of suffering from atopic dermatitis, including: obtaining a biosample of the subject; detecting the presence of the single-nucleotide polymorphism rs12313273 (C/T) at position 30881 of the ORAI1 gene (SEQ ID No.: 1) in the biosample; and determining the risk, for the subject, of suffering from atopic dermatitis, wherein the presence of a C allele or genotype CC of the single-nucleotide polymorphism rs12313273 (C/T) indicates that the subject is at increased risk for suffering from atopic dermatitis.
    Type: Application
    Filed: July 28, 2011
    Publication date: February 2, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Wei-Chiao Chang, Chih-Hung Lee, Suh-Hang Juo, Wei-Chiao Chen, Hsin-Su Yu
  • ANTI-POLYETHYLENE GLYCOL ANTIBODY EXPRESSING CELL QUANTIFY ANY FREE POLYETHYLENE GLYCOL AND POLYETHYLENE GLYCOL-DERIVATIZED MOLECULES
    Publication number: 20120015380
    Abstract: In this invention, anti-PEG antibodies or anti-methoxyl-PEG (anti-CH3O-PEG) antibodies were expressed on cell surface which can collocate with a biotinylated anti-PEG antibody (AGP4-Biotin) or biotinylated PEG (PEG-Biotin) to develop a cell-based sandwich ELISA or a cell-based competition ELISA, respectively. Both of these two methods could sensitively quantify free PEG and PEG-modified macromolecules (proteins, nanoparticles and liposomes) as sensitive as nano-gram level.
    Type: Application
    Filed: February 22, 2011
    Publication date: January 19, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Tian-Lu Cheng, Steven R. Roffler, Kuo-Hsiang Chuang, Ssu-Jung Lu
  • Implant Surface Treatment Method Having Tissues Integrated
    Publication number: 20110318835
    Abstract: The present disclosure uses different kinds of surface treatment processes on titanium-made dental implants. The growth and attachment conditions of bone cells (MC3T3-E), fibroblasts(NIH 3T3) and epidermal cells (XB-2) on the metal surface of titanium slices with different surface treatments are observed. Tetra-calcium phosphate is used to perform secondary sand-blasting process to clean up the metal surface and provide calcium ions for osteoblastoma physiology. Thus, by adjusting the cells adhesive and proliferative abilities, the success rate of the clinical applications in dental implant is improved.
    Type: Application
    Filed: September 1, 2010
    Publication date: December 29, 2011
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Wen-Cheng Chen, Chun-Cheng Hung, Chia-Ling Ko
  • Nanoparticles and Use Thereof
    Publication number: 20110318331
    Abstract: A novel nanoparticle and use thereof were provided in the present invention. In particular, the nanoparticle is used for delivering therapeutic component, such as oligonucleotide and hydrophobic drug.
    Type: Application
    Filed: June 29, 2010
    Publication date: December 29, 2011
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Chih-Kuang Wang, Gwo-Jaw Wang, Mei-Ling Ho, Cherng-Chyi Tzeng, Je-Ken Chang, Yin-Chih Fu
  • CONTROLLED RELEASE SYSTEM AND MANUFACTURING METHOD THEREOF
    Publication number: 20110312885
    Abstract: A controlled release system and manufacturing method is provided. The method comprises providing a first aqueous solution containing a hydrophilic drug and an alkaline agent, providing an organic solution containing a hydrophobic molecule, providing a second aqueous solution containing a hydrophilic surfactant, mixing the first hydrophilic solution with the organic solution to form a first emulsion, and mixing the first emulsion with a second aqueous solution to form a second emulsion containing delayed-release microsphere.
    Type: Application
    Filed: August 12, 2011
    Publication date: December 22, 2011
    Applicant: Kaohsiung Medical University
    Inventors: Yin-Chih Fu, Chih-Kuang Wang, Gwo-Jaw Wang, Mei-Ling Ho, Hui-Ting Chen, Je-Ken Chang, Cherng-Chyi Tzeng
  • Method for Controlled Release of Parathyroid Hormone from Encapsulated Poly(Lactic-Glycolic)Acid Microspheres
    Publication number: 20110305766
    Abstract: The present invention provides a method for producing a controlled release microsphere with mean average size greater than 50 ?m, comprising preparing a water-in-oil (w/o) emulsion comprising an inner aqueous layer containing a pharmaceutically effective amount of a biologically active polypeptide with activity similar to parathyroid hormone, and an oil layer containing a polymer substance of poly (lactic-co-glycolic acid) (PLGA), then adding the w/o emulsion into aqueous polyvinyl alcohol (PVA) solution to form a water-in-oil-in-water (w/o/w) double emulsion and then desorbing the solvent in the oil layer. The present invention also provides a controlled release microsphere prepared by the method and use thereof.
    Type: Application
    Filed: June 14, 2010
    Publication date: December 15, 2011
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Yin-Chih Fu, Cherng-Chyi Tzeng, Eswaramoorthy Rajalakshmanan